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Annals of breast surgery : an open access journal to bridge breast surgeons across the world最新文献

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Narrative review of breast reconstruction with a latissimus dorsi flap—is there a price to pay? 背阔肌皮瓣乳房再造术的叙事回顾——是否需要付出代价?
Jens H. Højvig, C. Bonde
: The musculocutaneous latissimus dorsi flap is a stable workhorse in reconstructive plastic surgery. It is commonly used as a safe and viable alternative to the DIEP flap and possesses the advantage that it does not require microsurgical expertise. It offers a natural and aesthetically satisfying result, the complications rates are generally low and the postoperative length of hospitalization is short. Although investigated numerous times through the past decades, the functional effect of raising a latissimus dorsi flap remain debatable. We performed a review of the literature and identified studies that have investigated the functional effects after breast reconstruction with a m. latissimus dorsi flap. A reduction in shoulder strength for motions to which the muscle contributes could be intuitively expected following its dissection and have been reported by some authors. However, range of shoulder motion is unaffected in most studies and the subjective effect of the procedure on shoulder function remains ambiguously reported. The following article presents an overview of functional outcomes such as range of motion, shoulder strength and patient reported ability to perform activities of daily living following breast reconstruction with a latissimus dorsi flap. We also discuss other important factors regarding the outcome after m. latissimus dorsi flap, that should ideally be considered, when choosing and informing the patients about strategy for breast reconstruction.
背阔肌皮瓣是重建整形手术中稳定的主力神。它通常被用作DIEP皮瓣的安全可行的替代方案,并且具有不需要显微外科专业知识的优点。手术效果自然美观,并发症发生率低,术后住院时间短。尽管在过去的几十年里研究了很多次,提起背阔肌皮瓣的功能效果仍然存在争议。我们对文献进行了回顾,并确定了研究背阔肌瓣乳房重建后功能影响的研究。一些作者已经报道,在剥离肩关节后,肌肉参与运动的肩部力量下降是可以直观预期的。然而,在大多数研究中,肩关节活动范围不受影响,手术对肩关节功能的主观影响仍有不明确的报道。以下文章概述了背阔肌瓣乳房重建术后的功能结果,如活动范围、肩部力量和患者报告的日常生活活动能力。我们还讨论了其他影响背阔肌瓣术后结果的重要因素,这些因素在选择和告知患者乳房重建策略时应该被理想地考虑。
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引用次数: 0
Breast cancer in the older population: a global challenge—an epidemiological perspective 老年人群中的乳腺癌:一个全球性的挑战——从流行病学角度看
A. Lemij, E. Bastiaannet, N. D. de Glas, F. van den Bos, J. Portielje, G. Liefers, M. Derks
Breast cancer is the most commonly diagnosed malignancy among women, with more than 30% of all patients being over 70 years at the time of diagnosis. The number of older women with breast cancer is expected to increase in the upcoming decades due to the ageing of the population worldwide. Incidence and mortality rates vary between and within continents because of variances in risk factors, health care quality and screening programmes. In older patients, breast cancer occurs to the background of ageing. Ageing increases the exposure to age-related diseases resulting in a heterogeneous population with large differences in multimorbidity. Multimorbidity is associated with mortality, functional impairment, poor quality of life, high health care utilization and costs, and it challenges traditional health care systems. It is therefore essential to get a grip on an individual’s fitness and frailty status. Geriatric screening tools and assessments should be used to get a general idea about these aspects. In that way, biological age, rather than chronological age, in combination with an individual’s life expectancy, patient preferences and potential side effects of a treatment can be the basis of individualized treatment strategies. Nowadays, this heterogeneous older population is underrepresented in clinical trials. Future research should focus on older patients with relevant endpoints, not only in developed countries, but also in less developed countries.
乳腺癌是女性中最常见的恶性肿瘤,超过30%的患者在确诊时年龄超过70岁。由于全球人口老龄化,患乳腺癌的老年妇女人数预计将在未来几十年增加。由于风险因素、保健质量和筛查方案的差异,各大洲之间和各大洲内部的发病率和死亡率各不相同。在老年患者中,乳腺癌发生的背景是衰老。老龄化增加了与年龄有关的疾病的暴露,导致在多发病方面存在巨大差异的异质人群。多发病与死亡率、功能障碍、生活质量差、高卫生保健利用率和高成本有关,并对传统卫生保健系统构成挑战。因此,有必要掌握一个人的健康和虚弱状态。应该使用老年筛查工具和评估来对这些方面有一个大致的了解。这样,生物年龄,而不是实足年龄,结合个人的预期寿命,患者的偏好和治疗的潜在副作用,可以成为个性化治疗策略的基础。如今,这种异质老年人群在临床试验中的代表性不足。未来的研究应关注具有相关终点的老年患者,不仅在发达国家,而且在欠发达国家。
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引用次数: 0
Sensory reinnervation after mastectomy with implant-based reconstruction 乳房切除术后植体重建的感觉神经重建
A. Peled, Z. Peled
As breast cancer therapies continue to improve, increasing focus has been placed on quality-oflife issues after breast cancer and breast cancer risk-reducing treatments. The loss of sensation that typically occurs after mastectomy can have significant negative psychological, sexual, and functional impact on patients after surgery. In order to minimize this impact, more recent attention has been paid to ways to both avoid nerve injury at the time of mastectomy and reconstruct injured nerves either during mastectomy or at the time of delayed reconstruction. These advances have been facilitated by anatomic studies investigating different variants of intercostal anatomy and better understanding the course of the nerves innervating the mastectomy skin and nipple-areolar complex. With improved knowledge of the intercostal nerve anatomy, surgeons are able to carefully preserve nerves at the time of mastectomy, thus improving sensory outcomes. Additionally, nerve reconstruction techniques have advanced, particularly with newer nerve allograft technologies, which allows for nerve reconstruction to be done both at the time of mastectomy, as well as in a delayed fashion. Much of the current literature on intercostal nerve reconstruction to improve postmastectomy sensation has been performed in the setting of autologous reconstruction, but several more recent studies have assessed outcomes following implant-based reconstruction. The focus of this article is to describe the current state of sensory preservation and reinnervation for mastectomy with implant-based reconstruction and the advances that have allowed for these new approaches.
随着乳腺癌治疗的不断改进,人们越来越关注乳腺癌治疗后的生活质量问题和降低乳腺癌风险的治疗。乳房切除术后通常发生的感觉丧失会对术后患者的心理、性和功能产生重大的负面影响。为了尽量减少这种影响,近年来人们越来越关注如何在乳房切除术时避免神经损伤,并在乳房切除术或延迟重建时重建损伤的神经。这些进展得益于对肋间解剖不同变体的解剖研究,以及对支配乳房切除皮肤和乳头-乳晕复合体的神经的更好理解。随着肋间神经解剖学知识的提高,外科医生能够在乳房切除术时小心地保护神经,从而改善感觉结果。此外,神经重建技术也取得了进步,特别是新的同种异体神经移植技术,这使得神经重建可以在乳房切除术时进行,也可以在延迟的方式进行。目前关于肋间神经重建以改善乳房切除术后感觉的文献大多是在自体重建的情况下进行的,但最近的一些研究评估了植入式重建的结果。这篇文章的重点是描述当前状态的感觉保存和神经再生乳房切除术与植入式重建和进步,已经允许这些新方法。
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引用次数: 1
Negative predictive value and specificity of contrast enhanced spectral mammography in 309 women with suspicious findings at breast ultrasound 309例乳腺超声检查结果可疑的女性对比增强光谱钼靶摄影的阴性预测价值和特异性
T. Emory, N. Hoven, Michael Nelson, A. Church, N. Rubin, J. Kuehn-Hajder
Background: There are ongoing efforts to discover readily available noninvasive techniques to accurately exclude the presence of cancer when a suspicious breast lesion is identified. In order to be useful, such a technique must also accurately exclude a sizeable number of women who would have been otherwise biopsied. Therefore, such a test should have a high negative predictive value in excluding malignancy and a high enough specificity in predicting which women will turn out to have a benign biopsy result. The goal of this study was to investigate the negative predictive value and specificity of contrast enhanced spectral mammography (CESM) in women with a suspicious finding on diagnostic mammography and ultrasound. Methods: With IRB approval, CESM reports from two academic breast centers were retrospectively evaluated. Four hundred and twenty-four women were identified, and 309 women met inclusion criteria. All women had a suspicious finding on diagnostic mammography and ultrasound and had CESM prior to a same day scheduled ultrasound guided core needle biopsy. Results: Two hundred/309 (65%) women had histologically proven malignancy and 109/309 (35%) women had benign results. One hundred and ninety-seven/200 cancers enhanced at CESM [sensitivity 98.5%; 95% confidence interval (CI): 95.7–99.7%]. Fifty-eight/109 women with benign results did not enhance and were true negatives (specificity 53.2%; 95% CI: 43.4–62.8%). Of the 248 women with CESM lesion enhancement, 197/248 were cancer (positive predictive value =79.4%; 95% CI: 76.0–82.5%). Of the 61 women without lesion enhancement on CESM, 58/61 were benign (negative predictive value =95.1%; 95% CI: 86.1–98.4%). The 3 false negatives consisted of 2 sub centimeter Nottingham grade 1/3 estrogen receptor (ER) positive HER2/neu negative invasive mammary cancers of no special type, and one case of ductal carcinoma in situ (DCIS) in a papilloma which was 3 mm in size at excision. Conclusions: CESM was accurate in excluding malignancy in over half of the women that had otherwise suspicious findings at diagnostic mammography and ultrasound. 12 fibrocystic changes, 5 of 8 papillomas, 1 of 8 stromal fibrosis, and 4 of 7 sclerosing adenosis results.
背景:目前正在努力发现容易获得的无创技术,以在发现可疑乳腺病变时准确排除癌症的存在。为了有用,这种技术还必须准确地排除大量本来会进行活检的女性。因此,这种检测在排除恶性肿瘤方面应该有很高的阴性预测价值,在预测哪些女性会得到良性活检结果方面应该有足够高的特异性。本研究的目的是研究对比度增强光谱乳腺摄影术(CESM)对诊断性乳腺摄影和超声发现可疑的女性的阴性预测价值和特异性。方法:在IRB批准的情况下,对来自两个学术乳腺中心的CESM报告进行回顾性评估。确定了424名妇女,309名妇女符合入选标准。所有女性在诊断性乳房X光检查和超声检查中都有可疑发现,并在同一天进行超声引导的核心针活检之前进行了CESM。结果:2309/309(65%)名妇女经组织学证实为恶性,109/309(35%)名妇女为良性。1097/200例癌症在CESM中增强[敏感性98.5%;95%置信区间(CI):95.7–99.7%]。有良性结果的女性中,有58例没有增强,为真阴性(特异性53.2%;95%可信区间:43.4–62.8%)。在有CESM病变增强的248名女性中,197/248为癌症(阳性预测值=79.4%;95%CI:76.0–82.5%)。在CESM上没有病变增强的61名女性中,58/61为良性(阴性预测值=95.1%;95%CI:86.1–98.4%),1例乳头状瘤中的导管原位癌(DCIS),切除时大小为3mm。结论:在超过一半的女性中,CESM在排除恶性肿瘤方面是准确的,这些女性在诊断性乳房X光检查和超声检查中有其他可疑的发现。纤维囊性改变12例,乳头状瘤8例中5例,间质纤维化8例中1例,硬化性腺病7例中4例。
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引用次数: 0
Breast reconstruction—the true multidisciplinary approach 乳房重建——真正的多学科方法
T. Damsgaard, J. Thomsen
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引用次数: 0
Transaxillary endoscopic breast reconstruction: case series from single institution 经颌内窥镜乳房重建:来自单个机构的病例系列
E. Esposito, U. Marone, R. Saponara, E. Morra, G. Di Monta, M. Rho, F. Avino, S. Mori
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引用次数: 0
Accuracy of mammography and magnetic resonance imaging to diagnose underlying malignancy in Paget’s disease of the nipple: a systematic review and meta-analysis 乳房x线摄影和磁共振成像诊断乳头佩吉特病潜在恶性肿瘤的准确性:系统回顾和荟萃分析
Karen-Lise Madsen, Anne D. H. Mosebo, S. Möller, B. H. Pedersen, C. Bille
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引用次数: 0
Postmastectomy radiation: an evolution 术后放疗:一种进化
Brianna M. Jones, V. Osborn
: Postmastectomy radiation therapy (PMRT) has long been utilized to improve locoregional control versus surgery alone, and recent decades have revealed a survival benefit for many higher risk patients based on tumor or nodal factors. During this time the landscape of cancer treatment has evolved towards less invasive surgeries and more effective chemotherapy—likewise, more precise methods of delivering radiation therapy have also emerged, drastically reducing the risk for significant side effects compared with cruder historical techniques. This paper will discuss modern era radiation techniques, toxicity profile, and reconstructive options. Several recent studies have demonstrated improved locoregional control and overall survival in patients whom received postmastectomy radiation. This review will pay special attention to utility of radiation after mastectomy in patients with positive nodes and negative nodes with high-risk features. The indications for radiation therapy after mastectomy have broadened over the past few decades and this review article hopes to explore evolving evidence, as well as, new considerations in setting of increasing use of neoadjuvant chemotherapy and trend towards shorter course radiation treatment. Future directions and ongoing trials exploring benefit of additional radiation and omission of radiation will also be discussed. While some questions remain unanswered on exactly who is likely to benefit, anyone with a large tumor, nodal involvement or other high-risk features should be considered for evaluation.
:长期以来,与单独手术相比,骨切除术后放射治疗(PMRT)一直被用于改善局部控制,近几十年来,基于肿瘤或淋巴结因素,许多高危患者的生存益处已经显现。在这段时间里,癌症治疗的前景已经朝着微创手术和更有效的化疗发展——同样,也出现了更精确的放射治疗方法,与更粗糙的历史技术相比,大大降低了严重副作用的风险。本文将讨论现代辐射技术、毒性概况和重建方案。最近的几项研究表明,接受骨切除术后放射治疗的患者的局部控制和总生存率有所改善。这篇综述将特别关注乳房切除术后放疗在具有高风险特征的阳性淋巴结和阴性淋巴结患者中的应用。在过去的几十年里,乳房切除术后放射治疗的适应症已经扩大,这篇综述文章希望探索不断发展的证据,以及在增加新辅助化疗的使用和缩短疗程放射治疗的趋势方面的新考虑。还将讨论未来的方向和正在进行的探索额外辐射和省略辐射的益处的试验。虽然关于谁可能受益的确切问题仍然没有答案,但任何有大肿瘤、淋巴结受累或其他高风险特征的人都应该被考虑进行评估。
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引用次数: 4
Alternative flaps for breast reconstruction: a narrative review on using the thigh, buttocks, and back 乳房重建的替代皮瓣:使用大腿、臀部和背部的叙述回顾
Chaoqing Zhou, R. R. van der Hulst
As the treatment of breast cancer has dramatically improved in the past decades, so have the techniques for breast reconstruction. Recent innovations in breast implants and the advent of acellular dermal matrices have expanded options for reconstructive surgeons, allowing for cosmetic results previously unattainable in selected cases. However, autologous reconstructive techniques using free flaps remain to provide results that are unparalleled in terms of durability and feel. In this narrative review, the authors share their current experience with free flaps for breast reconstruction harvested from regions other than the abdomen. These include flaps that can be harvested from the thigh, buttocks, and back regions such as upper gracilis myocutaneous flaps, the profunda artery perforator flap, the lateral thigh perforator (LTP) flap, gluteal artery perforator flaps, and the lumbar artery perforator flap. The aim of this article is to improve readers’ understanding of the advantages and caveats of each flap, patient selection, and key surgical points. For those interested in learning to perform any of these flaps, a 10-step summary is provided which describes our personal technique in flap harvesting in more detail. Furthermore, knowledge gaps that exist about the clinical outcomes of each technique and future research implications are also highlighted.
在过去的几十年里,随着乳腺癌的治疗有了显著的进步,乳房重建技术也有了长足的进步。最近乳房植入物的创新和脱细胞真皮基质的出现扩大了重建外科医生的选择范围,使以前在某些情况下无法实现的美容效果成为可能。然而,使用自由皮瓣的自体重建技术在耐久性和触感方面仍然可以提供无与伦比的结果。在这篇叙述性的回顾中,作者分享了他们目前的经验,从腹部以外的区域收获自由皮瓣重建乳房。这些皮瓣包括可从大腿、臀部和背部获取的皮瓣,如股薄上肌肌皮瓣、股深动脉穿支皮瓣、股外侧穿支皮瓣、臀动脉穿支皮瓣和腰动脉穿支皮瓣。本文的目的是提高读者对每个皮瓣的优点和注意事项、患者选择和手术要点的理解。对于那些有兴趣学习执行任何这些皮瓣,提供了一个10步的总结,其中描述了我们的个人技术在皮瓣收获更详细。此外,还强调了关于每种技术的临床结果和未来研究意义存在的知识差距。
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引用次数: 0
Investigating the time to adjuvant treatment following immediate breast reconstruction in breast cancer patients 探讨乳腺癌患者即刻乳房重建后辅助治疗的时间
Edward Antram, E. Shaari, R. Balasubramanian, B. in‘t Hout, T. Kovács, H. Hamed, A. Kothari
{"title":"Investigating the time to adjuvant treatment following immediate breast reconstruction in breast cancer patients","authors":"Edward Antram, E. Shaari, R. Balasubramanian, B. in‘t Hout, T. Kovács, H. Hamed, A. Kothari","doi":"10.21037/abs-21-37","DOIUrl":"https://doi.org/10.21037/abs-21-37","url":null,"abstract":"","PeriodicalId":72212,"journal":{"name":"Annals of breast surgery : an open access journal to bridge breast surgeons across the world","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45388637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Annals of breast surgery : an open access journal to bridge breast surgeons across the world
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