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Osteosarcoma of the breast: a case report of a rare breast malignancy in a patient with prior partial mastectomy 乳房骨肉瘤:一个罕见的乳房恶性肿瘤的病例报告,患者先前乳房部分切除术
Genevieve Hattingh, Diego A Hanssen, J. Medina, Mansi Sanghvi, Ajay Shah
: Primary osteosarcoma of the breast (OSB) is a rare malignancy of the breast with poor prognosis. There are some reported cases of this infrequent malignant neoplasia, showing that in some instances it can be related to prior trauma or local irradiation in the area. Most malignant mesenchymal neoplasia can be found on the extremities, retroperitoneum, the trunk area and less common, breast, heart, thyroid and the lung. We present a 68-year-old female without any significant medical problems but with prior history of right breast cancer treated with partial mastectomy, adjuvant chemotherapy and local radiation in 2004, presenting to our breast clinic in 2020 with a palpable lesion and biopsy proven poorly differentiated malignant neoplasm, favoring poorly differentiated mammary carcinoma with osteoblastic giant cells. This patient went for a right total mastectomy with final pathology showing high grade osteoblastic osteosarcoma, requiring subsequent re-excision for positive margins. Here we discuss the recommended management and treatment for such a rare diagnosis, as currently no official treatment guidelines exist. We recommend wide local excision without lymph node biopsy and adjuvant chemotherapy. Radiation may be an option but should be decided upon on a case by case basis given the lack of data on its efficacy.
原发性乳腺骨肉瘤(OSB)是一种罕见的乳腺恶性肿瘤,预后较差。有一些罕见的恶性肿瘤病例报道,表明在某些情况下,它可能与先前的创伤或局部照射有关。大多数恶性间质瘤可在四肢、腹膜后、躯干区域发现,较少见于乳房、心脏、甲状腺和肺部。我们报告一位68岁的女性患者,她没有任何重大的医学问题,但在2004年曾接受过乳房部分切除术、辅助化疗和局部放疗,于2020年在我们的乳腺诊所就诊,发现可及的病变,活检证实为低分化恶性肿瘤,倾向于低分化的成骨巨细胞乳腺癌。该患者行右侧全乳切除术,最终病理显示为高级别成骨细胞骨肉瘤,切缘呈阳性需要再次切除。在这里,我们讨论推荐的管理和治疗这种罕见的诊断,因为目前没有官方的治疗指南存在。我们建议局部广泛切除,不需要淋巴结活检和辅助化疗。辐射可能是一种选择,但由于缺乏有关其功效的数据,应根据具体情况决定。
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引用次数: 0
Perspectivising tumescent mastectomy: innovation in preserving mastectomy skin flap perfusion—a narrative review 乳房肿胀切除术的透视:保留乳房切除术皮瓣灌注的创新-一篇叙述性综述
C. Bille
: Mastectomy is used in breast cancer treatment and as risk-reducing in women with genetic high risk of breast cancer. Immediate breast reconstruction including direct to implant but also autologous breast reconstruction is increasingly offered to women planned to have mastectomy. Either simple mastectomy or skin sparring mastectomy followed by immediate breast reconstruction, two specific issues are crucial. (I) Oncologic safety. That is, removal of any diagnosed pathologic finding, but also all breast tissue including the often breast tissue containing Coopers ligaments and thereby minimizing residual breast tissue. (II) Low complication rate. During mastectomy, the skin flaps are dissected from the breast gland. The interruption of blood supply to the skin flaps from below results in diminished perfusion of the skin flaps. This comprises a risk of necrosis and infection and ultimately prolonged time to adjuvant therapy, prolonged recovery, and possible loss of reconstruction. Tumescent technique with epinephrine solution meets both challenges, especially when used under visual guidance. It accentuates breast tissue and makes it easier to dissect the breast tissue and Coopers ligaments free from the subcutaneous fatty tissue. Furthermore, it is atraumatic and preserves the insulating fatty tissue and the blood supply running through this. Maintaining skin flap perfusion diminishes the risk of necrosis and infection. On top of that, tumescent mastectomy leaves more fatty tissue resulting in a more pleasant aesthetic result regardless of either simple or skin sparring mastectomy and regardless of either direct to implant or autologous reconstruction. The powerful ICG-angiography, often used to assess areas with low perfusion and previously shown to be superior to clinical assessment, can, however, not be relied on when tumescent mastectomy technique has been used.
乳房切除术用于乳腺癌治疗,并用于降低乳腺癌遗传高风险妇女的风险。立即乳房重建包括直接植入和自体乳房重建越来越多地提供给计划进行乳房切除术的妇女。无论是单纯的乳房切除术还是皮肤切除后立即乳房重建,两个特定的问题是至关重要的。(一)肿瘤安全性。也就是说,切除任何诊断出的病理发现,以及所有的乳腺组织,包括通常含有Coopers韧带的乳腺组织,从而最大限度地减少残留的乳腺组织。(二)并发症发生率低。在乳房切除术中,皮瓣从乳腺上剥离。皮瓣从下方供血中断导致皮瓣灌注减少。这包括坏死和感染的风险,最终延长辅助治疗的时间,延长恢复时间,并可能丧失重建。肾上腺素溶液的肿胀技术遇到了这两个挑战,特别是在视觉引导下使用。它突出了乳房组织,使它更容易从皮下脂肪组织中剥离乳房组织和库伯斯韧带。此外,它是非创伤性的,并保留了绝缘脂肪组织和血液供应。维持皮瓣灌注可减少坏死和感染的风险。最重要的是,乳房肿胀切除术留下了更多的脂肪组织,无论是简单的还是皮肤切除,无论是直接植入还是自体重建,都能带来更愉快的美学结果。功能强大的icg血管造影通常用于评估低灌注区域,先前显示优于临床评估,然而,当使用肿胀性乳房切除术技术时,就不可靠了。
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引用次数: 0
Gestational gigantomastia complicated by breast infarctive necrosis in the setting of COVID-19 infection: a case report 新冠肺炎感染时妊娠期巨乳症合并乳腺梗死坏死1例报告
N. Ecanow, A. Chichura, K. Kopkash, C. Pesce, M. Sullivan, K. Yao
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引用次数: 0
Identification of factors that predict premature tissue expander loss in immediate breast reconstruction 确定预测乳房重建中过早组织扩张器丢失的因素
Bridgette Bolshem, A. Fahey, A. Melillo, Katherine A. Rodby, G. Rapaport, J. Gaughan, M. Matthews
Between 65–75% of breast reconstructions in the U.S. employ tissue expander (TE) and implant-based reconstruction (1). This method provides practical advantages including shorter operative time and faster recovery (1,2). Despite these advantages, there are still pitfalls to TE-based reconstruction. The overall prevalence of TE failure is unclear since this varies by institution, patient population, follow-up period. Original Article
美国65-75%的乳房重建采用组织扩张器(TE)和基于植入物的重建(1)。该方法具有操作时间短、恢复快等实际优点(1,2)。尽管有这些优点,但基于TE的重建仍然存在缺陷。TE失败的总体患病率尚不清楚,因为这因机构、患者群体和随访期而异。原始文章
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引用次数: 0
Work-up and management of breast pain 乳房疼痛的检查和处理
Pamela Li, A. Simpson, Jill M. Dietz
Breast pain, or mastalgia, is a common symptom and a frequent reason for breast center referrals. It can be categorized as cyclical or non-cyclical pain. Cyclical breast pain is more common and varies with the menstrual cycle. Non-cyclical breast pain includes true breast pain and extramammary causes. Categorizing breast pain helps to guide the work-up and management. A thorough history and physical exam should be performed in all patients presenting with breast pain. Though breast pain alone is rarely a sign of breast cancer, breast imaging may be still be appropriate. If there are no concerning findings on the physical exam, the imaging work-up is determined by patient age and the type of breast pain. Management of breast pain without suspicious findings on physical exam or breast imaging is driven by the severity of the pain. Reassurance of the negative findings and that the patient does not have breast cancer is often all that is required. Breast pain frequently resolves spontaneously and no further treatments are necessary. If pain is persistent or impacting quality of life, initial management is centered on conservative therapies such as physical support. Medications can be considered for severe and persistent pain, but the side effects of these therapies need to be considered.
乳房疼痛是一种常见的症状,也是乳房中心转诊的常见原因。它可以分为周期性疼痛和非周期性疼痛。周期性乳房疼痛更常见,并随月经周期而变化。非周期性乳房疼痛包括真正的乳房疼痛和乳房外原因。对乳房疼痛进行分类有助于指导检查和治疗。所有出现乳房疼痛的患者都应进行彻底的病史和体格检查。虽然乳房疼痛本身很少是乳腺癌的征兆,但乳房成像可能仍然是适当的。如果在体检中没有相关发现,则根据患者的年龄和乳房疼痛的类型进行影像学检查。乳房疼痛的管理没有可疑的发现体检或乳房影像学是由疼痛的严重程度驱动的。通常只需要确认阴性结果和病人没有患乳腺癌就够了。乳房疼痛通常会自行消退,不需要进一步治疗。如果疼痛持续或影响生活质量,最初的管理集中在保守治疗,如物理支持。对于严重和持续的疼痛,可以考虑药物治疗,但这些治疗的副作用需要考虑。
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引用次数: 0
Immediate or delayed breast reconstruction: the aspects of timing, a narrative review 立即或延迟乳房重建:时间方面,叙述回顾
L. Hölmich, Farah Sayegh, C. Salzberg
Department of Plastic Surgery, Herlev and Gentofte Hospital, Herlev, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark; Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA Contributions: (I) Conception and design: All authors; (II) Administrative support: CA Salzberg, LR Hölmich; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Lisbet Rosenkrantz Hölmich. Department of Plastic Surgery, Herlev and Gentofte Hospital, Herlev, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. Email: lisbet.rosenkrantz.hoelmich@regionh.dk.
丹麦赫列夫赫列夫和根托夫特医院整形外科;哥本哈根大学临床医学系,丹麦哥本哈根;美国纽约西奈山伊坎医学院整形与重建外科:(I)构思与设计:所有作者;(II) 行政支助:CA Salzberg、LR Hölmich;(III) 提供研究材料或患者:所有作者;(IV) 数据收集和汇编:所有作者;(V) 数据分析和解释:所有作者;(VI) 手稿写作:所有作者;(VII) 手稿的最终批准:所有作者。通信:Lisbet Rosenkrantz Hölmich。丹麦赫列夫赫列夫和根托夫特医院整形外科;哥本哈根大学临床医学系,丹麦哥本哈根。电子邮件:lisbet.rosenkrantz.hoelmich@regionh.dk.
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引用次数: 0
“Scarless” excision of a nipple adenoma case report—a good aesthetic outcome after a circular nipple excision with purse-string closure technique 乳头腺瘤“无疤痕”切除术一例报告——荷包扣技术环形乳头切除术后的良好美学效果
J. X. Hing, E. Kua, Wai Peng Lee
: Complete surgical excision of nipple adenoma with clear margins offers the lowest risk of recurrence of this locally infiltrative yet benign entity. A thorough triple assessment including histological assessment is crucial to exclude any malignant pathology, and confirm the diagnosis. There are many excisional and ablative techniques published that can give clear resection margins, but there remains a paucity of data on acceptable aesthetic outcomes. It is important to balance between adequate surgical margins to prevent recurrence and a good aesthetic outcome, particularly in a young patient. We wish to highlight a good aesthetic outcome following a simple circular excision with purse-string closure of the nipple defect. We present a 28-year-old lady with a progressively ulcerative lesion that involved the entire nipple. Ultrasound did not show any other underlying lesions or intraductal extension. Punch biopsy confirms the diagnosis of a benign nipple adenoma. She was counselled for complete nipple excision and the defect was primarily closed with purse-string technique. This may not be a novel technique as it has been described for closure of other defects. However, the benefit of a purse-string closure of a circular nipple excision defect to reduce scarring may be underreported in the literature. This technique helps to conceal the scar within the areola, retain its natural corrugated appearance, and prevent distortion to the overall shape of the areolar complex. The final outcome of a complete nipple excision resembles that of a ‘scarless’ excision and remains aesthetically pleasing. We hope to allay fears of clinician and patients faced with similar condition by offering a safe, easily reproducible, single staged technique that offers high patient satisfaction in selected patients. Using this technique may even preclude the need for further nipple reconstruction.
对边缘清晰的乳头腺瘤进行完全手术切除是这种局部浸润性良性肿瘤复发的最低风险。彻底的三重评估包括组织学评估是至关重要的,以排除任何恶性病理,并确认诊断。有许多已发表的切除和烧蚀技术可以给出清晰的切除边缘,但关于可接受的美学结果的数据仍然缺乏。重要的是要平衡足够的手术切缘,以防止复发和良好的审美结果,特别是在一个年轻的病人。我们希望强调一个良好的美学结果后,一个简单的圆形切除与钱包串关闭乳头缺陷。我们报告一位28岁的女性,她患有累及整个乳头的渐进性溃疡性病变。超声未见其他潜在病变或导管内延伸。穿刺活检证实为良性乳头腺瘤。她被建议完全切除乳头,并主要用钱包串技术关闭缺陷。这可能不是一种新的技术,因为它已经被描述为关闭其他缺陷。然而,在文献中,使用荷包缝合环状乳头切除缺陷以减少疤痕的益处可能被低估。这项技术有助于将疤痕隐藏在乳晕内,保持其自然的波纹外观,并防止对乳晕复合体整体形状的扭曲。完全乳头切除的最终结果类似于“无疤痕”切除,并保持美观。我们希望通过提供一种安全、易于重复、单阶段的技术来减轻临床医生和面临类似情况的患者的恐惧,并在选定的患者中提供高患者满意度。使用这种技术甚至可以避免进一步乳头重建的需要。
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引用次数: 0
Superparamagnetic iron oxide sentinel lymph node biopsy in early breast cancer: an analysis of artefacts on post-operative breast imaging 癌症早期乳腺癌超顺磁性铁氧化物前哨淋巴结活检术后乳腺成像伪影分析
V. Man, M. Cheung, Christine Lo, Tina Lam, A. Kwong
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引用次数: 1
An update on breast animation deformity grading systems—a systematic review 乳房动画畸形分级系统的更新-系统回顾
Farima Dalaei, D. L. Dyrberg, C. Bille, C. Salzberg, J. A. Sørensen, J. Thomsen
Breast animation deformity (BAD) is a common and afflicting sequelae of breast reconstruction or augmentation, and is estimated to occur with variable severity in anywhere from zero to 75% of reconstructions/augmentation (1). It is characterized by an unsightly deformation, a motion deformity, resulting in displacement of the implant and skin rippling associated with contraction of the pectoral muscle (2). BAD is an aesthetic concern, as well as a functional problem. Muscle twitching, pain, and impaired shoulder function are significant problems, especially in physically active women thus affecting patient’s healthrelated quality of life (HR-QOL) (3-5). Review Article
乳房动画畸形(BAD)是乳房重建或隆胸的一种常见且痛苦的后遗症,据估计,在0至75%的重建/隆胸中,其严重程度各不相同(1)。其特征是难看的变形、运动畸形,导致植入物移位和与胸肌收缩相关的皮肤波纹(2)。BAD是一个美学问题,也是一个功能问题。肌肉抽搐、疼痛和肩部功能受损是严重的问题,尤其是在体力活动的女性中,从而影响患者的健康相关生活质量(HR-QOL)(3-5)。审阅文章
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引用次数: 2
Novel innovations and advancements in breast reconstruction 乳房再造的创新与进步
E. Chang
The field of breast reconstruction has witnessed tremendous advancements over the years both in terms of breast conservation as well as reconstruction following a mastectomy. The field of oncoplastic surgery has quickly become the standard of care where techniques engrained in the field of cosmetic, aesthetic plastic surgery are now employed to provide the most optimal means of reconstruction for patients undergoing a partial mastectomy. However, other techniques including local pedicle flaps as well as fat grafting or lipofilling have also become useful adjuncts to improve the overall cosmetic results for these patients. For patients undergoing reconstruction following a mastectomy, new technologies are constantly emerging to optimize reconstruction using a prosthesis-based approach, not simply in terms of the devices themselves, but also in terms of surgical techniques and in particular acellular dermal matrices (ADM). The frequent use of ADM has ushered in an era where the prosthesis has returned to a subcutaneous or prepectoral location which was previously plagued with high complications including capsular contracture. Early studies examining this approach have demonstrated high satisfaction and promising results. However, just as there have been beneficial developments in breast reconstruction, so have controversies arisen, the most prevalent of which is the description of breast implant associatedanaplastic large cell lymphoma associated with textured devices. Tremendous advancements have also occurred in the arena of autologous reconstruction where free tissue transfer has quickly become the gold standard means of reconstruction. However, whereas previously the abdominal donor site was the only means of autologous reconstruction, novel donor sites including the thigh and lumbar region are quickly gaining in popularity with the increased comfort with perforator flaps and microvascular surgery. With the growing experience with microsurgery, free tissue transfer no longer focuses solely on achieving a viable flap, but on optimizing patient satisfaction and outcomes. The creation of a sensate flap through neurotization is also quickly becoming commonplace, but long-term outcomes remain to be determined. Finally, the field of lymphedema super microsurgery is now a critical component for reconstruction in patients undergoing treatment for breast cancer. Given the need for multimodality therapy including chemotherapy and radiation, coupled with the need for an axillary dissection in patients with more advanced disease, the risks of lymphedema are only expected to increase. The two physiologic techniques, the lymphovenous bypass (LVB) and vascularized lymph node transfer (VLNT) have proven to be remarkably effective and have dramatically altered the treatment for breast cancer related lymphedema (BCRL) and proven to be an effective means at improving the quality of life of patients suffering from BCRL. The current compendium of articles in the se
近年来,乳房重建领域在乳房保护和乳房切除术后重建方面取得了巨大的进步。肿瘤整形手术领域已经迅速成为护理的标准,在美容整形手术领域中根深蒂固的技术现在被用来为接受部分乳房切除术的患者提供最理想的重建手段。然而,其他技术,包括局部蒂皮瓣以及脂肪移植或脂肪填充也成为有用的辅助手段,以改善这些患者的整体美容效果。对于乳房切除术后进行重建的患者,新技术不断涌现,以优化使用假体为基础的重建方法,不仅在设备本身方面,而且在手术技术方面,特别是脱细胞真皮基质(ADM)。ADM的频繁使用开创了假体回到皮下或胸前位置的时代,这在以前是一个高并发症的困扰,包括包膜挛缩。检验这种方法的早期研究已经证明了高满意度和有希望的结果。然而,正如乳房重建的有益发展一样,争议也随之而来,其中最普遍的是对乳房植入物相关间变性大细胞淋巴瘤与纹理装置相关的描述。自体重建领域也取得了巨大的进步,其中游离组织移植已迅速成为重建的金标准手段。然而,尽管以前腹部供体部位是自体重建的唯一手段,但随着穿支皮瓣和微血管手术的舒适度提高,包括大腿和腰椎在内的新型供体部位迅速受到欢迎。随着显微外科手术经验的增长,自由组织移植不再仅仅关注于获得一个可行的皮瓣,而是关注于优化患者的满意度和结果。通过神经化创造感觉皮瓣也很快变得司空见惯,但长期结果仍有待确定。最后,淋巴水肿超显微手术领域现在是乳腺癌患者接受治疗重建的关键组成部分。考虑到需要包括化疗和放疗在内的多模式治疗,再加上疾病晚期患者需要进行腋窝清扫,淋巴水肿的风险只会增加。两种生理技术,淋巴静脉旁路(LVB)和血管化淋巴结转移(VLNT)已被证明是非常有效的,并显著改变了乳腺癌相关淋巴水肿(BCRL)的治疗方法,并被证明是改善BCRL患者生活质量的有效手段。该系列文章的当前纲要旨在从该领域一些最知名的专家那里提供现代乳房重建中最新颖问题的全面概述。虽然该系列并不意味着详尽无遗,但文章的汇编旨在为读者提供有关乳房重建中一些主要主题的新技术,数据和研究的广泛概述。
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引用次数: 0
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Annals of breast surgery : an open access journal to bridge breast surgeons across the world
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