Annals of nuclear cardiology最新文献

The pandemic of Coronavirus disease 2019 (COVID-19) caused a substantial negative impact on patients with cardiovascular disease. The negative impact of the pandemic on daily clinical practices for cardiovascular diseases (CVD) cannot be underestimated. The CVD patients (without COVID-19 infection), whose diagnosis and treatment have been delayed or postponed by the pandemic, are victims of COVID-19. In this context, COVID-19 is a "syndemic" disease. Several studies already revealed that negative changes already occurred in CVD patient management, such as increased in-hospital death, supply shortage of ^99mTc/⁹⁹Mo generator, etc. To clarify the impact of COVID-19 on the management of CVD, a global survey named "INCAPS-COVID" was conducted. This study revealed a substantial reduction (around 50%) of cardiovascular imaging practice in the early stage of the pandemic during March and April 2020. This pandemic has necessitated changes in cardiovascular management practices to adopt this condition. Some of those changes will become the legacy of the pandemic. Possible legacy will be; 1) Use of telemedicine; 2) Shift from exercise to pharmacological stress; 3) Shift from single photon emission computed tomography (SPECT) to positron emission tomography (PET). By adapting and changing to the challenges caused by the COVID-19 pandemic, nuclear cardiology will survive and will rise as an improved cardiovascular practice, even after the pandemic.

Purpose/Method: Aliskiren is a direct renin inhibitor that has been reported to be effective for CHF, but the usefulness of combined therapy with carvedilol and aliskiren has not been reported. Forty-four patients with dilated cardiomyopathy (DCM) were randomized into a group receiving add-on therapy with carvedilol plus aliskiren and another group receiving carvedilol alone for 6 months. Nuclear imagings with ¹²³I-Metaiodobenzylguanidine (MIBG) and ^99mTc-Sestamibi were performed. Exercise capacity using a specific activity scale (SAS) and the New York Heart Association (NYHA) class were evaluated. Cardiac sympathetic nerve activity was evaluated by ¹²³I-MIBG imaging, with the delayed heart-to-mediastinum activity ratio (H/M), delayed total defect score (TDS), and washout rate (WR). Results: Combined add-on therapy with carvedilol and aliskiren improved several parameters much more than carvedilol alone (p<0.05) with respect to TDS, ejection fraction (EF), NYHA, SAS on 6 months and the changes in TDS, EF, end-diastolic volume and brain natriuretic peptide (BNP). Conclusion: Add-on therapy with carvedilol and aliskiren is more effective than carvedilol alone for improving cardiac sympathetic nerve activity, cardiac function, symptoms, exercise capacity, and brain natriuretic peptide in patients with DCM.

Background: Triglyceride (TG) deposit cardiomyovasculopathy (TGCV) is a novel cardiovascular disorder and was recently encoded as an orphan disease in Europe (ORPHA code: 565612). Defective lipolysis results in TG accumulation in the myocardium and coronary arteries in TGCV. The myocardial washout rate (WR) of iodine-123-β-methyl iodophenyl-pentadecanoic acid (BMIPP) is an essential indicator to evaluate myocardial lipolysis in vivo. TGCV is classified into primary and idiopathic type with and without PNPLA2 mutation, respectively. Here, we present the clinical correlation perspectives of TGCV patients in Chiba, Japan, to increase the awareness of this orphan disease and facilitate its diagnosis. Methods: We enrolled 234 patients who underwent BMIPP scintigraphy between September 2015 and July 2019. The diagnosis of TGCV was made based on the criteria we reported previously. Blood smear tests were performed for TGCV classification. The distributions of TGCV in each comorbidity were investigated. Results: In total, 104 patients were diagnosed with definitive idiopathic TGCV (I-TGCV). They had various comorbid conditions, including heart failure with reduced ejection fraction and multivessel coronary artery disease requiring revascularization. Moreover, the serum TG levels in I-TGCV patients were not high, and there was no correlation between serum TG level and BMIPP WR (n=205, p-value=0.31), supporting the pathophysiological hypothesis of TGCV. Conclusion: I-TGCV patients showed multiple coexistence of coronary artery disease, heart failure of unknown etiology, or diabetes mellitus. For patients with such clinical characteristics, BMIPP scintigraphy and calculation of WR should be considered proactively for the diagnosis of TGCV.

Amyloidosis is a systemic disorder in which abnormal amyloid proteins deposit in body organs, leading to organ dysfunction and death. Cardiac amyloid deposition, causing a sort of restrictive cardiomyopathy and associated with increased risk of mortality. Most cases of cardiac amyloidosis are of either light chain or transthyretin type. Early and accurate diagnosis of cardiac amyloidosis may improve outcomes. However, diagnosis requires systematic approach including electrocardiography and biomarkers when encountered suspicious candidate. Diagnosis by multimodality noninvasive imaging have been substantially studied and established for differentiation from subtypes. Recent advance in the treatment of amyloidosis offers therapeutic monitoring and prognosis.

In this report, several issues relevant to scientific publishing in the field of medical imaging are described. How the quality of the research in medical imaging is evaluated is presented as well. The need for journals and the role of current metrics to judge the quality of articles and journals are discussed. Several recommendations are given to aspiring authors on how to write scientific articles in this field to help them optimize their chances of having their articles accepted. Recommendations on how to effectively deal with the review process and how to properly communicate with scientific journals are offered in order to facilitate authors' interaction with reviewers and editors of the journals in the field.

Non-invasive cardiac imaging modalities including single-photon emission computed tomography myocardial perfusion image (SPECT-MPI) and coronary computed tomography angiography (CTA) have been widely used for diagnosis of coronary artery disease (CAD). The American Society of Nuclear Cardiology and Society of Cardiovascular Computed Tomography have recently published the guidelines for the instrumentation, acquisition, processing, interpretation, as well as reporting of SPECT and coronary CTA. These guidelines have highlighted and well documented how the imaging reporting influences medical practice for physician and treatment care for patients, suggesting that cardiac imaging reports for interpretation for patient management. This review article here summarizes improving quality of cardiac imaging reports by SPECT-MPI and coronary CTA.

Background: Myocardial ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake is a sign of active inflammation in patients with cardiac sarcoidosis (CS) under the correct circumstance. However, even under the proper preparation, diffuse myocardial ¹⁸F-FDG uptake is frequently observed in the failing heart and misleads the CS disease activity. The aim of this study was to establish the diagnostic value of resting myocardial perfusion single photon emission computed tomography (SPECT) for assessing CS disease activity in patients with diffuse myocardial ¹⁸F-FDG uptake. Methods: We examined 39 patients with either histologically or clinically proven CS. All patients underwent ¹⁸F-FDG positron emission tomography (PET) and resting ^99mTc-SPECT. The presence of perfusion-metabolic mismatch was evaluated with generating polar maps of ¹⁸F-FDG PET and ^99mTc-SPECT images. Results: Increased myocardial ¹⁸F-FDG uptake was observed in 33 (85%) of 39 patients. Focal ¹⁸F-FDG uptake was detected in 16 patients and diffuse ¹⁸F-FDG uptake was seen in 17 patients. Brain natriuretic peptide (BNP) levels were significantly higher in patients with diffuse ¹⁸F-FDG uptake than those with focal ¹⁸F-FDG uptake (p=0.002). With comparing polar maps of ¹⁸F-FDG PET and ^99mTc-SPECT images, 8 of 16 patients with diffuse ¹⁸F-FDG uptake and myocardial perfusion defects demonstrated perfusion-metabolic mismatch which represented active inflammatory lesions in CS. Conclusions: Simultaneous evaluation of myocardial ¹⁸F-FDG PET and ^99mTc-SPECT by polar map analysis provides more relevant information for assessing disease activity in CS than ¹⁸F-FDG PET images alone. Perfusion-metabolic mismatch might indicate latent active inflammation in CS patients with diffuse myocardial ¹⁸F-FDG uptake, who had advanced heart failure.

Sarcoidosis, a multi-organ inflammatory condition commonly involving the heart and leading to high morbidity and mortality, is increasingly prevalent. PET imaging with ¹⁸F-FDG in conjunction with perfusion imaging is increasingly used for diagnosis, disease characterization, and to guide and follow treatment. However, various challenges remain with regard to protocols, interpretation of image findings, and how best to use test results to guide and monitor therapy. Further investigations of the testing technique, as well as better understanding of disease pathophysiology, are needed for better image utility in order to effectively improve patient outcome.