Aggregate (Hoboken, N.J.)最新文献

Aggregated lysine mimics antimicrobial peptides (AMPs) by disrupting bacterial membranes, interfering with metabolism, and inhibiting protein synthesis. With Fe³⁺ hydrolysis, lysine coordination, and ultrasmall Au nanoparticle deposition, FeOOH@Fe-Lysine@Au shows AMP-like antibacterial activity and reactive oxygen species generation, providing an effective approach for cariogenic biofilm microenvironment-activated caries treatment (e578).

Near unity photoluminescence efficiency has been achieved in green emitting (TEP)₂Cu₂Br₄ and orange emitting (TEP)₂Cu₄Br₆. In both cases, emission originates from self-trapped excitons localized on the copper(I) halide structural units. The sensitivity of these compounds to the external stimuli coupled with their ultrabright emission allows their consideration for applications such as solid-state lighting, scintillation, sensing, information storage, and anticounterfeiting (e602).

In this study, supramolecular self-assembled nanoparticles were developed with multi-functional properties of macrophage escape, cardiac targeting, and drug release for the treatment of myocardial infarction. The nanoparticles reduced cardiomyocyte apoptosis, alleviated myocardial interstitial fibrosis, and enhanced cardiac function based on the mechanism of the enhancement in mitophagy and alleviation in mitochondrial damage (e563).

Donor‒acceptor covalent organic frameworks (D‒A COFs) have been regarded as promising materials for photocatalytic water splitting because of their tunable band gaps. However, their efficiency is hindered by fast charge recombination and low photostability. Herein, we proposed a donor structural engineering strategy for improving the photocatalytic activity of D‒A COFs to tackle these problems. Two benzothiadiazole-based D‒A COFs (DHU-COF-BB and DHU-COF-BP) with distinct donors were prepared for photocatalytic H₂ evolution reaction (HER). As a comparison, DHU-COF-TB without benzothiadiazole moieties was also designed and synthesized. Impressively, the photocatalytic H₂ production rate of DHU-COF-BB reaches 12.80 mmol g⁻¹ h⁻¹ under visible light irradiation (≥420 nm), which was nearly 2.0 and 3.1 times higher than that of DHU-COF-BP (6.47 mmol g⁻¹ h⁻¹) and DHU-COF-TB (4.06 mmol g⁻¹ h⁻¹), respectively. In addition, the apparent quantum efficiency (AQE) of DHU-COF-BB was up to 5.04% at 420 nm. Photocatalytic and electrochemical measurements indicate that the enhanced hydrogen evolution activity of DHU-COF-BB can be ascribed to the introduction of appropriate benzene moiety into the donors, which increases the charge separation efficiency and thereby suppresses the electron‒hole recombination. Density functional theory (DFT) calculations revealed that both triphenylamine and benzothiadiazole units are the main active sites for HER over the DHU-COF-BB. This work provides new insight into the photocatalytic hydrogen production activity of D‒A COFs by a donor structural engineering strategy.

Biomolecules with metals can form supramolecular nanomaterials through coordination assembly, opening new avenues for cancer theranostics and bringing unique insights into personalized nanomedicine. These biomaterials have been considered versatile and innovative nanoagents due to their structure‒function control, biological nature, and simple preparation methods. This review article summarized the recent developments in multicomponent nanomaterials formed from metal coordination interactions with amino acids, peptides, and proteins, together with anticancer drugs, for cancer theranostics. We discussed the role of functional groups anchored in building blocks for coordination interactions, and subsequently, the types of interactions were examined from a structure‒function perspective. Amino acids with different metals and anticancer drugs forming supramolecular nanomaterials and their anticancer mechanisms were highlighted. Peptides with different metals and anticancer drugs, proteins with metals and anticancer drugs used for material formations, and anticancer activity have been discussed. Ultimately, the conclusion and future outlook for multicomponent supramolecular nanomaterials offer fundamental insights into fabrication design and precision medicine.

The design and fabrication of advanced soft actuators with programmable actuation are highly desirable in constructing intelligent soft robots. In this work, a programmable light-driven liquid crystalline network (LCN)-based soft actuator was judiciously designed and prepared by constructing structural anisotropy across the thickness of the film. A three-dimensional (3D) deformable LCN actuator was realized by polymerization-induced phase separation of small-molar-weight monomers and polymer networks. The resultant anisotropic LCN displays anisotropic microscale nanoporous architecture across the thickness in addition to uniform alignment at the molecular scale. The actuation behaviors of LCN film are tunable by adjusting the size and distribution of nanopores in LCN bulk via changing polymerization conditions and monomer components. More importantly, the nanoporous LCN film can be harnessed as a promising template to achieve diverse light responsiveness by changing the photothermal dyes via a feasible washing and refilling process, demonstrating a reprogrammable light-driven soft actuator.

Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non-invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle-targeted PDT strategy is supposed to be quite promising. Particularly, lipid droplets (LDs)-localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis. This review provides a comprehensive summary of the advancements of LDs-localized photosensitizers (PSs) according to their chemical structures and functions. Especially, these PSs are featured with fluorescence emission, thereby facilitating an imaging-guided phototherapy. The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed.

Persistent biofilm infections pose a critical health threat with their relentless presence and amplified antibiotic resistance. Traditional antibacterial photodynamic therapy can inhibit bacteria extracellularly but struggles to control biofilm formation and virulence. Thus, there is an urgent need to develop photosensitizers, such as ultra-small gold nanoclusters (AuNCs), that can penetrate biofilms and internalize into bacteria. However, AuNCs still face the challenge of insufficient reactive oxygen species (ROS) production and limited near-infrared light absorption. This study develops a model of indocyanine green (ICG)-sensitized AuNCs with atomic-precision size effect. This approach achieved near-infrared light absorption while inhibiting radiation transitions, thereby regulating the generation of ROS. Notably, different-sized AuNCs (Au₁₀NCs, Au₁₅NCs, Au₂₅NCs) yielded varied ROS types, resulting from different energy level distributions and electron transfer rates. ICG-Au₁₅NCs achieved a treatment efficacy of 99.94% against Staphylococcus aureus infections in vitro and significantly accelerated wound healing in vivo. Moreover, this study highlights the unique role of ICG-AuNCs in suppressing quorum sensing, virulence, and ABC transporters compared to their larger counterparts. This strategy demonstrates that atomic-precision size effect of AuNCs paves the way for innovative approaches in antibacterial photodynamic therapy for infection control.

Circularly polarized luminescence (CPL) materials with delayed fluorescence have attracted much attention due to their ability to efficiently trap triplet state excitons, thereby improving the photoluminescence quantum yields of CPL materials. However, much effort has been normally focused on the utilization of T₁ excitons but seldom on the utilization of higher excited triplet state T_n (n > 1) excitons. Rational manipulation of higher excited triplet state T_n (n > 1) excitons and suppression of Kasha's rule of CPL materials remains a major challenge. Herein, two gold complex enantiomers ((R/S)-BPAuBC) based on axially chiral binaphthyls and 3,6-Di-tert-butylcarbazole groups are synthesized and systematically investigated. These materials exhibit aggregation-induced circularly polarized delayed fluorescence. Circularly polarized delayed fluorescence was found to be enabled by activating high-level reverse intersystem crossing (hRISC). The anti-Kasha phosphorescence at 77 K proves that the exciton has a large population in the high-lying triplet state T₂, which allows the effective hRISC process to cross back to the singlet state S₁ and emit delayed fluorescence. In addition, CPL “on–off” switching is further achieved in nanoparticles by acid–base stimulus, showing its potential as an acid–base responsive material.