A. M. Haidary, A. Saqib, Samuel Sharif, Ahmad Walid Yousufzai, N. Nasir, Sarah, Noor, S. Noor, Abdul Jamil Rasooli, Ahmad Shekib Zahier, Ramin Saadaat, Haider Ali Malakzai, Abdul Sami Ibrahimkhil, Maryam Ahmad, Z. Ahmed
Ahmed Maseh Haidary1*, Abdul Hadi Saqib1, Samuel Sharif1, Ahmad Walid Yousufzai2, Najla Nasir3, Sarah Noor2, Sahar Noor4, Abdul Jamil Rasooli4, Ahmad Shekib Zahier5, Ramin Saadaat1, Haider Ali Malakzai1, Abdul Sami Ibrahimkhil1, Maryam Ahmad1, Zeeshan Ansar Ahmed6 1Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children, Kabul, Afghanistan 2Department of Hemato-oncology, Jumhoriat Hospital, Kabul, Afghanistan 3Department of Medicine, Rabia Balkhi Hospital, Kabul, Afghanistan 4Department of Pediatrics, French Medical Institute for Mothers and Children, Kabul Afghanistan 5Department of Hemato-oncology, Amiri Medical Complex, Kabul, Afghanistan 6Department of Pathology and Laboratory Medicine, Agha Khan University Hospital, Karachi, Pakistan *Correspondence should be addressed to Ahmed Maseh Haidary; ahmed.maseh9t9@gmail.com
Ahmed Maseh Haidary1*， Abdul Hadi Saqib1, Samuel Sharif1, Ahmad Walid Yousufzai2, Najla Nasir3, Sarah Noor2, Sahar Noor4, Abdul Jamil Rasooli4, Ahmad Shekib Zahier5, Ramin Saadaat1, Haider Ali Malakzai1, Abdul Sami Ibrahimkhil1, Maryam Ahmad1, Zeeshan Ansar Ahmed6阿富汗喀布尔法国母婴医学研究所病理与临床实验室2阿富汗喀布尔Jumhoriat医院血液肿瘤科3阿富汗喀布尔医学部4阿富汗喀布尔，拉比亚·巴尔希医院;4阿富汗喀布尔，法国妇幼医学研究所;5阿富汗喀布尔，阿米里综合医院，血液肿瘤科;6巴基斯坦卡拉奇，阿迦汗大学医院病理和检验医学系;*信件应寄给艾哈迈德·马塞赫·海德里;ahmed.maseh9t9@gmail.com
{"title":"Karyotypic Profile of Chronic Myeloid Leukemia in Patients Diagnosed at Tertiary Level in Afghanistan","authors":"A. M. Haidary, A. Saqib, Samuel Sharif, Ahmad Walid Yousufzai, N. Nasir, Sarah, Noor, S. Noor, Abdul Jamil Rasooli, Ahmad Shekib Zahier, Ramin Saadaat, Haider Ali Malakzai, Abdul Sami Ibrahimkhil, Maryam Ahmad, Z. Ahmed","doi":"10.33696/genetics.1.001","DOIUrl":"https://doi.org/10.33696/genetics.1.001","url":null,"abstract":"Ahmed Maseh Haidary1*, Abdul Hadi Saqib1, Samuel Sharif1, Ahmad Walid Yousufzai2, Najla Nasir3, Sarah Noor2, Sahar Noor4, Abdul Jamil Rasooli4, Ahmad Shekib Zahier5, Ramin Saadaat1, Haider Ali Malakzai1, Abdul Sami Ibrahimkhil1, Maryam Ahmad1, Zeeshan Ansar Ahmed6 1Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children, Kabul, Afghanistan 2Department of Hemato-oncology, Jumhoriat Hospital, Kabul, Afghanistan 3Department of Medicine, Rabia Balkhi Hospital, Kabul, Afghanistan 4Department of Pediatrics, French Medical Institute for Mothers and Children, Kabul Afghanistan 5Department of Hemato-oncology, Amiri Medical Complex, Kabul, Afghanistan 6Department of Pathology and Laboratory Medicine, Agha Khan University Hospital, Karachi, Pakistan *Correspondence should be addressed to Ahmed Maseh Haidary; ahmed.maseh9t9@gmail.com","PeriodicalId":72286,"journal":{"name":"Archives of molecular biology and genetics","volume":"177 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79577009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asma Sassi, J. Désir, A. Gheldof, S. Dooren, Xavier Peyrassol, M. Abramowicz, A. Delbaere
Asma Sassi1, Julie Désir2, Alexander Gheldof3, Sonia Van Dooren4, Xavier Peyrassol5, Marc Abramowicz5, Anne Delbaere1* 1Fertility Clinic, Department of Obstetrics and Gynecology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 2Institut de Pathologie et de Génétique (IPG), Gosselies, Belgium 3Centre for Medical Genetics, Reproduction and Genetics and Regenerative Medicine research cluster, Reproduction and Genetics research group, Vrije Universiteit Brussel-UZ Brussel, Brussels, Belgium 4Brussels Interuniversity Genomics High Throughput core (Bright Core), Brussels, Belgium 5Department of Genetics, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 6Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland *Correspondence should be addressed to Anne Delbaere, anne.delbaere@erasme.ulb.ac.be
Asma Sassi1, Julie dsamsi2, Alexander Gheldof3, Sonia Van Dooren4, Xavier Peyrassol5, Marc Abramowicz5, Anne Delbaere1* 1比利时布鲁塞尔布鲁塞尔自由大学Erasme医院妇产科生育诊所2比利时Gosselies病理与遗传研究所(IPG) 3医学遗传学、生殖与遗传学和再生医学研究集群中心，生殖与遗传学研究小组，布鲁塞尔自由大学，布鲁塞尔布鲁塞尔，比利时4布鲁塞尔大学间基因组学高通量中心(Bright core)，比利时布鲁塞尔5布鲁塞尔自由大学伊拉斯姆医院遗传学系，比利时布鲁塞尔6日内瓦大学医学院遗传医学与发展学系，日内瓦1211，瑞士*信件请寄给Anne Delbaere, anne.delbaere@erasme.ulb.ac.be
{"title":"Commentary on NOBOX Mutations in Premature Ovarian Insufficiency","authors":"Asma Sassi, J. Désir, A. Gheldof, S. Dooren, Xavier Peyrassol, M. Abramowicz, A. Delbaere","doi":"10.33696/genetics.1.005","DOIUrl":"https://doi.org/10.33696/genetics.1.005","url":null,"abstract":"Asma Sassi1, Julie Désir2, Alexander Gheldof3, Sonia Van Dooren4, Xavier Peyrassol5, Marc Abramowicz5, Anne Delbaere1* 1Fertility Clinic, Department of Obstetrics and Gynecology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 2Institut de Pathologie et de Génétique (IPG), Gosselies, Belgium 3Centre for Medical Genetics, Reproduction and Genetics and Regenerative Medicine research cluster, Reproduction and Genetics research group, Vrije Universiteit Brussel-UZ Brussel, Brussels, Belgium 4Brussels Interuniversity Genomics High Throughput core (Bright Core), Brussels, Belgium 5Department of Genetics, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 6Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland *Correspondence should be addressed to Anne Delbaere, anne.delbaere@erasme.ulb.ac.be","PeriodicalId":72286,"journal":{"name":"Archives of molecular biology and genetics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72903818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacterial communication via quorum sensing (QS) molecules, as well as toxin-antitoxin (TA) gene modules located on bacterial chromosomes are well-studied mechanisms. Escherichia coli mazEF is a stress-induced TA system mediating cell death requiring a QS extracellular death factor (EDF), the pentapeptide NNWNN. MazF is an endoribonuclease specific for ACA sites. During adverse conditions, the activated MazF generates a stress induced translation machinery, composed of MazF-processed mRNAs and selective ribosomes that specifically translate these processed mRNAs. Moreover, we identified the molecular mechanism underlying the formation of EDF from the zwf mRNA that involves distinct steps comprising the activity of MazF, the trans-translation system as well as the protease ClpPX. Bacterial trans-translation is generally known as a quality control process that rescues stalled translation complexes at the 3'-terminus of non-stop mRNAs. Our results indicate that trans-translation has a similar role in EDF generation from zwf mRNA. However, our data reveal that the trans-translation system may also provide a regulatory mechanism to attenuate EDF generation in the single cells. Thereby, the required threshold of EDF molecules is only achieved by the entire bacterial population, as expected for a genuine QS process.
{"title":"<i>Escherichia coli</i> Stress, Multi-cellularity, and the Generation of the Quorum Sensing Peptide EDF.","authors":"Isabella Moll, Hanna Engelberg-Kulka","doi":"10.33696/genetics.1.002","DOIUrl":"10.33696/genetics.1.002","url":null,"abstract":"<p><p>Bacterial communication via quorum sensing (QS) molecules, as well as toxin-antitoxin (TA) gene modules located on bacterial chromosomes are well-studied mechanisms. <i>Escherichia coli mazEF</i> is a stress-induced TA system mediating cell death requiring a QS extracellular death factor (EDF), the pentapeptide NNWNN. MazF is an endoribonuclease specific for ACA sites. During adverse conditions, the activated MazF generates a stress induced translation machinery, composed of MazF-processed mRNAs and selective ribosomes that specifically translate these processed mRNAs. Moreover, we identified the molecular mechanism underlying the formation of EDF from the <i>zwf</i> mRNA that involves distinct steps comprising the activity of MazF, the trans-translation system as well as the protease ClpPX. Bacterial trans-translation is generally known as a quality control process that rescues stalled translation complexes at the 3'-terminus of non-stop mRNAs. Our results indicate that trans-translation has a similar role in EDF generation from <i>zwf</i> mRNA. However, our data reveal that the trans-translation system may also provide a regulatory mechanism to attenuate EDF generation in the single cells. Thereby, the required threshold of EDF molecules is only achieved by the entire bacterial population, as expected for a genuine QS process.</p>","PeriodicalId":72286,"journal":{"name":"Archives of molecular biology and genetics","volume":"41 1","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83824084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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