Aging and health research最新文献

{"title":"Pain and sleep disturbance were negatively associated with function and community mobility after hospitalization","authors":"Susan N. Hastings ,&nbsp;Karen M. Stechuchak ,&nbsp;Kasey Decosimo ,&nbsp;Caitlin B. Kappler ,&nbsp;Daniel Guidot ,&nbsp;Kelli D. Allen ,&nbsp;Amy Webster ,&nbsp;Ashley Choate ,&nbsp;Courtney H. Van Houtven ,&nbsp;Cassie Meyer ,&nbsp;Jaime Hughes ,&nbsp;Cynthia J. Coffman","doi":"10.1016/j.ahr.2025.100268","DOIUrl":"10.1016/j.ahr.2025.100268","url":null,"abstract":"<div><h3>Background</h3><div>The inconsistent nature of functional recovery after hospitalization points to gaps in our understanding of its determinants. The goal of this study was to examine associations between post-discharge pain interference and sleep disturbance on function and community mobility following hospitalization for medical illness.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of data collected as part of a larger study evaluating a hospital-based mobility program. Participants were aged ≥60 and within one month of discharge from one of eight Veterans Affairs (VA) hospitals between September 2017 and August 2019. Data were collected through telephone surveys. Primary predictors of pain interference and sleep disturbance were measured by PROMIS-4 short forms. Outcomes were function measured by Late-Life Function and Disability Instruments (LLFDI overall function and advanced lower extremity function scores) and community mobility measured by Life Space. For each outcome, separate multiple linear regression models were fit including the key explanatory variables of interest and selected covariates.</div></div><div><h3>Results</h3><div>Participants (<em>n</em> = 618) were mean age 70.6 years, 95% male, 25% Black, and 34% lived alone; overall eight percent reported being discharged to a nursing home, and 15% being readmitted to the hospital. Overall, 39.9% of participants reported moderate/severe pain interference; of these, approximately half also reported at least some degree of sleep disturbance. Moderate/severe sleep disturbance was endorsed by 19%; of these, more than 75% also experienced some degree of pain interference. In adjusted models, pain interference and sleep disturbance were negatively associated with total function, lower extremity function, and community mobility (P-values &lt;0.01).</div></div><div><h3>Conclusions</h3><div>In this sample of recently hospitalized older adults, pain interference and sleep disturbance were independently associated with functional limitations and reduced community mobility. Primary care providers should consider assessing for pain and sleep problems during post-hospitalization visits to support optimal functional recovery.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"6 1","pages":"Article 100268"},"PeriodicalIF":2.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145941268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced cognitive assessment for dementia in Sub-Saharan Africa: Cultural adaptations and validity","authors":"Tsimona Dinku Bonger ,&nbsp;Zemichael Getu Alemayehu","doi":"10.1016/j.ahr.2025.100269","DOIUrl":"10.1016/j.ahr.2025.100269","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"6 1","pages":"Article 100269"},"PeriodicalIF":2.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double-edged sword: Exploring the neuroprotective/damaging mechanisms of complement activation in Alzheimer's disease","authors":"Jie Wang ,&nbsp;Jie Wu ,&nbsp;Xiaoxi Ma ,&nbsp;Yuhan Wu ,&nbsp;Zhenxu Xiao ,&nbsp;Xiaowen Zhou ,&nbsp;Ding Ding ,&nbsp;Qian-hua Zhao","doi":"10.1016/j.ahr.2025.100267","DOIUrl":"10.1016/j.ahr.2025.100267","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD), the most widespread neurodegenerative disorder afflicting older adults, is characterized by a progressive decline in cognitive function, behavior, and social skills. The complement system, a cornerstone of the innate immune system, plays a crucial role in rapidly recognizing and clearing foreign pathogens, damaged cells, and cellular debris. Recently, there has been growing interest in understanding the intricate roles of complement components in both normal brain development and neurodegenerative processes.</div></div><div><h3>Methods</h3><div>We reviewed the activation and role of the complement system in AD, specifically highlighting its stage-dependent functional duality, including both protective and detrimental roles. Furthermore, we assessed current and promising therapeutic strategies targeting complement components in AD.</div></div><div><h3>Results</h3><div>The early stage, defined by pre-plaque pathology, was dominated by protective clearance mechanisms, while the progressive phase, characterized by widespread amyloid and tau pathology, exhibited detrimental neuroinflammation and synaptic loss.</div></div><div><h3>Conclusions</h3><div>Understanding the dual roles of the complement system in AD is crucial for developing targeted therapies.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 4","pages":"Article 100267"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata regarding missing Editor Disclosure statements in previously published articles","authors":"","doi":"10.1016/j.ahr.2025.100260","DOIUrl":"10.1016/j.ahr.2025.100260","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 4","pages":"Article 100260"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Alzheimer’s disease perceptions among Korean Americans through an online community: A text mining approach","authors":"Grace E. Yi ,&nbsp;Michin Hong","doi":"10.1016/j.ahr.2025.100266","DOIUrl":"10.1016/j.ahr.2025.100266","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer’s disease and related dementia (ADRD) have a profound impact on older adults and their families. Research indicates that racial/ethnic minority groups, including Korean Americans (KAs), encounter disparities in disease prevalence, diagnosis delays, and access to social and healthcare resources. KAs, mostly first-generation immigrants, face unique challenges due to limited English proficiency and cultural differences that impede healthcare access. This study aims to explore discussions about ADRD among KAs to gain insights into their perceptions and experiences.</div></div><div><h3>Methods</h3><div>We analyzed 882 posts from MissyUSA, one of the largest online KAs communities, collected between 2015 and 2023. A text-mining thematic analysis was employed.</div></div><div><h3>Results</h3><div>Four themes emerged: (1) transnational caregiving, (2) the need for culturally and linguistically appropriate care services, (3) the need for caregiving assistance from the public sector, and (4) preventative measures for ADRD.</div></div><div><h3>Conclusions</h3><div>The findings highlight the complex needs of KAs in global contexts. Many participants struggled with finding reliable care information and facilities for parents in the U.S. and Korea, reflecting the challenges of caregiving as immigrants. Locating and accessing culturally and linguistically compatible healthcare services and public support in the U.S. intensified KA caregiving families. Culturally and linguistically tailored public health education to correct misinformation about ADRD and caregiving within this community is needed. Implications for practice and policy are discussed.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 4","pages":"Article 100266"},"PeriodicalIF":2.0,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does body mass index predict changes in body composition and metabolic markers in response to testosterone therapy?","authors":"Maryam Tetlay ,&nbsp;Marcos Villarreal ,&nbsp;Lina Aguirre ,&nbsp;Georgia Colleluori ,&nbsp;FNU Deepika ,&nbsp;Rui Chen ,&nbsp;Dennis T. Villareal ,&nbsp;Clifford Qualls ,&nbsp;Reina Armamento-Villareal","doi":"10.1016/j.ahr.2025.100265","DOIUrl":"10.1016/j.ahr.2025.100265","url":null,"abstract":"<div><h3>Background</h3><div>Despite reported improvements in body composition, metabolic profile, skeletal outcomes and symptoms from testosterone (T) therapy in men with hypogonadism, it remains unclear whether baseline body mass index (BMI) affects response. The objective of this study is to determine if baseline BMI influences response to T therapy.</div></div><div><h3>Methods</h3><div>This is a secondary analysis of data from a clinical trial on pharmacogenetics of response to T therapy in men with average morning <em>T</em> &lt; 300 ng/dl, given intramuscular T cypionate 200 mg every 2 weeks for 18 months. Participants were divided into BMI categories: BMI 1 (&lt; 30 kg/m²), BMI 2 (30–34.99 kg/m²), and BMI 3 (≥35 kg/m²). T, estradiol, adipokines, metabolic markers, body composition, bone mineral density, bone turnover markers and total symptom score were assessed at baseline, 6, 12 and 18 months.</div></div><div><h3>Results</h3><div>All 3 groups had improvement in body composition, though BMI 1 and 2 had greater increases in truncal fat-free and truncal lean mass than BMI 3. Appendicular fat mass declined the most in BMI 1 and the least in BMI 3.. Leptin declined in all 3 groups with the most in BMI 1, while adiponectin significantly decreased only BMI 2. All groups showed increase in lumbar spine BMD. BMI 1 and 2 had improvement in symptoms but not BMI 3.</div></div><div><h3>Conclusion</h3><div>Our study shows that men with a BMI &lt;35 derived the greatest benefit from T therapy in terms of changes in body composition and symptoms, while those with higher BMI benefited the least.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 4","pages":"Article 100265"},"PeriodicalIF":2.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health perceptions and behaviors among aging same-gender Kazakh ethnic minority siblings in rural and urban Xinjiang, China: The impact of migration","authors":"Jing Wang ,&nbsp;Tianjun Zhou ,&nbsp;Yinan Zhang ,&nbsp;Olivia Black ,&nbsp;Xiaolin Wang ,&nbsp;Ruolin Ren ,&nbsp;Morgan Shapiro ,&nbsp;Bei Wu","doi":"10.1016/j.ahr.2025.100264","DOIUrl":"10.1016/j.ahr.2025.100264","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates health perceptions and behaviors among Kazakh-Chinese same-sex siblings in rural and urban Xinjiang, China. It explores how environmental context and migration experiences shape differences in health-related outcomes.</div></div><div><h3>Methods</h3><div>We conducted semi-structured interviews with 24 participants (12 same-gender sibling dyads), with one sibling residing in an urban setting and the other in a rural area. A convergent mixed-methods approach was used, combining qualitative interview data with demographic and health screening information to examine health behaviors and perceptions across environments.</div></div><div><h3>Results</h3><div>Urban siblings demonstrated greater access to healthcare and health literacy but reported challenges including environmental pollution, stress, and diminished traditional social engagement. In contrast, rural siblings maintained traditional dietary habits and robust social rituals but faced limited healthcare access, irregular eating patterns, and more physical labor. Both groups expressed concern about food safety and environmental degradation. Religious and spiritual beliefs were found to influence participants' health behaviors and understanding of well-being.</div></div><div><h3>Conclusions</h3><div>Health outcomes among Kazakh-Chinese older adults are shaped by a complex interplay of cultural tradition, religious belief, and environmental exposure. These findings underscore the need for culturally sensitive, place-based public health strategies to support healthy aging among ethnic minorities undergoing rural–urban transitions.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 4","pages":"Article 100264"},"PeriodicalIF":2.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145271155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community nurses’ views on information provision at dementia diagnosis: A cross-sectional survey","authors":"Elise Mansfield ,&nbsp;Alison Zucca ,&nbsp;Claudia Meyer ,&nbsp;Jamie Bryant ,&nbsp;Amy Waller","doi":"10.1016/j.ahr.2025.100263","DOIUrl":"10.1016/j.ahr.2025.100263","url":null,"abstract":"<div><h3>Background</h3><div>Receiving a diagnosis of dementia can be overwhelming. Information provided to people with dementia and their support persons following diagnosis is suboptimal. Community nurses have a significant role in providing care to people with dementia.</div></div><div><h3>Method</h3><div>This study examined community nurses’ views on the information that should be provided to people with dementia at diagnosis, and how it should be delivered. Participants completed an online survey including nine items about the type of information that should be delivered at diagnosis, and three items about strategies for information delivery.</div></div><div><h3>Results</h3><div>Most participants (<em>n</em> = 92; 96.7–100 %) agreed with providing information about topics including future dementia symptoms, lifestyle modifications, and Advance Care Directives. Fewer participants (66.3 %) agreed with providing information about probable life expectancy. There was strong support (98.9 %) for offering a follow-up consultation within two weeks of the diagnosis.</div></div><div><h3>Conclusions</h3><div>These findings represent a first exploration of community nurses’ views on optimal dementia care.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 4","pages":"Article 100263"},"PeriodicalIF":2.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Short-term consequences after COVID-19 in older people with epilepsy” [Aging and Health Research Vol 4 Issue 2 (June 2024) 100184]","authors":"Yiling Chen ,&nbsp;Zhenxu Xiao ,&nbsp;Xiaowen Zhou ,&nbsp;Luxin Jiang ,&nbsp;Jianhong Wang ,&nbsp;Ding Ding ,&nbsp;Guoxing Zhu","doi":"10.1016/j.ahr.2025.100254","DOIUrl":"10.1016/j.ahr.2025.100254","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100254"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Synergistic effect of smoking and education on incident dementia among older adults: The Shanghai aging study” [Aging and Health Research Vol 5 Issue 1 (March 2025) 100212]","authors":"Chengyin Xu ,&nbsp;Zhenxu Xiao ,&nbsp;Xiaowen Zhou ,&nbsp;Xiaoniu Liang ,&nbsp;Qianhua Zhao ,&nbsp;Ding Ding ,&nbsp;Wei Deng","doi":"10.1016/j.ahr.2025.100253","DOIUrl":"10.1016/j.ahr.2025.100253","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100253"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}