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Worldwide Availability and Utilization of PET/CT from IAEA Survey 国际原子能机构调查中PET/CT的全球可得性和利用情况
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-00103
J. Vitola, M. Dondi, P. Prado, L. Shaw, D. Paez
Hybrid imaging using PET/CT have various applications in cardiology. Anatomy, physiology or both can be evaluated. Routine attenuation correction can be performed and improve accuracy for nuclear cardiology studies. The extent of availability and utilization of hybrid imaging technology worldwide is currently unknown. The International Atomic Energy Agency (IAEA) in cooperation with QUANTA performed a web-based survey among physicians working with nuclear imaging to evaluate the current availability of hybrid imaging and its use for nuclear cardiology (NC). Contact e mails of physicians working in the field of nuclear cardiology were available from a data base at the human health department of the IAEA in Vienna, Austria and an international network of nuclear cardiologist at QUANTA in Curitiba, Brazil. Data from 80 countries in both high-income countries (HIC, n = 16) and low-and-middle income countries (LMIC, n = 64) representing all world regions, was obtained. At the country level, PET/CT is available in all world regions being widely available in North and Latin America, Europe, Asia and Oceania with a heterogeneous availability in Africa. Nevertheless, only 22.4% of centers in HIC and 10.9% in LMIC that have PET/CT available use it for NC applications. These data will help us to work with scientific societies and institutions to design strategies to diffuse information for physicians so they can take full advantage of PET/CT technology to obtain additional information that could impact patient care.
PET/CT混合成像在心脏病学中有多种应用。解剖,生理或两者都可以评估。可以进行常规衰减校正,提高核心脏病学研究的准确性。目前,混合成像技术在世界范围内的可用性和利用程度尚不清楚。国际原子能机构(IAEA)与QUANTA合作,对从事核成像工作的医生进行了一项基于网络的调查,以评估混合成像的现有可用性及其在核心脏病学(NC)中的应用。在奥地利维也纳的原子能机构人类健康司的一个数据库和巴西库里蒂巴的QUANTA核心脏病专家国际网络提供了在核心脏病学领域工作的医生的联系电子邮件。来自80个国家的数据,包括高收入国家(HIC, n = 16)和低收入和中等收入国家(LMIC, n = 64),代表世界所有地区。在国家一级,PET/CT在世界所有区域都可以使用,在北美和拉丁美洲、欧洲、亚洲和大洋洲广泛使用,在非洲的可用性不同。然而,只有22.4%的HIC中心和10.9%的LMIC中心将PET/CT用于NC应用。这些数据将帮助我们与科学协会和机构合作,为医生设计传播信息的策略,这样他们就可以充分利用PET/CT技术来获得可能影响患者护理的额外信息。
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引用次数: 4
Increasing the Presence of ANC among Academia 增加非国大在学术界的存在
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-00108
K. Yoshinaga
L ast weekend, the Japanese Society of Nuclear Cardiology (JSNC) conducted its 29 th annual scientific meeting in Hakodate on Hokkaido island. Dr. Tomoaki Nakata put great effort into preparations for this meeting. Dr. Nakata’s scientific program attracted many JSNC members to join the annual scientific meeting, and participation was estimated to be at a record high. From an academic research point of view, the highlights of this scientific gathering were the young investigator award session (YIA) and the technologist awards sessions. According to the scientific committee, a total of 14 abstracts were submitted to YIA and a total of 26 abstracts were submitted to the technologist sessions. Five finalists in the technological sessions had especially strong and sophisticated presentations showing important technical approaches with great potential to contribute to daily clinical practice. One of the aims of JSNC includes promoting technical and clinical aspects of research in nuclear cardiology. In this regard, the technologist award sessions should be considered one of the greatest achievements of JSNC. The JSNC annual scientific meeting also had record high numbers of scientific abstract presentations, and attendees participated in intensive discussions at each presentation. Presentation of an abstract is important but is only part of the overall process of accomplishing a research project. As editor-in-chief of the Annals of Nuclear Cardiology (ANC), I strongly hope that those who presented their abstract will publish their research in our journal, ANC.
上周末,日本核心脏病学会(JSNC)在北海道函馆召开了第29届年度科学会议。中田智明博士为本次会议的筹备工作付出了巨大的努力。Nakata博士的科学计划吸引了许多JSNC成员参加年度科学会议,估计参与人数创历史新高。从学术研究的角度来看,这次科学会议的亮点是青年研究者奖(YIA)和技术专家奖。据科学委员会称,共有14篇摘要提交给了YIA,共有26篇摘要提交给了技术专家会议。五名决赛选手在技术环节的演讲中表现出色,展示了重要的技术方法,这些技术方法在日常临床实践中具有很大的潜力。JSNC的目标之一包括促进核心脏病学的技术和临床研究。在这方面,技术专家奖励会议应该被视为JSNC最伟大的成就之一。JSNC年度科学会议也有创纪录数量的科学摘要报告,与会者在每次报告中都参与了密集的讨论。摘要的呈现很重要,但这只是完成一个研究项目的整个过程的一部分。作为《核心脏病学年鉴》(ANC)的主编,我强烈希望那些提交摘要的人将他们的研究发表在我们的期刊《ANC》上。
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引用次数: 0
Survey Research 调查研究
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-00102
David N. Williams, K. Williams
Survey research studies are frequently done badly, resulting in unreliable data. Response rates for clinical research are commonly below 30%, far less than considered reasonable for accuracy or validity. Addressing 10 weak points common to many studies would help to improve the quality of outcomes. Careful attention to the data needed to meet the research objective, clearly defined population definition, frame, sample and implementation planning all build a foundation for rigorous research. The survey delivery method(s), questionnaire design, write-up, pre-test of the questionnaire and mixed method, multiple follow-ups all should all work toward maximizing response rates. Well cleaned data will deliver high quality final results.
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引用次数: 0
Usefulness of Hyper Early Granulocyte-colony-stimulating Factor Therapy for Patients with Acute Myocardial Infarction 超早期粒细胞集落刺激因子治疗急性心肌梗死的有效性
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-00099
T. Toyama, H. Hoshizaki, S. Kasama, Yusuke Miyaishi, Hakuken Kan, E. Yamashita, R. Kawaguchi, S. Oshima, M. Kurabayashi
Objective: It has been reported that granulocyte-colony-stimulating-factor (G-CSF) induces myocardial regeneration and revascularization after acute myocardial infarction (AMI) by mobilizing bone marrow stem cells and suppressing apoptosis of endothelial cells in the injured heart. This study investigated whether hyper early G-CSF therapy was beneficial for AMI patients. Methods: Forty consecutive patients with initial ST-segment elevation AMI were randomized to receive intravenous infusion of G-CSF at 2μg/kg over 30 min (G-CSF group) or infusion of normal saline (control group) once daily for 5 days. The first dose was administered during primary percutaneous coronary intervention just after hospitalization. In the subacute period and 6 months after AMI, all patients underwent myocardial scintigraphy, including 99m Tc-sestamibi imaging of myocardial perfusion and 123 I-beta-methyl-piodophenylpentadecanoic-acid ( 123 I-BMIPP) imaging to assess fatty acid metabolism. Results: The two groups had a similar myocardial area at risk, as evaluated by the extent score on subacute 123 IBMIPP imaging. Compared with the control group, the G-CSF group had a significantly smaller (p<0.05) total defect score on 99m Tc-sestamibi and 123 I-BMIPP imaging at 6 months. In addition, the left ventricular ejection fraction and regional wall motion score were larger in the G-CSF group than in the control group during the subacute period and after 6 months. Conclusions: Hyper early G-CSF therapy improves myocardial perfusion, fatty acid metabolism, and cardiac function after AMI.
目的:有报道称,粒细胞集落刺激因子(G-CSF)通过动员骨髓干细胞和抑制心肌内皮细胞凋亡诱导急性心肌梗死(AMI)后心肌再生和血运重建。本研究探讨了早期高G-CSF治疗是否对AMI患者有益。方法:连续40例st段抬高型AMI患者,随机分为两组,分别静脉滴注G-CSF 2μg/kg / 30 min (G-CSF组)和生理盐水(对照组),每日1次,连用5 d。第一次剂量是在住院后的初级经皮冠状动脉介入治疗期间给予的。在亚急性期和AMI后6个月,所有患者均行心肌显像,包括99m Tc-sestamibi心肌灌注显像和123 i - β -甲基-聚苯五酸(123 I-BMIPP)显像评估脂肪酸代谢。结果:通过亚急性123 IBMIPP成像程度评分评估,两组有相似的心肌危险面积。与对照组相比,G-CSF组在6个月时99m Tc-sestamibi和123 I-BMIPP成像的总缺损评分明显低于对照组(p<0.05)。此外,在亚急性期和6个月后,G-CSF组左室射血分数和局部壁运动评分均高于对照组。结论:早期高G-CSF治疗可改善AMI后心肌灌注、脂肪酸代谢和心功能。
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引用次数: 1
From Myocardial Blood Flow to Receptor Imaging with PET 从心肌血流到PET受体成像
Pub Date : 2019-01-01 DOI: 10.17996/ANC.19-00094
T. Schindler
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引用次数: 0
Quantitative Assessment of Lower-limb Perfusion for Patients with Peripheral Artery Disease 外周动脉疾病患者下肢灌注的定量评估
Pub Date : 2019-01-01 DOI: 10.17996/ANC.19-00089
Y. Fukushima, S. Kumita
Diagnostic procedures of noninvasive assessment for patients with peripheral artery disease (PAD) have been advancing for decades. Among diagnostic imaging modalities, lower-limb perfusion (LLP) planar scintigraphy and SPECT/CT are exclusively used for diagnosing lower-limb ischemia, therapeutic efficacies, and risk stratification in PAD patients. Of these modalities, LLP SPECT/CT particularly shows more accuracy in providing quantitative assessment of LLP using innovative imaging devices and dedicated software. dividing
外周动脉疾病(PAD)的无创诊断方法已经发展了几十年。在诊断成像方式中,下肢灌注(LLP)平面显像和SPECT/CT专门用于诊断PAD患者下肢缺血、治疗效果和风险分层。在这些模式中,LLP SPECT/CT在使用创新的成像设备和专用软件提供LLP定量评估方面尤其显示出更高的准确性。分
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引用次数: 2
The JSNC 2019 Annual Scientific Meeting in Hakodate Highlights JSNC 2019年度科学会议在函馆召开
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-001
T. Nakata
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引用次数: 0
Positron Emission Tomography Myocardial Perfusion Imaging Tracer Choice for Assessment of Myocardial Blood Flow 评价心肌血流的正电子发射断层显像示踪剂选择
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-00107
N. Tamaki, K. Yoshinaga
Myocardial perfusion imaging (MPI) using positron emission tomography (PET) has high diagnostic accuracy and prognostic value in patients with known or suspected coronary artery disease (CAD). In addition, PET MPI can be used to quantify global left ventricle (LV) and regional LV myocardial blood flow (MBF) and myocardial flow reserve (MFR). Currently, there are four major PET perfusion tracers: 82 rubidium, 13 N-ammonia, 15 Owater, and 18 F-flurpiridaz. The characteristics of each tracer have been described and fully compared. Given increasing clinical needs for accurate MBF and MFR measurements, the use of PET MPI should be expanded in clinical settings in the near future.
使用正电子发射断层扫描(PET)进行心肌灌注成像(MPI)对已知或疑似冠状动脉疾病(CAD)的患者具有较高的诊断准确性和预后价值。此外,PET MPI可用于量化左室整体(LV)和局部左室心肌血流量(MBF)和心肌血流储备(MFR)。目前PET灌注示踪剂主要有四种:铷82种,n -氨13种,Owater 15种,氟吡唑18种。对每种示踪剂的特性进行了描述和比较。鉴于对精确MBF和MFR测量的临床需求日益增加,PET MPI的使用应在不久的将来在临床环境中扩大。
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引用次数: 1
Current Status of Kawasaki Disease and the Role of Nuclear Cardiology 川崎病的现状及核心学的作用
Pub Date : 2019-01-01 DOI: 10.17996/anc.19-00097
E. Tsuda, A. Miyake, T. Iwasa
Kawasaki disease (KD) has become a commonly acquired heart disease worldwide in children over the past five decades, because of the related cardiac sequelae. KD is an acute generalized medium vasculitis resulting from hypercytokinemia, and the coronary artery lesions caused by KD from childhood to adulthood lead to ischemic heart disease. To treat and manage KD appropriately, the optimal use of nuclear imaging is required.
川崎病(KD)由于其相关的心脏后遗症,在过去的50年里已成为一种全球范围内常见的儿童获得性心脏病。KD是一种由高细胞素血症引起的急性全身性中血管炎,KD从儿童期到成年期引起的冠状动脉病变可导致缺血性心脏病。为了适当地治疗和管理KD,需要最佳地使用核成像。
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引用次数: 0
Current Status of Myocardial Perfusion Imaging in Taiwan 台湾心肌灌注显像的现况
Pub Date : 2019-01-01 DOI: 10.17996/ANC.19-00093
G. Hung
In 2008 in Taiwan, the National Health Insurance (NHI) administration revised the guidelines regarding appropriately utilizing percutaneous coronary intervention (PCI) for patients with stable CAD to mandatory demonstration of functional ischemia by treadmill exercise test (TET), stress echocardiography (SE) or MPI. Notably, anatomic-based non-invasive imaging with coronary computed tomography (CT) angiography remains not reimbursed by Taiwan’s NHI. According to the NHI database, the total number of MPI significantly increased from 34,016 in 2000 to 151,254 in 2016 with an annual growth rate of 21.5%, much higher than the 7.9% growth of overall nuclear medicine tests during this period. Recently we investigated the frequency of stress testing within 90 days prior to PCI for stable CAD and showed that 79.1% of patients had MPI, 66.4% had TET and only 0. 05% had SE. We conclude that MPI currently plays a gatekeeper role for invasive coronary procedures for stable CAD in Taiwan.
2008年在台湾,国民健康保险(NHI)管理部门修订了关于对稳定型CAD患者适当使用经皮冠状动脉介入治疗(PCI)的指南,强制通过跑步机运动试验(TET)、应激超声心动图(SE)或MPI证明功能性缺血。值得注意的是,以解剖为基础的冠状动脉计算机断层扫描(CT)血管造影的非侵入性成像仍然没有得到台湾国民健康保险的报销。根据国民健康保险数据库,MPI总数从2000年的34,016项显著增加到2016年的151,254项,年增长率为21.5%,远高于同期整体核医学试验7.9%的增长率。最近,我们调查了稳定性CAD PCI术前90天内压力测试的频率,结果显示79.1%的患者有MPI, 66.4%有TET,只有0。05%的人有SE。我们的结论是,MPI目前在台湾稳定期冠心病的冠脉介入治疗中扮演着守门人的角色。
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引用次数: 0
期刊
Annals of nuclear cardiology
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