{"title":"Serum Fetuin–A Level Association with Coronary Artery Disease","authors":"Z. Saad, M. Essa","doi":"10.33425/2639-8486.1045","DOIUrl":"https://doi.org/10.33425/2639-8486.1045","url":null,"abstract":"","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42415410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implementing the Get with the Guidelines - Heart Failure Tools to Improve Transitional Care Efficiency","authors":"Madeline Gervase","doi":"10.33425/2639-8486.1043","DOIUrl":"https://doi.org/10.33425/2639-8486.1043","url":null,"abstract":"","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43981393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camara Abdoulaye, S. Aly, Samoura Sana, K. Diarra, B. Abdoulaye, Doumbouya Mohamed, S. Djibril, Barry Ibrahima Sory, Baldé El Hadj Yaya, Béavogui Mariama, S. Thierno, Baldé Mamadou Dadhi, Condé Mamady
{"title":"Valvulopathy: Epidemiological and Clinical Aspects in the Cardiology Department of the Ignace Deen National Hospital CHU of Conakry","authors":"Camara Abdoulaye, S. Aly, Samoura Sana, K. Diarra, B. Abdoulaye, Doumbouya Mohamed, S. Djibril, Barry Ibrahima Sory, Baldé El Hadj Yaya, Béavogui Mariama, S. Thierno, Baldé Mamadou Dadhi, Condé Mamady","doi":"10.33425/2639-8486.1047","DOIUrl":"https://doi.org/10.33425/2639-8486.1047","url":null,"abstract":"","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44373338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The treatment of heart failure (HF) in the United States is estimated to exceed $30 billion each year and is anticipated to increase to a staggering $70 billion by the year 2030. This makes the management of HF one of the leading challenges Medicare will face in the years to come. Traditional methods to detect impending congestion such as body weight and physical examination findings are often non-specific and lack sensitivity making them inadequate to recognize fluid overload and prevent decompensation. It has been suggested that bioimpedance spectroscopy (BIS) can be used as a surrogate marker for detecting fluid overload and therefore, serve as an adjunct to clinical exam findings. Methods: This study examines the relationship between a BIS device and echocardiographic parameters associated with volume overload with same day measurements in the first 8 patients with NYHA Class II/III HF on an IRB approved protocol. Each patient was followed 3 times a week for 4 weeks within the hospital outpatient setting. At each visit BIS measures were recorded for whole body as well as arms and legs. Additionally, signs and symptoms, weight and echocardiograph findings were all recorded. Results: Correlations of BIS measurements with echo parameters were performed. The leg impedance measurement correlated strongly with echo findings; inferior vena cava (IVC) size (p=0.001), right atrial pressure (RAP) (p<0.001), and pulmonary artery systolic pressure (PAS) measurements (p<0.001). Conclusion: Preliminary findings demonstrated excellent correlations with BIS measurements and IVC size, right atrial pressure and pulmonary artery systolic pressure measurements which suggest a possible alternative method to detect fluid overload despite the small sample size. Trending a patient's impedance using the SOZO device at home or the practitioner's office may assist clinicians in providing more accurate, individualized HF care.
{"title":"Correlation of Limb Bioimpedance to Echocardiographic Indicators of Congestion in Patients with NYHA Class II/III Heart Failure","authors":"Accardi Aj, A. Burns, Heywood Jt","doi":"10.33425/2639-8486.1039","DOIUrl":"https://doi.org/10.33425/2639-8486.1039","url":null,"abstract":"Purpose: The treatment of heart failure (HF) in the United States is estimated to exceed $30 billion each year and is anticipated to increase to a staggering $70 billion by the year 2030. This makes the management of HF one of the leading challenges Medicare will face in the years to come. Traditional methods to detect impending congestion such as body weight and physical examination findings are often non-specific and lack sensitivity making them inadequate to recognize fluid overload and prevent decompensation. It has been suggested that bioimpedance spectroscopy (BIS) can be used as a surrogate marker for detecting fluid overload and therefore, serve as an adjunct to clinical exam findings. Methods: This study examines the relationship between a BIS device and echocardiographic parameters associated with volume overload with same day measurements in the first 8 patients with NYHA Class II/III HF on an IRB approved protocol. Each patient was followed 3 times a week for 4 weeks within the hospital outpatient setting. At each visit BIS measures were recorded for whole body as well as arms and legs. Additionally, signs and symptoms, weight and echocardiograph findings were all recorded. Results: Correlations of BIS measurements with echo parameters were performed. The leg impedance measurement correlated strongly with echo findings; inferior vena cava (IVC) size (p=0.001), right atrial pressure (RAP) (p<0.001), and pulmonary artery systolic pressure (PAS) measurements (p<0.001). Conclusion: Preliminary findings demonstrated excellent correlations with BIS measurements and IVC size, right atrial pressure and pulmonary artery systolic pressure measurements which suggest a possible alternative method to detect fluid overload despite the small sample size. Trending a patient's impedance using the SOZO device at home or the practitioner's office may assist clinicians in providing more accurate, individualized HF care.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45383007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Manga, M. Leye, M. Dioum, Quinta Indafa Te, E. Sarr, A. Diagne, S. Sy, I. Diop
Background: Heart failure is a major public health problem in Africa where it is the main circumstance for the discovery of cardiovascular diseases. The objective of this work was to analyze the characteristics of heart failure in the African semi-urban zone and to identify the difficulties related to the long-term follow-up of heart failure patients at the hospital de la Paix in Ziguinchor (southern Senegal). Method: We conducted a 1-year prospective study (March 2017 to March 2018) in the cardiology department of the hospital de la Paix in Ziguinchor (southern Senegal). We included in the study all patients of both sexes hospitalized for heart failure. The studied parameters were recorded on a data collection sheet. Results: The mean age was 54.5 ± 19.1 years with male predominance (53.6%). The majority of our patients were of low socioeconomic status (38.3%). High blood pressure was the most common cardiovascular risk factor (37.4%). This was most commonly an overall heart failure (52%) and the most common clinical signs were NYHA dyspnea III and IV (96%), hepatopathies (51.5%), cough (50.6%) and edema of the lower limbs (72.8%). Electrocardiographic abnormalities were dominated by left ventricular hypertrophy (39.6%) and left ventricular function was impaired in 59.1% of cases on cardiac ultrasound. Isolated high blood pressure was the leading cause of heart failure (26.3%), followed by dilated cardiomyopathies (20.4%) and chronic lung hearts (13.1%). The in-hospital mortality rate was 20.9% and the overall mortality was 27.2%. Patients rehospitalized during follow-up accounted for 31.9% of cases while 17% of our patients were lost to follow-up. The main cause of cardiac decompensation in rehospitalized patients was therapeutic disruption. Conclusion: Syndrome with multiple etiologies, heart failure is the evolutionary term of most heart disease. Prevention requires better management of cardiovascular risk factors and good education of patients with heart failure.
背景：心力衰竭是非洲的一个主要公共卫生问题，也是发现心血管疾病的主要环境。这项工作的目的是分析非洲半城市地区心力衰竭的特征，并确定与Ziguinchor（塞内加尔南部）de la Paix医院心力衰竭患者长期随访相关的困难。方法：我们在Ziguinchor（塞内加尔南部）de la Paix医院的心脏科进行了一项为期一年的前瞻性研究（2017年3月至2018年3月）。我们将所有因心力衰竭住院的男女患者纳入研究。研究的参数记录在数据收集表上。结果：平均年龄54.5±19.1岁，男性占主导地位（53.6%）。我们的大多数患者社会经济地位较低（38.3%）。高血压是最常见的心血管危险因素（37.4%）。这最常见的是全面心力衰竭（52%），最常见的临床症状是NYHA呼吸困难III和IV（96%）、肝病（51.5%），心电图异常以左心室肥厚（39.6%）为主，心超声检查发现59.1%的患者左心室功能受损。孤立性高血压是心力衰竭的主要原因（26.3%），其次是扩张型心肌病（20.4%）和慢性肺心病（13.1%）。住院死亡率为20.9%，总死亡率为27.2%。随访期间再次住院的患者占31.9%，而我们的患者中有17%因随访而失去。再住院患者心脏失代偿的主要原因是治疗中断。结论：多种病因的综合征，心力衰竭是大多数心脏病的进化术语。预防需要更好地管理心血管危险因素，并对心力衰竭患者进行良好的教育。
{"title":"Heart Failure Characteristics and Difficulties of the Long-Term Follow-Up in Semi-Urban African Area: About A Prospective Study at the Hospital De La Paix in Ziguinchor (Southern Senegal)","authors":"S. Manga, M. Leye, M. Dioum, Quinta Indafa Te, E. Sarr, A. Diagne, S. Sy, I. Diop","doi":"10.33425/2639-8486.1036","DOIUrl":"https://doi.org/10.33425/2639-8486.1036","url":null,"abstract":"Background: Heart failure is a major public health problem in Africa where it is the main circumstance for the discovery of cardiovascular diseases. The objective of this work was to analyze the characteristics of heart failure in the African semi-urban zone and to identify the difficulties related to the long-term follow-up of heart failure patients at the hospital de la Paix in Ziguinchor (southern Senegal). Method: We conducted a 1-year prospective study (March 2017 to March 2018) in the cardiology department of the hospital de la Paix in Ziguinchor (southern Senegal). We included in the study all patients of both sexes hospitalized for heart failure. The studied parameters were recorded on a data collection sheet. Results: The mean age was 54.5 ± 19.1 years with male predominance (53.6%). The majority of our patients were of low socioeconomic status (38.3%). High blood pressure was the most common cardiovascular risk factor (37.4%). This was most commonly an overall heart failure (52%) and the most common clinical signs were NYHA dyspnea III and IV (96%), hepatopathies (51.5%), cough (50.6%) and edema of the lower limbs (72.8%). Electrocardiographic abnormalities were dominated by left ventricular hypertrophy (39.6%) and left ventricular function was impaired in 59.1% of cases on cardiac ultrasound. Isolated high blood pressure was the leading cause of heart failure (26.3%), followed by dilated cardiomyopathies (20.4%) and chronic lung hearts (13.1%). The in-hospital mortality rate was 20.9% and the overall mortality was 27.2%. Patients rehospitalized during follow-up accounted for 31.9% of cases while 17% of our patients were lost to follow-up. The main cause of cardiac decompensation in rehospitalized patients was therapeutic disruption. Conclusion: Syndrome with multiple etiologies, heart failure is the evolutionary term of most heart disease. Prevention requires better management of cardiovascular risk factors and good education of patients with heart failure.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44883672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case A 70-year-old man admitted for chest tightness on exertion for approximately 5 days. The patient had a history of systemic hypertension as risk factor for coronary artery disease. He had no history of tobacco or alcohol use. Physical examination was normal. His resting electrocardiogram was normal. Electrocardiography revealed normal sinus rhythm with no ST segment changes. Echocardiography revealed normal left ventricular function. The patient referred for catheterization due to suspected coronary artery disease with angina. Angiography through the right radial artery and use of a 6F left Judkins catheter was unable to cannulate the ostium of main stem. With the use of the same catheter selective injection of the right coronary artery revealed a single coronary artery (right coronary artery) and left main (LM) arising from the same right coronary ostium. Following the course of the coronary vessel LM was divided to left anterior descending artery (LAD) and left circumflex artery (LCX). The coronary artery was free of atherosclerotic changes and no intervention was planned. Figure 1: Anomalous origin of the LM from the RSOV.
{"title":"Anomalous Origin of all Coronary Arteries from Right Sinus of Valsalva (RSOV)","authors":"Manousopoulos Bourboulis Nikolaos, Bourboulis Nikolaos","doi":"10.33425/2639-8486.1037","DOIUrl":"https://doi.org/10.33425/2639-8486.1037","url":null,"abstract":"Case A 70-year-old man admitted for chest tightness on exertion for approximately 5 days. The patient had a history of systemic hypertension as risk factor for coronary artery disease. He had no history of tobacco or alcohol use. Physical examination was normal. His resting electrocardiogram was normal. Electrocardiography revealed normal sinus rhythm with no ST segment changes. Echocardiography revealed normal left ventricular function. The patient referred for catheterization due to suspected coronary artery disease with angina. Angiography through the right radial artery and use of a 6F left Judkins catheter was unable to cannulate the ostium of main stem. With the use of the same catheter selective injection of the right coronary artery revealed a single coronary artery (right coronary artery) and left main (LM) arising from the same right coronary ostium. Following the course of the coronary vessel LM was divided to left anterior descending artery (LAD) and left circumflex artery (LCX). The coronary artery was free of atherosclerotic changes and no intervention was planned. Figure 1: Anomalous origin of the LM from the RSOV.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42952458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Personality traits are thought to be 50% heritable from pleotropic genes. Most frequently studied genes for personality traits are those of neurotransmitters. Since neurotransmitters control the autonomic nervous system, genes for neurotransmitters are candidate genes for personality traits. Heart rate and heart rate variability in response to various stimuli are thought to be an expression primarily of the autonomic nervous system and the metabolic rate. Studying heart rate and variability could reveal both autonomic nervous system function as well as personality traits. Maternal heart tracings via finger pulse oximetry are routinely a part of labor monitoring. Although not as standardized as state of the art adult heart rate variability measures, maternal heart tracings should correlate with personality testing. All patients seen in office were logged on an Excel spread sheet as to their diagnoses and were offered as a way of understanding personality connections with illness an online personality test to test aggressiveness as a sympathetic nervous system correlate as well as parasympathetic (non-aggressiveness) nervous system correlates. The test used is NPA (Narcissism, Perfectionism, and Aggression) personality test, an online test based on genetic and physiologic roots of personality. Portions of 51 laboring patients’ heart rate tracings were correlated with their results on the NPA personality test. Results showed that maternal heart rate was higher and our variability measure was lower for those with aggressive trait. Decelerations of maternal heart rate from baseline rate were found in 6 of 30 of those without aggressive trait and in none of those with aggressive trait. Accelerations of maternal heart rate from baseline rate were found in 3 of 21 of those with aggressive trait and in none of those without aggressive trait consistent with sympathetic effects on behavioral aggression and on heart rate.
{"title":"Maternal Heart Rate Tracings in Labor as A Reflection of Personality Traits","authors":"Donna K. Hobgood","doi":"10.33425/2639-8486.1040","DOIUrl":"https://doi.org/10.33425/2639-8486.1040","url":null,"abstract":"Personality traits are thought to be 50% heritable from pleotropic genes. Most frequently studied genes for personality traits are those of neurotransmitters. Since neurotransmitters control the autonomic nervous system, genes for neurotransmitters are candidate genes for personality traits. Heart rate and heart rate variability in response to various stimuli are thought to be an expression primarily of the autonomic nervous system and the metabolic rate. Studying heart rate and variability could reveal both autonomic nervous system function as well as personality traits. Maternal heart tracings via finger pulse oximetry are routinely a part of labor monitoring. Although not as standardized as state of the art adult heart rate variability measures, maternal heart tracings should correlate with personality testing. All patients seen in office were logged on an Excel spread sheet as to their diagnoses and were offered as a way of understanding personality connections with illness an online personality test to test aggressiveness as a sympathetic nervous system correlate as well as parasympathetic (non-aggressiveness) nervous system correlates. The test used is NPA (Narcissism, Perfectionism, and Aggression) personality test, an online test based on genetic and physiologic roots of personality. Portions of 51 laboring patients’ heart rate tracings were correlated with their results on the NPA personality test. Results showed that maternal heart rate was higher and our variability measure was lower for those with aggressive trait. Decelerations of maternal heart rate from baseline rate were found in 6 of 30 of those without aggressive trait and in none of those with aggressive trait. Accelerations of maternal heart rate from baseline rate were found in 3 of 21 of those with aggressive trait and in none of those without aggressive trait consistent with sympathetic effects on behavioral aggression and on heart rate.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48119776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Hirose, S. Miwa, H. Sakaguchi, Shinya Takimoto, K. Yamanaka
Background: The configuration of the mitral valve under cardiac arrest differs significantly from the configuration while the heart is beating, which often makes it difficult to reproduce the configuration including the region of prolapse, and mitral valve plasty (MVP) is difficult under these circumstances. We retrospectively investigated cases where more than 5 years has passed since the surgery to ascertain the midterm outcomes of MVP under beating heart (bMVP) and compared these outcomes of MVP under cardiac arrest (aMVP) around the same time. Methods: 43 patients, whom more than 5 years had passed since MVP alone for mitral valve prolapse implemented between July 2009 and September 2013, were divided into two groups, bMVP (n=17) and aMVP (n=26), and the outcomes were compared. There were no significant differences in preoperative factors. Results: There were no patient deaths during the observation period. There were no significant differences in MR grade between two groups. There were also no significant differences in freedom from reoperation between two groups. Conclusion: When it is difficult to reproduce the configuration of mitral valve and the region of regurgitation under cardiac arrest during the operation, bMVP may be a useful option.
{"title":"Midterm Results of Completely Beating Mitral Valve Plasty for Mitral Valve Prolapse","authors":"K. Hirose, S. Miwa, H. Sakaguchi, Shinya Takimoto, K. Yamanaka","doi":"10.33425/2639-8486.1038","DOIUrl":"https://doi.org/10.33425/2639-8486.1038","url":null,"abstract":"Background: The configuration of the mitral valve under cardiac arrest differs significantly from the configuration while the heart is beating, which often makes it difficult to reproduce the configuration including the region of prolapse, and mitral valve plasty (MVP) is difficult under these circumstances. We retrospectively investigated cases where more than 5 years has passed since the surgery to ascertain the midterm outcomes of MVP under beating heart (bMVP) and compared these outcomes of MVP under cardiac arrest (aMVP) around the same time. Methods: 43 patients, whom more than 5 years had passed since MVP alone for mitral valve prolapse implemented between July 2009 and September 2013, were divided into two groups, bMVP (n=17) and aMVP (n=26), and the outcomes were compared. There were no significant differences in preoperative factors. Results: There were no patient deaths during the observation period. There were no significant differences in MR grade between two groups. There were also no significant differences in freedom from reoperation between two groups. Conclusion: When it is difficult to reproduce the configuration of mitral valve and the region of regurgitation under cardiac arrest during the operation, bMVP may be a useful option.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43715174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perry Wengrofsky, Aron Soleiman, Fuad Benyaminov, Filip Oleszak, Louis Salciccioli, Samy I McFarlane
While traditionally an infection of the endocardial surface of heart valves, infective endocarditis (IE), can atypically present as infection of cardiac implantable electronic devices (CIED), including permanent pacemakers (PPM) or automatic implantable cardioverter-defibrillators (AICD). CIED endocarditis, similar to valvular IE, is generally caused by Gram-positive organisms such as Staphylococcus spp., most frequently S. Auerus, but is rarely caused by gram-negative bacteria, both HACEK and non-HACEK species. We present the case of Enterobacter cloacae CIED endocarditis. We also present a scoping study of previous case reports and case series highlighting the risk factors, surgical interventions, and mortality outcomes associated with E. Cloacae endocarditis. We also discuss the current guidelines and recommendations on antibiotic therapies for non-HACEK Gram-negative endocarditis and surgical management of infected CIED extraction and replacement.
{"title":"Enterobacter Cloacae Device Endocarditis: Case Report, Scoping Study, and Guidelines Review.","authors":"Perry Wengrofsky, Aron Soleiman, Fuad Benyaminov, Filip Oleszak, Louis Salciccioli, Samy I McFarlane","doi":"10.33425/2639-8486.1050","DOIUrl":"https://doi.org/10.33425/2639-8486.1050","url":null,"abstract":"<p><p>While traditionally an infection of the endocardial surface of heart valves, infective endocarditis (IE), can atypically present as infection of cardiac implantable electronic devices (CIED), including permanent pacemakers (PPM) or automatic implantable cardioverter-defibrillators (AICD). CIED endocarditis, similar to valvular IE, is generally caused by Gram-positive organisms such as Staphylococcus spp., most frequently S. Auerus, but is rarely caused by gram-negative bacteria, both HACEK and non-HACEK species. We present the case of Enterobacter cloacae CIED endocarditis. We also present a scoping study of previous case reports and case series highlighting the risk factors, surgical interventions, and mortality outcomes associated with E. Cloacae endocarditis. We also discuss the current guidelines and recommendations on antibiotic therapies for non-HACEK Gram-negative endocarditis and surgical management of infected CIED extraction and replacement.</p>","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.33425/2639-8486.1050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9109455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. L., F. B, Chotuleva A, S. P, Lole O, Yukhno M, Prozorova I, P. N, R. S, A. A, D. A.
Use of the principles personalized medicine for preventing such widespread conditions as metabol-ic syndrome (MS) representing a complex of pathogenetically interrelated metabolic disorders ab-dominal obesity, hypertension, insulin resistance, dislipidemia, actual, as according a number of large epidemiological studies it with products versus about 20 to 45% of fatal complications. MS, allocation of a separate pathology is of great clinical value, claim about Since, on the one hand, this condition is reversible, that is, with appropriate therapy, it is possible to reduce the se-verity of its main manifestations, on the other hand, the presence of MS acts as the main cause of high cardiometabolic risk, combining the risk cardiovascular diseases and the risk of developing diabetes mellitus (DM) type 2, which are the main causes of increased mortality in industrialized countries. With the development of MS, there is a 5-fold increase in the risk of type 2 diabetes and a 2-fold increase in the risk of developing cardiovascular diseases over the next 5-10 years. In ad-dition, in patients with MS, the risk of stroke increases by 2-4 times, by 3-4 times myocardial in-farction, the risk of death from these diseases increases by 2 times compared with patients without MS, regardless of the history of cardiovascular events. Based on the monitoring of individuals after genetic testing and a critical analysis of the results of a prospective genetic analysis, information about the possibilities of pre-symptomatic (prognostic) genetic testing becomes more and more practical. The obtained genotyping data allowed to evaluate the effectiveness of preclinical diagnosis and determine the tactics of treating patients. Materials and Methods: Release of DNA for the subsequent genotyping is made of whole blood by sets of «S-Sorb» reagents of the «Sintol» company with use of a sorbent of dioxide of silicon for 135 patients of State-funded health institution "Central City Clinical Hospital" Veliky Novgo-rod, from them 101 patients – with stroke, 34 patients – with a hypertension, obesity, diabetes 2 types. For studying of genetic predisposition to development of complications of a metabolic syndrome the complex of genetic polymorphisms is allocated. Genotyping on the following genes was carried out: Blood pressure regulation system Thr174Met (rs4762) polymorphism of the angiotensinogen gene (AGT); Hemostasis system polymorphism G-455A (rs1800790) of the fibrinogen gene (FGB); The system of regulation of the inflammatory process polymorphism C174G (rs1800795) of the gene for interleukin-6 (IL6). Single nucleotide genetic polymorphisms of the studied genes were revealed using the “real-time” polymerase chain reaction using «Sintol» reagent kits with specific oligonucleotide primers and TaqMan probes.
{"title":"Features of Genotyping of Complications of The Metabolic Syndrome at The Preclinical Stage","authors":"K. L., F. B, Chotuleva A, S. P, Lole O, Yukhno M, Prozorova I, P. N, R. S, A. A, D. A.","doi":"10.33425/2639-8486.1051","DOIUrl":"https://doi.org/10.33425/2639-8486.1051","url":null,"abstract":"Use of the principles personalized medicine for preventing such widespread conditions as metabol-ic syndrome (MS) representing a complex of pathogenetically interrelated metabolic disorders ab-dominal obesity, hypertension, insulin resistance, dislipidemia, actual, as according a number of large epidemiological studies it with products versus about 20 to 45% of fatal complications. MS, allocation of a separate pathology is of great clinical value, claim about Since, on the one hand, this condition is reversible, that is, with appropriate therapy, it is possible to reduce the se-verity of its main manifestations, on the other hand, the presence of MS acts as the main cause of high cardiometabolic risk, combining the risk cardiovascular diseases and the risk of developing diabetes mellitus (DM) type 2, which are the main causes of increased mortality in industrialized countries. With the development of MS, there is a 5-fold increase in the risk of type 2 diabetes and a 2-fold increase in the risk of developing cardiovascular diseases over the next 5-10 years. In ad-dition, in patients with MS, the risk of stroke increases by 2-4 times, by 3-4 times myocardial in-farction, the risk of death from these diseases increases by 2 times compared with patients without MS, regardless of the history of cardiovascular events. Based on the monitoring of individuals after genetic testing and a critical analysis of the results of a prospective genetic analysis, information about the possibilities of pre-symptomatic (prognostic) genetic testing becomes more and more practical. The obtained genotyping data allowed to evaluate the effectiveness of preclinical diagnosis and determine the tactics of treating patients. Materials and Methods: Release of DNA for the subsequent genotyping is made of whole blood by sets of «S-Sorb» reagents of the «Sintol» company with use of a sorbent of dioxide of silicon for 135 patients of State-funded health institution \"Central City Clinical Hospital\" Veliky Novgo-rod, from them 101 patients – with stroke, 34 patients – with a hypertension, obesity, diabetes 2 types. For studying of genetic predisposition to development of complications of a metabolic syndrome the complex of genetic polymorphisms is allocated. Genotyping on the following genes was carried out: Blood pressure regulation system Thr174Met (rs4762) polymorphism of the angiotensinogen gene (AGT); Hemostasis system polymorphism G-455A (rs1800790) of the fibrinogen gene (FGB); The system of regulation of the inflammatory process polymorphism C174G (rs1800795) of the gene for interleukin-6 (IL6). Single nucleotide genetic polymorphisms of the studied genes were revealed using the “real-time” polymerase chain reaction using «Sintol» reagent kits with specific oligonucleotide primers and TaqMan probes.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69746708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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