Aggregate (Hoboken, N.J.)最新文献

The prosperous evolution of conductive hydrogel-based skin sensors is attracting tremendous attention nowadays. Nevertheless, it remains a great challenge to simultaneously integrate excellent mechanical strength, desirable electrical conductivity, admirable sensing performance, and brilliant healability in hydrogel-based skin sensors for high-performance diagnostic healthcare sensing and wearable human-machine interface, as well as robust photothermal performance for promptly intelligent photothermal therapy followed by the medical diagnosis and superior electromagnetic interference (EMI) shielding performance for personal protection. Herein, a flexible healable MXene hydrogel-based skin sensor is prepared through a delicate combination of MXene (Ti₃C₂T_x) nanosheets network with the polymeric network. The as-prepared skin sensor is featured with significantly enhanced mechanical, conducting, and sensing performances, along with robust self-healability, good biocompatibility, and reliable injectability, enabling ultrasensitive human motion monitoring and teeny electrophysiological signals sensing. As a frontier technology in artificial intelligence, machine learning can facilitate to efficiently and precisely identify the electromyography signals produced by various human motions (such as variable finger gestures) with up to 99.5% accuracy, affirming the reliability of the machine learning-assisted gesture identification with great potential in smart personalized healthcare and human-machine interaction. Moreover, the MXene hydrogel-based skin sensor displays prominent EMI shielding performance, demonstrating the great promise of effective personal protection.

In this work, Yoon and co-workers developed a nanostructured supramolecular phototherapeutic agent based on Förster resonance energy transfer mechanism. Such nanostructured phototherapeutic agent can enable the visualization of a tumor with a photoacoustic signal-to-liver ratio as high as 11.9, and ultimately achieving a notable therapeutic effect in a preclinical model at a low dose through the photodynamic and photothermal synergistic therapy (e514).

A novel strategy for nanoparticle size enlargement is developed by constructing a pair of similar nanodrugs, referred to as “twins-like nanodrugs (TLNs)”. The TLNs synchronously transport in blood, coalesce inside tumor and achieve particle aggregation for ultrasound-triggerable penetrative drug delivery (e476).

Aggregation-induced emission (AIE) materials emitting near-infrared (NIR) light offer advantages like deep tissue penetration, minimal background interference, and negligible tissue damage. Consequently, NIR-AIE holds great promise in biomedical applications, including cell and living imaging, photothermal and photodynamic therapy, making it a prominent research focus (e505).

An anti-drug-resistant bacteria core-shell structure is designed, containing antibacterial zeolitic imidazolate framework-8 (ZIF-8) as the core and bactericidal benzalkonium chloride (BAC) templated rough-surface mesostructured silica nanocomposite (RMSN) as the shell. The resultant ZIF-8@RMSN nanocomposite exhibits sustained release of BAC and zinc ions, leading to enhanced antibacterial and biofilm elimination properties against drug-resistant bacterial. In addition, ZIF-8@RMSN modified antibacterial band-aid possesses excellent anti-drug-resistant bacterial infection properties both in vitro and in vivo (e523).

Clusterization-triggered emissive (CTE) materials have attracted great attention in recent years. The regulation of the emission property of materials with CTE property through supramolecular interactions is an excellent strategy for the construction of smart fluorescent materials. In this work, we have prepared a regulatable supramolecular polymer network with CTE properties through pillararene-based host−guest interactions. The pillar[5]arene-grafted poly(methyl methacrylate) (PMMA) showed a classic CTE character. After adding Brooker's merocyanine-grafted polymer to the solution of the pillar[5]arene-containing PMMA, the supramolecular polymer network gel formed by the host−guest interactions between pillararene and Brooker's merocyanine guest. This supramolecular network showed brighter fluorescence than the pillar[5]arene-grafted PMMA in the solid state. In addition, the fluorescence emission of the supramolecular network can be further regulated by pH conditions. After adding an acid, the Brooker's merocyanine-containing guest polymer was protonated, and the supramolecular network changed to a protonated network through host−guest interactions between protonated Brooker's merocyanine guest and pillararene. Interestingly, the fluorescence was quenched when the supramolecular network turned into the protonated network. After adding a base, the protonated network can convert back to the original network, along with recovery of the fluorescence. Therefore, the regulation of the fluorescence of the supramolecular polymer materials with CTE was successfully realized by pillararene-based host−guest interactions. Furthermore, this tailorable fluorescent supramolecular polymer network system was applied as an information encryption material.

Droplet-based bioprinting has shown remarkable potential in tissue engineering and regenerative medicine. However, it requires bioinks with low viscosities, which makes it challenging to create complex 3D structures and spatially pattern them with different materials. This study introduces a novel approach to bioprinting sophisticated volumetric objects by merging droplet-based bioprinting and cryobioprinting techniques. By leveraging the benefits of cryopreservation, we fabricated, for the first time, intricate, self-supporting cell-free or cell-laden structures with single or multiple materials in a simple droplet-based bioprinting process that is facilitated by depositing the droplets onto a cryoplate followed by crosslinking during revival. The feasibility of this approach is demonstrated by bioprinting several cell types, with cell viability increasing to 80%–90% after up to 2 or 3 weeks of culture. Furthermore, the applicational capabilities of this approach are showcased by bioprinting an endothelialized breast cancer model. The results indicate that merging droplet and cryogenic bioprinting complements current droplet-based bioprinting techniques and opens new avenues for the fabrication of volumetric objects with enhanced complexity and functionality, presenting exciting potential for biomedical applications.

Existential state of solutes substantially affects the efficiency and direction of various chemical and biological processes, about which current consensus is still limited at macro and micro levels. At the trace level, solutes assume a pivotal role across a spectrum of critical fields. However, their existential states, especially at interfaces, remain largely elusive. Herein, an exceptional evolution of solute molecules is unveiled from micro to trace, solution to interface, with the aid of surface-enhanced Raman spectroscopy, extinction, DLS and theoretical simulations. Given predominant existence of monomers within the solution, these aggregates dominate the interfacial behavior of solute molecules. Moreover, a universal, aggregate-controlled mechanism is demonstrated that aggregates triggered by cosolvent, which can dramatically promote efficiency of catalytic reactions. The results provide novel insights into the interaction mechanisms between reactants and catalysts, potentially offering fresh perspectives for the manipulation of multiphase catalysis and related biological processes.

The development of tumor drug microcarriers has attracted considerable interest due to their distinctive therapeutic performances. Current attempts tend to elaborate on the micro/nano-structure design of the microcarriers to achieve multiple drug delivery and spatiotemporal responsive features. Here, the desired hydrogel microspheres are presented with spatiotemporal responsiveness for the treatment of gastric cancer. The microspheres are generated based on inverse opals, their skeleton is fabricated by biofriendly hyaluronic acid methacrylate (HAMA) and gelatin methacrylate (GelMA), and is then filled with a phase-changing hydrogel composed of fish gelatin and agarose. Besides, the incorporated black phosphorus quantum dots (BPQDs) within the filling hydrogel endow the microspheres with outstanding photothermal responsiveness. Two antitumor drugs, sorafenib (SOR) and doxorubicin (DOX), are loaded in the skeleton and filling hydrogel, respectively. It is found that the drugs show different release profiles upon near-infrared (NIR) irradiation, which exerts distinct performances in a controlled manner. Through both in vitro and in vivo experiments, it is demonstrated that such microspheres can significantly reduce tumor cell viability and enhance the efficiency in treating gastric cancer, indicating a promising stratagem in the field of drug delivery and tumor therapy.