Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13112384
子豪 王
Osteomyelitis is a complex disease in orthopedics, and its diagnosis and treatment are challenging. If not treated in time, it may lead to serious consequences such as amputation and cancer. At present, many new achievements have been made in the study of osteomyelitis, but its diagnosis still depends on imaging, laboratory examination and clinical symptoms. This article provides a
{"title":"Research Progress in Classification, Diagnosis and Treatment of Osteomyelitis","authors":"子豪 王","doi":"10.12677/acm.2023.13112384","DOIUrl":"https://doi.org/10.12677/acm.2023.13112384","url":null,"abstract":"Osteomyelitis is a complex disease in orthopedics, and its diagnosis and treatment are challenging. If not treated in time, it may lead to serious consequences such as amputation and cancer. At present, many new achievements have been made in the study of osteomyelitis, but its diagnosis still depends on imaging, laboratory examination and clinical symptoms. This article provides a","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135319347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13112399
超 王
The incidence of breast cancer has gradually increased in recent years, surgery remains an important treatment for breast cancer patients. Surgery cannot be performed without the involvement of anaesthesia, and studies related to the effects of anaesthetic drugs on breast cancer are gradually gaining ground. Propofol and sevoflurane are the most commonly used intravenous anaesthetics and inhalation anaesthetics, respectively, and have been found to have a significant
{"title":"Advances in the Study of the Effects of Propofol and Sevoflurane on Breast Cancer","authors":"超 王","doi":"10.12677/acm.2023.13112399","DOIUrl":"https://doi.org/10.12677/acm.2023.13112399","url":null,"abstract":"The incidence of breast cancer has gradually increased in recent years, surgery remains an important treatment for breast cancer patients. Surgery cannot be performed without the involvement of anaesthesia, and studies related to the effects of anaesthetic drugs on breast cancer are gradually gaining ground. Propofol and sevoflurane are the most commonly used intravenous anaesthetics and inhalation anaesthetics, respectively, and have been found to have a significant","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.1392030
美铭 王
{"title":"Research Progress in Conflict of Decision Making by Proxy Decision-Makers in Breast Cancer Patients","authors":"美铭 王","doi":"10.12677/acm.2023.1392030","DOIUrl":"https://doi.org/10.12677/acm.2023.1392030","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.1392033
盼 张
{"title":"A Case of Occult Gastrointestinal Bleeding with Literature Review","authors":"盼 张","doi":"10.12677/acm.2023.1392033","DOIUrl":"https://doi.org/10.12677/acm.2023.1392033","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13112394
·甫拉提 古丽巴努尔
Chronic eczema is a kind of physical and mental disease with complicated etiology and difficult treatment. It often develops from acute and subacute eczema, the common manifestations are
{"title":"Recent Research on External Therapy of Tra-ditional Chinese Medicine for Chronic Ecze-ma","authors":"·甫拉提 古丽巴努尔","doi":"10.12677/acm.2023.13112394","DOIUrl":"https://doi.org/10.12677/acm.2023.13112394","url":null,"abstract":"Chronic eczema is a kind of physical and mental disease with complicated etiology and difficult treatment. It often develops from acute and subacute eczema, the common manifestations are","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135445622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13112414
胜楠 庞
Objective: Data were obtained from public databases to analyze differentially expressed genes in gastric cancer (GC) and normal gastric tissue, and preliminarily explore potential biomarkers. Method: Gene expression profiles (GSE54129, GSE13911, GSE19826) were obtained from GEO data-base. Differentially expressed genes were screened out by GEO2R, and the Venndiagram plotted the intersection of three gene expression profiles to obtain common differentially expressed Genes; using online analysis websites such as DAVID, String, KM-Plot to analyze the functions of DEGs, construct protein interaction network (PPI) and the relationship with GC prognosis, and visualize the analysis results with Cytoscape, 15 candidate core genes were obtained; furthermore, GEPIA online software was used to verify the expression of core genes and the relationship with clinical stage, and the genomic changes of GC target genes were explored by using cBioPortal, and finally six core genes related to GC prognosis and stage were screened. Results: A total of 106 DEGs were obtained, and functional enrichment analysis showed that the effects of these DEGs were mainly protein degradation and cell adhesion. Predominantly affects the extracellular space in cellular components; mainly affects the same protein binding in molecular function; pathway enrichment analysis mainly focused on gastric acid secretion, protein digestion and absorption, cytochrome P450 drug metabolism, etc, 12 genes (COL1A1, COL1A2, COL11A1, COL10A1, BGN, TFF2, MUC6, ATP4A, THBS2, SULF1, CLDN18, ATP4B) were associated with GC overall survival, of which 6 key genes (COL1A1, COL1A2, THBS2, BGN, TFF2, COL11A1) is closely related to the staging of gastric cancer. Conclusion: Screening of differentially expressed genes and signalling pathways by bioinformatics may contribute to the study of the molecular mechanism of gastric cancer and obtain key genes related to the survival and prognosis of gastric cancer, providing new ideas for cancer diagnosis and treatment.
{"title":"Identification of Potential Critical Genes in Gastric Cancer by Bioinformatic Analysis","authors":"胜楠 庞","doi":"10.12677/acm.2023.13112414","DOIUrl":"https://doi.org/10.12677/acm.2023.13112414","url":null,"abstract":"Objective: Data were obtained from public databases to analyze differentially expressed genes in gastric cancer (GC) and normal gastric tissue, and preliminarily explore potential biomarkers. Method: Gene expression profiles (GSE54129, GSE13911, GSE19826) were obtained from GEO data-base. Differentially expressed genes were screened out by GEO2R, and the Venndiagram plotted the intersection of three gene expression profiles to obtain common differentially expressed Genes; using online analysis websites such as DAVID, String, KM-Plot to analyze the functions of DEGs, construct protein interaction network (PPI) and the relationship with GC prognosis, and visualize the analysis results with Cytoscape, 15 candidate core genes were obtained; furthermore, GEPIA online software was used to verify the expression of core genes and the relationship with clinical stage, and the genomic changes of GC target genes were explored by using cBioPortal, and finally six core genes related to GC prognosis and stage were screened. Results: A total of 106 DEGs were obtained, and functional enrichment analysis showed that the effects of these DEGs were mainly protein degradation and cell adhesion. Predominantly affects the extracellular space in cellular components; mainly affects the same protein binding in molecular function; pathway enrichment analysis mainly focused on gastric acid secretion, protein digestion and absorption, cytochrome P450 drug metabolism, etc, 12 genes (COL1A1, COL1A2, COL11A1, COL10A1, BGN, TFF2, MUC6, ATP4A, THBS2, SULF1, CLDN18, ATP4B) were associated with GC overall survival, of which 6 key genes (COL1A1, COL1A2, THBS2, BGN, TFF2, COL11A1) is closely related to the staging of gastric cancer. Conclusion: Screening of differentially expressed genes and signalling pathways by bioinformatics may contribute to the study of the molecular mechanism of gastric cancer and obtain key genes related to the survival and prognosis of gastric cancer, providing new ideas for cancer diagnosis and treatment.","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135447362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.1392079
新涛 杨
{"title":"Anatomical Classification of Biliary Tract Based on Three-Dimensional Visualization and Its Clinical Significance","authors":"新涛 杨","doi":"10.12677/acm.2023.1392079","DOIUrl":"https://doi.org/10.12677/acm.2023.1392079","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135594697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.1392087
红进 陈
{"title":"Clinical Effects of Percutaneous Total Visual Spinal Endoscopic Surgery in Calcified Lum-bar Disc Herniation","authors":"红进 陈","doi":"10.12677/acm.2023.1392087","DOIUrl":"https://doi.org/10.12677/acm.2023.1392087","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135594961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102142
洁 胡
{"title":"Relationship between Acute Renal Injury In-duced by Sepsis and Microcirculation Disturbance","authors":"洁 胡","doi":"10.12677/acm.2023.13102142","DOIUrl":"https://doi.org/10.12677/acm.2023.13102142","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102153
健健 尹
{"title":"<sup>18</sup>F-FDG-PET/CT and <sup>99m</sup>Tc-MDP for Bone Metastasis in Breast Cancer Patients Comparison of Diagnostic Values","authors":"健健 尹","doi":"10.12677/acm.2023.13102153","DOIUrl":"https://doi.org/10.12677/acm.2023.13102153","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135801315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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