Clinical nutrition research最新文献

Vaccinium meridionale Swartz (commonly known as agraz or Andean blueberry is a wild fruit native to Colombia and rich in anthocyanins. In this systematic review, we evaluated the effects of agraz supplementation on inflammatory and oxidative stress markers in individuals with metabolic syndrome (MetS). A comprehensive literature search was conducted using PubMed, Scopus, ISI Web of Science, and Google Scholar for articles published up to March 2024, without restrictions on language, publication date, or geographical region. Among the 2,616 records identified initially through the database searches, 6 studies were included in this review. The risk of bias in the included studies was assessed using the Cochrane Collaboration's tool. Six randomized controlled trials (RCTs) involving 252 participants were analyzed. The intervention durations ranged from 21 days to 4 weeks, and the agraz supplementation doses were between 200 and 250 mL per day. Agraz supplementation significantly reduced urinary and serum levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG). However, among 3 studies examining high-sensitivity C-reactive protein (hs-CRP) levels, only 1 reported a statistically significant decrease in its levels. No significant effects were observed for other inflammatory or oxidative stress biomarkers. Agraz supplementation notable reduced urinary and serum 8-OHdG levels, suggesting potential antioxidant effects; however, its effect on hs-CRP levels remains inconclusive. No significant changes were observed in the levels of the other biomarkers. Further RCTs with larger doses and longer durations are necessary to confirm these findings and to clarify the therapeutic potential of agraz in MetS.

Trial registration: PROSPERO Identifier: CRD42022369292.

Obesity is a multifactorial chronic disease influenced by behavioral, environmental, genetic, and psychological factors. One primary determinant of childhood obesity is the presence of dietary factors commonly acquired through the shared home food environment, which parents can greatly influence. Thus, the present study examined the similarity in diet quality between children or adolescents with obesity and their mothers. We analyzed baseline data collected from the Intervention for Children and Adolescent obesity via Activity and Nutrition study. Seventy mother-offspring dyads were identified, which included children and adolescents with obesity aged 8-16 years and their mothers living in Seoul and Gyeonggi Province, South Korea. Food or nutrient intake and diet quality were evaluated from 3-day food records. Childhood obesity was defined as body mass index ≥ 95th percentile based on the 2007 Korean National Growth Charts. No significant difference was observed in the diet quality score between children with obesity and their mothers. However, correlation coefficients between mothers and their children's total Diet Quality Index-International (DQI-I) score (r = 0.30) and subcategories, such as variety (r = 0.29), adequacy (r = 0.43), moderation (r = 0.45), and overall balance (r = 0.30), were positively correlated (p < 0.05). Linear regression analysis of the influence of maternal diet quality on offspring diet quality revealed that the maternal DQI-I score influenced the offspring's DQI-I score, consistent with our prediction. Further studies with larger and more representative samples are needed to confirm the applicability of our findings to all children and adolescent populations.

Trial registration: Clinical Research Information Service Identifier: KCT0002718.

Chronic obstructive pulmonary disease (COPD) is a major respiratory disorder characterized by irreversible airflow limitation. The role of diet in the prevention and management of COPD is receiving increasing attention. This study aimed to examine the association between the composite intake of vegetables, fruits, meat, and fish and pulmonary function as well as COPD prevalence in a representative sample of Korean adults aged ≥ 40 years using data from the 7th Korea National Health and Nutrition Examination Survey. Higher vegetable intake was associated with significantly better pulmonary function parameters, including forced vital capacity (p < 0.001), forced vital capacity percent predicted (p = 0.050), forced expiratory volume (FEV) in 1 second (FEV₁; p < 0.001), FEV₁ percent predicted (p = 0.038), FEV in 6 seconds (p < 0.001), and peak expiratory flow (p < 0.001). Furthermore, individuals with a high combined intake of vegetables, fruits, meat, and fish demonstrated a 0.261-fold lower COPD prevalence than those without such intake (p = 0.039). The dietary inflammatory index (DII) was significantly lower among participants without COPD than among those with COPD (mean DII = -3.6947, p = 0.002), indicating that a diet rich in anti-inflammatory nutrients can help reduce COPD risk. These findings suggest that vegetable consumption supports improved respiratory function, and a composite dietary pattern incorporating various food groups may help reduce the prevalence of COPD in the adult population.

We investigated adolescents' perceptions of meat alternatives and examined the relationships among their views on various types of these alternatives. A survey was conducted with 372 middle and high school students, focusing on their perceptions of 3 categories of meat alternatives: plant-based meats, edible insects, and cultured meats. The relationships among these perceptions were subsequently analyzed. Overall, 77.4% of respondents were aware of meat alternatives, and 38.7% reported having consumed them. Perception levels differed by category, with plant-based meats receiving the highest scores, followed by cultured meats and edible insects. Notably, perceptions across the different categories of meat alternatives were significantly correlated. These findings suggest that increasing awareness about meat alternatives-particularly through education-may help promote sustainable and healthy eating behaviors among adolescents.

Protein intake has been identified as a key modifiable factor in preventing and managing sarcopenia, a common age-related condition characterized by the loss of muscle mass, strength, and function. This scoping review aimed to summarize the available literature on the association between protein intake and sarcopenia-related outcomes among Korean older adults and identify current research trends and gaps in this field. The review followed the 5-step methodological framework developed by Arksey and O'Malley for scoping reviews and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist to ensure a comprehensive search strategy. Protein intake was assessed using various methods, including grams per day, grams per kilogram of body weight per day, and intake quartiles. Sarcopenia-related outcomes were categorized into 3 domains as follows: muscle mass, strength, and physical performance. Although most intervention studies demonstrated improvements in muscle mass following protein supplementation, findings on muscle strength and physical function were inconsistent. Cross-sectional studies generally reported better sarcopenia-related outcomes with higher protein intake, particularly when the intake was expressed relative to body weight or analyzed according to quartiles. However, heterogeneity in protein intake assessments and variations in sarcopenia definitions could have contributed to the inconsistent findings across studies. This review highlights the need for applying standardized approaches for protein intake measurement and sarcopenia diagnosis. Future studies should consider the quantity, quality, and timing of protein intake while also focusing on the implementation of integrated, multidisciplinary intervention strategies to promote healthy aging among Korean older adults.

Children with autism spectrum disorder (ASD) often present with selective eating behaviors and dietary imbalances, which contribute to nutritional deficiencies that can adversely impact growth and development. Despite increasing awareness of the role of nutrition in ASD management, existing nutritional interventions frequently fail to accommodate the unique dietary needs of this population. This study aimed to develop tailored nutritional counseling materials for ASD children by adapting the food exchange list framework originally designed for individuals with diabetes. A comprehensive food database was constructed using data from the Korean Diabetes Association, the Korea Rural Development Administration, and related resources, specifically addressing the dietary habits and nutritional deficiencies observed in ASD children. Representative foods were selected, standardized for exchange units, and visually documented through photographs to enhance usability. These elements were integrated into a practical, visually engaging educational brochure, which includes detailed food exchange unit tables, photographic representations of portion sizes, and portion standards to guide caregivers in meal planning. The materials focus on enhancing dietary diversity, correcting common nutrient deficiencies, and fostering balanced eating habits. However, limitations exist in adapting a diabetes-centric framework, which may not fully capture the unique dietary preferences and challenges of ASD children. Nevertheless, the developed materials provide a valuable resource for nutritional education and intervention, supporting the health and development of ASD children. Further research is required to refine these materials and evaluate their effectiveness across diverse settings and populations.

Exercise, especially when prolonged or highly intense, can temporarily increase inflammation in both trained and untrained individuals. C-reactive protein (CRP) is an established biomarker of inflammation. However, clinical trials assessing the impact of fish oil supplementation on CRP levels in trained individuals have yielded inconsistent and often contradictory results. The main objective of this study was to conduct a systematic review of clinical trials exploring the effects of fish oil supplementation on CRP levels among trained individuals. We performed structured searches on the PubMed, Scopus, and ISI Web of Science databases for articles published from the earliest available date until September 2023. Of the 385 articles found and screened, three clinical trials met our criteria for inclusion in this review. The results suggested that fish oil supplementation may help prevent spikes in CRP levels after exercise. However, only one of the three studies produced statistically significant findings. The differences in statistical significance among these studies could be due to variations in the study design, sample populations, dosages, and duration of supplementation. In summary, this systematic review provides evidence that fish oil supplementation can reduce circulating CRP levels in trained individuals. Additional studies with long-term follow-up and larger sample sizes are needed to investigate this effect further.

The primary aim of this study was to evaluate the value of predictive equation (PE) standard care compared with indirect calorimetry (IC)-based nutrition therapy. The secondary aim was to compare the results among 3 groups to assess the accuracy of IC and PE. This was a single-center, retrospective study of patients admitted to the neurosurgery (NS) intensive care unit (ICU), from January 2019, to August 2020. Anthropometric, biochemical, clinical, and dietary data were collected from NS ICU admission to discharge. If patients had an IC: PE ratio of 90%-110%, they were classified into the optimal estimation group (OEG); if the ratio was < 90%, they were classified into the underestimation group (UG); and if the ratio was > 110%, they were classified into the overestimation group (OG). There were no significant differences in anthropometric, biochemical, clinical data and nutrition assessment between baseline and discharge from the NS ICU. The OEG showed a larger cumulative caloric deficit rate compared to UG and OG, though this difference was not statistically significant. There was a negative association between calf circumference (CC) and length of stay (LOS). Repeated measures of CC showed a significant difference according to LOS and groups (p < 0.001). Anthropometric, biochemical, clinical, and dietary data of 77 NS patients were analyzed to determine the effectiveness of concordance between IC and PE. The UG and OG showed a significant decrease in CC during hospitalization, but CC in the OEG was maintained or increased from 4 weeks onward.

Trial registration: Clinical Research Information Service Identifier: KCT0006381.

Nutrition fact labels (NFLs) are a simple way to help people improve their nutritional intake by making healthier food choices. This study aimed to evaluate NFL use and eating habit changes among quarantined and hospitalized coronavirus disease 2019 (COVID-19) patients during the pandemic. This cross-sectional study used data from the 2019 and 2020 Korean Community Health Surveys (KCHSs). Data were collected from 229,099 subjects in 2019 and 229,269 subjects in 2020. In the 2020 KCHS, data from 1,073 COVID-19 patients were included. NFL use was divided into 4 categories based on a questionnaire: affect, read, aware, and never heard. Among COVID-19 patients, 32.15% reported that they had not heard of NFLs (never heard group) compared to 44.36% of the healthy population (p < 0.001). A total of 35.1% of COVID-19 patients who reported daily life change scores of 20 or less were in the affect group compared to 23.8% of healthy subjects. In the affect group, the proportion of respondents who reported increased consumption of delivered food was 38.7% in the COVID-19 group, which was 17.1% higher than that in the never heard group (Cramér's V = 0.257; p < 0.001). Respondents with increased consumption of fast food/soda showed a higher ratio of having never heard of NFLs among healthy subjects (28.5%) than among COVID-19 patients (22.5%; p = 0.043). Confirmed COVID-19 infections and more unfavorable daily life changes due to COVID-19 led to increased nutritional information seeking and NFL use.

Malnutrition is prevalent among older patients, leading to increased morbidity, prolonged hospitalization, and diminished quality of life. The Comprehensive Geriatric Assessment (CGA) facilitates the evaluation of multifaceted health issues, enabling individualized nutritional interventions. This case report describes nutritional management guided by CGA in a 75-year-old female hospitalized for severe hypernatremia with significant malnutrition and high-risk for refeeding syndrome. Upon admission, CGA identified multiple comorbidities, cognitive impairment, and complete dependence on caregivers for daily activities. Due to persistent refusal of oral intake, enteral nutrition (EN) was cautiously initiated at 25% of the target energy requirement, with close monitoring of electrolyte levels. Despite an initial decrease in phosphorus levels suggestive of refeeding syndrome, gradual advancement of nutritional support successfully stabilized her clinical condition. Following discharge, structured caregiver education was provided to support EN at home; however, suboptimal intake persisted due to gastrointestinal intolerance, resulting in weight loss. Post-discharge follow-ups identified feeding rate-related symptoms, necessitating formula adjustments and caregiver re-education. This case emphasizes the critical role of CGA in early malnutrition detection, individualized nutritional intervention, prevention of refeeding syndrome, and the importance of continuous post-discharge monitoring and caregiver education. Although the findings are limited by the single-case design, proactive CGA-based nutritional interventions remain crucial for optimizing clinical outcomes in older patients hospitalized due to acute medical problems. Further research involving larger samples and prolonged follow-up periods is required to validate the long-term benefits of CGA-based nutritional intervention.