{"title":"Reporting and Journalistic Ethics as an Ecological Issue in Contemporary Times","authors":"","doi":"10.31038/cst.2022724","DOIUrl":"https://doi.org/10.31038/cst.2022724","url":null,"abstract":"","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72544774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Audit on Incidences of Oxaliplatin Induced Hypersensitivity Reactions during Infusion in Day Care Oncology at a Tertiary Care Hospital, Karachi, Pakistan","authors":"","doi":"10.31038/cst.2022722","DOIUrl":"https://doi.org/10.31038/cst.2022722","url":null,"abstract":"","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87267699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgery has a role starting from prevention in high risk individuals to diagnosis in certain clinical scenarios to staging, treatment and palliation of advanced cancers. This article aims to focus on role of surgery in the prevention, diagnosis, staging and treatment of early and advanced epithelial ovarian cancer in the current scenario. A brief discussion on palliative surgery has also been added.
{"title":"The Role of Surgery in Epithelial Ovarian Cancer","authors":"N. Hulikal","doi":"10.31038/cst.2022721","DOIUrl":"https://doi.org/10.31038/cst.2022721","url":null,"abstract":"Surgery has a role starting from prevention in high risk individuals to diagnosis in certain clinical scenarios to staging, treatment and palliation of advanced cancers. This article aims to focus on role of surgery in the prevention, diagnosis, staging and treatment of early and advanced epithelial ovarian cancer in the current scenario. A brief discussion on palliative surgery has also been added.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87776058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
mask or equivalent hospital policy at this time). Anaesthesia was induced with propofol, fentanyl and rocuronium and was maintained with sevofurane in a mixture of oxygen and nitrous oxide. The patient’s trachea was intubated orally using a McGrath video-laryngoscope with a size 8 mm (ID) standard tracheal tube. Following intubation, a radial arterial line was sited and the patient placed in the left lateral position. A consultant anaesthetist with extensive experience in the use of ultrasound assisted neuraxial techniques scanned the patient’s back with a curvilinear probe. Using ultrasound, the consultant demonstrated the sacrum and identified the lumbar intervertebral spaces showing narrow gaps and a longitudinally rotated spine. Spinous process shadow on the ultrasound showed that in the left lateral position the midline was significantly superior to the previous decompression scar (Figure 1). Abstract We present the case of an anaesthetic registrar learning ultrasound assisted neuraxial anaesthesia during the COVID-19 pandemic. An 81-year-old patient with significant scoliosis required anaesthesia for a revision hip replacement following periprosthetic fracture. Despite the communication difficulties presented by wearing full personal protective equipment to reduce potential transmission of COVID-19 an experienced consultant anaesthetist was able to demonstrate the relevant lumbar spine sonoanatomy to a year six anaesthetic registrar. The registrar was then able to perform a first pass neuraxial procedure in the left lateral position under general anaesthesia. The anaesthetic had good effect and the patient was comfortable post operatively with minimal opiate requirements. The patient was discharged to his home from hospital 14 days later.
{"title":"Learning US Assisted Neuraxial Technique during a Pandemic: Case Report","authors":"Galitzine, J. Matthews","doi":"10.31038/cst.2022714","DOIUrl":"https://doi.org/10.31038/cst.2022714","url":null,"abstract":"mask or equivalent hospital policy at this time). Anaesthesia was induced with propofol, fentanyl and rocuronium and was maintained with sevofurane in a mixture of oxygen and nitrous oxide. The patient’s trachea was intubated orally using a McGrath video-laryngoscope with a size 8 mm (ID) standard tracheal tube. Following intubation, a radial arterial line was sited and the patient placed in the left lateral position. A consultant anaesthetist with extensive experience in the use of ultrasound assisted neuraxial techniques scanned the patient’s back with a curvilinear probe. Using ultrasound, the consultant demonstrated the sacrum and identified the lumbar intervertebral spaces showing narrow gaps and a longitudinally rotated spine. Spinous process shadow on the ultrasound showed that in the left lateral position the midline was significantly superior to the previous decompression scar (Figure 1). Abstract We present the case of an anaesthetic registrar learning ultrasound assisted neuraxial anaesthesia during the COVID-19 pandemic. An 81-year-old patient with significant scoliosis required anaesthesia for a revision hip replacement following periprosthetic fracture. Despite the communication difficulties presented by wearing full personal protective equipment to reduce potential transmission of COVID-19 an experienced consultant anaesthetist was able to demonstrate the relevant lumbar spine sonoanatomy to a year six anaesthetic registrar. The registrar was then able to perform a first pass neuraxial procedure in the left lateral position under general anaesthesia. The anaesthetic had good effect and the patient was comfortable post operatively with minimal opiate requirements. The patient was discharged to his home from hospital 14 days later.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74203967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Aboelhassan, SohaAli, M. Ali, Noura A. Abdel-fatah
Purpose: With daily increase of GIT cancer incidence, there is more discovery of new regimens, raising the question: how much can cancer patient afford effective safe treatment? Methods: Safety and efficacy grades version 2021 NCCN evidence-based blocks are used in this research, Egyptian population divided according to income in to 5 categories: Poorest (4860), poor (8460), middle (22800), rich (41100), richest (66583). We considered a medicine as affordable if 20% or less of monthly income is needed to cover monthly need of medicine. Affordability divided to 5 grades according to percentage of income needed to cover treatment: very inexpensive: ≤20%, inexpensive: 20-40%, moderately expensive 40-60%, expensive 60-80%, awfully expensive ≥ 80%. Binary logistic regression model was performed to assess affordability of cancer treatments in different cancer types using efficacy of regimen, safety of regimen, line of therapy, site of treatment and income class as predictors. Results: Most GIT regimens are moderately effective 223 (51.6), while most regimens 277 (64.1) are mildly toxic. Minimally effective regimens increase the chance of being affordable by 15 times if compared to highly effective P<0.0001, moderately effective increase the chance of affordability by 3 times if compared to highly effective P<0.0001. Mildly toxic regimen increases the chance of affordability by 3 times if compared to occasionally toxic treatment. P=0.002. Adjuvant regimens have increased chance of affordability by 17 times if compared to second line. Conclusion : GIT cancer patients have more treatment affordability for neo-adjuvant/adjuvant than other regimens first-line therapy is more affordable than other regimens for stage IV disease, highly effective regimens have the low affordability while mildly toxic regimens have more chance of affordability than other regimens
{"title":"Efficacy, Safety and Affordability Disparities of Gastrointestinal Cancer Changing Plans of Treatment of Cancer Patients","authors":"R. Aboelhassan, SohaAli, M. Ali, Noura A. Abdel-fatah","doi":"10.31038/cst.2022713","DOIUrl":"https://doi.org/10.31038/cst.2022713","url":null,"abstract":"Purpose: With daily increase of GIT cancer incidence, there is more discovery of new regimens, raising the question: how much can cancer patient afford effective safe treatment? Methods: Safety and efficacy grades version 2021 NCCN evidence-based blocks are used in this research, Egyptian population divided according to income in to 5 categories: Poorest (4860), poor (8460), middle (22800), rich (41100), richest (66583). We considered a medicine as affordable if 20% or less of monthly income is needed to cover monthly need of medicine. Affordability divided to 5 grades according to percentage of income needed to cover treatment: very inexpensive: ≤20%, inexpensive: 20-40%, moderately expensive 40-60%, expensive 60-80%, awfully expensive ≥ 80%. Binary logistic regression model was performed to assess affordability of cancer treatments in different cancer types using efficacy of regimen, safety of regimen, line of therapy, site of treatment and income class as predictors. Results: Most GIT regimens are moderately effective 223 (51.6), while most regimens 277 (64.1) are mildly toxic. Minimally effective regimens increase the chance of being affordable by 15 times if compared to highly effective P<0.0001, moderately effective increase the chance of affordability by 3 times if compared to highly effective P<0.0001. Mildly toxic regimen increases the chance of affordability by 3 times if compared to occasionally toxic treatment. P=0.002. Adjuvant regimens have increased chance of affordability by 17 times if compared to second line. Conclusion : GIT cancer patients have more treatment affordability for neo-adjuvant/adjuvant than other regimens first-line therapy is more affordable than other regimens for stage IV disease, highly effective regimens have the low affordability while mildly toxic regimens have more chance of affordability than other regimens","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75437391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Opinion: Why Should We Care about Endocrine Disruptors?","authors":"","doi":"10.31038/cst.2022711","DOIUrl":"https://doi.org/10.31038/cst.2022711","url":null,"abstract":"","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87765706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sidy Ka, M. Dieng, J. Thiam, A. Diallo, Yaye C Diouf, Yacine Mbacké, M. Mouelle, Doudou, Diouf, A. Dem
We results. Abstract Objective: To study the technical aspects of the marking of the resection margins with a dye in breast-conserving surgery and to evaluate its aesthetic and oncological impacts. Methods: Injection of methylene blue on a perpendicular path, at a controlled distance from the tumor. The tumor has previously been located by ultrasound or palpation. Then we study the carcinological and aesthetic results. Results: Over a period of 4 years we operated on 36 patients. The average age was 43. Large breasts of average size were found in the majority of cases. Tumor sizes were dominated by T3 tumors and tumors were mostly located in the upper outer quadrant. The most frequently encountered histological types were invasive carcinomas with non specific type. The incisions were classic in more than 80% of cases or sometimes oncoplastic. The aesthetic results were satisfactory in 78% of cases. The carcinological results were marked by invaded margins in 3% of patients. Conclusion: The results of the methylene blue injection technique to secure the excision margins and perform breast conserving surgery are satisfactory from the aesthetic and oncological point of view.
{"title":"Marking with a Dye to Visualize the Limits of Resection in Breast Conserving Surgery","authors":"Sidy Ka, M. Dieng, J. Thiam, A. Diallo, Yaye C Diouf, Yacine Mbacké, M. Mouelle, Doudou, Diouf, A. Dem","doi":"10.31038/cst.2020544","DOIUrl":"https://doi.org/10.31038/cst.2020544","url":null,"abstract":"We results. Abstract Objective: To study the technical aspects of the marking of the resection margins with a dye in breast-conserving surgery and to evaluate its aesthetic and oncological impacts. Methods: Injection of methylene blue on a perpendicular path, at a controlled distance from the tumor. The tumor has previously been located by ultrasound or palpation. Then we study the carcinological and aesthetic results. Results: Over a period of 4 years we operated on 36 patients. The average age was 43. Large breasts of average size were found in the majority of cases. Tumor sizes were dominated by T3 tumors and tumors were mostly located in the upper outer quadrant. The most frequently encountered histological types were invasive carcinomas with non specific type. The incisions were classic in more than 80% of cases or sometimes oncoplastic. The aesthetic results were satisfactory in 78% of cases. The carcinological results were marked by invaded margins in 3% of patients. Conclusion: The results of the methylene blue injection technique to secure the excision margins and perform breast conserving surgery are satisfactory from the aesthetic and oncological point of view.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76544200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective to analyze the influence of various factors the of Abstract Objective: Prolonged Postoperative Ileus (PPOI) is a common complication after abdominal surgery, but data about incidence and risk factors of PPOI for patients with gastric cancer are rare. We sought to investigate the incidence and related incidental factors of PPOI. Methods: A retrospective cohort study was carried out using a registry database consecutively collected from June 2016 to October 2016. The incidence and incidental factors of PPOI after gastric cancer surgery were calculated and analyzed. Results: There were 22 patients diagnosed with PPOI. The incidence of PPOI after gastric cancer surgery was 26.5%. There were significant differences in the PPOI among ages, postoperative body temperature, postoperative opioid agents use (Dezocine) (P<0.05). Logistic regression analysis results showed the age ≥65 years, postoperative temperature ≥38 ℃ the use of Dezocine after surgery were the independent risk factors of PPOI after gastric cancer surgery. Conclusion: The of after cancer relationship surgery. We may accelerate the course of convalescence by strengthening the management of perioperative periodandtaking reasonable measures to against the risk factors.
{"title":"Incidence and Factors of Prolonged Postoperative Ileus in Gastric Cancer Surgery","authors":"W. Ning, Chen Runkai, Cui Hao, Zheng Yiqiong","doi":"10.31038/cst.2021612","DOIUrl":"https://doi.org/10.31038/cst.2021612","url":null,"abstract":"Objective to analyze the influence of various factors the of Abstract Objective: Prolonged Postoperative Ileus (PPOI) is a common complication after abdominal surgery, but data about incidence and risk factors of PPOI for patients with gastric cancer are rare. We sought to investigate the incidence and related incidental factors of PPOI. Methods: A retrospective cohort study was carried out using a registry database consecutively collected from June 2016 to October 2016. The incidence and incidental factors of PPOI after gastric cancer surgery were calculated and analyzed. Results: There were 22 patients diagnosed with PPOI. The incidence of PPOI after gastric cancer surgery was 26.5%. There were significant differences in the PPOI among ages, postoperative body temperature, postoperative opioid agents use (Dezocine) (P<0.05). Logistic regression analysis results showed the age ≥65 years, postoperative temperature ≥38 ℃ the use of Dezocine after surgery were the independent risk factors of PPOI after gastric cancer surgery. Conclusion: The of after cancer relationship surgery. We may accelerate the course of convalescence by strengthening the management of perioperative periodandtaking reasonable measures to against the risk factors.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80002791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
this index was originally examined. In this study, a low NI was seen as a poor survival predictor. Abstract Background: Ovarian Cancer (OC) cases with low CA-125 concentration during routine physical examination testing are troublesome and raise false negative findings ratio. The aim of this analysis was to determine whether the Lymphocyte-To-Monocyte Ratio (LMR) and the Nutritional Index (NI) of OC patients with normal CA-125 levels had a predictive role. Methods: This retrospective study enrolled a total of 102 OC-diagnosed patients who underwent primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2010 to 2019. Using Receiver Operating Characteristic Curves (ROC) for survival analysis, optimum cut-off values for NI and LMR were calculated. The Kaplan-Meier (KM) curve and Cox regression determined the prognostic value for Overall Survival (OS) and Progression-Free Survival (PFS). Results: The results showed that the optimal cutoff values were 47.5 and 4.25, respectively, for NI and LMR. NI was shown to be significantly correlated with FIGO stage, Grade, the involvement of malignant ascites, and platinum response, and LMR with FIGO stage, lymph node metastasis, malignant ascites, and platinum response when the population was separated using optimized cut-off. The 5-year OS and PFS were greatly enhanced by a high NI ( ≧ 47.5). A low LMR (<4.25) was associated significantly with poor 5-year PFS and OS. Both NI and LMR were independent prognosticators for the 5-year OS in multivariate analysis. Conclusions: In CA125-normal ovarian cancer cases, elevated NI and LMR are positive prognosticators.
{"title":"The Prognostic Value of Lymphocyte-to-Monocyte Ratio and Nutritional Index for Ovarian Cancer Patients with Normal CA125 Level","authors":"Songwei Feng, Shanhui Luo, Chenchen Ji, Yi Li","doi":"10.31038/cst.2021611","DOIUrl":"https://doi.org/10.31038/cst.2021611","url":null,"abstract":"this index was originally examined. In this study, a low NI was seen as a poor survival predictor. Abstract Background: Ovarian Cancer (OC) cases with low CA-125 concentration during routine physical examination testing are troublesome and raise false negative findings ratio. The aim of this analysis was to determine whether the Lymphocyte-To-Monocyte Ratio (LMR) and the Nutritional Index (NI) of OC patients with normal CA-125 levels had a predictive role. Methods: This retrospective study enrolled a total of 102 OC-diagnosed patients who underwent primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2010 to 2019. Using Receiver Operating Characteristic Curves (ROC) for survival analysis, optimum cut-off values for NI and LMR were calculated. The Kaplan-Meier (KM) curve and Cox regression determined the prognostic value for Overall Survival (OS) and Progression-Free Survival (PFS). Results: The results showed that the optimal cutoff values were 47.5 and 4.25, respectively, for NI and LMR. NI was shown to be significantly correlated with FIGO stage, Grade, the involvement of malignant ascites, and platinum response, and LMR with FIGO stage, lymph node metastasis, malignant ascites, and platinum response when the population was separated using optimized cut-off. The 5-year OS and PFS were greatly enhanced by a high NI ( ≧ 47.5). A low LMR (<4.25) was associated significantly with poor 5-year PFS and OS. Both NI and LMR were independent prognosticators for the 5-year OS in multivariate analysis. Conclusions: In CA125-normal ovarian cancer cases, elevated NI and LMR are positive prognosticators.","PeriodicalId":72517,"journal":{"name":"Cancer studies and therapeutics","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88299805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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