Attila Gere, Jordan C. Stanley, Camilla Habsburg-Lothringen, H. Moskowitz
The dramatic worldwide increase in use of smartphones has prompted concerns regarding potential carcinogenic effects of exposure to RFM-EF (Radiofrequency-Modulated Electromagnetic Fields). Previous studies indicated epidemiologic evidence for many risks arising from exposure to smartphones. Despite this growing evidence, the exposure to smartphones is rising across age groups. This study identified communication messaging which increases awareness of risks, and convinces the respondent of the seriousness of these risks. We revealed two mind-set segments (Focus on Work; Focus on Safety) illustrated how to use our viewpoint identifier tool to assign the belonging of a people in the population into mind-set segments.
{"title":"https://researchopenworld.com/health-threats-awareness-responses-to-warning-messages-about-cancer-and-smartphone-usage/#","authors":"Attila Gere, Jordan C. Stanley, Camilla Habsburg-Lothringen, H. Moskowitz","doi":"10.31038/cst.2019415","DOIUrl":"https://doi.org/10.31038/cst.2019415","url":null,"abstract":"The dramatic worldwide increase in use of smartphones has prompted concerns regarding potential carcinogenic effects of exposure to RFM-EF (Radiofrequency-Modulated Electromagnetic Fields). Previous studies indicated epidemiologic evidence for many risks arising from exposure to smartphones. Despite this growing evidence, the exposure to smartphones is rising across age groups. This study identified communication messaging which increases awareness of risks, and convinces the respondent of the seriousness of these risks. We revealed two mind-set segments (Focus on Work; Focus on Safety) illustrated how to use our viewpoint identifier tool to assign the belonging of a people in the population into mind-set segments.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"356 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73964519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The aim of this research is to figure out the effectiveness of the Sorush Cancer Treatment Protocol (SCTP) which is based on the Evolutionary Metabolic Hypothesis of Cancer (EMHC) and introducing the Specific Ketogenic Diet (SKD) plus Intravenous Ozone Therapy (IOT) in Phase (1) on 54 cancer patients, and combination of Hyperbaric Oxygen Therapy with vitamin/mineral and herbal supplementation beside the SKD and IOT in Phase (2) of this research on the remaining 31 cancer patients. Introduction: an and the of the Reactive Oxygen Species and the Butterfly in normal eukaryotic the or shut down. Cancer cells primitive eukaryotic cells which Methods: Based on the researches and the experimentation of cancer treatments and protocols on cancer patients, we have reached a treatment and decided to test it on 54 voluntary cancer patients in the first stage of their disease. In this treatment we used a 5-day water fasting state, the Specific Ketogenic Diet (SKD) designed by ourselves and Intravenous Ozone Therapy (IOT) in the duration of 90 days (Phase 1) and another 90 days (Phase 2) with the entrance of Hyperbaric Oxygen Therapy (HBO2T) and several supplements which have been effective in previous studies on cancer patients. We have used the measurement of saliva PH, the MRI device and statistical methods to test the shrinkage of the tumors. Results: After Phase (1) of this research on 54 patients the average percentage decrease in the tumors was 58% and after Phase (2) on 31 remaining cancer patients the average percentage decrease in the tumors was 98.8%. The average saliva PH in the fasting state of the cancer patients improved from acidic to alkaline as well. Conclusion: in conclusion, we have reached an effective cancer treatment based on SCTP by the usage of SKD, IOT, HBO2T and several supplements. There was an obvious improvement of cancer tumor decrease, lifestyle, saliva PH and we did not observe any side effects or cachexia in any of the patients.
{"title":"https://researchopenworld.com/the-positive-effect-of-skd-plus-iot-and-hbo2t-in-the-treatment-of-cancer-introducing-sorush-cancer-treatment-protocol-sctp/#","authors":"S. Zaminpira, Sorush Niknamian, D. D'Agostino","doi":"10.31038/cst.2019414","DOIUrl":"https://doi.org/10.31038/cst.2019414","url":null,"abstract":"Background: The aim of this research is to figure out the effectiveness of the Sorush Cancer Treatment Protocol (SCTP) which is based on the Evolutionary Metabolic Hypothesis of Cancer (EMHC) and introducing the Specific Ketogenic Diet (SKD) plus Intravenous Ozone Therapy (IOT) in Phase (1) on 54 cancer patients, and combination of Hyperbaric Oxygen Therapy with vitamin/mineral and herbal supplementation beside the SKD and IOT in Phase (2) of this research on the remaining 31 cancer patients. Introduction: an and the of the Reactive Oxygen Species and the Butterfly in normal eukaryotic the or shut down. Cancer cells primitive eukaryotic cells which Methods: Based on the researches and the experimentation of cancer treatments and protocols on cancer patients, we have reached a treatment and decided to test it on 54 voluntary cancer patients in the first stage of their disease. In this treatment we used a 5-day water fasting state, the Specific Ketogenic Diet (SKD) designed by ourselves and Intravenous Ozone Therapy (IOT) in the duration of 90 days (Phase 1) and another 90 days (Phase 2) with the entrance of Hyperbaric Oxygen Therapy (HBO2T) and several supplements which have been effective in previous studies on cancer patients. We have used the measurement of saliva PH, the MRI device and statistical methods to test the shrinkage of the tumors. Results: After Phase (1) of this research on 54 patients the average percentage decrease in the tumors was 58% and after Phase (2) on 31 remaining cancer patients the average percentage decrease in the tumors was 98.8%. The average saliva PH in the fasting state of the cancer patients improved from acidic to alkaline as well. Conclusion: in conclusion, we have reached an effective cancer treatment based on SCTP by the usage of SKD, IOT, HBO2T and several supplements. There was an obvious improvement of cancer tumor decrease, lifestyle, saliva PH and we did not observe any side effects or cachexia in any of the patients.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91382088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To develop a general course of action for oxygen distribution calculations, in macroscopic tumours, using Graphics Processing Units (GPU) for parallel computation.Methods: A vessel tree st ...
{"title":"https://researchopenworld.com/a-parallel-computation-approach-to-detailed-3d-modelling-of-the-complete-oxygen-distribution-in-large-tumours/#","authors":"J. Lagerlöf, T. Rydén, P. Bernhardt","doi":"10.31038/cst.2018343","DOIUrl":"https://doi.org/10.31038/cst.2018343","url":null,"abstract":"Purpose: To develop a general course of action for oxygen distribution calculations, in macroscopic tumours, using Graphics Processing Units (GPU) for parallel computation.Methods: A vessel tree st ...","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85460556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The groups were similar in demographics, comorbidities, lobe resected, and lung pathology. Length of stay, chest tube days, and chest tube drainage were less in the single tube group; however, they did not achieve statistical significance. Similarly, post-operative airleak and residual pneumothorax after tube removal were not significantly different but were less in the single tube group. While the post-operative day to oral pain control was similar in the single and double chest tube groups, postoperative pain as assessed by the VAS pain scale was lower in the single tube group each of the first four PODs with the difference achieving significance on postoperative days 3 (3.6 ± 0.5 versus 5.9 ± 0.5) and 4 (3.2 ± 0.6 versus 5.4 ± 0.6).
{"title":"https://researchopenworld.com/single-versus-double-chest-tube-drainage-after-thoracotomy-for-cancer/#","authors":"C. Gayer, F. Baciewicz","doi":"10.31038/cst.2018342","DOIUrl":"https://doi.org/10.31038/cst.2018342","url":null,"abstract":"The groups were similar in demographics, comorbidities, lobe resected, and lung pathology. Length of stay, chest tube days, and chest tube drainage were less in the single tube group; however, they did not achieve statistical significance. Similarly, post-operative airleak and residual pneumothorax after tube removal were not significantly different but were less in the single tube group. While the post-operative day to oral pain control was similar in the single and double chest tube groups, postoperative pain as assessed by the VAS pain scale was lower in the single tube group each of the first four PODs with the difference achieving significance on postoperative days 3 (3.6 ± 0.5 versus 5.9 ± 0.5) and 4 (3.2 ± 0.6 versus 5.4 ± 0.6).","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90229695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose : Transitioning away from fixed beam toward VMAT approach for multi-target SRS, we developed a standardized algorithmic approach for treatment planning, and a script-based evaluation application characterizing high, intermediate and low dose regions proximal to targets and throughout the brain. The evaluation script was used to compare metrics for clinically treated fixed- and VMAT-based plans to quantify benchmark norms. Methods and Materials: Plans were examined for 79 patients (37 Fixed/47 VMAT) treating 179 (120 fixed/59 VMAT) targets. Dual purpose structures used for optimization and evaluation include 5 mm thick shells around the PTV (HDRing) and around the HDRing (MDRing) to control/measure dose fall off around the targets, and Brain – (PTV + 5 mm) to quantify for low dose regions. Effective gradients (GrEff) were calculated using V100% [cc] and V50% [cc] in HDRing and MDRings. Volume dependence of metric value distributions were characterized with quantile regression. Results: Conformity index (CI) decreased rapidly toward unity with increasing volume, plateauing near 0. 5 cc. Conformity index was significantly improved for VMAT plans (1. 19 ± 0. 17 vs 1. 40 ± 0. 46, p<0. 001) whereas effective gradients (%/cm) were reduced (117. 55 ± 17. 26 vs 137. 62 ± 26. 50, p<0. 001). Gradients decreased with increasing target volume (TV) converging near 4 cc for fixed field plans. Quantiles for volumes outside the PTVs receiving 12 Gy or more were smaller for VMAT than fixed beams, increasing as smaller powers of volume (e. g. 0. 45 vs 0. 51). Doses 5-10 mm from targets were similar. Volume of Brain – (PTV+05) receiving at least 5 Gy depended on cumulative PTV volumes and were less for fixed vs VMAT beams. Automation of metric collection improved evaluation of newly generated treatment plans and expedited the transition to multi-target VMAT-based SRS. Conclusions: Development of standardized algorithmic approach to optimization plus script based metrics calculation improved the SRS planning process and evaluation.
{"title":"Results from application of scripted based, algorithmic approach to multi-target SRS planning, evaluation and characterization of volume dependent metrics","authors":"C. Mayo","doi":"10.31038/cst.2018115","DOIUrl":"https://doi.org/10.31038/cst.2018115","url":null,"abstract":"Purpose : Transitioning away from fixed beam toward VMAT approach for multi-target SRS, we developed a standardized algorithmic approach for treatment planning, and a script-based evaluation application characterizing high, intermediate and low dose regions proximal to targets and throughout the brain. The evaluation script was used to compare metrics for clinically treated fixed- and VMAT-based plans to quantify benchmark norms. Methods and Materials: Plans were examined for 79 patients (37 Fixed/47 VMAT) treating 179 (120 fixed/59 VMAT) targets. Dual purpose structures used for optimization and evaluation include 5 mm thick shells around the PTV (HDRing) and around the HDRing (MDRing) to control/measure dose fall off around the targets, and Brain – (PTV + 5 mm) to quantify for low dose regions. Effective gradients (GrEff) were calculated using V100% [cc] and V50% [cc] in HDRing and MDRings. Volume dependence of metric value distributions were characterized with quantile regression. Results: Conformity index (CI) decreased rapidly toward unity with increasing volume, plateauing near 0. 5 cc. Conformity index was significantly improved for VMAT plans (1. 19 ± 0. 17 vs 1. 40 ± 0. 46, p<0. 001) whereas effective gradients (%/cm) were reduced (117. 55 ± 17. 26 vs 137. 62 ± 26. 50, p<0. 001). Gradients decreased with increasing target volume (TV) converging near 4 cc for fixed field plans. Quantiles for volumes outside the PTVs receiving 12 Gy or more were smaller for VMAT than fixed beams, increasing as smaller powers of volume (e. g. 0. 45 vs 0. 51). Doses 5-10 mm from targets were similar. Volume of Brain – (PTV+05) receiving at least 5 Gy depended on cumulative PTV volumes and were less for fixed vs VMAT beams. Automation of metric collection improved evaluation of newly generated treatment plans and expedited the transition to multi-target VMAT-based SRS. Conclusions: Development of standardized algorithmic approach to optimization plus script based metrics calculation improved the SRS planning process and evaluation.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75648431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-25DOI: 10.31532/cancerstud.2.1.003
Kana Tominaga
Postoperative or post-treatment survival is greater among breast cancer patients than among those with other types of cancer. However, recurrence and metastasis to the bones, 1 lungs, and brain are possible after a latent period of 5–10 years. Various reports suggested that the cancer stem-like cells (CSC) are found in breast cancer and are considered to deter 2–5 the prognosis of events including tumor recurrence and metastasis. Tumors are speculated to comprise a heterogeneous cell population constituted by CSC, transit-amplifying (TA) cells, 6,7 and terminally differentiated cells. CSC can undergo self-renewal, symmetric cell division, and can yield terminally differentiated cells and somatic stem cells via asymmetric cell .8,9 division In this heterogeneous cell population, CSC, a small cell population, occupies the highest position in tumor hierarchy. With slow cell cycles and high anti-oxidative capacity compared with non-CSC, CSC are resistant to conventional chemoand radiotherapy 10–12 targeting proliferating cancer cells. Despite large cancer cell populations being eliminated through chemotherapy, only a few CSC may survive and cause tumor recurrence and metastasis. Hence, it is essential to elucidate the characteristics of CSC and standardize methods of assessing CSC-enriched populations and associated culture methods. Flow cytometry analysis using known CSC-specific antibodies is a popular and simple method for 13–15 assessing CSC. The CSC population can be enriched and fractionated through flow cytometry analysis because cell membrane characteristics of CSC is analyzed in only living cells. In standardizing culture methods for CSC, tumor sphere culture and organoid culture 16,17 are useful tools to assess the self-renewal capacity of CSC in vitro. Sphere culture has 18 been used to assess the survival and self-renewal capacity of neural stem cells in culture. Abstract
{"title":"Signaling Factors Involved in Self-Renewal of Breast Cancer Stem-like Cells","authors":"Kana Tominaga","doi":"10.31532/cancerstud.2.1.003","DOIUrl":"https://doi.org/10.31532/cancerstud.2.1.003","url":null,"abstract":"Postoperative or post-treatment survival is greater among breast cancer patients than among those with other types of cancer. However, recurrence and metastasis to the bones, 1 lungs, and brain are possible after a latent period of 5–10 years. Various reports suggested that the cancer stem-like cells (CSC) are found in breast cancer and are considered to deter 2–5 the prognosis of events including tumor recurrence and metastasis. Tumors are speculated to comprise a heterogeneous cell population constituted by CSC, transit-amplifying (TA) cells, 6,7 and terminally differentiated cells. CSC can undergo self-renewal, symmetric cell division, and can yield terminally differentiated cells and somatic stem cells via asymmetric cell .8,9 division In this heterogeneous cell population, CSC, a small cell population, occupies the highest position in tumor hierarchy. With slow cell cycles and high anti-oxidative capacity compared with non-CSC, CSC are resistant to conventional chemoand radiotherapy 10–12 targeting proliferating cancer cells. Despite large cancer cell populations being eliminated through chemotherapy, only a few CSC may survive and cause tumor recurrence and metastasis. Hence, it is essential to elucidate the characteristics of CSC and standardize methods of assessing CSC-enriched populations and associated culture methods. Flow cytometry analysis using known CSC-specific antibodies is a popular and simple method for 13–15 assessing CSC. The CSC population can be enriched and fractionated through flow cytometry analysis because cell membrane characteristics of CSC is analyzed in only living cells. In standardizing culture methods for CSC, tumor sphere culture and organoid culture 16,17 are useful tools to assess the self-renewal capacity of CSC in vitro. Sphere culture has 18 been used to assess the survival and self-renewal capacity of neural stem cells in culture. Abstract","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80144010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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