Background: Previous trials showed a promising potential use of epinephrine in the treatment of no-reflow phenomenon (the no-reflow phenomenon is multiple pathogenetic processes, which may be attributed to ischemic injuries, distal atherothrombotic embolization, coronary-microcirculation susceptibility to injury, and reperfusion injuries (6)). This study aimed to compare the safety and efficacy of distal intracoronary delivery of epinephrine versus verapamil to prevent no-reflow during primary percutaneous coronary intervention (PPCI). Materials and Methods: We conducted a randomized, open-label, trial on patients undergoing PPCI. Patients were randomized to one of three groups: group I who received distal intracoronary administration of epinephrine; group II who received verapamil; and group III who served as a control group. The primary endpoint in our study was the incidence of no-reflow, defined as a post-procedural (Thrombolysis in Myocardial Infarction) TIMI flow grade (TFG) is < 3 or, in the case of a TFG of 3, when TIMI myocardial perfusion grade (TMPG) is 0 or 1. Results: A total of 120 patients were randomized. The angiographic flow and perfusion parameters were significantly improved in group I and II versus the control group, with better results in epinephrine group only TMPG3 was significantly higher with epinephrine (77.5%) than verapamil (55%) (p = 0.037) and TMPG2 was higher in verapamil (32.5%) than epinephrine (7.5%) (p = 0.003). No reflow is lower with epinephrine than verapamil (25% vs 27.5%); however, with no statistically significant difference (P=0.785). Patients in the three groups has no statistical significant difference in (MACE) or heart failure hospitalization. Conclusion: Epinephrine and verapamil are safe and effective in managing patients with no-reflow during PPCIs. Further studies with a larger sample and a longer duration of follow-up are required to confirm these findings
背景:以往的试验显示肾上腺素在治疗无血流再流现象方面具有潜在的应用前景(无血流再流现象是一个多重发病过程，可能与缺血性损伤、远端动脉粥样硬化血栓栓塞、冠状动脉微循环损伤易感性和再灌注损伤有关(6))。本研究旨在比较原发性经皮冠状动脉介入治疗(PPCI)期间远端冠状动脉内输送肾上腺素与维拉帕米预防无血流循环的安全性和有效性。材料和方法:我们对接受PPCI的患者进行了一项随机、开放标签的试验。患者被随机分为三组:第一组接受远端冠状动脉内注射肾上腺素;第二组给予维拉帕米;第三组作为对照组。我们研究的主要终点是无再流发生率，定义为手术后(心肌梗死溶栓)TIMI血流等级(TFG) < 3，或者在TFG为3的情况下，TIMI心肌灌注等级(TMPG)为0或1。结果:共纳入120例患者。与对照组相比，I组和II组血管造影血流和灌注参数均有明显改善，其中肾上腺素组效果较好，仅肾上腺素组TMPG3(77.5%)明显高于维拉帕米(55%)(p = 0.037)，维拉帕米组TMPG2(32.5%)明显高于肾上腺素(7.5%)(p = 0.003)。肾上腺素的无血流比维拉帕米低(25% vs 27.5%);差异无统计学意义(P=0.785)。三组患者在MACE和心力衰竭住院方面无统计学差异。结论:肾上腺素联合维拉帕米治疗PPCIs期间无血流倒流患者安全有效。进一步的研究需要更大的样本和更长的随访时间来证实这些发现
{"title":"Distal Intracoronary Delivery of Epinephrine versus Verapamil to Prevent No-Reflow During Primary Percutaneous Coronary Intervention: A Randomized, Open-Label, Trial","authors":"Ihab M. Yassin, Ashraf Ahmed, G. Abdelhady","doi":"10.33425/2639-8486.1120","DOIUrl":"https://doi.org/10.33425/2639-8486.1120","url":null,"abstract":"Background: Previous trials showed a promising potential use of epinephrine in the treatment of no-reflow phenomenon (the no-reflow phenomenon is multiple pathogenetic processes, which may be attributed to ischemic injuries, distal atherothrombotic embolization, coronary-microcirculation susceptibility to injury, and reperfusion injuries (6)). This study aimed to compare the safety and efficacy of distal intracoronary delivery of epinephrine versus verapamil to prevent no-reflow during primary percutaneous coronary intervention (PPCI). Materials and Methods: We conducted a randomized, open-label, trial on patients undergoing PPCI. Patients were randomized to one of three groups: group I who received distal intracoronary administration of epinephrine; group II who received verapamil; and group III who served as a control group. The primary endpoint in our study was the incidence of no-reflow, defined as a post-procedural (Thrombolysis in Myocardial Infarction) TIMI flow grade (TFG) is < 3 or, in the case of a TFG of 3, when TIMI myocardial perfusion grade (TMPG) is 0 or 1. Results: A total of 120 patients were randomized. The angiographic flow and perfusion parameters were significantly improved in group I and II versus the control group, with better results in epinephrine group only TMPG3 was significantly higher with epinephrine (77.5%) than verapamil (55%) (p = 0.037) and TMPG2 was higher in verapamil (32.5%) than epinephrine (7.5%) (p = 0.003). No reflow is lower with epinephrine than verapamil (25% vs 27.5%); however, with no statistically significant difference (P=0.785). Patients in the three groups has no statistical significant difference in (MACE) or heart failure hospitalization. Conclusion: Epinephrine and verapamil are safe and effective in managing patients with no-reflow during PPCIs. Further studies with a larger sample and a longer duration of follow-up are required to confirm these findings","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48258933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Analysis of research and clinical data demonstrated the efficacy and ponderability of thrombolysis as the method of choice. Significant reserve of thrombolytic therapy beetles conjunctive application of tissue and urokinase plasminogen activators in decreased doses. The perspective of this combined approach consists in forming of bolus thrombolytic compositions on the base of plasminogen activators due to burly science-medical cooperation of researchers and clinical coworkers.
{"title":"Conversion of Fibrinolysis Reserves into Thrombolysis Resources. Bolus Compositions of Plasminogen Activators","authors":"A. Maksimenko","doi":"10.33425/2639-8486.1118","DOIUrl":"https://doi.org/10.33425/2639-8486.1118","url":null,"abstract":"Analysis of research and clinical data demonstrated the efficacy and ponderability of thrombolysis as the method of choice. Significant reserve of thrombolytic therapy beetles conjunctive application of tissue and urokinase plasminogen activators in decreased doses. The perspective of this combined approach consists in forming of bolus thrombolytic compositions on the base of plasminogen activators due to burly science-medical cooperation of researchers and clinical coworkers.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44801215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Galal A. Fattah Fahmy, Gamal Abd el hady, M. Hassan, K. Moussa, M. Bordy
Background: Following myocardial infarction (MI), left ventricle (LV) remodeling is a complex and multifactorial mechanism with therapeutic and prognostic consequences. Medications that reduce LV remodeling increase survival and quality of life. Exercising following a myocardial infarction (MI) is effective according to several trials. The implications on operation and remodeling, however, are still debated Aim of work: To evaluate continuous moderate-intensity aerobic training effects by using cardiac magnetic resonance imaging on left ventricular remodeling after one month of percutaneous coronary intervention (PCI) following myocardial infarction. Methods: Forty eligible patients (5 females and 35 males) who had PCI after one month of having MI with age 45-65 years old. They underwent conventional medical treatment in addition to a supervised intensive recovery regimen that included 36 hours of continuous moderate aerobic exercise (three times /week for 12 weeks). Evaluation of the effect of this program was done by magnetic resonance imaging (CMR) to calculate EF. Result: This research was done on 40 patients (5 females and 35 males) who had PCI after myocardial infarction. The mean age of the participants was 54.1 ± 7.0. Most patients have Killip class I. LAD was the culprit artery in 70% of the patients. The most common risk factors were smoking, dyslipidemia, and overweight. Post-treatment BMI decreased compared with pre-treatment BMI (p <0.05) for an improvement average of 5.37 percent. There was also a substantial improvement in the pretreatment systolic blood pressure and functional parameters as compared for post-treatment (p<0.05). As regard cardiac MRI, There was a significant reduction in post-treatment LV mass (117.2 ± 27.2) relative to pretreatment (128.7 ± 38.9). EF % was marked improvement from 49.32 ± 5.12 to 56.63 ± 5.49 (P value < 000.1). EDV and all other parameters show marked improvement post treatment as compared to pretreatment. Conclusion: Moderate-intensity aerobic exercise improved LV remodeling after percutaneous coronary intervention (PCI) one month following myocardial Infarction.
{"title":"Continuous Moderate Exercise Influence on Cardiac Remodeling in Patients Underwent Percutaneous Coronary Intervention","authors":"Ahmed Galal A. Fattah Fahmy, Gamal Abd el hady, M. Hassan, K. Moussa, M. Bordy","doi":"10.33425/2639-8486.1109","DOIUrl":"https://doi.org/10.33425/2639-8486.1109","url":null,"abstract":"Background: Following myocardial infarction (MI), left ventricle (LV) remodeling is a complex and multifactorial mechanism with therapeutic and prognostic consequences. Medications that reduce LV remodeling increase survival and quality of life. Exercising following a myocardial infarction (MI) is effective according to several trials. The implications on operation and remodeling, however, are still debated Aim of work: To evaluate continuous moderate-intensity aerobic training effects by using cardiac magnetic resonance imaging on left ventricular remodeling after one month of percutaneous coronary intervention (PCI) following myocardial infarction. Methods: Forty eligible patients (5 females and 35 males) who had PCI after one month of having MI with age 45-65 years old. They underwent conventional medical treatment in addition to a supervised intensive recovery regimen that included 36 hours of continuous moderate aerobic exercise (three times /week for 12 weeks). Evaluation of the effect of this program was done by magnetic resonance imaging (CMR) to calculate EF. Result: This research was done on 40 patients (5 females and 35 males) who had PCI after myocardial infarction. The mean age of the participants was 54.1 ± 7.0. Most patients have Killip class I. LAD was the culprit artery in 70% of the patients. The most common risk factors were smoking, dyslipidemia, and overweight. Post-treatment BMI decreased compared with pre-treatment BMI (p <0.05) for an improvement average of 5.37 percent. There was also a substantial improvement in the pretreatment systolic blood pressure and functional parameters as compared for post-treatment (p<0.05). As regard cardiac MRI, There was a significant reduction in post-treatment LV mass (117.2 ± 27.2) relative to pretreatment (128.7 ± 38.9). EF % was marked improvement from 49.32 ± 5.12 to 56.63 ± 5.49 (P value < 000.1). EDV and all other parameters show marked improvement post treatment as compared to pretreatment. Conclusion: Moderate-intensity aerobic exercise improved LV remodeling after percutaneous coronary intervention (PCI) one month following myocardial Infarction.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44117700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We had the great opportunity to host the following Ukrainian paediatric cardiologists: Bohdan Cherpak (2007 and 2010; works in Kiev), Slava Volodin (2007, 2009 and 2014; works in Kharkiv), Nataliia Yashchuk (2015, works in Kiev) and Iryna Avramanienko (2019, works in Lviv). The trainings lasted from one to six months and were covered by our Foundation of the Friends of Children with Heart Diseases in Zabrze. The knowledge of all the trainees was very good, therefore, the primary goal of the fellowship was to improve skills in the interventional cardiology.
{"title":"Different Aspects of Polish – Ukrainian Medical Cooperation","authors":"J. Białkowski","doi":"10.33425/2639-8486.1116","DOIUrl":"https://doi.org/10.33425/2639-8486.1116","url":null,"abstract":"We had the great opportunity to host the following Ukrainian paediatric cardiologists: Bohdan Cherpak (2007 and 2010; works in Kiev), Slava Volodin (2007, 2009 and 2014; works in Kharkiv), Nataliia Yashchuk (2015, works in Kiev) and Iryna Avramanienko (2019, works in Lviv). The trainings lasted from one to six months and were covered by our Foundation of the Friends of Children with Heart Diseases in Zabrze. The knowledge of all the trainees was very good, therefore, the primary goal of the fellowship was to improve skills in the interventional cardiology.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47192490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olugbemi Aj, Ogunleye Eo, Olusoji Oo, Ojo Oo, Sanni Sb, Olugbemi M
Introduction Central venous catheterization refers to insertion of a catheter into one of the large veins. It is done using the Seldinger’s technique. This technique of venous access has been in use since the 50s, and can be performed using the internal jugular, subclavian, or femoral veins. The subclavian vein is usually preferred because of its distinct landmarks and low rates of complications associated with it. [1-5]. Femoral venous catheterization is not advised due to increased risk of infectious and thrombotic problems [1-3].
{"title":"A Prospective Study of Central Venous Catheterization in Lagos University Teaching Hospital, Nigeria","authors":"Olugbemi Aj, Ogunleye Eo, Olusoji Oo, Ojo Oo, Sanni Sb, Olugbemi M","doi":"10.33425/2639-8486.1112","DOIUrl":"https://doi.org/10.33425/2639-8486.1112","url":null,"abstract":"Introduction Central venous catheterization refers to insertion of a catheter into one of the large veins. It is done using the Seldinger’s technique. This technique of venous access has been in use since the 50s, and can be performed using the internal jugular, subclavian, or femoral veins. The subclavian vein is usually preferred because of its distinct landmarks and low rates of complications associated with it. [1-5]. Femoral venous catheterization is not advised due to increased risk of infectious and thrombotic problems [1-3].","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42132441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Loubelle B. Rirao, Jeremy Owen G. Go, Ronald S. Perez, G. Ong-Cabrera
Coronavirus Disease 2019 (COVID-19) is an emerging disease from SARS-CoV2 that can cause acute respiratory distress syndrome (ARDS) that can present with extrapulmonary symptoms such as rhabdomyolysis. This is a case of a 55-year-old male known case of pulmonary tuberculosis (PTB) recently started on fixed dose combination therapy admitted due to non-rotatory dizziness and diaphoresis. He had hyponatremia (119mmol/L) and was given Tolvaptan 15mg OD. In the interim, he was noted to have myalgia, weakness, fever and watery diarrhea. COVID-19 RT-PCR swab was positive. CK-MM (52.11U/L) and CPK-total (2954U/L) levels were elevated. He was managed as a case of rhabdomyolysis and PTB medications were withheld. Chest x-ray showed bilateral infiltrates. Inflammatory markers showed elevations in LDH 734U/L, CRP 62mg/L, Ferritin 4374.08ng/mL and Procalcitonin 0.12ng/mL. ABG showed respiratory alkalosis with severe hypoxemia (pO2 43mmHg). Patient was started on ceftriaxone 2gm IV OD, remdesivir (200mg IV loading dose, then 100mg IV OD), dexamethasone 6mg IV OD, hemodialysis and hemoperfusion, convalescent plasma (2 aliquots), enoxaparin 0.6cc SC OD, and was hooked to high flow nasal cannula (FiO2 80%, Flow 30LPM, Temp 35°C). During the course of admission, HE HAD atrial fibrillation in rapid ventricular response, hypomagnesemia (0.75mmol/L), hypokalemia (2.9 mmol/L), and acute liver injury (AST 142U/L, ALT 116U/L), and was managed with colchicine 0.5mg/tab OD, trimetazidine 35mg/tab BID, digoxin 0.25mg IV (q4 hours for 6 doses then OD), ivabradine 7.5mg/tab BID, magnesium and potassium supplementation, and ademetionine 300mg/tab 2 tablets TID. Patient’s symptoms resolved and was weaned from oxygen support, and underwent pulmonary rehabilitation (incentive spirometry, musculoskeletal training/exercises) then discharged. In this article, we discussed the correlation of ARDS and rhabdomyolysis to COVID-19 and its implications on patient’s course of illness and recovery.
2019冠状病毒病（新冠肺炎）是一种新出现的SARS-CoV2疾病，可导致急性呼吸窘迫综合征（ARDS），并可出现肺外症状，如横纹肌溶解症。这是一例55岁男性已知肺结核（PTB）病例，最近开始接受固定剂量的联合治疗，因非旋转性头晕和发汗入院。他有低钠血症（119mmol/L），给予托伐普坦15mg OD。在此期间，他出现肌痛、虚弱、发烧和水样腹泻。新冠肺炎RT-PCR拭子阳性。CK-MM（52.11U/L）和CPK总水平（2954U/L）升高。他因横纹肌溶解症接受治疗，PTB药物被扣留。胸部x光片显示双侧浸润。炎症标志物显示LDH 734U/L、CRP 62mg/L、Ferritin 4374.08ng/mL和降钙素原0.12ng/mL升高。ABG显示呼吸性碱中毒伴严重低氧血症（pO2 43mmHg）。患者开始静脉滴注头孢曲松2gm OD，瑞德西韦（200mg IV负荷剂量，然后100mg IV OD），地塞米松6mg IV OD，血液透析和血液灌流，恢复期血浆（2份等分试样），依诺肝素0.6cc SC OD，并连接到高流量鼻插管（FiO2 80%，流量30LPM，温度35°C）。入院期间，他出现快速心室反应性心房颤动、低镁血症（0.75mmol/L）、低钾血症（2.9mmol/L）和急性肝损伤（AST142U/L，ALT116U/L），并接受秋水仙碱0.5mg/tab OD、曲美他嗪35mg/tab BID、地高辛0.25mg IV（q4小时，6次给药，然后OD）、伊伐布雷定7.5mg/tab BID、补充镁和钾治疗，腺苷300mg/tab 2片，每天三次。患者的症状得到缓解，停止了氧气支持，并接受了肺部康复（激励性肺活量测定、肌肉骨骼训练/锻炼），然后出院。在这篇文章中，我们讨论了ARDS和横纹肌溶解症与新冠肺炎的相关性及其对患者病程和康复的影响。
{"title":"A Case Report of Acute Respiratory Distress Syndrome and Rhabdomyolysis in Covid-19 Disease: An Interchange of Causes and Effects","authors":"Loubelle B. Rirao, Jeremy Owen G. Go, Ronald S. Perez, G. Ong-Cabrera","doi":"10.33425/2639-8486.1113","DOIUrl":"https://doi.org/10.33425/2639-8486.1113","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) is an emerging disease from SARS-CoV2 that can cause acute respiratory distress syndrome (ARDS) that can present with extrapulmonary symptoms such as rhabdomyolysis. This is a case of a 55-year-old male known case of pulmonary tuberculosis (PTB) recently started on fixed dose combination therapy admitted due to non-rotatory dizziness and diaphoresis. He had hyponatremia (119mmol/L) and was given Tolvaptan 15mg OD. In the interim, he was noted to have myalgia, weakness, fever and watery diarrhea. COVID-19 RT-PCR swab was positive. CK-MM (52.11U/L) and CPK-total (2954U/L) levels were elevated. He was managed as a case of rhabdomyolysis and PTB medications were withheld. Chest x-ray showed bilateral infiltrates. Inflammatory markers showed elevations in LDH 734U/L, CRP 62mg/L, Ferritin 4374.08ng/mL and Procalcitonin 0.12ng/mL. ABG showed respiratory alkalosis with severe hypoxemia (pO2 43mmHg). Patient was started on ceftriaxone 2gm IV OD, remdesivir (200mg IV loading dose, then 100mg IV OD), dexamethasone 6mg IV OD, hemodialysis and hemoperfusion, convalescent plasma (2 aliquots), enoxaparin 0.6cc SC OD, and was hooked to high flow nasal cannula (FiO2 80%, Flow 30LPM, Temp 35°C). During the course of admission, HE HAD atrial fibrillation in rapid ventricular response, hypomagnesemia (0.75mmol/L), hypokalemia (2.9 mmol/L), and acute liver injury (AST 142U/L, ALT 116U/L), and was managed with colchicine 0.5mg/tab OD, trimetazidine 35mg/tab BID, digoxin 0.25mg IV (q4 hours for 6 doses then OD), ivabradine 7.5mg/tab BID, magnesium and potassium supplementation, and ademetionine 300mg/tab 2 tablets TID. Patient’s symptoms resolved and was weaned from oxygen support, and underwent pulmonary rehabilitation (incentive spirometry, musculoskeletal training/exercises) then discharged. In this article, we discussed the correlation of ARDS and rhabdomyolysis to COVID-19 and its implications on patient’s course of illness and recovery.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49025631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdel-madjid Zakaria Zakaria, K. Souley, K. Mahamat, B. Ali, Hassan Yousra, Toulo Koché, T. A. Ibrahim
Introduction Congenital heart disease are abnormalities of the heart that appear during heart formation during intrauterine life [1]. Their incidence is estimated between 7 to 8 per 1,000 births, according to the literature [2]. Doppler echocardiography is nowadays the essential examination in the diagnosis of congenital heart disease. This is how we decided to do this study entitled "Epidemiological and echocardiographic aspects of 167 cases at Lamorde university hospital." In order to have an inventory of congenital heart disease, In Niger.
{"title":"Congenital Heart Disease: Epidemiological and Echocardiographic Aspects of 167 Cases at The Teaching Hospital of Lamorde / Niamey / Niger","authors":"Abdel-madjid Zakaria Zakaria, K. Souley, K. Mahamat, B. Ali, Hassan Yousra, Toulo Koché, T. A. Ibrahim","doi":"10.33425/2639-8486.1114","DOIUrl":"https://doi.org/10.33425/2639-8486.1114","url":null,"abstract":"Introduction Congenital heart disease are abnormalities of the heart that appear during heart formation during intrauterine life [1]. Their incidence is estimated between 7 to 8 per 1,000 births, according to the literature [2]. Doppler echocardiography is nowadays the essential examination in the diagnosis of congenital heart disease. This is how we decided to do this study entitled \"Epidemiological and echocardiographic aspects of 167 cases at Lamorde university hospital.\" In order to have an inventory of congenital heart disease, In Niger.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44725313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olugbemi Aj, Thomas F. Mo, Ogunleye Eo, Olusoji Oo, Ojo Oo, Sanni Sb
Candida species are fungi, which are ubiquitous organisms. It is a normal flora of the oral cavity, genitourinary and gastrointestinal tract. An increasing incidence of fungal infections with Candida species has been noted in immunocompromised patients such as intensive care, postsurgical, and neutropenic patients. Candida species are detected in approximately 31 to 55% of healthy individuals. They are more common in immunocompromised individuals. Colonization rates increase with severity of illness and duration of hospitalization. We present a 32-year-old male who presented at our institution with a thoracoabdominal penetrating injury following assault. He had injury to the stomach and left hemi diaphragm, with moderate hemothorax. He had surgery done with repair of the stomach and diaphragm. He however developed chest infection with empyma thoracis thereafter. Culture of the pleural effluent revealed growth of Canddida glabrata which was sensitive to Ketoconazole. He was treated for two weeks and subsequently discharged from the ward and followed up in the clinic. Though C. glabrata infection of the chest is rare, it is however useful to exclude fungal infection in patients with empyema thoracic, as early diagnosis and treatment provides good outcome.
{"title":"Candida glabrata Infection: A Rare Complication of Chest Trauma","authors":"Olugbemi Aj, Thomas F. Mo, Ogunleye Eo, Olusoji Oo, Ojo Oo, Sanni Sb","doi":"10.33425/2639-8486.1111","DOIUrl":"https://doi.org/10.33425/2639-8486.1111","url":null,"abstract":"Candida species are fungi, which are ubiquitous organisms. It is a normal flora of the oral cavity, genitourinary and gastrointestinal tract. An increasing incidence of fungal infections with Candida species has been noted in immunocompromised patients such as intensive care, postsurgical, and neutropenic patients. Candida species are detected in approximately 31 to 55% of healthy individuals. They are more common in immunocompromised individuals. Colonization rates increase with severity of illness and duration of hospitalization. We present a 32-year-old male who presented at our institution with a thoracoabdominal penetrating injury following assault. He had injury to the stomach and left hemi diaphragm, with moderate hemothorax. He had surgery done with repair of the stomach and diaphragm. He however developed chest infection with empyma thoracis thereafter. Culture of the pleural effluent revealed growth of Canddida glabrata which was sensitive to Ketoconazole. He was treated for two weeks and subsequently discharged from the ward and followed up in the clinic. Though C. glabrata infection of the chest is rare, it is however useful to exclude fungal infection in patients with empyema thoracic, as early diagnosis and treatment provides good outcome.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45172353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diop Kr, Mingou Js, Beye Sm, Ndiaye Pg, Diop Cmbm, Diouf Y, Diallo Sd, A. S., Sarr Sa, F. Aw, Bodian M, Ndiaye Mb, Kane Ad, D. M, K. A
Introduction: Occlusion of the sinus node artery is a rare situation. It is responsible for sinus node dysfunction and often occurs accidentally during percutaneous coronary intervention of a proximal lesion of the right coronary artery Case Report: This is a sixty-year-old woman with high blood pressure treat by dual therapy (an enzyme conversion inhibitor and a thiazide diuretic), who presented to the cardiological emergency room for a typical angina pain that had been evolving for 48 hours without a lull. Her clinical examination was normal apart from grade 3 arterial hypertension. The 18-lead surface electrocardiogram showed an electrical left ventricular hypertrophy with undershift of the ST segment in lateral and posterior territories, with an overshift of the ST segment in the antero-septal without any sign of necrosis. Biologically, the ultra-sensitive troponinemia was 88 times normal. The diagnosis of NSTEMI with troponin was retained with an intermediate ischaemic risk. Transthoracic Doppler echocardiography showed concentric hypertrophy of the left ventricular walls and dyskinesia of the right ventricle infero-apical wall. The coronary angiography showed an occlusion of the sinus node artery and a left coronary artery atheromatous with an intermediate lesion in the middle segment of the anterior interventricular artery. Conclusion: The present clinical case highlights the diversity in the expression of a sinus node artery occlusion that can occur spontaneously outside of a percutaneous coronary intervention.
{"title":"Spontaneous Occlusion of the Sinus Node Artery: A Case Report","authors":"Diop Kr, Mingou Js, Beye Sm, Ndiaye Pg, Diop Cmbm, Diouf Y, Diallo Sd, A. S., Sarr Sa, F. Aw, Bodian M, Ndiaye Mb, Kane Ad, D. M, K. A","doi":"10.33425/2639-8486.1110","DOIUrl":"https://doi.org/10.33425/2639-8486.1110","url":null,"abstract":"Introduction: Occlusion of the sinus node artery is a rare situation. It is responsible for sinus node dysfunction and often occurs accidentally during percutaneous coronary intervention of a proximal lesion of the right coronary artery Case Report: This is a sixty-year-old woman with high blood pressure treat by dual therapy (an enzyme conversion inhibitor and a thiazide diuretic), who presented to the cardiological emergency room for a typical angina pain that had been evolving for 48 hours without a lull. Her clinical examination was normal apart from grade 3 arterial hypertension. The 18-lead surface electrocardiogram showed an electrical left ventricular hypertrophy with undershift of the ST segment in lateral and posterior territories, with an overshift of the ST segment in the antero-septal without any sign of necrosis. Biologically, the ultra-sensitive troponinemia was 88 times normal. The diagnosis of NSTEMI with troponin was retained with an intermediate ischaemic risk. Transthoracic Doppler echocardiography showed concentric hypertrophy of the left ventricular walls and dyskinesia of the right ventricle infero-apical wall. The coronary angiography showed an occlusion of the sinus node artery and a left coronary artery atheromatous with an intermediate lesion in the middle segment of the anterior interventricular artery. Conclusion: The present clinical case highlights the diversity in the expression of a sinus node artery occlusion that can occur spontaneously outside of a percutaneous coronary intervention.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42776281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Channelopathy constitute significant proportion of SCD worldwide (around 10% or 370000 deaths annually). Besides LQTS, the channelopathies include Brugada syndrome (BrS), short QT syndrome, Early Repolarization Syndrome (ERS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and congenital sick sinus syndrome. It was constituting a mysterious group of disease until the second half of the last century when Anton Jervell and Fred Lange-Nielsen described Jervell Lange-Nielsen syndrome in 1957.It was late until 1995 where genetic characterization commenced. Later on, the massive genetic information obtained in the field with discovery of genetic heterogeneity and allelic heterogeneity were all part of our new understanding and clues to solve the historical conundrum of channelopathies. Here, we review the genetic basis of sudden cardiac death with a focus on the current knowledge on the genetics of the primary electric disorders caused primarily by mutations in genes encoding ion channels. Diving deep into the genetic details of those syndromes enable us to improve our knowdelege and decode the pathophysiology of those malignant arrhythmias. The ultimate ambition is prevention of channelopathy based sudden cardiac death and associated disorders in human.
渠道病在全世界SCD中占很大比例（每年约有10%或370000人死亡）。除了LQTS，通道病还包括Brugada综合征（BrS）、短QT综合征、早期复极综合征（ERS）、儿茶酚胺能多态性室性心动过速（CPVT）和先天性病态窦房结综合征。直到上世纪下半叶，Anton Jervell和Fred Lange Nielsen在1957年描述了Jervell-Lange-Nielsen综合征，它一直是一组神秘的疾病。直到1995年，基因特征才开始。后来，随着基因异质性和等位基因异质性的发现，该领域获得的大量遗传信息都是我们新理解的一部分，也是解决通道病历史难题的线索。在这里，我们回顾了心脏性猝死的遗传学基础，重点介绍了主要由编码离子通道的基因突变引起的原发性电性疾病的遗传学的最新知识。深入研究这些综合征的遗传细节使我们能够提高我们的知识，并解码这些恶性心律失常的病理生理学。最终目标是预防基于通道病的人类心脏性猝死和相关疾病。
{"title":"Genetics of Sudden Cardiac Death, the Channelopathies: Today's Perspective and the Future","authors":"A. Alabdulgader","doi":"10.33425/2639-8486.1115","DOIUrl":"https://doi.org/10.33425/2639-8486.1115","url":null,"abstract":"Channelopathy constitute significant proportion of SCD worldwide (around 10% or 370000 deaths annually). Besides LQTS, the channelopathies include Brugada syndrome (BrS), short QT syndrome, Early Repolarization Syndrome (ERS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and congenital sick sinus syndrome. It was constituting a mysterious group of disease until the second half of the last century when Anton Jervell and Fred Lange-Nielsen described Jervell Lange-Nielsen syndrome in 1957.It was late until 1995 where genetic characterization commenced. Later on, the massive genetic information obtained in the field with discovery of genetic heterogeneity and allelic heterogeneity were all part of our new understanding and clues to solve the historical conundrum of channelopathies. Here, we review the genetic basis of sudden cardiac death with a focus on the current knowledge on the genetics of the primary electric disorders caused primarily by mutations in genes encoding ion channels. Diving deep into the genetic details of those syndromes enable us to improve our knowdelege and decode the pathophysiology of those malignant arrhythmias. The ultimate ambition is prevention of channelopathy based sudden cardiac death and associated disorders in human.","PeriodicalId":72522,"journal":{"name":"Cardiology & vascular research (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46051517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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