首页 > 最新文献

Clinical nutrition research最新文献

英文 中文
Does a High Ratio of Dietary Omega-6/Omega-3 Fatty Acids Increase the Risk of Helicobacter pylori Infection? A Case-Control Study. 膳食中欧米茄-6/欧米茄-3 脂肪酸比例过高会增加幽门螺旋杆菌感染风险吗?一项病例对照研究。
Pub Date : 2024-07-26 eCollection Date: 2024-07-01 DOI: 10.7762/cnr.2024.13.3.176
Masoumeh Khalighi Sikaroudi, Zohreh Ebrahimi, Melika Darzi, Zainab Shateri, Mehran Nouri, Mohsen Masoodi, Mahdi Hejazi, Farzad Shidfar

Helicobacter pylori infection is the cause of 90% of non-cardia gastric cancer. Several dietary elements have been identified as possible contributors to H. pylori infection and its advancement through various pathways. Based on the anti-inflammatory and anti-microbial effects of a diet low in omega-6 and high in omega-3 polyunsaturated fatty acids (PUFAs), this study aimed to assess the ratio of dietary omega-6 to omega-3 PUFAs and the risk of developing H. pylori. The present case-control study was conducted on 150 cases with H. pylori infection and 302 controls. The omega-6 to omega-3 ratio was calculated using food intake information sourced from a validated food frequency questionnaire. Physical activity and demographic data were collected through a related questionnaire. The association between the odds of H. pylori infection and the omega-6 to omega-3 ratio was evaluated using logistic regression models. A p value < 0.05 was considered statistically significant. The findings revealed that individuals in the third tertile had significantly higher odds of H. pylori (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.30-3.40) in the crude model. Furthermore, even after adjusting the potential confounders including sex, age, body mass index, physical activity, energy intake, alcohol, and smoking status, this association remained significant (fully adjusted model: OR, 2.00; 95% CI, 1.17-3.34). Our study revealed a higher ratio of omega-6 to omega-3 was related to a higher likelihood of H. pylori infection. Therefore, it is advisable to maintain a balanced intake of PUFAs in the diet.

幽门螺杆菌感染是 90% 非贲门胃癌的病因。目前已发现多种饮食元素可能会导致幽门螺杆菌感染,并通过各种途径使其恶化。基于低ω-6和高ω-3多不饱和脂肪酸(PUFAs)饮食的抗炎和抗微生物作用,本研究旨在评估膳食中ω-6和ω-3 PUFAs的比例以及幽门螺杆菌的发病风险。本病例对照研究以 150 例幽门螺杆菌感染病例和 302 例对照病例为对象。omega-6和omega-3的比例是通过有效的食物频率调查问卷中的食物摄入信息计算得出的。体育锻炼和人口统计学数据通过相关问卷收集。使用逻辑回归模型评估了幽门螺杆菌感染几率与欧米伽-6 和欧米伽-3 比率之间的关系。P值小于0.05被认为具有统计学意义。研究结果显示,在粗略模型中,处于第三梯队的人感染幽门螺杆菌的几率明显更高(几率比 [OR],2.10;95% 置信区间 [CI],1.30-3.40)。此外,即使在调整了潜在的混杂因素(包括性别、年龄、体重指数、体力活动、能量摄入、酒精和吸烟状况)后,这种关联仍然显著(完全调整模型:OR,2.00;95% CI,1.17-3.34)。我们的研究表明,ω-6 和ω-3 的比例越高,感染幽门螺杆菌的可能性就越大。因此,在饮食中保持均衡摄入 PUFAs 是明智之举。
{"title":"Does a High Ratio of Dietary Omega-6/Omega-3 Fatty Acids Increase the Risk of <i>Helicobacter pylori</i> Infection? A Case-Control Study.","authors":"Masoumeh Khalighi Sikaroudi, Zohreh Ebrahimi, Melika Darzi, Zainab Shateri, Mehran Nouri, Mohsen Masoodi, Mahdi Hejazi, Farzad Shidfar","doi":"10.7762/cnr.2024.13.3.176","DOIUrl":"10.7762/cnr.2024.13.3.176","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> infection is the cause of 90% of non-cardia gastric cancer. Several dietary elements have been identified as possible contributors to <i>H. pylori</i> infection and its advancement through various pathways. Based on the anti-inflammatory and anti-microbial effects of a diet low in omega-6 and high in omega-3 polyunsaturated fatty acids (PUFAs), this study aimed to assess the ratio of dietary omega-6 to omega-3 PUFAs and the risk of developing <i>H. pylori</i>. The present case-control study was conducted on 150 cases with <i>H. pylori</i> infection and 302 controls. The omega-6 to omega-3 ratio was calculated using food intake information sourced from a validated food frequency questionnaire. Physical activity and demographic data were collected through a related questionnaire. The association between the odds of <i>H. pylori</i> infection and the omega-6 to omega-3 ratio was evaluated using logistic regression models. A p value < 0.05 was considered statistically significant. The findings revealed that individuals in the third tertile had significantly higher odds of <i>H. pylori</i> (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.30-3.40) in the crude model. Furthermore, even after adjusting the potential confounders including sex, age, body mass index, physical activity, energy intake, alcohol, and smoking status, this association remained significant (fully adjusted model: OR, 2.00; 95% CI, 1.17-3.34). Our study revealed a higher ratio of omega-6 to omega-3 was related to a higher likelihood of <i>H. pylori</i> infection. Therefore, it is advisable to maintain a balanced intake of PUFAs in the diet.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 3","pages":"176-185"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Assessment of Protein and Sodium Contents in Commercial Senior-Friendly Foods. 商业老年友好食品中蛋白质和钠含量的营养评估。
Pub Date : 2024-07-25 eCollection Date: 2024-07-01 DOI: 10.7762/cnr.2024.13.3.156
Yun-A Lee, Mi-Kyeong Choi

The purpose of this study was to evaluate the nutritional adequacy of senior-friendly foods sold in Korea, focusing on protein and sodium. This study examined the nutritional content of 170 products with nutritional labels that were sold in online stores in Korea and categorized the products into 93 staple foods (cooked rice, porridge, and mousse) and 77 side-dish and snack foods (braized·steam·roast products, broth, sauces, and snacks). Then, the adequacy of the nutritional content of these foods, focusing on protein and sodium, was evaluated according to product type. The 93 staple products and 77 side-dish products had average serving sizes of 163.27 g and 127.92 g, prices of $3.25 and $2.72, and energy contents of 295.25 kcal and 141.95 kcal, respectively. For staple foods, the energy content was significantly greater in cooked rice, but the protein content and index of nutrition quality (INQ) were significantly greater in mousse. There were no significant differences in sodium content or contribution to adequate intake (AI) by product type, but the sodium INQ was significantly greater in the mousse and porridge. For side-dish foods and snack products, the protein content, contribution to the recommended intake, and INQ were all significantly greater for the braized·steam·roast products. Sauces and braized·steam·roast products were significantly higher in sodium content and contribution to the AI, while broth was significantly higher in sodium INQ. These findings can be used to guide proper product selection and nutritional management that considers the health characteristics of health-vulnerable and elderly people.

本研究的目的是评估在韩国销售的老年友好型食品的营养充足性,重点是蛋白质和钠。本研究调查了韩国网上商店销售的 170 种带有营养标签的产品的营养成分,并将这些产品分为 93 种主食(熟米饭、粥和慕斯)和 77 种副食和零食(烩-蒸-烤产品、肉汤、酱汁和零食)。然后,根据产品种类评估这些食品的营养成分是否充足,重点是蛋白质和钠含量。93 种主食和 77 种副食的平均食用量分别为 163.27 克和 127.92 克,价格分别为 3.25 美元和 2.72 美元,能量含量分别为 295.25 千卡和 141.95 千卡。就主食而言,熟米饭的能量含量明显更高,但慕斯的蛋白质含量和营养质量指数(INQ)明显更高。各类产品的钠含量或对充足摄入量(AI)的贡献没有明显差异,但慕斯和粥的钠 INQ 明显更高。在配菜食品和零食产品中,红烧-蒸烤产品的蛋白质含量、对推荐摄入量的贡献率和 INQ 都明显高于其他产品。酱汁和红烧-清炖-烤肉产品的钠含量和对AI的贡献率明显更高,而肉汤的钠INQ明显更高。这些发现可用于指导正确的产品选择和营养管理,以考虑到健康脆弱人群和老年人的健康特点。
{"title":"Nutritional Assessment of Protein and Sodium Contents in Commercial Senior-Friendly Foods.","authors":"Yun-A Lee, Mi-Kyeong Choi","doi":"10.7762/cnr.2024.13.3.156","DOIUrl":"10.7762/cnr.2024.13.3.156","url":null,"abstract":"<p><p>The purpose of this study was to evaluate the nutritional adequacy of senior-friendly foods sold in Korea, focusing on protein and sodium. This study examined the nutritional content of 170 products with nutritional labels that were sold in online stores in Korea and categorized the products into 93 staple foods (cooked rice, porridge, and mousse) and 77 side-dish and snack foods (braized·steam·roast products, broth, sauces, and snacks). Then, the adequacy of the nutritional content of these foods, focusing on protein and sodium, was evaluated according to product type. The 93 staple products and 77 side-dish products had average serving sizes of 163.27 g and 127.92 g, prices of $3.25 and $2.72, and energy contents of 295.25 kcal and 141.95 kcal, respectively. For staple foods, the energy content was significantly greater in cooked rice, but the protein content and index of nutrition quality (INQ) were significantly greater in mousse. There were no significant differences in sodium content or contribution to adequate intake (AI) by product type, but the sodium INQ was significantly greater in the mousse and porridge. For side-dish foods and snack products, the protein content, contribution to the recommended intake, and INQ were all significantly greater for the braized·steam·roast products. Sauces and braized·steam·roast products were significantly higher in sodium content and contribution to the AI, while broth was significantly higher in sodium INQ. These findings can be used to guide proper product selection and nutritional management that considers the health characteristics of health-vulnerable and elderly people.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 3","pages":"156-164"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Intensive Support in a Pediatric Patient With Severe Traumatic Brain Injury: A Case Report. 严重创伤性脑损伤儿科患者的营养强化支持:病例报告。
Pub Date : 2024-07-25 eCollection Date: 2024-07-01 DOI: 10.7762/cnr.2024.13.3.149
In Seok Lee, Kyounglan Kang, Yun Mi Chung, Junghwa Lee

Estimating the nutritional requirements for pediatric patients requires a comprehensive approach with various factors including age, gender, body mass index, and physical activity level, due to the significant growth and developmental changes observed in this population. This complexity renders the use of a simplistic generalization or a standard formula impractical. A number of methodologies have been established to calculate nutritional needs for the pediatric population. However, the application of these methodologies is challenging due to the variability in the aforementioned factors. Determining nutritional requirements for pediatric patients with underlying medical conditions is complicate, influenced by variables such as the nature of the illness, treatment modalities, and the patient's overall condition. Nutritional support in severely traumatically brain-injured pediatric patients is directly correlated with prognosis and growth outcomes. Therefore, this case study aims to validate existing methodologies for estimating nutritional requirements in pediatric patients with severe traumatic brain injury and to provide primary data for the development of effective nutritional support strategies. A case of a 5-year-old male patient admitted to the intensive care unit due to severe traumatic brain injury is examined. Future case studies and ongoing research are imperative to ensure the safe and effective nutritional support of pediatric patients with severe traumatic brain injury.

由于儿科患者的生长发育变化很大,因此在估算儿科患者的营养需求时需要综合考虑各种因素,包括年龄、性别、体重指数和体力活动水平。这种复杂性使得使用简单概括或标准公式的方法变得不切实际。目前已制定了许多方法来计算儿科人群的营养需求。然而,由于上述因素的差异性,这些方法的应用具有挑战性。确定患有基础疾病的儿科患者的营养需求非常复杂,会受到疾病性质、治疗方式和患者整体状况等变量的影响。严重脑损伤儿科患者的营养支持与预后和生长结果直接相关。因此,本病例研究旨在验证现有的估算严重脑外伤儿科患者营养需求的方法,并为制定有效的营养支持策略提供原始数据。本病例研究的对象是一名因严重脑外伤入住重症监护室的 5 岁男性患者。为确保对严重脑外伤儿科患者提供安全有效的营养支持,未来的病例研究和持续研究势在必行。
{"title":"Nutritional Intensive Support in a Pediatric Patient With Severe Traumatic Brain Injury: A Case Report.","authors":"In Seok Lee, Kyounglan Kang, Yun Mi Chung, Junghwa Lee","doi":"10.7762/cnr.2024.13.3.149","DOIUrl":"10.7762/cnr.2024.13.3.149","url":null,"abstract":"<p><p>Estimating the nutritional requirements for pediatric patients requires a comprehensive approach with various factors including age, gender, body mass index, and physical activity level, due to the significant growth and developmental changes observed in this population. This complexity renders the use of a simplistic generalization or a standard formula impractical. A number of methodologies have been established to calculate nutritional needs for the pediatric population. However, the application of these methodologies is challenging due to the variability in the aforementioned factors. Determining nutritional requirements for pediatric patients with underlying medical conditions is complicate, influenced by variables such as the nature of the illness, treatment modalities, and the patient's overall condition. Nutritional support in severely traumatically brain-injured pediatric patients is directly correlated with prognosis and growth outcomes. Therefore, this case study aims to validate existing methodologies for estimating nutritional requirements in pediatric patients with severe traumatic brain injury and to provide primary data for the development of effective nutritional support strategies. A case of a 5-year-old male patient admitted to the intensive care unit due to severe traumatic brain injury is examined. Future case studies and ongoing research are imperative to ensure the safe and effective nutritional support of pediatric patients with severe traumatic brain injury.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 3","pages":"149-155"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association of Serum Vitamin D With Anthropometric Indices, Lipid Profile, ICAM-1, and IL-17 in Patients Undergoing Coronary Artery Bypass Graft Surgery. 接受冠状动脉旁路移植手术的患者血清维生素 D 与人体测量指标、血脂概况、ICAM-1 和 IL-17 的关系。
Pub Date : 2024-07-23 eCollection Date: 2024-07-01 DOI: 10.7762/cnr.2024.13.3.165
Nazanin Tafteh, Shahab Rezaeian, Hadi Abdollahzad, Feridoun Sabzi

This study aimed to assess the relationship between serum levels of vitamin D with anthropometric indices, lipid profile and vascular inflammatory factors, in patients who candidate for coronary artery bypass grafting (CABG). This analytical cross-sectional study was conducted in patients who were candidate for CABG. Demographic information, medical records, anthropometric indicators, blood samples, and physical activity of 150 patients were collected. 146 participants with mean ± standard deviation of age: 61.8 ± 10.0 years and body mass index: 26.9 ± 3.7 kg/m2 completed the study. Based on serum levels of vitamin D, patients were divided into 2 groups; groups with sufficient (≥ 30 ng/mL) and insufficient amount of vitamin D (< 30 ng/mL). The 30.14% of the patients had serum vitamin D deficiency. Ejection fraction (EF) % between the 2 groups had significant difference. Unexpectedly the EF% increased 7% in patients with insufficient level of vitamin D (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.03-1.11; p = 0.001). Vitamin D status had a significant inverse association with body weight. The odds of vitamin D deficiency significantly increased by 4% with increasing one kg in weight (OR, 1.04; 95% CI, 1-1.08; p = 0.044). There were no significant association between serum vitamin D level and intra cellular adhesion molecule-1, interleukin-17, fasting blood glucose, and lipid profile (p > 0.05). Considering the inverse association observed between serum vitamin D with EF% and body weight, vitamin D may play a role in modulating of these indices.

本研究旨在评估冠状动脉旁路移植术(CABG)候选患者血清中维生素 D 水平与人体测量指数、血脂状况和血管炎症因子之间的关系。这项分析性横断面研究的对象是冠状动脉旁路移植术的候选患者。研究收集了 150 名患者的人口统计学信息、医疗记录、人体测量指标、血液样本和体力活动。146名参与者的平均年龄为(61.8±10.0)岁,体重指数为(26.9±3.7)千克:体重指数为 26.9 ± 3.7 kg/m2。根据血清维生素 D 水平,患者被分为两组:维生素 D 充足组(≥ 30 纳克/毫升)和维生素 D 不足组(< 30 纳克/毫升)。30.14%的患者血清维生素 D 缺乏。两组患者的射血分数(EF)有显著差异。意外的是,维生素 D 水平不足的患者 EF% 增加了 7%(几率比 [OR],1.07;95% 置信区间 [CI],1.03-1.11;P = 0.001)。维生素 D 状态与体重呈显著的反向关系。体重每增加一公斤,维生素 D 缺乏的几率就会明显增加 4%(OR,1.04;95% 置信区间 [CI],1-1.08;P = 0.044)。血清维生素 D 水平与细胞内粘附分子-1、白细胞介素-17、空腹血糖和血脂谱之间无明显关联(P > 0.05)。考虑到在血清维生素 D 与 EF% 和体重之间观察到的反向关系,维生素 D 可能在调节这些指数方面发挥作用。
{"title":"The Association of Serum Vitamin D With Anthropometric Indices, Lipid Profile, ICAM-1, and IL-17 in Patients Undergoing Coronary Artery Bypass Graft Surgery.","authors":"Nazanin Tafteh, Shahab Rezaeian, Hadi Abdollahzad, Feridoun Sabzi","doi":"10.7762/cnr.2024.13.3.165","DOIUrl":"10.7762/cnr.2024.13.3.165","url":null,"abstract":"<p><p>This study aimed to assess the relationship between serum levels of vitamin D with anthropometric indices, lipid profile and vascular inflammatory factors, in patients who candidate for coronary artery bypass grafting (CABG). This analytical cross-sectional study was conducted in patients who were candidate for CABG. Demographic information, medical records, anthropometric indicators, blood samples, and physical activity of 150 patients were collected. 146 participants with mean ± standard deviation of age: 61.8 ± 10.0 years and body mass index: 26.9 ± 3.7 kg/m<sup>2</sup> completed the study. Based on serum levels of vitamin D, patients were divided into 2 groups; groups with sufficient (≥ 30 ng/mL) and insufficient amount of vitamin D (< 30 ng/mL). The 30.14% of the patients had serum vitamin D deficiency. Ejection fraction (EF) % between the 2 groups had significant difference. Unexpectedly the EF% increased 7% in patients with insufficient level of vitamin D (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.03-1.11; p = 0.001). Vitamin D status had a significant inverse association with body weight. The odds of vitamin D deficiency significantly increased by 4% with increasing one kg in weight (OR, 1.04; 95% CI, 1-1.08; p = 0.044). There were no significant association between serum vitamin D level and intra cellular adhesion molecule-1, interleukin-17, fasting blood glucose, and lipid profile (p > 0.05). Considering the inverse association observed between serum vitamin D with EF% and body weight, vitamin D may play a role in modulating of these indices.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 3","pages":"165-175"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Soy Supplementation Does Not Affect Serum Adiponectin Levels in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 补充大豆不会影响成人血清脂肪连接蛋白水平:随机对照试验的系统回顾和元分析》。
Pub Date : 2024-05-02 eCollection Date: 2024-04-01 DOI: 10.7762/cnr.2024.13.2.130
Jahangir Karimian, Parivash Shekarchizadeh-Esfahani

Numerous studies have indicated that low levels of serum adiponectin are linked with the development of various chronic diseases. While some recent research has suggested that soy has a positive impact on serum adiponectin levels, the results are inconsistent. Therefore, we aim to conduct a thorough systematic review and meta-analysis of randomized controlled trials (RCTs) that investigate the effects of soy on serum adiponectin levels in adults. The search was conducted until March 2024 on PubMed, Scopus, Web of Science, and Cochrane Library databases to identify RCTs that studied the effects of soy supplementation on serum adiponectin levels. A random-effects model was used to pool the weighted mean differences (WMDs). Ten and nine RCTs were selected for the systematic review and meta-analysis, respectively. After analyzing data from 9 eligible RCTs, it was found that soy supplementation did not significantly impact the concentrations of adiponectin (WMD = -0.24 μg/mL; 95% confidence interval, -1.56 to 1.09; p = 0.72). However, there was significant heterogeneity between the studies (I2 = 89.8%, p < 0.001). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias. In conclusion, soy supplementation did not have a significant effect on adiponectin levels in adults. However, further RCTs are needed with longer intervention duration, higher doses, and studies conducted in different countries.

大量研究表明,血清脂肪连接蛋白水平低与各种慢性疾病的发生有关。虽然最近的一些研究表明,大豆对血清脂肪连接蛋白水平有积极影响,但结果并不一致。因此,我们旨在对研究大豆对成人血清脂肪连接蛋白水平影响的随机对照试验(RCT)进行全面的系统回顾和荟萃分析。该研究在 PubMed、Scopus、Web of Science 和 Cochrane Library 数据库中进行了检索,以确定研究大豆补充剂对血清脂肪连素水平影响的 RCT,检索时间截止到 2024 年 3 月。采用随机效应模型汇集加权平均差(WMD)。系统综述和荟萃分析分别选择了 10 项和 9 项研究性试验。在对 9 项符合条件的研究性试验的数据进行分析后发现,补充大豆对脂肪连通素的浓度没有显著影响(WMD = -0.24 μg/mL;95% 置信区间,-1.56 至 1.09;p = 0.72)。然而,研究之间存在明显的异质性(I2 = 89.8%,p < 0.001)。敏感性分析表明,剔除任何一项研究都不会影响总体估计值。我们没有发现任何有关发表偏倚的证据。总之,补充大豆对成年人的脂肪连接蛋白水平没有显著影响。不过,还需要进一步开展干预时间更长、剂量更大、在不同国家进行的研究。
{"title":"Soy Supplementation Does Not Affect Serum Adiponectin Levels in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Jahangir Karimian, Parivash Shekarchizadeh-Esfahani","doi":"10.7762/cnr.2024.13.2.130","DOIUrl":"10.7762/cnr.2024.13.2.130","url":null,"abstract":"<p><p>Numerous studies have indicated that low levels of serum adiponectin are linked with the development of various chronic diseases. While some recent research has suggested that soy has a positive impact on serum adiponectin levels, the results are inconsistent. Therefore, we aim to conduct a thorough systematic review and meta-analysis of randomized controlled trials (RCTs) that investigate the effects of soy on serum adiponectin levels in adults. The search was conducted until March 2024 on PubMed, Scopus, Web of Science, and Cochrane Library databases to identify RCTs that studied the effects of soy supplementation on serum adiponectin levels. A random-effects model was used to pool the weighted mean differences (WMDs). Ten and nine RCTs were selected for the systematic review and meta-analysis, respectively. After analyzing data from 9 eligible RCTs, it was found that soy supplementation did not significantly impact the concentrations of adiponectin (WMD = -0.24 μg/mL; 95% confidence interval, -1.56 to 1.09; p = 0.72). However, there was significant heterogeneity between the studies (I<sup>2</sup> = 89.8%, p < 0.001). Sensitivity analysis showed that overall estimates were not affected by the elimination of any study. We did not observe any evidence regarding publication bias. In conclusion, soy supplementation did not have a significant effect on adiponectin levels in adults. However, further RCTs are needed with longer intervention duration, higher doses, and studies conducted in different countries.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 2","pages":"130-138"},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Snack Provision Practice in Long-Term Care Hospitals and Facilities in Korea. 韩国长期护理医院和设施的小吃供应实践。
Pub Date : 2024-04-30 eCollection Date: 2024-04-01 DOI: 10.7762/cnr.2024.13.2.108
Dayeong Yeo, Hae Jin Kang, Hyejin Ahn, Yoo Kyoung Park

The study aimed to investigate the basic data to derive plans for snack provision to improve the nutritional status of older adults living in long-term care facilities (LFs) or long-term care hospitals (LHs). The 252 respondents (118 from LHs and 134 from LFs) were included in the study. The questionnaire of nationwide cross-sectional survey was developed by the authors and registered dietitians. The written questionnaire was sent to the food service managers across 800 LFs or LHs. The online survey was introduced using the online platform and network site for dietitians. More than 70% of live-in and non-live-in LFs provided snacks, which were mainly provided one to two times a day. Most institutions provided fruits one to three times a week. The main considerations when providing fruit were in the order of residents' preference, cost, and ease of consumption. The reasons for not serving fruit included cost and differences in the residents' eating and mastication abilities. Most institutions also provided dairy products at a frequency of one to three times a week. The reasons for not serving dairy products included cost and the lack of awareness of the need to provide them. To improve the quality of life and the offer benefits of fruits and dairy products to older people, efforts are needed to propose a plan to expand the provision of snacks in appropriate quantities and varieties.

这项研究旨在调查基本数据,以制定小吃供应计划,改善居住在长期护理设施(LFs)或长期护理医院(LHs)的老年人的营养状况。252 名受访者(118 名来自长期护理机构,134 名来自长期护理医院)被纳入研究范围。全国横断面调查问卷由作者和注册营养师共同制定。书面问卷发给了 800 家 LF 或 LH 的餐饮服务经理。在线调查通过营养师在线平台和网络站点进行。超過七成的留宿及非留宿長者宿舍提供小食,主要為每天一至兩次。大部分院舍每周提供一至三次水果。提供水果的主要考虑因素依次为住客的喜好、成本和食用方便程度。不提供水果的原因包括成本以及住客进食和咀嚼能力的差异。大多数养老院还以每周一至三次的频率提供奶制品。不提供奶制品的原因包括成本和缺乏提供奶制品的意识。为了提高老年人的生活质量,增加水果和奶制品对老年人的益处,需要努力提出一项计划,扩大提供适当数量和品种的零食。
{"title":"Snack Provision Practice in Long-Term Care Hospitals and Facilities in Korea.","authors":"Dayeong Yeo, Hae Jin Kang, Hyejin Ahn, Yoo Kyoung Park","doi":"10.7762/cnr.2024.13.2.108","DOIUrl":"10.7762/cnr.2024.13.2.108","url":null,"abstract":"<p><p>The study aimed to investigate the basic data to derive plans for snack provision to improve the nutritional status of older adults living in long-term care facilities (LFs) or long-term care hospitals (LHs). The 252 respondents (118 from LHs and 134 from LFs) were included in the study. The questionnaire of nationwide cross-sectional survey was developed by the authors and registered dietitians. The written questionnaire was sent to the food service managers across 800 LFs or LHs. The online survey was introduced using the online platform and network site for dietitians. More than 70% of live-in and non-live-in LFs provided snacks, which were mainly provided one to two times a day. Most institutions provided fruits one to three times a week. The main considerations when providing fruit were in the order of residents' preference, cost, and ease of consumption. The reasons for not serving fruit included cost and differences in the residents' eating and mastication abilities. Most institutions also provided dairy products at a frequency of one to three times a week. The reasons for not serving dairy products included cost and the lack of awareness of the need to provide them. To improve the quality of life and the offer benefits of fruits and dairy products to older people, efforts are needed to propose a plan to expand the provision of snacks in appropriate quantities and varieties.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 2","pages":"108-120"},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity. 脂肪连接素、BDNF 和 GLP-1 对皮层神经元的积极作用可抵消棕榈酸诱导的神经毒性
Pub Date : 2024-04-26 eCollection Date: 2024-04-01 DOI: 10.7762/cnr.2024.13.2.121
Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Song

The prevalence of metabolic syndrome caused by diets containing excessive fatty acids is increasing worldwide. Patients with metabolic syndrome exhibit abnormal lipid profiles, chronic inflammation, increased levels of saturated fatty acids, impaired insulin sensitivity, excessive fat accumulation, and neuropathological issues such as memory deficits. In particular, palmitic acid (PA) in saturated fatty acids aggravates inflammation, insulin resistance, impaired glucose tolerance, and synaptic failure. Recently, adiponectin, brain-derived neurotrophic factor (BDNF), and glucose-like peptide-1 (GLP-1) have been investigated to find therapeutic solutions for metabolic syndrome, with findings suggesting that they are involved in insulin sensitivity, enhanced lipid profiles, increased neuronal survival, and improved synaptic plasticity. We investigated the effects of adiponectin, BDNF, and GLP-1 on neurite outgrowth, length, and complexity in PA-treated primary cortical neurons using Sholl analysis. Our findings demonstrate the therapeutic potential of adiponectin, BDNF, and GLP-1 in enhancing synaptic plasticity within brains affected by metabolic imbalance. We underscore the need for additional research into the mechanisms by which adiponectin, BDNF, and GLP-1 influence neural complexity in brains with metabolic imbalances.

在全球范围内,因饮食中含有过量脂肪酸而导致的代谢综合征的发病率正在上升。代谢综合征患者表现出血脂异常、慢性炎症、饱和脂肪酸水平升高、胰岛素敏感性受损、脂肪过度堆积以及记忆力减退等神经病理学问题。尤其是饱和脂肪酸中的棕榈酸(PA)会加重炎症、胰岛素抵抗、糖耐量受损和突触衰竭。最近,人们研究了脂肪连素、脑源性神经营养因子(BDNF)和类葡萄糖肽-1(GLP-1),以寻找代谢综合征的治疗方案,研究结果表明,它们参与了胰岛素敏感性、脂质状况的改善、神经元存活率的提高和突触可塑性的改善。我们利用 Sholl 分析法研究了脂肪连接素、BDNF 和 GLP-1 对 PA 处理的原发性皮质神经元的神经元生长、长度和复杂性的影响。我们的研究结果表明,在受代谢失衡影响的大脑中,脂肪连接素、BDNF 和 GLP-1 在增强突触可塑性方面具有治疗潜力。我们强调有必要对脂联素、BDNF 和 GLP-1 影响代谢失衡大脑神经复杂性的机制进行更多研究。
{"title":"Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity.","authors":"Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Song","doi":"10.7762/cnr.2024.13.2.121","DOIUrl":"10.7762/cnr.2024.13.2.121","url":null,"abstract":"<p><p>The prevalence of metabolic syndrome caused by diets containing excessive fatty acids is increasing worldwide. Patients with metabolic syndrome exhibit abnormal lipid profiles, chronic inflammation, increased levels of saturated fatty acids, impaired insulin sensitivity, excessive fat accumulation, and neuropathological issues such as memory deficits. In particular, palmitic acid (PA) in saturated fatty acids aggravates inflammation, insulin resistance, impaired glucose tolerance, and synaptic failure. Recently, adiponectin, brain-derived neurotrophic factor (BDNF), and glucose-like peptide-1 (GLP-1) have been investigated to find therapeutic solutions for metabolic syndrome, with findings suggesting that they are involved in insulin sensitivity, enhanced lipid profiles, increased neuronal survival, and improved synaptic plasticity. We investigated the effects of adiponectin, BDNF, and GLP-1 on neurite outgrowth, length, and complexity in PA-treated primary cortical neurons using Sholl analysis. Our findings demonstrate the therapeutic potential of adiponectin, BDNF, and GLP-1 in enhancing synaptic plasticity within brains affected by metabolic imbalance. We underscore the need for additional research into the mechanisms by which adiponectin, BDNF, and GLP-1 influence neural complexity in brains with metabolic imbalances.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 2","pages":"121-129"},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Thickened Beverage and Swallowing Aid Jelly Used for Dysphagic Patients on the Disintegration of Orally Administered Tablets. 用于吞咽困难患者的增稠饮料和吞咽辅助果冻对口服片剂崩解的影响
Pub Date : 2024-04-25 eCollection Date: 2024-04-01 DOI: 10.7762/cnr.2024.13.2.89
Won Hyeong Cho, Whachun Yoo, Byoungseung Yoo

Thickened beverages or swallowing aid jelly (SAJ), commonly used as tablet-swallowing aids for dysphagic patients, may influence the disintegration of orally administered tablets. With this in mind, we evaluated the disintegration times of therapeutic tablets immersed in thickened beverages or SAJ compared to immersion in ones without them. Thickened beverages and SAJs were prepared with various beverages (water, orange juice, and milk) using food thickeners and SAJ powders marketed in Korea. The tablet disintegration times were the same in thickened beverages and SAJs, and there was no statistically significant difference associated with the thickness levels of the thickened beverages. The disintegration times of Tylenol immersed in orange juice or milk were slightly higher compared to those immersed in water. Moreover, there was no difference in disintegration time when using the thickened beverages and SAJs. The disintegration times of Aspirin were similar in all of the thickened beverages or SAJs, and there were no differences between non-immersed and immersed tablets. These results demonstrate that the disintegration of Tylenol and Aspirin is not greatly affected by immersion in any of the thickened beverages and SAJs.

增稠饮料或助吞果冻(SAJ)是吞咽困难患者常用的吞片辅助工具,可能会影响口服片剂的崩解。有鉴于此,我们对治疗药片浸泡在增稠饮料或助吞果冻中的崩解时间与不浸泡在增稠饮料或助吞果冻中的崩解时间进行了评估。我们使用韩国市场上销售的食品增稠剂和 SAJ 粉,用各种饮料(水、橙汁和牛奶)制备了增稠饮料和 SAJ。片剂在增稠饮料和 SAJ 中的崩解时间相同,且与增稠饮料的浓度水平无明显统计学差异。与浸泡在水中的泰诺相比,浸泡在橙汁或牛奶中的泰诺崩解时间略长。此外,在使用浓缩饮料和 SAJ 时,崩解时间没有差异。阿司匹林在所有增稠饮料或 SAJ 中的崩解时间相似,非浸泡片剂和浸泡片剂之间也没有差异。这些结果表明,泰诺和阿司匹林在任何一种增稠饮料和 SAJ 中的崩解都不会受到很大影响。
{"title":"Effect of Thickened Beverage and Swallowing Aid Jelly Used for Dysphagic Patients on the Disintegration of Orally Administered Tablets.","authors":"Won Hyeong Cho, Whachun Yoo, Byoungseung Yoo","doi":"10.7762/cnr.2024.13.2.89","DOIUrl":"10.7762/cnr.2024.13.2.89","url":null,"abstract":"<p><p>Thickened beverages or swallowing aid jelly (SAJ), commonly used as tablet-swallowing aids for dysphagic patients, may influence the disintegration of orally administered tablets. With this in mind, we evaluated the disintegration times of therapeutic tablets immersed in thickened beverages or SAJ compared to immersion in ones without them. Thickened beverages and SAJs were prepared with various beverages (water, orange juice, and milk) using food thickeners and SAJ powders marketed in Korea. The tablet disintegration times were the same in thickened beverages and SAJs, and there was no statistically significant difference associated with the thickness levels of the thickened beverages. The disintegration times of Tylenol immersed in orange juice or milk were slightly higher compared to those immersed in water. Moreover, there was no difference in disintegration time when using the thickened beverages and SAJs. The disintegration times of Aspirin were similar in all of the thickened beverages or SAJs, and there were no differences between non-immersed and immersed tablets. These results demonstrate that the disintegration of Tylenol and Aspirin is not greatly affected by immersion in any of the thickened beverages and SAJs.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 2","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association of Body Mass Index on Falls Risk and Mortality in Hospitalized Patients of Different Old-Age Categories Requiring Nutritional Support. 身体质量指数与需要营养支持的不同老年住院患者的跌倒风险和死亡率的关系。
Pub Date : 2024-04-25 eCollection Date: 2024-04-01 DOI: 10.7762/cnr.2024.13.2.96
Eunjung Kim, Eun-Mi Seol, Hyuk-Joon Lee

Malnutrition affect clinical outcomes in hospitalized old age patients, but the data on the related outcomes on the basis of different age categories are still limited. We aimed to investigate the interplay of associations among body mass index (BMI), falls risk, and mortality rate in different older adult patient age categories. This retrospective study included hospitalized patients aged ≥ 65 years who received artificial nutrition. Demographic, biochemical, and survival data were collected. BMI was evaluated using the World Health Organization BMI cutoffs for Asians, and patients were classified into high (≥ 23.0 kg/m2), normal (18.5-22.9 kg/m2), and low (< 18.5 kg/m2) BMI groups. The Morse Fall Scale was used to assess falls risk. By age categories, all patients (n = 4,642) were divided into the 65-74 (n = 2,649) and ≥ 75 (n = 1,993) years age groups. We found that the proportion of low-BMI and high risk of falls increased with age. Further, low-BMI was associated with increased falls risk in both age groups. Overall survival rate tended to be lower in the low-BMI and ≥ 75 years group than that in other patient groups, but did not differ significantly compared with the low-BMI and 65-74 years group. Low-BMI was associated with increased falls risk and mortality; however, the association depended on specific patient age groups.

营养不良会影响住院老年患者的临床预后,但基于不同年龄类别的相关预后数据仍然有限。我们旨在研究不同年龄段老年患者的体重指数(BMI)、跌倒风险和死亡率之间的相互影响。这项回顾性研究纳入了年龄≥ 65 岁、接受人工营养的住院患者。研究收集了人口统计学、生化和生存数据。采用世界卫生组织亚洲人 BMI 临界值对 BMI 进行评估,并将患者分为高 BMI 组(≥ 23.0 kg/m2)、正常 BMI 组(18.5-22.9 kg/m2)和低 BMI 组(< 18.5 kg/m2)。莫尔斯跌倒量表用于评估跌倒风险。所有患者(4,642 人)按年龄分为 65-74 岁组(2,649 人)和≥ 75 岁组(1,993 人)。我们发现,低体重指数和高跌倒风险的比例随着年龄的增长而增加。此外,在两个年龄组中,低体重指数都与跌倒风险增加有关。低体重指数且年龄≥75 岁组的总体存活率往往低于其他患者组,但与低体重指数且年龄在 65-74 岁组相比没有显著差异。低体重指数与跌倒风险和死亡率增加有关,但这种关联取决于特定的患者年龄组。
{"title":"The Association of Body Mass Index on Falls Risk and Mortality in Hospitalized Patients of Different Old-Age Categories Requiring Nutritional Support.","authors":"Eunjung Kim, Eun-Mi Seol, Hyuk-Joon Lee","doi":"10.7762/cnr.2024.13.2.96","DOIUrl":"10.7762/cnr.2024.13.2.96","url":null,"abstract":"<p><p>Malnutrition affect clinical outcomes in hospitalized old age patients, but the data on the related outcomes on the basis of different age categories are still limited. We aimed to investigate the interplay of associations among body mass index (BMI), falls risk, and mortality rate in different older adult patient age categories. This retrospective study included hospitalized patients aged ≥ 65 years who received artificial nutrition. Demographic, biochemical, and survival data were collected. BMI was evaluated using the World Health Organization BMI cutoffs for Asians, and patients were classified into high (≥ 23.0 kg/m<sup>2</sup>), normal (18.5-22.9 kg/m<sup>2</sup>), and low (< 18.5 kg/m<sup>2</sup>) BMI groups. The Morse Fall Scale was used to assess falls risk. By age categories, all patients (n = 4,642) were divided into the 65-74 (n = 2,649) and ≥ 75 (n = 1,993) years age groups. We found that the proportion of low-BMI and high risk of falls increased with age. Further, low-BMI was associated with increased falls risk in both age groups. Overall survival rate tended to be lower in the low-BMI and ≥ 75 years group than that in other patient groups, but did not differ significantly compared with the low-BMI and 65-74 years group. Low-BMI was associated with increased falls risk and mortality; however, the association depended on specific patient age groups.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 2","pages":"96-107"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials. 口服甘菊对焦虑的影响:临床试验系统回顾
Pub Date : 2024-04-23 eCollection Date: 2024-04-01 DOI: 10.7762/cnr.2024.13.2.139
Sogand Saadatmand, Foad Zohroudi, Hadith Tangestani

Anxiety disorder is a prevalent psychiatric issue that affects 4.05% of the global population. As complementary and alternative medicine gains popularity, many individuals with anxiety symptoms seek herbal remedies. This systematic review aims to explore the sedative efficacy of chamomile as an herbal medicine for anxiety treatment. Our search was conducted in PubMed, Google Scholar, and Scopus databases until August 2023. Among 389 papers found, after removing duplicates and irrelevant papers, 10 clinical trials investigating the effect of oral consumption of chamomile on anxiety were included. Two researchers independently completed all steps, including the screening process and data extraction. Out of the 10 articles selected, 9 studies have concluded that chamomile is effective in reducing anxiety. Even though, the exact mechanism of chamomile's anxiolytic action is not well understood, evidence suggests that its active compounds, including apigenin, may modulate the function of the hypothalamic-pituitary-adrenocortical axis by affecting neurotransmitter pathways. This systematic review showed that chamomile potentially has an anxiolytic effect. In addition, due to the side effects of drugs used to treat anxiety disorders, the use of chamomile seems to be effective and less dangerous.

焦虑症是一种普遍的精神问题,影响着全球 4.05% 的人口。随着补充和替代医学的普及,许多有焦虑症状的人开始寻求草药疗法。本系统综述旨在探讨甘菊作为一种草药在治疗焦虑症方面的镇静功效。我们在 PubMed、Google Scholar 和 Scopus 数据库中进行了检索,检索期至 2023 年 8 月。在找到的 389 篇论文中,去除重复和不相关的论文后,纳入了 10 项研究口服甘菊对焦虑症影响的临床试验。两名研究人员独立完成了所有步骤,包括筛选过程和数据提取。在所选的 10 篇文章中,有 9 项研究认为洋甘菊能有效缓解焦虑。尽管洋甘菊抗焦虑作用的确切机制还不十分清楚,但有证据表明,包括芹菜素在内的洋甘菊活性化合物可能会通过影响神经递质通路来调节下丘脑-垂体-肾上腺皮质轴的功能。本系统综述显示,洋甘菊可能具有抗焦虑作用。此外,由于治疗焦虑症的药物会产生副作用,使用洋甘菊似乎更有效且危险性更低。
{"title":"The Effect of Oral Chamomile on Anxiety: A Systematic Review of Clinical Trials.","authors":"Sogand Saadatmand, Foad Zohroudi, Hadith Tangestani","doi":"10.7762/cnr.2024.13.2.139","DOIUrl":"10.7762/cnr.2024.13.2.139","url":null,"abstract":"<p><p>Anxiety disorder is a prevalent psychiatric issue that affects 4.05% of the global population. As complementary and alternative medicine gains popularity, many individuals with anxiety symptoms seek herbal remedies. This systematic review aims to explore the sedative efficacy of chamomile as an herbal medicine for anxiety treatment. Our search was conducted in PubMed, Google Scholar, and Scopus databases until August 2023. Among 389 papers found, after removing duplicates and irrelevant papers, 10 clinical trials investigating the effect of oral consumption of chamomile on anxiety were included. Two researchers independently completed all steps, including the screening process and data extraction. Out of the 10 articles selected, 9 studies have concluded that chamomile is effective in reducing anxiety. Even though, the exact mechanism of chamomile's anxiolytic action is not well understood, evidence suggests that its active compounds, including apigenin, may modulate the function of the hypothalamic-pituitary-adrenocortical axis by affecting neurotransmitter pathways. This systematic review showed that chamomile potentially has an anxiolytic effect. In addition, due to the side effects of drugs used to treat anxiety disorders, the use of chamomile seems to be effective and less dangerous.</p>","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"13 2","pages":"139-147"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11109927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical nutrition research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1