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IMPROVING COMMUNICATION OF 30-YEAR CARDIOVASCULAR DISEASE RISK ESTIMATES: AGE- AND SEX-STANDARDIZED PERCENTILES 改善 30 年心血管疾病风险估计的传播:年龄和性别标准化百分位数
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100818
Vaishnavi Krishnan BS

Therapeutic Area

ASCVD/CVD Risk Assessment

Background

American Heart Association/American College of Cardiology primary prevention guidelines recommend estimation of 30-year cardiovascular disease (CVD) risk to guide clinician-patient discussions in younger adults. While the novel AHA PREVENT equations included 30-year risk models, interpretation of these risk estimates is challenging for both clinicians and patients. Standardized risk percentiles based on the U.S. population may provide a useful and accessible tool to optimize risk communication.

Methods

Using data from the 2011 to 2018 National Health and Nutrition Examination Surveys (NHANES) in U.S. adults aged 30-59 years, we estimated the population-level distribution of 30-year risk for CVD (which includes atherosclerotic CVD [ASCVD] and heart failure [HF]) using the AHA PREVENT equations. We calculated the 30-year risk corresponding to percentile ranks and generated age- and sex-specific standardized risk percentiles for CVD, ASCVD, and HF.

Results

Among 9,204 participants, representing approximately 109 million US adults, 34% were 30-39 years old, 31% were 40-49 years old, and 35% were 50-59 years old. The population-level distribution of 30-year risk for CVD, ASCVD, and HF was significantly higher in older age strata and in males compared with females (Figure). Among females, the 30-year absolute risk for CVD that represented the 75th percentile (i.e., only 25% of age- and sex-matched peers would have higher risk) was 6% for 30 to 39- year-olds, 16% for 40 to 49-year-olds, and 29% for 50 to 59-year-olds. Among males, the 30-year absolute risk for CVD that represented the 75th percentile was 11% for 30 to 39-year-olds, 23% for 40 to 49-year-olds, and 33% for 50 to 59-year-olds. Similar patterns were observed for percentile distributions in 30-year risk estimates for ASCVD and HF.

Conclusions

Translation of PREVENT-based 30-year CVD, ASCVD, and HF risk estimates into age- and sex-standardized percentiles may offer a useful tool for clinicians and patients to interpret risk.
治疗领域心血管疾病/心血管疾病风险评估背景美国心脏协会/美国心脏病学院一级预防指南建议估算 30 年心血管疾病 (CVD) 风险,以指导临床医生与年轻成人患者之间的讨论。虽然新的 AHA PREVENT 方程包括 30 年风险模型,但对临床医生和患者来说,解释这些风险估计值具有挑战性。基于美国人口的标准化风险百分位数可为优化风险交流提供一个有用且易用的工具。方法利用 2011 年至 2018 年美国全国健康与营养调查 (NHANES) 中 30-59 岁美国成年人的数据,我们使用 AHA PREVENT 方程估算了心血管疾病(包括动脉粥样硬化性心血管疾病 [ASCVD] 和心力衰竭 [HF])30 年风险的人口级分布。我们计算了与百分位数等级相对应的 30 年风险,并生成了心血管疾病、ASCVD 和心力衰竭的年龄和性别特异性标准化风险百分位数。结果在 9204 名参与者中,约有 1.09 亿美国成年人,其中 34% 年龄在 30-39 岁之间,31% 年龄在 40-49 岁之间,35% 年龄在 50-59 岁之间。30年心血管疾病、ASCVD和心房颤动风险在人群中的分布情况是,与女性相比,男性在较高年龄段的风险明显更高(图)。在女性中,代表第 75 百分位数的 30 年心血管疾病绝对风险(即只有 25% 的年龄和性别匹配的同龄人有更高风险)在 30 至 39 岁人群中为 6%,在 40 至 49 岁人群中为 16%,在 50 至 59 岁人群中为 29%。在男性中,30 至 39 岁的人 30 年心血管疾病绝对风险的第 75 百分位数为 11%,40 至 49 岁的人为 23%,50 至 59 岁的人为 33%。结论将基于 PREVENT 的 30 年心血管疾病、心血管并发症和心房颤动风险估计值转换为年龄和性别标准化百分位数可为临床医生和患者解释风险提供有用的工具。
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引用次数: 0
PLANT-FORWARD CULINARY MEDICINE FOR THE PREVENTION OF CARDIOVASCULAR DISEASE FOR PRIMARY CARE RESIDENTS: A RANDOMIZED CONTROLLED TRIAL 针对初级保健居民的预防心血管疾病的植物烹饪医学:随机对照试验
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100809
Nathan Wood MD

Therapeutic Area

Nutrition/Exercise

Background

In the United States, cardiovascular disease (CVD) is the leading cause of death, and nutrition is the leading risk factor. However, fewer than a third of internal medicine residents feel confident discussing nutrition with patients. “Culinary medicine,” by combining didactics with hands-on cooking instruction, empowers medical trainees to prevent and treat diet-related disease with their patients.

Methods

All 51 primary care residents at an academic medical center in New England participated in this randomized controlled study. Twenty-five residents were randomized to the intervention group and 26 to the control group. Both groups participated in 3 hours of cased-based learning, group discussion, lecture, and dietitian Q&A sessions. The intervention group also received 1 hour of culinary medicine instruction in a “virtual teaching kitchen,” cooking together on Zoom and learning strategies for modifying recipes for heart-healthiness. The control group watched 1 hour of videos from the Nutrition Made Clear curriculum. Nutrition knowledge was assessed via multiple-choice questions. Confidence was measured on 6-point Likert scales. Attitudes were measured via a subscale of the Nutrition in Patient Care Survey (NIPS).

Results

NIPS subscale scores did not differ from baseline to immediate post in the control group (mean score 33.1 to 34.3, p=0.08) but did in the intervention group (34.7 to 36.1, p=0.04). Nutrition knowledge scores increased significantly from baseline to immediate post in both groups (mean % correct 53.6% to 93.7%, p=0.001 for control vs. 60.0% to 92.2%, p=0.001 for intervention). Percent of residents who felt confident providing patient-accessible dietary counseling for CVD increased significantly in the intervention group (8.3% to 52.2%, p=0.002) but did not in the control group (36.4% to 63.2%, p=0.453). At 8 weeks post, 96% of all residents reported implementing something they had learned from the curriculum into caring for patients, and their nutrition knowledge scores remained high. All residents said they would recommend the curriculum to colleagues and wanted additional nutrition education.

Conclusions

Both culinary medicine and didactics-only nutrition education can be feasible, well-received, and effective in improving nutrition knowledge. Culinary medicine may be superior in improving learners’ attitudes about nutrition and confidence in providing dietary counseling.
治疗领域营养/运动背景在美国,心血管疾病(CVD)是导致死亡的主要原因,而营养是主要的风险因素。然而,只有不到三分之一的内科住院医生有信心与病人讨论营养问题。"烹饪医学 "通过将教学与实际烹饪指导相结合,使医学学员有能力与病人一起预防和治疗与饮食有关的疾病。方法新英格兰一家学术医疗中心的 51 名初级保健住院医师参加了这项随机对照研究。25 名住院医师被随机分配到干预组,26 名被分配到对照组。两组均参加了 3 个小时的案例学习、小组讨论、讲座和营养师问答。干预组还在 "虚拟教学厨房 "中接受了 1 小时的烹饪医学指导,一起在 Zoom 上烹饪,并学习如何修改食谱以达到有益心脏健康的目的。对照组则观看了一小时的《营养清晰》课程视频。营养知识通过多项选择题进行评估。信心通过 6 点李克特量表进行测量。结果对照组的 NIPS 分值从基线到刚结束时没有差异(平均分从 33.1 到 34.3,p=0.08),但干预组有差异(从 34.7 到 36.1,p=0.04)。两组居民的营养知识得分从基线到刚结束时都有显著提高(对照组平均正确率从 53.6% 提高到 93.7%,p=0.001;干预组从 60.0% 提高到 92.2%,p=0.001)。在干预组中,有信心为患者提供无障碍心血管疾病饮食咨询的住院医师百分比显著增加(从 8.3% 增加到 52.2%,p=0.002),但在对照组中没有增加(从 36.4% 增加到 63.2%,p=0.453)。培训结束 8 周后,96% 的住院医师表示他们将从课程中学到的知识应用到了病人护理中,而且他们的营养知识得分仍然很高。所有住院医师都表示会向同事推荐该课程,并希望获得更多的营养教育。结论烹饪医学和纯说教式营养教育在提高营养知识方面都是可行的、受欢迎的和有效的。烹饪医学在改善学员的营养态度和提供饮食咨询的信心方面可能更胜一筹。
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引用次数: 0
STRESS CARDIOMYOPATHY AFTER DOWNHILL SKIING: A CASE REPORT 下坡滑雪后的应激性心肌病:病例报告
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100798
Anne Marie Arcidiacono DO

Therapeutic Area

Heart Failure

Case Presentation

A 61-year-old female presented after a day of anxiety-filled downhill skiing, with 2 syncopal episodes in the ski lodge. The patient had an electrocardiogram (ECG) showing deep T-wave inversions in anterior leads, QTc 600 msec, troponin of 0.299 ng/mL (normal <0.034 ng/mL), and BNP of 4,530 pg/mL (normal <221 pg/mL). The patient was given intravenous magnesium, furosemide, and an infusion of lidocaine for polymorphic ventricular tachycardia seen on telemetry. A transthoracic echocardiogram (TTE) revealed reduced ejection fraction (LVEF) of 30-35% with akinesis of the apex, hypokinesis of all mid-apical myocardial segments, suspicious for takotsubo cardiomyopathy (TTC). The patient underwent a diagnostic coronary angiography revealing no signs of ischemic disease. On day 3 of hospitalization, the patient's ECG normalized with resolution of prolonged QTc, repeat TTE showed recovered LVEF of 50-55%, and was discharged home with complete cardiovascular recovery.

Background

TTC, also called stress cardiomyopathy or broken heart syndrome, is characterized by chest pain, ECG changes, transient apical “ballooning” of the left ventricle with mid-ventricular akinesis seen on TTE, and absence of obstructive coronary artery disease or plaque rupture. TTC is typically preceded by intense psychological or physical stress, diagnosed in 2% of patients presenting with acute myocardial infarction and has a 6% incidence for female patients, ages 50 and older. TTC has an in-hospital mortality from 0–8% and is thought to occur due to the negative inotropy effect of high levels of epinephrine on the largest density of β-adrenoceptors in the apical ventricular myocardium. As epinephrine levels return to normal, left ventricular function and apical wall motion return to baseline within days to weeks. At 6-month follow-up, women with TTC showed a better survival rate (97% vs 86%) and less major events such as death, reinfarction, or rehospitalization than women with CAD (8% vs 31%).

Conclusions

Our case highlights an inciting event of TTC with combined physical and emotional stress. Stress management, emotional regulation, and treatment of mood disorders, represent a crucial point to prevent TTC, reduce medical costs, and improve the long-term quality of life of patients.
治疗领域心力衰竭病例介绍一名 61 岁的女性在一天充满焦虑的下坡滑雪后,在滑雪小屋内出现了两次晕厥。患者的心电图(ECG)显示前导联出现深T波倒置,QTc为600毫秒,肌钙蛋白为0.299纳克/毫升(正常值为0.034纳克/毫升),BNP为4530皮克/毫升(正常值为221皮克/毫升)。患者接受了静脉注射镁剂、呋塞米和利多卡因的治疗,以缓解遥测到的多形性室性心动过速。经胸超声心动图(TTE)显示射血分数(LVEF)降低了 30%-35%,心尖无运动,所有心尖中段心肌运动减弱,怀疑是塔克次博心肌病(TTC)。患者接受了诊断性冠状动脉造影术,未发现缺血性疾病的迹象。背景TTC又称应激性心肌病或心碎综合征,其特征是胸痛、心电图改变、TTE显示左心室心尖一过性 "膨胀 "和心室中段僵直,但无阻塞性冠状动脉疾病或斑块破裂。急性心肌梗死发生前通常会有强烈的心理或生理压力,2%的急性心肌梗死患者可确诊为急性心肌梗死,50 岁及以上女性患者的发病率为 6%。TTC 的院内死亡率为 0-8%,其发生原因被认为是高水平的肾上腺素对心室心尖部密度最大的 β 肾上腺素受体产生负性肌力作用。随着肾上腺素水平恢复正常,左心室功能和心尖壁运动会在数天至数周内恢复基线。在 6 个月的随访中,与患有 CAD 的妇女(8% 对 31%)相比,患有 TTC 的妇女存活率更高(97% 对 86%),死亡、再梗死或再次住院等重大事件也更少。压力管理、情绪调节和情绪障碍治疗是预防 TTC、降低医疗费用和改善患者长期生活质量的关键点。
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引用次数: 0
STATIN RATES ONE YEAR AFTER OPPORTUNISTIC SCREENING FOR CORONARY ARTERY CALCIUM ON NON-GATED CHEST CT SCANS (NOTIFY-EXTEND PROJECT) 非门控胸部 CT 扫描冠状动脉钙化机会性筛查一年后他汀类药物的使用率(通知-扩展项目)
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100804
Sarkis G. Bouladian BS

Therapeutic Area

ASCVD /CVD Risk Reduction

Background

Cardiovascular disease prevention is suboptimal, especially among high-risk individuals who would benefit from lipid-lowering therapy. The NOTIFY-1 project demonstrated that screening for incidental coronary artery calcium (CAC) on non-gated chest computed tomography (CT) scans with a deep-learning algorithm, followed by patient and clinician notification, significantly increased statin prescriptions at 6 months. NOTIFY-EXTEND assessed statin initiation and persistence in a larger sample at 12 months post-notification.

Methods

The NOTIFY-1 project identified Stanford Healthcare patients without prior diagnosis of atherosclerotic cardiovascular disease (ASCVD) or statin therapy who underwent non-gated, non-contrast chest CT. Patients with CAC were identified via a deep-learning algorithm and initially randomized to notification (“early notification,” including their primary care clinicians) or usual care. Following completion of the project, patients in usual care who had not started statin therapy received a similar notification (“delayed notification”). The primary outcome of this follow-up study was statin prescription rates at 12 months. Secondary outcomes included discontinuation rates, cholesterol levels, cardiovascular testing, and outpatient encounters.

Results

There were 163 patients that received CAC notification, including 86 with early notification and 77 with delayed notification. Following notification, 75 participants (46%) were prescribed a statin within 6 months and 86 participants (53%) within 12 months. There were 117 participants (72%) that were either prescribed a statin or had a documented discussion regarding statin therapy within 12 months post-notification. Of participants prescribed a statin, 5% discontinued statin therapy within the 12-month follow-up period.
There was a significant decrease in low-density lipoprotein cholesterol (115.6 mg/dL to 90.6 mg/dL; p<0.001) and triglyceride (106.2 mg/dL to 91.3 mg/dL; p=0.003) levels from baseline to 12 months post-notification. Additionally, we observed increased healthcare utilization in the post-notification period (Table 1).

Conclusions

Opportunistic screening and notification of CAC from non-gated chest CTs was associated with an increase in statin prescription rates that persisted at 12 months post-notification. Opportunistic screening for incidental CAC may be a powerful approach to motivating statin initiation and persistence.
治疗领域心血管疾病/降低心血管疾病风险背景心血管疾病的预防效果并不理想,尤其是在可从降脂治疗中获益的高危人群中。NOTIFY-1项目表明,利用深度学习算法筛查非门控胸部计算机断层扫描(CT)中的偶发冠状动脉钙化(CAC),然后通知患者和临床医生,可显著增加6个月后的他汀类药物处方量。NOTIFY-EXTEND评估了通知后12个月内更大样本中他汀类药物的启动和持续情况。方法NOTIFY-1项目确定了斯坦福医疗保健公司的患者,这些患者之前没有诊断出动脉粥样硬化性心血管疾病(ASCVD)或他汀类药物治疗,并接受了非门控、非对比胸部CT检查。通过深度学习算法识别出患有 CAC 的患者,并将其随机分配到通知("早期通知",包括其初级保健临床医生)或常规护理中。项目结束后,接受常规治疗但尚未开始他汀类药物治疗的患者也会收到类似的通知("延迟通知")。这项随访研究的主要结果是 12 个月的他汀类药物处方率。次要结果包括停药率、胆固醇水平、心血管检测和门诊就诊情况。结果共有 163 名患者收到了 CAC 通知,其中 86 人收到了早期通知,77 人收到了延迟通知。接到通知后,75 名参与者(46%)在 6 个月内服用了他汀类药物,86 名参与者(53%)在 12 个月内服用了他汀类药物。在收到通知后的 12 个月内,有 117 名参与者(72%)获得了他汀类药物处方或就他汀类药物治疗进行了有记录的讨论。低密度脂蛋白胆固醇(115.6 mg/dL 降至 90.6 mg/dL;p<0.001)和甘油三酯(106.2 mg/dL 降至 91.3 mg/dL;p=0.003)水平从基线到通知后 12 个月内显著下降。结论通过非门控胸部 CT 对 CAC 进行机会性筛查和通知与他汀类药物处方率的增加有关,这种情况在通知后 12 个月内持续存在。对偶发 CAC 进行机会性筛查可能是促进他汀类药物使用和坚持使用的有效方法。
{"title":"STATIN RATES ONE YEAR AFTER OPPORTUNISTIC SCREENING FOR CORONARY ARTERY CALCIUM ON NON-GATED CHEST CT SCANS (NOTIFY-EXTEND PROJECT)","authors":"Sarkis G. Bouladian BS","doi":"10.1016/j.ajpc.2024.100804","DOIUrl":"10.1016/j.ajpc.2024.100804","url":null,"abstract":"<div><h3>Therapeutic Area</h3><div>ASCVD /CVD Risk Reduction</div></div><div><h3>Background</h3><div>Cardiovascular disease prevention is suboptimal, especially among high-risk individuals who would benefit from lipid-lowering therapy. The NOTIFY-1 project demonstrated that screening for incidental coronary artery calcium (CAC) on non-gated chest computed tomography (CT) scans with a deep-learning algorithm, followed by patient and clinician notification, significantly increased statin prescriptions at 6 months. NOTIFY-EXTEND assessed statin initiation and persistence in a larger sample at 12 months post-notification.</div></div><div><h3>Methods</h3><div>The NOTIFY-1 project identified Stanford Healthcare patients without prior diagnosis of atherosclerotic cardiovascular disease (ASCVD) or statin therapy who underwent non-gated, non-contrast chest CT. Patients with CAC were identified via a deep-learning algorithm and initially randomized to notification (“early notification,” including their primary care clinicians) or usual care. Following completion of the project, patients in usual care who had not started statin therapy received a similar notification (“delayed notification”). The primary outcome of this follow-up study was statin prescription rates at 12 months. Secondary outcomes included discontinuation rates, cholesterol levels, cardiovascular testing, and outpatient encounters.</div></div><div><h3>Results</h3><div>There were 163 patients that received CAC notification, including 86 with early notification and 77 with delayed notification. Following notification, 75 participants (46%) were prescribed a statin within 6 months and 86 participants (53%) within 12 months. There were 117 participants (72%) that were either prescribed a statin or had a documented discussion regarding statin therapy within 12 months post-notification. Of participants prescribed a statin, 5% discontinued statin therapy within the 12-month follow-up period.</div><div>There was a significant decrease in low-density lipoprotein cholesterol (115.6 mg/dL to 90.6 mg/dL; p&lt;0.001) and triglyceride (106.2 mg/dL to 91.3 mg/dL; p=0.003) levels from baseline to 12 months post-notification. Additionally, we observed increased healthcare utilization in the post-notification period (Table 1).</div></div><div><h3>Conclusions</h3><div>Opportunistic screening and notification of CAC from non-gated chest CTs was associated with an increase in statin prescription rates that persisted at 12 months post-notification. Opportunistic screening for incidental CAC may be a powerful approach to motivating statin initiation and persistence.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"19 ","pages":"Article 100804"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remembering Dr. George L. Bakris: A pillar of cardiorenal medicine and mentorship 缅怀乔治-L-巴克里斯博士:心肾医学和导师的支柱
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100728
Yuichiro Yano , Donald M. Lloyd-Jones , Martha Gulati
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引用次数: 0
ASSOCIATION BETWEEN PEAK METABOLIC WORKLOAD (METS) AND CARDIOVASCULAR MORBIDITY IN A LOW SOCIOECONOMIC POPULATION: A RETROSPECTIVE STUDY 社会经济地位较低人群的代谢峰值工作量(METS)与心血管疾病发病率之间的关系:一项回顾性研究
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100731
Moiud Mohyeldin MD

Therapeutic Area

CVD Prevention – Primary and Secondary

Background

The non-linear correlation between peak metabolic workload and cardiovascular disease incidence is under scrutiny in this study, particularly within the low socioeconomic residents of South Bronx.

Methods

A retrospective examination of 190 patients subjected to cardiac graded treadmill stress testing and MET level evaluation between January 2007 and July 2023 was performed. Patients with incomplete testing, known heart disease, prior strokes, peripheral artery disease, severe systemic conditions, and pregnancy were excluded. Participants were segregated into low (<5), moderate (5-8), and high (>8) MET groups. The primary outcome was cardiovascular morbidity incidence. Data analysis was controlled for age, sex, cardiac disease family history, BMI, smoking, and DM, HTN, and HLD histories.

Results

Of the 190 participants, (47.9% females, 52.1% males, mean age 53 ± 14) 20 (11%) had at least one CV morbidity during the study period. Adjusted models demonstrated that patients with MET >5 had 0.14 lower odds of a cardiovascular event than MET 5-8 patients (OR 0.86; 95% CI 0.20-3.82), whereas METS >8 patients had 1.8 times higher odds (OR 1.8, CI 95% 0.51-6.46).

Conclusions

Among the low-income population, our findings challenge previous studies, suggesting a linear relationship between higher METs and increased cardiovascular events. This warrants further investigation to validate our findings.
治疗领域心血管疾病预防--一级和二级背景本研究仔细研究了代谢工作量峰值与心血管疾病发病率之间的非线性关系,尤其是南布朗克斯区低社会经济地位居民的心血管疾病发病率。未完成测试、已知患有心脏病、曾中风、外周动脉疾病、严重全身性疾病和怀孕的患者被排除在外。参与者被分为低(5)、中(5-8)和高(8)MET 组。主要结果是心血管发病率。数据分析与年龄、性别、心脏病家族史、体重指数(BMI)、吸烟以及糖尿病、高血压和高血脂病史进行了对照。结果 在 190 名参与者中,有 20 人(11%)(女性占 47.9%,男性占 52.1%,平均年龄为 53 ± 14 岁)在研究期间至少发生过一次心血管疾病。调整后的模型显示,MET>5 患者发生心血管事件的几率比 MET 5-8 患者低 0.14(OR 0.86; 95% CI 0.20-3.82),而 METS >8患者发生心血管事件的几率高 1.8 倍(OR 1.8,CI 95% 0.51-6.46)。这需要进一步调查以验证我们的发现。
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引用次数: 0
INCIDENTAL CORONARY ARTERY CALCIUM REPORTING ON CHEST CT SCANS USING NATURAL LANGUAGE PROCESSING: INSIGHTS FROM VETERANS HEALTH ADMINISTRATION 使用自然语言处理报告胸部 CT 扫描中偶然出现的冠状动脉钙化:退伍军人健康管理局的见解
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100763
Natasha Din MD, MAS

Therapeutic Area

ASCVD/CVD Risk Assessment

Background

Coronary artery calcium (CAC) is the strongest predictor of cardiovascular events. CAC can be identified on non-cardiac chest CTs, but reporting is inconsistent. We developed a natural language processing (NLP) algorithm to identify incidental CAC reporting on non-gated chest CT reports and described patterns in CAC reporting across the Veterans Health Administration (VHA).

Methods

We identified non-cardiac CT scan reports across the VHA between 2006-2024. We developed an NLP algorithm by creating Regex rules to detect mentions of CAC (none, mild, moderate, severe, or unclassified). We manually annotated 1,060 reports as the gold standard for algorithm development. We iteratively refined an NLP algorithm based on accuracy with the development scans. We validated the algorithm's performance on an independent sample of 1,000 scans and applied the algorithm to all non-cardiac chest CTs in the VHA over the study period. We described the frequency of CAC reporting over time in addition to facility-level variation.

Results

Across 1,000 validation reports, the algorithm had a sensitivity of 99% and a positive predictive value (PPV) of 94% for CAC being mentioned in the CT report. Among reports in which CAC was mentioned, the algorithm had a 99% sensitivity and 97% PPV for correctly noting the presence of CAC. The algorithm had a 96% accuracy for correctly detecting the reported CAC severity.
There were 6,825,889 non-cardiac chest CTs between January 2006 and March 2024 in the VHA. The presence or absence of CAC was described in 2,519,296 reports (37%). CAC reporting was highest among lung cancer screening CTs (49%). CAC reporting increased over time (Table). In 2023, reporting ranged from 0% to 63% across 128 VA facilities.
Among CTs that reported CAC presence or absence, CAC was described as present on 2,425,416 reports (96%). Among CTs that reported CAC presence, CAC severity was unclassified in 56%, mild in 16%, moderate in 13%, and severe in 15% of scans.

Conclusions

CAC is not reported on a majority of non-cardiac chest CTs in a large national cohort, but reporting is increasing over time. Strategies to improve CAC reporting or leverage emerging automated CAC detection algorithms are needed.
治疗领域心血管疾病/心血管疾病风险评估背景冠状动脉钙化(CAC)是预测心血管事件的最有力指标。非心脏胸部 CT 可识别出 CAC,但报告并不一致。我们开发了一种自然语言处理 (NLP) 算法来识别非门控胸部 CT 报告中的偶然 CAC 报告,并描述了退伍军人健康管理局 (VHA) 中 CAC 报告的模式。我们开发了一种 NLP 算法,通过创建 Regex 规则来检测 CAC 的提及情况(无、轻度、中度、重度或未分类)。我们手动注释了 1,060 份报告,作为算法开发的黄金标准。我们根据开发扫描的准确性反复改进 NLP 算法。我们在 1,000 份扫描的独立样本上验证了该算法的性能,并将该算法应用于研究期间 VHA 的所有非心脏胸部 CT。结果在 1000 份验证报告中,该算法对 CT 报告中提及 CAC 的灵敏度为 99%,阳性预测值 (PPV) 为 94%。在提到 CAC 的报告中,该算法正确指出 CAC 存在的灵敏度为 99%,PPV 为 97%。2006 年 1 月至 2024 年 3 月期间,VHA 共进行了 6,825,889 次非心脏胸部 CT 检查。2006年1月至2024年3月期间,美国退伍军人事务部共进行了6,825,889次非心脏胸部CT检查,其中2,519,296份报告(37%)描述了是否存在CAC。在肺癌筛查 CT 中,CAC 报告率最高(49%)。CAC 报告随时间推移而增加(表)。2023 年,128 家退伍军人机构的报告率从 0% 到 63% 不等。在报告是否存在 CAC 的 CT 中,有 2425416 份报告(96%)将 CAC 描述为存在。在报告存在 CAC 的 CT 中,CAC 严重程度未分类的占 56%,轻度的占 16%,中度的占 13%,重度的占 15%。需要制定策略来改进 CAC 报告或利用新出现的自动 CAC 检测算法。
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引用次数: 0
COMORBIDITIES AND PROCEDURAL OUTCOMES IN STEMI PATIENTS WITH AND WITHOUT A HISTORY OF DRUG ABUSE 有吸毒史和无吸毒史的干细胞成像患者的合并症和程序结果
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100794
Sai Allu MD

Therapeutic Area

ASCVD/CVD Risk Factors

Background

Patients with a history of drug abuse are at increased risk for cardiovascular events, including ST-segment elevation myocardial infarction (STEMI). However, the prevalence of comorbidities and procedural outcomes in this population remain understudied. This study aimed to compare the prevalence of comorbidities and procedural outcomes in STEMI patients with and without a history of drug abuse.

Methods

A total of 180,265 patients diagnosed with STEMI in 2020 with NIS data using SPSS were included in this registry study. Patients were categorized into two groups: those with a history of drug abuse (n=8,843; 4.9%) and those without (n=171,422; 95.1%). The prevalence of comorbidities, including congestive heart failure, diabetes, and renal failure, was compared between the two groups using odds ratios (OR) and 95% confidence intervals (CI). Procedural outcomes, such as percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), were also analyzed.

Results

Drug users had a higher prevalence of congestive heart failure (69% vs. 62%) and renal failure (31% vs. 39%) compared to non-drug users. However, diabetes was less prevalent among drug users (14% vs. 43%). Non-drug users with congestive heart failure had higher odds of mortality (OR 1.353, 95% CI: 1.301-1.408) compared to those without, while drug users had lower odds (OR 0.724, 95% CI: 0.581-0.902). No significant differences in mortality odds were observed for diabetes in either group. Non-drug users with renal failure had higher odds of mortality (OR 1.266, 95% CI: 1.218-1.314), while drug users exhibited no significant change. Among patients undergoing procedures, non-drug users had higher rates of single-vessel PCI (0.436% vs. 0.339%), double-vessel PCI (0.080% vs. 0.034%), and single-vessel CABG (0.046% vs. 0.034%) compared to drug users.

Conclusions

This study highlights the differences in comorbidities and procedural outcomes between STEMI patients with and without a history of drug abuse. Drug users had a higher prevalence of congestive heart failure and renal failure but a lower prevalence of diabetes compared to non-drug users. Non-drug users with congestive heart failure and renal failure had higher odds of mortality, while drug users had lower or no significant change in mortality odds. Non-drug users also had higher rates of PCI and CABG procedures compared to drug users. These findings emphasize the need for tailored management strategies considering the unique comorbidity profiles and procedural outcomes in STEMI patients with a history of drug abuse.
治疗领域心血管疾病/心血管疾病风险因素背景有吸毒史的患者发生心血管事件(包括 ST 段抬高型心肌梗塞)的风险更高。然而,对这一人群的合并症发生率和手术结果的研究仍然不足。本研究旨在比较有和无药物滥用史的 STEMI 患者的合并症发生率和手术结果。方法本登记研究共纳入了 180,265 名 2020 年诊断为 STEMI 的患者,这些患者的 NIS 数据使用了 SPSS。患者分为两组:有药物滥用史的患者(n=8,843;4.9%)和无药物滥用史的患者(n=171,422;95.1%)。使用几率比(OR)和 95% 置信区间(CI)比较了两组患者的合并症患病率,包括充血性心力衰竭、糖尿病和肾功能衰竭。结果与非用药者相比,用药者的充血性心力衰竭(69% 对 62%)和肾功能衰竭(31% 对 39%)发病率更高。然而,糖尿病在吸毒者中的发病率较低(14% 对 43%)。与没有充血性心力衰竭的人相比,非药物使用者的死亡几率更高(OR 1.353,95% CI:1.301-1.408),而药物使用者的几率较低(OR 0.724,95% CI:0.581-0.902)。两组糖尿病患者的死亡几率均无明显差异。肾功能衰竭的非用药者的死亡几率更高(OR 1.266,95% CI:1.218-1.314),而用药者则无明显变化。在接受手术的患者中,与吸毒者相比,非吸毒者的单血管 PCI(0.436% vs. 0.339%)、双血管 PCI(0.080% vs. 0.034%)和单血管 CABG(0.046% vs. 0.034%)发生率更高。与非吸毒者相比,吸毒者的充血性心力衰竭和肾功能衰竭发病率较高,但糖尿病发病率较低。非吸毒者出现充血性心力衰竭和肾功能衰竭的死亡率较高,而吸毒者的死亡率较低或无明显变化。与用药者相比,非用药者接受 PCI 和 CABG 手术的比例也更高。这些发现强调,考虑到有吸毒史的 STEMI 患者独特的合并症情况和手术结果,有必要制定量身定制的管理策略。
{"title":"COMORBIDITIES AND PROCEDURAL OUTCOMES IN STEMI PATIENTS WITH AND WITHOUT A HISTORY OF DRUG ABUSE","authors":"Sai Allu MD","doi":"10.1016/j.ajpc.2024.100794","DOIUrl":"10.1016/j.ajpc.2024.100794","url":null,"abstract":"<div><h3>Therapeutic Area</h3><div>ASCVD/CVD Risk Factors</div></div><div><h3>Background</h3><div>Patients with a history of drug abuse are at increased risk for cardiovascular events, including ST-segment elevation myocardial infarction (STEMI). However, the prevalence of comorbidities and procedural outcomes in this population remain understudied. This study aimed to compare the prevalence of comorbidities and procedural outcomes in STEMI patients with and without a history of drug abuse.</div></div><div><h3>Methods</h3><div>A total of 180,265 patients diagnosed with STEMI in 2020 with NIS data using SPSS were included in this registry study. Patients were categorized into two groups: those with a history of drug abuse (n=8,843; 4.9%) and those without (n=171,422; 95.1%). The prevalence of comorbidities, including congestive heart failure, diabetes, and renal failure, was compared between the two groups using odds ratios (OR) and 95% confidence intervals (CI). Procedural outcomes, such as percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), were also analyzed.</div></div><div><h3>Results</h3><div>Drug users had a higher prevalence of congestive heart failure (69% vs. 62%) and renal failure (31% vs. 39%) compared to non-drug users. However, diabetes was less prevalent among drug users (14% vs. 43%). Non-drug users with congestive heart failure had higher odds of mortality (OR 1.353, 95% CI: 1.301-1.408) compared to those without, while drug users had lower odds (OR 0.724, 95% CI: 0.581-0.902). No significant differences in mortality odds were observed for diabetes in either group. Non-drug users with renal failure had higher odds of mortality (OR 1.266, 95% CI: 1.218-1.314), while drug users exhibited no significant change. Among patients undergoing procedures, non-drug users had higher rates of single-vessel PCI (0.436% vs. 0.339%), double-vessel PCI (0.080% vs. 0.034%), and single-vessel CABG (0.046% vs. 0.034%) compared to drug users.</div></div><div><h3>Conclusions</h3><div>This study highlights the differences in comorbidities and procedural outcomes between STEMI patients with and without a history of drug abuse. Drug users had a higher prevalence of congestive heart failure and renal failure but a lower prevalence of diabetes compared to non-drug users. Non-drug users with congestive heart failure and renal failure had higher odds of mortality, while drug users had lower or no significant change in mortality odds. Non-drug users also had higher rates of PCI and CABG procedures compared to drug users. These findings emphasize the need for tailored management strategies considering the unique comorbidity profiles and procedural outcomes in STEMI patients with a history of drug abuse.</div></div>","PeriodicalId":72173,"journal":{"name":"American journal of preventive cardiology","volume":"19 ","pages":"Article 100794"},"PeriodicalIF":4.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CARDIAC INPATIENTS ARE HIGHLY INTERESTED IN VIRTUAL CARDIAC REHABILITATION 心脏病住院患者对虚拟心脏康复非常感兴趣
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100797
Vennela Avula BSPH

Therapeutic Area

Rehabilitation

Background

Cardiac rehabilitation (CR) improves cardiovascular health and decreases hospital readmissions; unfortunately, it is widely underused by patients. Digital health interventions offer a potential solution to increase participation in CR. However, patients’ interest and concerns regarding virtual CR have not been fully explored.

Methods

A Qualtrics survey was administered to cardiac inpatients in the progressive cardiac care unit at Johns Hopkins Hospital from 2020-2024. This study included English-speaking patients, >18 years of age who met medical eligibility for CR. One-way ANOVA, Chi-square, and Fisher's Exact test were used to assess differences in interest in engaging in virtual CR by age, sex, and race, respectively.

Results

A total of 150 cardiac inpatients were included: age 64 ± 13 years, 62% (93/150) male, 57% (85/150) White, and 41% (61/150) completing a 4-year degree or higher. 93% (139/150) of patients reported owning a smartphone. The patients reported that their primary barriers to CR participation were traveling to the CR center (49%, 73/150), costs/insurance coverage (29%, 44/150), and a tight schedule (28%, 42/150). Notably, the majority of patients (71%, 107/150) expressed interest in engaging in virtual CR. Interest in virtual CR did not differ by age (p=0.35) or sex (p=0.49); however, Black (90%, 46/51) and Asian (83%, 5/6) adults reported being more interested in virtual CR than White (61%, 52/85) adults (p<0.001). While 39% of patients (58/150) felt less safe exercising at home compared to a supervised center, 83% (48/58) of these patients reported they would feel more confident exercising at home if able to communicate by phone with specialized staff during training sessions. Additionally, 39% (58/150) of patients expressed concerns about decreased motivation training alone at home; however, 52% (30/58) of these patients felt group calls with other patients could enhance engagement.

Conclusions

Virtual CR may advance health equity by overcoming traditional barriers to participation, with the majority of patients, especially Black and Asian adults, expressing interest. High prevalence of smartphone ownership suggests this may be feasible. Virtual CR efforts should focus on addressing safety concerns and enhancing motivation via direct communication with staff and other patients.
治疗领域康复背景心脏康复(CR)可改善心血管健康并降低再入院率;但遗憾的是,患者对它的利用率普遍较低。数字健康干预为提高患者参与心脏康复提供了一个潜在的解决方案。然而,患者对虚拟 CR 的兴趣和担忧尚未得到充分探究。方法:2020-2024 年期间,对约翰霍普金斯医院渐进式心脏护理病房的心脏病住院患者进行了一项 Qualtrics 调查。研究对象包括英语患者,年龄在 18 周岁以上,符合 CR 的医疗条件。采用单因素方差分析、卡方检验和费雪精确检验分别评估不同年龄、性别和种族的患者对参与虚拟 CR 的兴趣差异。93%(139/150)的患者表示拥有智能手机。患者表示,他们参加 CR 的主要障碍是前往 CR 中心(49%,73/150)、费用/保险范围(29%,44/150)和日程安排紧张(28%,42/150)。值得注意的是,大多数患者(71%,107/150)表示有兴趣参与虚拟 CR。不同年龄(p=0.35)或性别(p=0.49)的患者对虚拟 CR 的兴趣不尽相同;但是,黑人(90%,46/51)和亚裔(83%,5/6)成人对虚拟 CR 的兴趣高于白人(61%,52/85)成人(p<0.001)。虽然 39% 的患者(58/150)认为在家锻炼比在有监督的中心锻炼更不安全,但其中 83% 的患者(48/58)表示,如果能在培训课程期间通过电话与专业人员沟通,他们会更有信心在家锻炼。此外,39%(58/150)的患者表示担心独自在家训练会降低积极性;但是,52%(30/58)的患者认为与其他患者进行小组通话可以提高参与度。智能手机的普及率很高,这表明虚拟 CR 是可行的。虚拟 CR 工作应侧重于解决安全问题,并通过与工作人员和其他患者的直接交流提高积极性。
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引用次数: 0
PROVIDER-LEVEL VARIATION IN NOVEL CARDIOVASCULAR MEDICATION PRESCRIPTION AMONG PATIENTS HOSPITALIZED FOR HEART FAILURE AND CORONARY ARTERY DISEASE IN THE VETERANS AFFAIRS SYSTEM 退伍军人事务系统中因心力衰竭和冠状动脉疾病住院的患者在提供者层面的新型心血管药物处方差异
IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-09-01 DOI: 10.1016/j.ajpc.2024.100828
Taufiq Salahuddin MD

Therapeutic Area

Preventive Cardiology Best Practices – clinic operations, team approaches, outcomes research

Background

Novel therapies such as angiotensin receptor-neprilysin inhibitors (ARNI), sodium-glucose cotransporter-2 inhibitors (SGLT2i), and glucagon-like peptide-1 receptor agonists (GLP-1 RA) have well-established benefit for patients with heart failure (HF) and coronary artery disease (CAD), but use remains low. We aimed to characterize provider-level variation in the use of these medications in the Veterans Health Administration (VA).

Methods

Using VA health record and administrative data, two patient cohorts were retrospectively identified with hospitalization from 2017-2023 for either HF or CAD with concurrent Type 2 diabetes (T2D). Provider-level data for use of ARNI and SGLT2i for HF and SGTL2i or GLP-1 RA for CAD+T2D were assessed, including at hospital admission, discharge, or within 6 months of discharge. Providers were considered users if they had an outpatient visit with a patient who had a filled prescription for a given medication within 6 months of discharge, regardless of when or by whom the prescription was written. Providers with above-median utilization for all 3 classes were considered high utilizers. Histograms and adjusted median odds ratios were used to characterize provider-level variability in prevalent use of novel medications by medical subspecialty.

Results

The HF and CAD+T2D cohorts included 83,849 and 71,678 unique patients, respectively, with 14,645 providers. Distributions of providers by prevalent use of each respective medication class are shown by medical subspecialty in the Figure. Mean prevalent use over the study period ranged from 17-44% for a given specialty and medication class. Most providers had <50% use of each medication class, though there were smaller numbers of providers with near-100% prevalent use of novel medications. Endocrinology and cardiology had the highest proportions of high utilizers (44% and 39%, respectively, compared with 24% and 15% for primary care and nephrology). Adjusted median odds ratios across all providers over the full study period were 1.7 and 1.8 for ARNI and SGLT2i in the HF cohort and 1.8 in the CAD+T2D cohort.

Conclusions

Cardiologists and endocrinologists were mostly likely to use novel cardiovascular medications, but there was substantial provider-level variation across all prescribing subspecialities. Further research is needed to identify implementation strategies to improve uptake among all providers.
治疗领域预防性心脏病学最佳实践--诊所运营、团队方法、结果研究背景血管紧张素受体-去甲肾上腺素抑制剂(ARNI)、钠-葡萄糖共转运体-2 抑制剂(SGLT2i)和胰高血糖素样肽-1 受体激动剂(GLP-1 RA)等新型疗法对心力衰竭(HF)和冠状动脉疾病(CAD)患者具有公认的益处,但使用率仍然很低。我们的目的是描述退伍军人健康管理局(VA)在提供者层面使用这些药物的差异。方法利用退伍军人健康管理局的健康记录和管理数据,回顾性地确定了 2017-2023 年期间因 HF 或 CAD 住院并同时患有 2 型糖尿病(T2D)的两个患者队列。评估了使用 ARNI 和 SGLT2i 治疗高血压以及使用 SGTL2i 或 GLP-1 RA 治疗 CAD+T2D 的医疗服务提供者层面的数据,包括入院、出院或出院后 6 个月内的数据。如果医疗服务提供者的门诊患者在出院后 6 个月内开具了指定药物的处方,无论处方何时开具或由谁开具,均被视为使用者。如果医疗机构在所有 3 个类别中的使用率均高于中位数,则被视为高使用率医疗机构。结果高频和 CAD+T2D 队列中分别有 83849 名和 71678 名患者,共 14645 家医疗机构。图中显示了按医学亚专科划分的医疗服务提供者对各类药物的普遍使用分布情况。在研究期间,特定专科和药物类别的平均普遍使用率为 17%-44%。大多数医疗机构每类药物的使用率为 50%,但也有少数医疗机构新型药物的使用率接近 100%。内分泌科和心脏科的高使用率比例最高(分别为 44% 和 39%,而初级保健科和肾脏科分别为 24% 和 15%)。在整个研究期间,所有医疗服务提供者的调整后中位赔率分别为:在高血压队列中,ARNI 和 SGLT2i 的赔率为 1.7 和 1.8;在 CAD+T2D 队列中,ARNI 和 SGLT2i 的赔率为 1.8。需要进一步研究确定实施策略,以提高所有医疗机构的使用率。
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引用次数: 0
期刊
American journal of preventive cardiology
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