Anaerobic microorganisms are often associated with chronic mucosal infections including periodontal disease, inflammatory bowel diseases, and recurrent colitis caused by Clostridioides difficile. Management of these diseases requires a long term strategy, but available antibiotics (e.g., metronidazole) can only be used short term. Conceptually, therapeutics that control chronic inflammation would lessen the risk of associated autoimmune diseases including atherosclerosis, arthritis, type II diabetes, Crohn's and ulcerative colitis and even Alzheimer's disease. To meet this need, an antibiotic must overcome inevitable antibiotic resistance, toxicity to humans or their mitochondria and limit collateral damage (dysbiosis) to gut microbiota. This review describes attributes of amixicile (AMIX), a novel systemic therapeutic, that shows efficacy in animal models for treatment of C. difficile colitis and gastric infections caused by Helicobacter pylori, while limiting collateral damage to gut microflora. Together with the apparent absence of drug resistance, toxicities, and drug metabolism, might qualify amixicile for consideration as a long term therapeutic for management of chronic and acute anaerobic infections.
{"title":"Amixicile: A Concept Therapeutic for Treatment of Chronic Anaerobic Infections.","authors":"Paul S Hoffman","doi":"10.31488/bjg.1000108","DOIUrl":"https://doi.org/10.31488/bjg.1000108","url":null,"abstract":"<p><p>Anaerobic microorganisms are often associated with chronic mucosal infections including periodontal disease, inflammatory bowel diseases, and recurrent colitis caused by <i>Clostridioides difficile</i>. Management of these diseases requires a long term strategy, but available antibiotics (e.g., metronidazole) can only be used short term. Conceptually, therapeutics that control chronic inflammation would lessen the risk of associated autoimmune diseases including atherosclerosis, arthritis, type II diabetes, Crohn's and ulcerative colitis and even Alzheimer's disease. To meet this need, an antibiotic must overcome inevitable antibiotic resistance, toxicity to humans or their mitochondria and limit collateral damage (dysbiosis) to gut microbiota. This review describes attributes of amixicile (AMIX), a novel systemic therapeutic, that shows efficacy in animal models for treatment of C. <i>difficile</i> colitis and gastric infections caused by <i>Helicobacter pylori</i>, while limiting collateral damage to gut microflora. Together with the apparent absence of drug resistance, toxicities, and drug metabolism, might qualify amixicile for consideration as a long term therapeutic for management of chronic and acute anaerobic infections.</p>","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283079/pdf/nihms-1907493.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 53-year-old woman presented with abdominal pain and obstructive jaundice and was diagnosed with metastatic pancreatic adenocarcinoma. She received FOLFIRINOX chemotherapy and achieved complete response. Germline testing detected CHEK2 and treatment was switched to Olaparib maintenance.
{"title":"Complete Response of Metastatic Pancreatic Cancer In A CHEK2 Mutation Carrier Treated With Platinum-Based Therapy- A Case Report And Literature Review","authors":"Kai Sun, H. Sarfraz, M. Abdelrahim","doi":"10.31488/bjg.1000121","DOIUrl":"https://doi.org/10.31488/bjg.1000121","url":null,"abstract":"A 53-year-old woman presented with abdominal pain and obstructive jaundice and was diagnosed with metastatic pancreatic adenocarcinoma. She received FOLFIRINOX chemotherapy and achieved complete response. Germline testing detected CHEK2 and treatment was switched to Olaparib maintenance.","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69833393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laparoscopic and Robotic Gastrojejunostomy Revision for Complicationsafter Roux En Y Gastric Bypass: Results from a High-VolumeReferral Center","authors":"","doi":"10.31488/bjg.10000111","DOIUrl":"https://doi.org/10.31488/bjg.10000111","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69832212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Spraying and Nebulized Lidocaine in Patients Undergoing Esophago-Gastro-Duodenoscopy: A Randomized Trial","authors":"","doi":"10.31488/bjg.1000116","DOIUrl":"https://doi.org/10.31488/bjg.1000116","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69832695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GastrointestinalConditions Among Medical Students a Single Center Study","authors":"","doi":"10.31488/bjg.1000117","DOIUrl":"https://doi.org/10.31488/bjg.1000117","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69832772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long Term Results of Mesalazine Desensitization to Intolerant Patients with Inflammatory Bowel Disease","authors":"","doi":"10.31488/bjg.1000115","DOIUrl":"https://doi.org/10.31488/bjg.1000115","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69833009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Ulcerative Colitis, The Damage Caused to Gut Cells Is Inflicted by the toxic Effects of Auto Immune Complexes, Neutrophils Nets and Pro Inflammatory Agents, Cationic Histones and Bacteriolyis Which Can All Be Strongly Modulated by Highly Anionic Heparins","authors":"","doi":"10.31488/bjg.1000118","DOIUrl":"https://doi.org/10.31488/bjg.1000118","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69833184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Enteral Administration of Bifidobacterium Breve on Dysbiosis Infants and Children: A Review","authors":"","doi":"10.31488/bjg.1000119","DOIUrl":"https://doi.org/10.31488/bjg.1000119","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69833196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Enteral Administration of Lactobacillus Casei Strain Shirotaon Healthy Children, Dysbiosis in Obese Children, and the Elderly","authors":"","doi":"10.31488/bjg.1000120","DOIUrl":"https://doi.org/10.31488/bjg.1000120","url":null,"abstract":"","PeriodicalId":72465,"journal":{"name":"British journal of gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69833261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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