Osteoporosis has emerged as a significant health issue among postmenopausal women. Addressing this concern necessitates a multifaceted approach encompassing genetics, pharmacogenomics, bone turnover markers, lifestyle factors, concurrent medical conditions, biomarkers, and advanced imaging techniques. Nonetheless, challenges in terms of cost-effectiveness and ethical considerations do exist. Fortunately, the convergence of technological progress and research endeavors offers a promising trajectory. The integration of genetic testing and pharmacogenomics into clinical practice holds substantial potential. This integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility, thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes – personalized medicine. Given the intricate nature of osteoporosis, personalized strategies stand to greatly benefit women grappling with this condition. Further research and collaborative efforts are imperative to propel advancements within this domain, paving the way for further breakthroughs.
{"title":"Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments","authors":"Seyi Samson Enitan, Esther Ngozi Adejumo, John Osaigbovoh Imaralu, Ayodele Ademola Adelakun, Oluwakemi Anike Ladipo, Comfort Bosede Enitan","doi":"10.53388/crc2023018","DOIUrl":"https://doi.org/10.53388/crc2023018","url":null,"abstract":"Osteoporosis has emerged as a significant health issue among postmenopausal women. Addressing this concern necessitates a multifaceted approach encompassing genetics, pharmacogenomics, bone turnover markers, lifestyle factors, concurrent medical conditions, biomarkers, and advanced imaging techniques. Nonetheless, challenges in terms of cost-effectiveness and ethical considerations do exist. Fortunately, the convergence of technological progress and research endeavors offers a promising trajectory. The integration of genetic testing and pharmacogenomics into clinical practice holds substantial potential. This integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility, thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes – personalized medicine. Given the intricate nature of osteoporosis, personalized strategies stand to greatly benefit women grappling with this condition. Further research and collaborative efforts are imperative to propel advancements within this domain, paving the way for further breakthroughs.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ling-Ling Yu, Guo-Jun Zhang, Bao Zhang, Hai-Yue Yu, Guo-Liang Zheng
1Department of Integrated Chinese and Western Medicine, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), Shenyang 110042, China. 2Department of Pathophysiology, College of Basic Medicine Science, China Medical University, Shenyang 110122, China. 3Department of Gastric Surgery, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), Shenyang 110042, China.
{"title":"How to select gastric cancer patients suitable for immunotherapy?","authors":"Ling-Ling Yu, Guo-Jun Zhang, Bao Zhang, Hai-Yue Yu, Guo-Liang Zheng","doi":"10.53388/crc2023021","DOIUrl":"https://doi.org/10.53388/crc2023021","url":null,"abstract":"1Department of Integrated Chinese and Western Medicine, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), Shenyang 110042, China. 2Department of Pathophysiology, College of Basic Medicine Science, China Medical University, Shenyang 110122, China. 3Department of Gastric Surgery, Cancer Hospital of China Medical University (Liaoning Cancer Hospital and Institute), Shenyang 110042, China.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135749904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meta analysis on the effectiveness of auricular therapy combined with modern medicine in the treatment of depression/anxiety disorders in maintenance hemodialysis patients","authors":"Yang Liu, Luo Guo, N. Hao","doi":"10.53388/crc2023009","DOIUrl":"https://doi.org/10.53388/crc2023009","url":null,"abstract":"","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70803921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Defendi, G. Morgantetti, Guilherme Alencar de Medeiros, M. Balancin
{"title":"Chromoblastomycosis: a tropical – subtropical fungal disease with pathognomonic features not to be neglected in a global health scenario","authors":"L. Defendi, G. Morgantetti, Guilherme Alencar de Medeiros, M. Balancin","doi":"10.53388/crc2023001","DOIUrl":"https://doi.org/10.53388/crc2023001","url":null,"abstract":"","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70803973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Junctional epidermolysis bullosa in children: an overview","authors":"S. Namboothiri","doi":"10.53388/crc2023002","DOIUrl":"https://doi.org/10.53388/crc2023002","url":null,"abstract":"","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Juvenile Localized Scleroderma (JLS) is a rare pediatric rheumatic disease characterized by inflammation and skin sclerosis. The side effect of consensus-recommended medications and the risk of disability posed challenges to the JLS treatment. We intend to demonstrate the potential of traditional Chinese medicine in treating JLS with skin ulcers and reducing the dose of glucocorticoid. Method: Here we report a case of a 13-year-old male with JLS who took oral methotrexate tablets of 10 mg/week and methylprednisolone of 6 mg/day for over six months without significant effect and suffered from skin ulcers on the dorsal feet one month after drug cessation. Subsequently, the patient was treated with integrated traditional Chinese and Western medicine of low-dose glucocorticosteroid, adjusted Shenqi Huoxue formula and Jinshe Xiaoyan formula, etc. Results: After integrated treatment, the patient’s dorsal feet ulcers healed and the skin sclerosis and hyperpigmentation improved significantly. Conclusions: This case report suggests that integrated traditional Chinese and Western medicine can be used as an effective treatment for JLS.
{"title":"Application of integrated traditional Chinese and Western medicine in the treatment of juvenile localized scleroderma with skin ulcer: a case report","authors":"Jia-Qian Zhang, Xiao-Han Wang, Wenjing Tu, Li-Ming Chen, Q. Kong, Yin-Huan Zhao","doi":"10.53388/crc2023016","DOIUrl":"https://doi.org/10.53388/crc2023016","url":null,"abstract":"Background: Juvenile Localized Scleroderma (JLS) is a rare pediatric rheumatic disease characterized by inflammation and skin sclerosis. The side effect of consensus-recommended medications and the risk of disability posed challenges to the JLS treatment. We intend to demonstrate the potential of traditional Chinese medicine in treating JLS with skin ulcers and reducing the dose of glucocorticoid. Method: Here we report a case of a 13-year-old male with JLS who took oral methotrexate tablets of 10 mg/week and methylprednisolone of 6 mg/day for over six months without significant effect and suffered from skin ulcers on the dorsal feet one month after drug cessation. Subsequently, the patient was treated with integrated traditional Chinese and Western medicine of low-dose glucocorticosteroid, adjusted Shenqi Huoxue formula and Jinshe Xiaoyan formula, etc. Results: After integrated treatment, the patient’s dorsal feet ulcers healed and the skin sclerosis and hyperpigmentation improved significantly. Conclusions: This case report suggests that integrated traditional Chinese and Western medicine can be used as an effective treatment for JLS.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Fang, Xiu-Li Wang, W. Di, T. Liu, Lei Wen, Na Liu, Fuping Shi
{"title":"Report of a case of neuromyelitis optica spectrum disease with symptomatic epilepsy","authors":"C. Fang, Xiu-Li Wang, W. Di, T. Liu, Lei Wen, Na Liu, Fuping Shi","doi":"10.53388/crc2023013","DOIUrl":"https://doi.org/10.53388/crc2023013","url":null,"abstract":"","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ke-Qiang He, Jingyi Wu, Bin Hu, Ji Yuan, Chao-Liang Tang
Background: Delayed mediastinal emphysema with subcutaneous emphysema after extubation is rarely reported in current literature. Symptomatic treatment is considered effective for management. Case presentation: We report a case of a 56-year-old female with longstanding rheumatoid arthritis under corticosteroid therapy who developed mediastinal emphysema with subcutaneous emphysema 2 days after recovering from general anesthesia for orthopedic surgery treating a femoral neck fracture. The patient received aggressive subcutaneous decompression and symptomatic management. Results: The patient’s condition improved after treatment. Based on computed tomography scan results, we hypothesize that the longstanding rheumatoid arthritis may have resulted in fragile lung tissue. Violent postoperative coughing likely caused rupture of small airways, leading to mediastinal emphysema. Conclusions: It is crucial to preoperatively assess the risk of airway injury in high-risk patients with longstanding rheumatoid arthritis. Delayed postoperative mediastinal emphysema should be carefully evaluated and managed aggressively to avoid exacerbation or life-threatening scenarios. Further research is warranted to elucidate the pathology and guide perioperative management in these patients.
{"title":"Life-threatening delayed mediastinal and subcutaneous emphysema after general anesthesia in a rheumatoid arthritis patient: a case report","authors":"Ke-Qiang He, Jingyi Wu, Bin Hu, Ji Yuan, Chao-Liang Tang","doi":"10.53388/crc2023019","DOIUrl":"https://doi.org/10.53388/crc2023019","url":null,"abstract":"Background: Delayed mediastinal emphysema with subcutaneous emphysema after extubation is rarely reported in current literature. Symptomatic treatment is considered effective for management. Case presentation: We report a case of a 56-year-old female with longstanding rheumatoid arthritis under corticosteroid therapy who developed mediastinal emphysema with subcutaneous emphysema 2 days after recovering from general anesthesia for orthopedic surgery treating a femoral neck fracture. The patient received aggressive subcutaneous decompression and symptomatic management. Results: The patient’s condition improved after treatment. Based on computed tomography scan results, we hypothesize that the longstanding rheumatoid arthritis may have resulted in fragile lung tissue. Violent postoperative coughing likely caused rupture of small airways, leading to mediastinal emphysema. Conclusions: It is crucial to preoperatively assess the risk of airway injury in high-risk patients with longstanding rheumatoid arthritis. Delayed postoperative mediastinal emphysema should be carefully evaluated and managed aggressively to avoid exacerbation or life-threatening scenarios. Further research is warranted to elucidate the pathology and guide perioperative management in these patients.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The term thrombophilia refers to a number of inherited and/or acquired conditions that may be associated with an increased tendency to develop thrombosis. In this sense, hereditary thrombophilia is a genetic disorder of hemostatic proteins that is present at birth and contributes to individuals being at increased risk for venous thrombosis. Three important questions arise from the still ongoing debate about the benefits and limitations of testing for hereditary thrombophilia, which can be summarized as follows: “which tests?”, “when?”, and “how?”. This article attempts to answer these questions by providing an up-to-date overview of the most common and clinically significant inherited thrombophilic disorders (i.e., antithrombin, protein S and protein C deficiencies, activated protein C resistance, factor V Leiden, and prothrombin gene mutationG20210A), their prevalence, clinical severity, and diagnostic approach, while also highlighting the potential advantages and limitations of testing for inherited thrombophilia.
{"title":"An update on common inherited thrombophilic conditions","authors":"Giuseppe Lippi","doi":"10.53388/crc2023022","DOIUrl":"https://doi.org/10.53388/crc2023022","url":null,"abstract":"The term thrombophilia refers to a number of inherited and/or acquired conditions that may be associated with an increased tendency to develop thrombosis. In this sense, hereditary thrombophilia is a genetic disorder of hemostatic proteins that is present at birth and contributes to individuals being at increased risk for venous thrombosis. Three important questions arise from the still ongoing debate about the benefits and limitations of testing for hereditary thrombophilia, which can be summarized as follows: “which tests?”, “when?”, and “how?”. This article attempts to answer these questions by providing an up-to-date overview of the most common and clinically significant inherited thrombophilic disorders (i.e., antithrombin, protein S and protein C deficiencies, activated protein C resistance, factor V Leiden, and prothrombin gene mutationG20210A), their prevalence, clinical severity, and diagnostic approach, while also highlighting the potential advantages and limitations of testing for inherited thrombophilia.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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