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Plasma exchange and intravenous immunoglobulin for the peri-operative management of type 2 heparin-induced thrombocytopaenia in a patient requiring urgent surgery for critical limb ischaemia 血浆置换和静脉注射免疫球蛋白用于围手术期治疗因严重肢体缺血而需要紧急手术的患者因 2 型肝素引起的血小板减少症。
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-07-08 DOI: 10.1002/anr3.12311
Y. Perera, R. Taylor, K. D. Bera, L. Holman, N. Curry, A. Shah

We report the case of a 61-year-old female who developed heparin-induced thrombocytopaenia following treatment of a submassive pulmonary embolism, and who then required an above knee amputation for critical limb ischaemia. Heparin-induced thrombocytopaenia is a rare, immune-mediated complication associated with an in-hospital mortality rate of 10%. It is more common in surgical patients, with patients undergoing orthopaedic surgery more likely to develop it than patients undergoing cardiac surgery, but heparin-dependent immunoglobulin G antibodies are more likely to be formed in the latter. Peri-operative management remains a challenge. Ideally, it is preferable to wait for the platelet count to improve; but in certain cases, surgery cannot be delayed. Heparin-induced thrombocytopaenia is usually managed with direct thrombin inhibitors, such as argatroban and bivalirudin. Newer therapeutic modalities, such as plasmapheresis and intravenous immunoglobulin, as used in this case, can rapidly remove antibodies, but the certainty of evidence is low. Our case adds to the literature regarding the use of these modalities and highlights the multidisciplinary team approach required to manage such complex cases.

我们报告了一例 61 岁女性的病例,她在治疗亚严重肺栓塞后出现了肝素诱导的血小板减少症,随后因严重肢体缺血而需要进行膝上截肢手术。肝素诱导的血小板减少症是一种罕见的免疫介导并发症,院内死亡率为 10%。这种并发症在外科患者中更为常见,骨科手术患者比心脏手术患者更容易出现这种并发症,但后者更容易形成肝素依赖性免疫球蛋白 G 抗体。围手术期管理仍是一项挑战。理想情况下,最好等待血小板计数改善;但在某些情况下,手术不能延迟。肝素引起的血小板减少症通常使用直接凝血酶抑制剂,如阿加曲班和比伐卢定。较新的治疗方法,如血浆置换术和静脉注射免疫球蛋白(如本病例中使用的方法),可以快速清除抗体,但证据的确定性较低。我们的病例补充了有关使用这些方法的文献,并强调了处理此类复杂病例所需的多学科团队方法。
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引用次数: 0
A resonance sonorheometry guided dose reduction of plasma transfusion in repetitive hip surgery in a patient with a severe factor XI deficiency: a case report 在重度 XI 因子缺乏症患者的重复性髋关节手术中,在共振超声波测量法的指导下减少血浆输注剂量:病例报告。
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-06-24 DOI: 10.1002/anr3.12308
H. Supthut, P. Peck, B. Hertenstein, C. Delle, M. Winterhalter

Factor XI deficiency is a rare disorder with an unpredictable bleeding tendency. Here, we report the successful use of the sonic estimation of elasticity via resonance sonorheometry for guiding the management of haemostasis in a patient with a severe factor XI deficiency in repeated revision hip surgeries. Regardless of an administration of fresh frozen plasma, a significant haemorrhage occurred at the first of three hip surgeries. The repeat application of fresh frozen plasma normalised the prolonged activated partial thromboplastin time and the resonance sonorheometry clot time values; the factor XI activity increased to a sufficient level. No significant bleeding occurred in the second and third hip surgery. Using a resonance sonorheometry guided approach in haemostasis management has the potential to improve safety for patients with factor XI deficiency undergoing surgery by ensuring sufficient clotting and preventing side effects.

因子 XI 缺乏症是一种罕见疾病,具有不可预测的出血倾向。在此,我们报告了通过共振超声波测量法对弹性的声波估算成功用于指导一名严重因子 XI 缺乏症患者在反复翻修髋关节手术中的止血治疗。尽管使用了新鲜冰冻血浆,但在三次髋关节手术中的第一次手术中发生了严重出血。再次使用新鲜冰冻血浆后,延长的活化部分凝血活酶时间和共振超声凝血时间值恢复正常;XI因子活性也上升到足够水平。第二次和第三次髋关节手术均未出现明显出血。在止血管理中使用共振超声引导方法有可能通过确保充分凝血和防止副作用来提高接受手术的 XI 因子缺乏症患者的安全性。
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引用次数: 0
Peripheral regional anaesthesia in an adult with Schwartz-Jampel syndrome 对一名患有施瓦茨-詹佩尔综合征的成人进行外周区域麻醉
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-06-18 DOI: 10.1002/anr3.12310
B. U. Gruber, A. Kohler, H. Bomberg, R. Labèr, U. Eichenberger
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引用次数: 0
Feasibility of a virtual reality course on adult tracheostomy safety skills* 成人气管造口术安全技能虚拟现实课程的可行性。
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-06-17 DOI: 10.1002/anr3.12305
J. R. Abbas, E. Bertram-Ralph, S. Hatton, T. Garth, C. Doherty, I. A. Bruce, B. A. McGrath

The National Tracheostomy Safety Project has run high-quality, face-to-face skills courses since 2009. The aim of this project was to produce a virtual reality version of the established course and evaluate its impact on participant learning, and participant and faculty satisfaction. Healthcare staff and students were recruited and randomised to attend one of (1) a face-to-face traditional course (control); (2) a virtual reality course at a conference centre with on-site technical support; (3) a fully remote virtual reality course; the virtual reality groups were combined for the analysis of learning outcomes and satisfaction. The primary outcome was the difference in pre/post-course knowledge scores on a 30-item questionnaire; secondary outcomes included knowledge retention, usability, comfort/side effects and participant performance in a simulated tracheostomy emergency. Thirty-seven participants and 15 faculty participated in this study. There was no significant difference between mean pre/post-course scores from the face-to-face (from 21.1 to 23.1; +2) and combined virtual reality (from 17.1 to 21.1; +4) groups, with both showing improvement (p = 0.21). The mean System Usability Scale score for virtual reality was 76.8 (SD 12.6), which is above average; the median Simulator Sickness Questionnaire score was 7.5 (IQR 3.7–22.4), indicating minimal symptoms. All participants resolved the primary clinical problem in the simulated emergency, but the virtual reality (VR) group was slower overall (mean difference 61.8 s, p = 0.003). This technical feasibility study demonstrated that there was no difference in participant knowledge immediately after and 4 weeks following face-to-face and virtual reality courses. Virtual reality offers an immersive experience that can be delivered remotely and offers potential benefits of reducing travel and venue costs for attendees, therefore increasing the flexibility of training opportunities.

自 2009 年以来,国家气管造口术安全项目一直在开展高质量的面对面技能课程。该项目的目的是制作一个虚拟现实版本的既定课程,并评估其对学员学习的影响以及学员和教师的满意度。医护人员和学生被招募并随机分配参加以下课程之一:(1) 面对面传统课程(对照组);(2) 在会议中心举办的虚拟现实课程,并有现场技术支持;(3) 完全远程虚拟现实课程;虚拟现实组合并分析学习成果和满意度。主要结果是课程前/后在 30 项调查问卷中知识得分的差异;次要结果包括知识保留率、可用性、舒适度/副作用以及学员在模拟气管切开术紧急情况中的表现。37 名学员和 15 名教师参与了这项研究。面对面组(从 21.1 分到 23.1 分;+2)和虚拟现实组合组(从 17.1 分到 21.1 分;+4)的课程前后平均得分没有明显差异,都有所提高(p = 0.21)。虚拟现实系统可用性量表的平均得分为 76.8(标准差为 12.6),高于平均水平;模拟器晕机问卷的中位得分为 7.5(IQR 为 3.7-22.4),表明症状极轻。所有参与者都在模拟紧急情况下解决了主要临床问题,但虚拟现实(VR)组的总体速度较慢(平均差异为 61.8 秒,P = 0.003)。这项技术可行性研究表明,在面授课程和虚拟现实课程结束后 4 周内,学员的知识水平没有差别。虚拟现实技术提供了一种身临其境的体验,可以远程授课,并具有减少学员差旅费和场地费的潜在优势,因此提高了培训机会的灵活性。
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引用次数: 0
Airway fire with use of diathermy in conjunction with high-flow nasal oxygen 在使用高流量鼻氧的同时使用电热治疗法,气道起火
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-06-12 DOI: 10.1002/anr3.12309
M. Aldridge

Operating theatre fires are rare but can result in significant morbidity. A 76-year-old male with complex airway disease sustained superficial facial burns during an elective airway debulking procedure. His airway was being managed with high-flow nasal oxygen at 70 l.min−1 and FiO2 1.0 delivered by Optiflow™ (Fisher and Paykel Healthcare Limited, Auckland, New Zealand). When suction monopolar diathermy was used to excise hyperkeratotic tissue beside his epiglottis, an arc was created to the tip of the suspension laryngoscope, followed by a jet of flame as the Optiflow circuit ignited. This resulted in burns to the patient's face and shoulder. He required admission to the intensive care unit and had a complicated postoperative course that included the need for surgical tracheostomy to facilitate weaning from mechanical ventilation. This case highlights the dangers of using high-flow nasal oxygen alongside an ignition source.

手术室火灾十分罕见,但可导致严重的发病率。一名 76 岁的男性患者患有复杂气道疾病,在一次择期气道清创手术中面部表皮烧伤。当时正在使用 Optiflow™(新西兰奥克兰 Fisher and Paykel Healthcare Limited)提供的 70 升/分钟和 FiO2 1.0 的高流量鼻氧管理他的气道。在使用单极透热吸引术切除会厌旁的角化过度组织时,悬吊喉镜的顶端产生了电弧,随后 Optiflow 电路被点燃,喷射出火焰。这导致患者面部和肩部烧伤。他需要住进重症监护室,术后情况复杂,包括需要进行外科气管造口术,以便于脱离机械通气。本病例强调了在使用高流量鼻氧的同时使用火源的危险性。
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引用次数: 0
Interpretation of chest fluoroscopy: the risk of misdiagnosing atelectasis as pneumothorax due to greyscale inversion 解读胸部透视:灰阶反转导致将气胸误诊为肺不张的风险
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-06-01 DOI: 10.1002/anr3.12307
C. Y. Lin, N. B. Cavanaugh, S. Subramani, A. K. Singhal, S. Hanada

Anaesthetists may be required to work in hybrid theatres for procedures using fluoroscopic imaging. Adequate knowledge of fluoroscopic images allows prompt and effective emergency management of complications which arise during procedures. Here, we present a case of severe hypotension and hypoxia occurring shortly after induction of anaesthesia. Atelectasis was mistaken for a pneumothorax due to misinterpretation of fluoroscopic imaging, which demonstrated a dark pleural cavity peripheral to a partially collapsed left lung, leading to an incorrect diagnosis. This case highlights the importance of understanding greyscale inversion in fluoroscopy.

麻醉师可能需要在混合手术室工作,进行使用透视成像的手术。对透视图像有足够的了解可以对手术过程中出现的并发症进行及时有效的紧急处理。在此,我们介绍一例在麻醉诱导后不久发生严重低血压和缺氧的病例。由于对透视成像的误读,将气胸误认为是气胸,透视成像显示左肺部分塌陷的周围有一个深色胸膜腔,从而导致了错误的诊断。该病例强调了了解透视灰阶反转的重要性。
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引用次数: 0
Combined interscalene, superficial cervical plexus and thoracic intertransverse process blocks for surgical anaesthesia of the shoulder disarticulation 用于肩关节离断手术麻醉的椎间隙、颈浅丛和胸横突联合阻滞术
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-05-29 DOI: 10.1002/anr3.12306
A. Kilicaslan, F. Gok, T. S. Colak, O. Keklicek, M. F. Kucuksen
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引用次数: 0
Comment on ‘Brachial plexus blockade arising from a combined pectoralis (PECS) 1 and 2 block’ 就 "胸肌(PECS)1 和 2 联合阻滞引起的臂丛阻滞 "发表评论
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-05-28 DOI: 10.1002/anr3.12304
Rohan Magoon, Varun Suresh
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引用次数: 0
Remimazolam sedation for awake tracheal intubation 清醒气管插管时使用雷马唑仑镇静剂
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-05-27 DOI: 10.1002/anr3.12298
B. Kolb, T. Lewis, J. Large, M. Wilson, K. Ode

We present a case of a 55-year-old woman presenting for an elective minor procedure. Following a previous anaesthetic, a ‘can't intubate, can't oxygenate’ incident had been documented. She had since undergone awake tracheal intubation for procedures requiring general anaesthesia. We were able to safely facilitate awake tracheal intubation using remimazolam for sedation. Remimazolam is a novel ultra-short acting benzodiazepine with similar pharmacodynamic effects to its parent compound midazolam, having minimal cardiovascular or respiratory effects and offering excellent anxiolysis and amnesia. It has a significantly shorter duration of action than midazolam, making it a valuable sedative agent for awake tracheal intubation. The patient remained stable throughout the procedure, with minimal effects on the respiratory and cardiovascular systems. The quality of sedation was reported as highly satisfactory by both the patient and the team.

我们要介绍的是一例 55 岁女性的病例,她是来做一个择期小手术的。在之前的一次麻醉后,曾发生过 "无法插管、无法吸氧 "的事件。此后,她在需要全身麻醉的手术中接受了清醒气管插管。我们使用雷马唑仑镇静,安全地完成了清醒气管插管。雷马唑仑是一种新型超短效苯二氮卓类药物,其药效学效应与其母体化合物咪达唑仑相似,对心血管或呼吸系统的影响极小,并具有良好的抗焦虑和失忆作用。它的作用持续时间明显短于咪达唑仑,因此是清醒气管插管的重要镇静剂。患者在整个手术过程中保持稳定,对呼吸系统和心血管系统的影响极小。患者和医护人员都对镇静效果非常满意。
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引用次数: 0
The spread of injectate after deep serratus anterior plane and superficial parasternal intercostal plane blocks: a cadaveric dye study 深层前锯肌平面和浅层胸骨旁肋间平面阻滞后注射剂的扩散:尸体染色研究
IF 0.8 Q3 ANESTHESIOLOGY Pub Date : 2024-05-24 DOI: 10.1002/anr3.12297
M. A. Perez-Herrero, M. Fajardo, F. Galluccio, E. Yamak Altinpulluk, K. Espinoza

We investigated the distribution of injected dye after deep serratus anterior plane and superficial parasternal intercostal plane blocks in 15 Thiel embalmed cadavers. We injected 0.4 ml.kg−1 of 0.25% aqueous methylene blue solution into the deep serratus anterior and superficial parasternal intercostal planes using real-time ultrasound needle visualisation followed by posterior dissection to observe the distribution of the injected dye in the chest wall. The two blocks were performed bilaterally in 15 cadavers at the T5/T6 level, comprising 60 blocks in 30 hemithoraces in total. At dissection, the intercostal nerve territories were observed to be dyed completely from T2 to T6 in 28 of 30 hemithoraces, and extending caudal to T6 in 10 hemithoraces. Following the deep serratus anterior plane blocks in all cadavers, the dye was found to have spread to the axillae. Following the superficial parasternal intercostal plane blocks, the dye reached T7 in four cadaver dissections. We concluded that the territories innervated by the intercostal nerves (T2–T6 dermatomes) are dyed following the combination of the two blocks when performed at the T5–T6 intercostal space level. These techniques might provide an effective option for anaesthesia in breast surgery.

我们研究了 15 具蒂尔防腐尸体的前锯肌深面和肋间浅面阻滞后注射染料的分布情况。我们使用实时超声针可视技术将 0.25% 亚甲蓝水溶液 0.4 ml.kg-1 注射到锯肌前深面和肋间浅表旁,然后进行后方解剖,观察注射染料在胸壁的分布。在 15 具尸体的 T5/T6 水平上进行了双侧阻滞,共包括 30 个半椎体的 60 个阻滞。解剖时观察到,在 30 个半椎体中的 28 个中,从 T2 到 T6 的肋间神经区域被完全染色,在 10 个半椎体中,肋间神经区域向尾部延伸至 T6。在对所有尸体的前锯肌深面进行阻滞后,发现染色剂已扩散到腋窝。在浅层胸骨旁肋间平面阻滞后,有四具尸体的染色剂到达了 T7。我们的结论是,在 T5-T6 肋间水平进行两种阻滞后,肋间神经支配的区域(T2-T6 皮节)会被染色。这些技术可为乳房手术的麻醉提供有效的选择。
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引用次数: 0
期刊
Anaesthesia reports
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