Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13112472
·卡哈尔 木热提
{"title":"Progress of Artificial Cervical Intervertebral Disc and Bridge-Type Self-Ligating Fusion in the Treatment of Single-Segment Cervical Spondylosis","authors":"·卡哈尔 木热提","doi":"10.12677/acm.2023.13112472","DOIUrl":"https://doi.org/10.12677/acm.2023.13112472","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135659528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13112471
晓玮 王
Objective: To investigate the expression of PD-L1 in different subtypes of triple-negative breast cancer and its correlation with the prognosis of patients. Methods: A total of 240 patients with triple-negative breast cancer (TNBC) who had not received neoadjuvant therapy before radical resection were selected for immunohistochemical study of PD-L1 expression, including 60 patients with four subtypes of TNBC. Kaplan-Meier and univariate Cox proportional hazard model analysis were used to compare the relationship between PD-L1 expression and survival time of patients with different subtypes. Results: The median follow-up time was 55.75 months (range: 23.28~120.02 months). Overall survival (OS) was significantly increased in PD-L1-positive TNBC patients compared with PD-L1-negative TNBC patients (P = 0.029). Among the different types of TNBC tissues, the highest expression rate of PD-L1 was 26.7% in immunomodulatory type (IM), which was accompanied by a better prognosis. There were significant differences in the positive expression rate of PD-L1 among different types of TNBC with different TNM stages, histological grades, and lymph node metastasis (P < 0.05), and OS was significantly prolonged in the four sub-types of TNBC patients with IM. Univariate Cox proportional model analysis showed that PD-L1 was an independent prognostic factor for TNBC. Conclusion: PD-L1 has different effects on prognosis in different types of TNBC, and the relationship between PD-L1 and prognosis is most close in IM type.
{"title":"The Expression of PD-L1 in Different Molecular Subtypes of Triple-Negative Breast Cancer and Its Correlation with Prognosis","authors":"晓玮 王","doi":"10.12677/acm.2023.13112471","DOIUrl":"https://doi.org/10.12677/acm.2023.13112471","url":null,"abstract":"Objective: To investigate the expression of PD-L1 in different subtypes of triple-negative breast cancer and its correlation with the prognosis of patients. Methods: A total of 240 patients with triple-negative breast cancer (TNBC) who had not received neoadjuvant therapy before radical resection were selected for immunohistochemical study of PD-L1 expression, including 60 patients with four subtypes of TNBC. Kaplan-Meier and univariate Cox proportional hazard model analysis were used to compare the relationship between PD-L1 expression and survival time of patients with different subtypes. Results: The median follow-up time was 55.75 months (range: 23.28~120.02 months). Overall survival (OS) was significantly increased in PD-L1-positive TNBC patients compared with PD-L1-negative TNBC patients (P = 0.029). Among the different types of TNBC tissues, the highest expression rate of PD-L1 was 26.7% in immunomodulatory type (IM), which was accompanied by a better prognosis. There were significant differences in the positive expression rate of PD-L1 among different types of TNBC with different TNM stages, histological grades, and lymph node metastasis (P < 0.05), and OS was significantly prolonged in the four sub-types of TNBC patients with IM. Univariate Cox proportional model analysis showed that PD-L1 was an independent prognostic factor for TNBC. Conclusion: PD-L1 has different effects on prognosis in different types of TNBC, and the relationship between PD-L1 and prognosis is most close in IM type.","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135660490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102127
远离 余
{"title":"New Progress in Screening and Management of Cervical Cancer and Precancerous Lesions","authors":"远离 余","doi":"10.12677/acm.2023.13102127","DOIUrl":"https://doi.org/10.12677/acm.2023.13102127","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135750308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102172
·别克沙特 夏尔巴提
{"title":"Research Progress of Non-Compaction of the Ventricular Myocardium in Children","authors":"·别克沙特 夏尔巴提","doi":"10.12677/acm.2023.13102172","DOIUrl":"https://doi.org/10.12677/acm.2023.13102172","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136202533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102174
瑞祺 张
{"title":"A Case of Ifosfamide Encephalopathy Characterized by Generalized Convulsions and Literature Review","authors":"瑞祺 张","doi":"10.12677/acm.2023.13102174","DOIUrl":"https://doi.org/10.12677/acm.2023.13102174","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136203214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102168
晓庆 吴
{"title":"Comparison of Therapeutic Effects of Peritoneal Dialysis and Hemodialysis on Acute Renal Injury","authors":"晓庆 吴","doi":"10.12677/acm.2023.13102168","DOIUrl":"https://doi.org/10.12677/acm.2023.13102168","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136203223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102191
刚 杨
{"title":"Clinical Experience of Treating Osteoarthritis in Qian Jin San Huang Soup","authors":"刚 杨","doi":"10.12677/acm.2023.13102191","DOIUrl":"https://doi.org/10.12677/acm.2023.13102191","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136208397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102200
欣莹 庄
{"title":"Research Progress of Tanshinone IIA in Preventing and Treating Restenosis after PCI","authors":"欣莹 庄","doi":"10.12677/acm.2023.13102200","DOIUrl":"https://doi.org/10.12677/acm.2023.13102200","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136208401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102218
倩倩 何
{"title":"Research Progress on Risk Factors of Hepatic Encephalopathy after TIPS","authors":"倩倩 何","doi":"10.12677/acm.2023.13102218","DOIUrl":"https://doi.org/10.12677/acm.2023.13102218","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.12677/acm.2023.13102208
银娇 赵
{"title":"Observation of Injection of Platelet Rich Plasma in the Treatment of Partial Thickness Rotator Cuff Tear","authors":"银娇 赵","doi":"10.12677/acm.2023.13102208","DOIUrl":"https://doi.org/10.12677/acm.2023.13102208","url":null,"abstract":"","PeriodicalId":7237,"journal":{"name":"Advances in Clinical Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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