Sean Lee, Yiming Li, Luis R Mateo, Guofeng Xu, Carl P Myers, Divino Rajah, Nicky Li, Yun-Po Zhang
Background: The objective of this randomized controlled trial was the comparison of a stannous fluoride (SnF2) dentifrice stabilized with nitrate and phosphates (test) to a regular fluoride dentifrice (negative control) for the control of plaque and gingivitis over 6 months.
Methods: A total of 80 adult participants were enrolled in this study that was conducted in Loma Linda, California. After randomization and blinding of study personnel and patients, enrolled participants were provided instructions for the use of their assigned dentifrice. At three visits (0, 3, and 6 months), various gingival and plaque indices were collected to determine the clinical efficacy of the SnF2 stabilized dentifrice. These results were compared with the results of the negative control dentifrice.
Results: A total of 77 participants completed the study. The test dentifrice demonstrated statistically significant reductions versus baseline in all plaque and gingivitis indices after 3 and 6 months of product use. The negative control dentifrice demonstrated significant reductions versus baseline in all plaque indices, but not gingivitis indices, after 3 months of product use and in all plaque and gingivitis indices after 6 months of product use, with the exception of the interproximal gingivitis index, which did not reach statistical significance. The test SnF2 dentifrice showed statistically significant reductions in all plaque and gingivitis indices compared to baseline and with the negative control dentifrice (P less than .001) after 3 months and 6 months of product use.
Conclusions: The results of this clinical trial showed statistically significantly improved clinical outcomes for reduction of gingival inflammation and improvement in plaque control over 6 months when using a new SnF2 dentifrice stabilized with nitrate and phosphates as compared to the results from a regular fluoride dentifrice.
Practical implications: This newly formulated SnF2 dentifrice may be of benefit to patients who need help controlling plaque biofilm and in reducing gingivitis, leading to an improvement in overall oral health.
{"title":"A 6-Month Randomized Controlled Trial to Measure the Efficacy of a Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) on Dental Plaque and Gingivitis.","authors":"Sean Lee, Yiming Li, Luis R Mateo, Guofeng Xu, Carl P Myers, Divino Rajah, Nicky Li, Yun-Po Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The objective of this randomized controlled trial was the comparison of a stannous fluoride (SnF2) dentifrice stabilized with nitrate and phosphates (test) to a regular fluoride dentifrice (negative control) for the control of plaque and gingivitis over 6 months.</p><p><strong>Methods: </strong>A total of 80 adult participants were enrolled in this study that was conducted in Loma Linda, California. After randomization and blinding of study personnel and patients, enrolled participants were provided instructions for the use of their assigned dentifrice. At three visits (0, 3, and 6 months), various gingival and plaque indices were collected to determine the clinical efficacy of the SnF2 stabilized dentifrice. These results were compared with the results of the negative control dentifrice.</p><p><strong>Results: </strong>A total of 77 participants completed the study. The test dentifrice demonstrated statistically significant reductions versus baseline in all plaque and gingivitis indices after 3 and 6 months of product use. The negative control dentifrice demonstrated significant reductions versus baseline in all plaque indices, but not gingivitis indices, after 3 months of product use and in all plaque and gingivitis indices after 6 months of product use, with the exception of the interproximal gingivitis index, which did not reach statistical significance. The test SnF2 dentifrice showed statistically significant reductions in all plaque and gingivitis indices compared to baseline and with the negative control dentifrice (P less than .001) after 3 months and 6 months of product use.</p><p><strong>Conclusions: </strong>The results of this clinical trial showed statistically significantly improved clinical outcomes for reduction of gingival inflammation and improvement in plaque control over 6 months when using a new SnF2 dentifrice stabilized with nitrate and phosphates as compared to the results from a regular fluoride dentifrice.</p><p><strong>Practical implications: </strong>This newly formulated SnF2 dentifrice may be of benefit to patients who need help controlling plaque biofilm and in reducing gingivitis, leading to an improvement in overall oral health.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 Suppl 3","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Alpha Omega International Dental Society represents around 5,000 active dentists and dental students across the United States, Canada, South America, Europe, Israel, South Africa, Australia, and New Zealand, with combined charitable contributions estimated at over $60 million. As the oldest international Jewish dental society in the world, Alpha Omega was founded in Baltimore, Maryland, in 1907, with a mission to combat the widespread anti-Semitism present in educational institutions and the broader dental community. From its inception, philanthropy has been central to its goals.
{"title":"Alpha Omega: Envisioning the Next Generation of Leaders.","authors":"Marc Rothman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Alpha Omega International Dental Society represents around 5,000 active dentists and dental students across the United States, Canada, South America, Europe, Israel, South Africa, Australia, and New Zealand, with combined charitable contributions estimated at over $60 million. As the oldest international Jewish dental society in the world, Alpha Omega was founded in Baltimore, Maryland, in 1907, with a mission to combat the widespread anti-Semitism present in educational institutions and the broader dental community. From its inception, philanthropy has been central to its goals.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 10","pages":"538"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julian Conejo, Alejandro Sanchez-Lara, Christina Rivet, Frank LaMar
Implant-supported hybrid prostheses have become popular solutions when treating patients with terminal dentitions or who are completely edentulous. Since the implementation of osseointegrated dental implants to treat edentulism, multiple prosthetic designs and materials have been used for full-arch fixed hybrid prostheses. While these restorations can be highly successful, the most common restorative failures are attributed to lack of prosthetic space or a framework without passive fit, consequently leading to possible chippings, delamination, and/or fractures. This article reviews the clinical and laboratory steps for fabrication of definitive implant-supported hybrid prostheses with the implementation of bone reduction guides, implant osteotomy guides, and immediate provisionalization using digital manufacturing technologies.
{"title":"Digital Workflow for a Definitive Implant-Supported Hybrid Prosthesis.","authors":"Julian Conejo, Alejandro Sanchez-Lara, Christina Rivet, Frank LaMar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Implant-supported hybrid prostheses have become popular solutions when treating patients with terminal dentitions or who are completely edentulous. Since the implementation of osseointegrated dental implants to treat edentulism, multiple prosthetic designs and materials have been used for full-arch fixed hybrid prostheses. While these restorations can be highly successful, the most common restorative failures are attributed to lack of prosthetic space or a framework without passive fit, consequently leading to possible chippings, delamination, and/or fractures. This article reviews the clinical and laboratory steps for fabrication of definitive implant-supported hybrid prostheses with the implementation of bone reduction guides, implant osteotomy guides, and immediate provisionalization using digital manufacturing technologies.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 10","pages":"520-524"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lata Goyal, Shivani Bansal, Arshad Ernakulum, Manjit Kaur Rana
Plasma cell gingivitis and cheilitis are diagnostic challenges for dental practitioners. To the best of the authors' knowledge, concomitant plasma cell gingivitis and plasma cell cheilitis in the same patient has not been reported in the dental literature, although these conditions have been reported separately (on lips and gingiva) several times. Underreporting of these coexisting clinical conditions may be attributed to a lack of awareness of both conditions and underperformance of comprehensive histopathological examinations. This article describes a case of plasma cell gingivitis with plasma cell cheilitis in a 63-year-old female patient. Histopathology and immunohistochemistry evaluations confirmed the diagnosis. After being informed about her condition and educated about possible allergens, which could be present in certain toothpastes, foods, and other foreign substances, the patient responded well to the stoppage of the use of suspected allergens. Identification and elimination of causative allergens is considered the accepted treatment for these conditions.
{"title":"Plasma Cell Gingivitis With Plasma Cell Cheilitis: A Diagnostic Challenge.","authors":"Lata Goyal, Shivani Bansal, Arshad Ernakulum, Manjit Kaur Rana","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma cell gingivitis and cheilitis are diagnostic challenges for dental practitioners. To the best of the authors' knowledge, concomitant plasma cell gingivitis and plasma cell cheilitis in the same patient has not been reported in the dental literature, although these conditions have been reported separately (on lips and gingiva) several times. Underreporting of these coexisting clinical conditions may be attributed to a lack of awareness of both conditions and underperformance of comprehensive histopathological examinations. This article describes a case of plasma cell gingivitis with plasma cell cheilitis in a 63-year-old female patient. Histopathology and immunohistochemistry evaluations confirmed the diagnosis. After being informed about her condition and educated about possible allergens, which could be present in certain toothpastes, foods, and other foreign substances, the patient responded well to the stoppage of the use of suspected allergens. Identification and elimination of causative allergens is considered the accepted treatment for these conditions.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 10","pages":"e1-e4"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Digital smile design has transformed the approach to planning and executing esthetic dental treatments, allowing clinicians to digitally visualize and customize a patient's smile before taking any clinical interventions. By leveraging modern digital technologies, clinicians can streamline diagnostics and treatment planning while also improving accuracy in predicting the final results. This article explores the advantages of digital smile design in esthetic treatment planning along with the key principles of smile design and facial harmony that must be considered for a successful smile transformation.
{"title":"Leveraging Digital Smile Design Technology in Esthetic Restorative Dentistry.","authors":"Macarena Rivera, Markus B Blatz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Digital smile design has transformed the approach to planning and executing esthetic dental treatments, allowing clinicians to digitally visualize and customize a patient's smile before taking any clinical interventions. By leveraging modern digital technologies, clinicians can streamline diagnostics and treatment planning while also improving accuracy in predicting the final results. This article explores the advantages of digital smile design in esthetic treatment planning along with the key principles of smile design and facial harmony that must be considered for a successful smile transformation.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 10","pages":"498-502"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jose Maria Ayub, Telmo Santos, Mauricio Figueredo, Julian Conejo, Markus B Blatz
Digital technology that utilizes 3D printing has become a viable alternative to the traditional fabrication of wax patterns and definitive restorations for pressable ceramics. Digital workflows afford clinicians fewer variables, improved repeatability, and faster design and fabrication times. The print/press technique for producing zirconia-reinforced lithium-disilicate restorations offers benefits in terms of convenience, precision, and improved mechanical properties. This article describes an efficient workflow for monolithic ceramic restorations using the print/press technique and a novel zirconia-reinforced silicate ceramic.
{"title":"Print/Press Workflow With a Novel Silicate Ceramic Material: A Case Report.","authors":"Jose Maria Ayub, Telmo Santos, Mauricio Figueredo, Julian Conejo, Markus B Blatz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Digital technology that utilizes 3D printing has become a viable alternative to the traditional fabrication of wax patterns and definitive restorations for pressable ceramics. Digital workflows afford clinicians fewer variables, improved repeatability, and faster design and fabrication times. The print/press technique for producing zirconia-reinforced lithium-disilicate restorations offers benefits in terms of convenience, precision, and improved mechanical properties. This article describes an efficient workflow for monolithic ceramic restorations using the print/press technique and a novel zirconia-reinforced silicate ceramic.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 10","pages":"508-512"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 1948, the United Nations General Assembly in Paris declared that a standard of health was a universal human right.1 There is no reason to suggest that this affirmation should not include oral health as well. Oral health is a human right! Oral diseases are a public health problem that impair quality of life and generate increased costs and demands.2 The World Economic Forum reported this year that almost half the world's population suffers from oral diseases that impact daily life and subject the population to a higher risk of systemic health issues.3 It is time for radical policy action. Governments, industries, academic institutions, and scientific organizations must help change the burden of oral diseases.4 Concerned about the lack of attention to oral health, a historic resolution was adopted by the World Health Assembly in 2021 stating that oral health should be firmly embedded within the noncommunicable disease agenda and that oral healthcare interventions should be included in universal health coverage programs.5.
{"title":"Advanced Oral Health Protection: A Multifunctional Dentifrice Designed to Prevent Oral Diseases and Conditions.","authors":"Cassiano Kuchenbecker Rösing","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 1948, the United Nations General Assembly in Paris declared that a standard of health was a universal human right.1 There is no reason to suggest that this affirmation should not include oral health as well. Oral health is a human right! Oral diseases are a public health problem that impair quality of life and generate increased costs and demands.2 The World Economic Forum reported this year that almost half the world's population suffers from oral diseases that impact daily life and subject the population to a higher risk of systemic health issues.3 It is time for radical policy action. Governments, industries, academic institutions, and scientific organizations must help change the burden of oral diseases.4 Concerned about the lack of attention to oral health, a historic resolution was adopted by the World Health Assembly in 2021 stating that oral health should be firmly embedded within the noncommunicable disease agenda and that oral healthcare interventions should be included in universal health coverage programs.5.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 Suppl 3","pages":"2-5"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aileen Cabelly, Mania Bankova, Jason Darling, Tracy Bariexca, Catalina Monroy, Deyu Hu, Luis R Mateo, Pamela Monty, Robert D'Ambrogio, Maria Ryan, Yun-Po Zhang
Background: Oral malodor, whether from systemic disease, dietary sources, or bacteria in the oral cavity, can negatively impact patients' quality of life. Oral malodor due to bacteria in the oral cavity can be managed by mechanically or chemically removing bacteria. Dentifrices are ideal vehicles to deliver therapeutic active ingredients that promote and maintain oral health since most consumers brush their teeth daily. Consumer preference drives consistency in oral hygiene routine. This study first identified a favorite flavor via consumer flavor testing and then measured the clinical efficacy of the dentifrice with a new flavor formulation to reduce malodor.
Methods: Consumer testing was conducted via an online product evaluation questionnaire to gauge consumer flavor preferences for stannous fluoride toothpaste stabilized with nitrate and phosphates (SNaP). In a 3-week randomized, single-center, double-blind clinical study, the malodor reduction ability of SNaP was compared to the negative control toothpaste containing 0.76% sodium monofluorophosphate via the organoleptic method.
Results: Consumer testing was used to determine a winning flavor for the new flavor formulation of SNaP tested in the clinical study. In this study, after 3 weeks of product use, on average, malodor clinical trial subjects (n = 97) randomized into the SNaP group had a 32.7% malodor score reduction from baseline (P less than .001) 12 hours post-brushing compared to a 9.4% reduction in the negative control group. Relative to the negative control group, the SNaP group had a statistically significant reduction of 25.7% (P less than .001) in oral malodor via organoleptic scores.
Conclusions: SNaP toothpaste delivered superior malodor reduction 12 hours post-brushing when compared to a negative control toothpaste.
Practical implications: Incorporating therapeutic active ingredients like stannous fluoride into toothpaste is an effective way to deliver oral health benefits, such as caries prevention, reduction in gingivitis and dentin hypersensitivity, and protection against enamel erosion and bad breath.
{"title":"Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) Reduces Oral Malodor: A Randomized Clinical Study.","authors":"Aileen Cabelly, Mania Bankova, Jason Darling, Tracy Bariexca, Catalina Monroy, Deyu Hu, Luis R Mateo, Pamela Monty, Robert D'Ambrogio, Maria Ryan, Yun-Po Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oral malodor, whether from systemic disease, dietary sources, or bacteria in the oral cavity, can negatively impact patients' quality of life. Oral malodor due to bacteria in the oral cavity can be managed by mechanically or chemically removing bacteria. Dentifrices are ideal vehicles to deliver therapeutic active ingredients that promote and maintain oral health since most consumers brush their teeth daily. Consumer preference drives consistency in oral hygiene routine. This study first identified a favorite flavor via consumer flavor testing and then measured the clinical efficacy of the dentifrice with a new flavor formulation to reduce malodor.</p><p><strong>Methods: </strong>Consumer testing was conducted via an online product evaluation questionnaire to gauge consumer flavor preferences for stannous fluoride toothpaste stabilized with nitrate and phosphates (SNaP). In a 3-week randomized, single-center, double-blind clinical study, the malodor reduction ability of SNaP was compared to the negative control toothpaste containing 0.76% sodium monofluorophosphate via the organoleptic method.</p><p><strong>Results: </strong>Consumer testing was used to determine a winning flavor for the new flavor formulation of SNaP tested in the clinical study. In this study, after 3 weeks of product use, on average, malodor clinical trial subjects (n = 97) randomized into the SNaP group had a 32.7% malodor score reduction from baseline (P less than .001) 12 hours post-brushing compared to a 9.4% reduction in the negative control group. Relative to the negative control group, the SNaP group had a statistically significant reduction of 25.7% (P less than .001) in oral malodor via organoleptic scores.</p><p><strong>Conclusions: </strong>SNaP toothpaste delivered superior malodor reduction 12 hours post-brushing when compared to a negative control toothpaste.</p><p><strong>Practical implications: </strong>Incorporating therapeutic active ingredients like stannous fluoride into toothpaste is an effective way to deliver oral health benefits, such as caries prevention, reduction in gingivitis and dentin hypersensitivity, and protection against enamel erosion and bad breath.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 Suppl 3","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Designing and fabricating dental restorations via the indirect method emerged as a strategic response to the loss of tooth coronal structure that prompted the need for different treatment options depending on the extent of the damage (eg, partial-coverage restorations such as inlays/onlays and laminate veneers, or full-coverage restorations such as crowns). The complexities of the oral environment and patient management in the dental chair also factored into the development of indirect restorations. Indirect restorations involve manufacturing them away from the oral cavity, avoiding some of the difficulties of direct techniques, such as polymerization contraction and marginal adaptation, as polymerization shrinkage stresses only affect the cement layer, reducing the impact on the cavity walls.
{"title":"A New Era for Indirect Restorations With CAD/CAM and 3D Printing Technologies.","authors":"Macarena Rivera, Markus B Blatz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Designing and fabricating dental restorations via the indirect method emerged as a strategic response to the loss of tooth coronal structure that prompted the need for different treatment options depending on the extent of the damage (eg, partial-coverage restorations such as inlays/onlays and laminate veneers, or full-coverage restorations such as crowns). The complexities of the oral environment and patient management in the dental chair also factored into the development of indirect restorations. Indirect restorations involve manufacturing them away from the oral cavity, avoiding some of the difficulties of direct techniques, such as polymerization contraction and marginal adaptation, as polymerization shrinkage stresses only affect the cement layer, reducing the impact on the cavity walls.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 10","pages":"526-527"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yangxi Liu, Stacey Lavender, Farid Ayad, Maha Hetata, Luis R Mateo, Carl P Myers, Guofeng Xu, Elizabeth Gittins, Yun-Po Zhang, Bayardo García-Godoy
Background: Dentin hypersensitivity is a global oral health concern. This in vitro study and clinical evaluation tested the efficacy of 0.454% stannous fluoride toothpaste stabilized with nitrate and phosphates (SNaP) to occlude dentin and reduce dentin hypersensitivity.
Methods: Human dentin specimens were treated with test and control toothpaste slurries and evaluated for dentin occlusion. In a phase III randomized controlled trial, eligible participants were randomized to SNaP toothpaste (test group), a potassium nitrate desensitizing dentifrice (positive control), or a non-desensitizing sodium monofluorophosphate dentifrice (negative control). Baseline, day 1, day 3, and day 7 dentin hypersensitivity was assessed using tactile and air blast stimuli. Mean tactile and air blast hypersensitivity scores were calculated for each treatment group. For statistical analysis, significance was set to P ≤ .05.
Results: In vitro mean percent tubule occlusion for test and control samples were 86% and 35%, respectively (P less than .05). One-hundred-twenty participants completed the clinical trial. After 7 days of product use, relative to the positive control and negative control groups, the test group exhibited significant reduction in tactile hypersensitivity (79.8% and 90.2%, respectively; P less than .001) and reduction in air blast hypersensitivity (47.1% and 47.9%, respectively; P less than .001). SNaP significantly reduced hypersensitivity pain after 1, 3, and 7 days.
Conclusions: In vitro and clinical evaluation results indicate that SNaP is highly effective in coating the dentin surface, occluding exposed dentin tubules, and offering sensitivity relief from the first day of use, a benefit that continues to improve with use.
Practical implications: This multi-benefit formula reduces dentin hypersensitivity, thereby improving the daily lives of patients, promoting better oral health, and potentially helping patients avoid more serious dental problems in the future.
{"title":"Effect of a Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) on Dentin Hypersensitivity: In Vitro Study and Randomized Controlled Trial.","authors":"Yangxi Liu, Stacey Lavender, Farid Ayad, Maha Hetata, Luis R Mateo, Carl P Myers, Guofeng Xu, Elizabeth Gittins, Yun-Po Zhang, Bayardo García-Godoy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Dentin hypersensitivity is a global oral health concern. This in vitro study and clinical evaluation tested the efficacy of 0.454% stannous fluoride toothpaste stabilized with nitrate and phosphates (SNaP) to occlude dentin and reduce dentin hypersensitivity.</p><p><strong>Methods: </strong>Human dentin specimens were treated with test and control toothpaste slurries and evaluated for dentin occlusion. In a phase III randomized controlled trial, eligible participants were randomized to SNaP toothpaste (test group), a potassium nitrate desensitizing dentifrice (positive control), or a non-desensitizing sodium monofluorophosphate dentifrice (negative control). Baseline, day 1, day 3, and day 7 dentin hypersensitivity was assessed using tactile and air blast stimuli. Mean tactile and air blast hypersensitivity scores were calculated for each treatment group. For statistical analysis, significance was set to P ≤ .05.</p><p><strong>Results: </strong>In vitro mean percent tubule occlusion for test and control samples were 86% and 35%, respectively (P less than .05). One-hundred-twenty participants completed the clinical trial. After 7 days of product use, relative to the positive control and negative control groups, the test group exhibited significant reduction in tactile hypersensitivity (79.8% and 90.2%, respectively; P less than .001) and reduction in air blast hypersensitivity (47.1% and 47.9%, respectively; P less than .001). SNaP significantly reduced hypersensitivity pain after 1, 3, and 7 days.</p><p><strong>Conclusions: </strong>In vitro and clinical evaluation results indicate that SNaP is highly effective in coating the dentin surface, occluding exposed dentin tubules, and offering sensitivity relief from the first day of use, a benefit that continues to improve with use.</p><p><strong>Practical implications: </strong>This multi-benefit formula reduces dentin hypersensitivity, thereby improving the daily lives of patients, promoting better oral health, and potentially helping patients avoid more serious dental problems in the future.</p>","PeriodicalId":72651,"journal":{"name":"Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)","volume":"45 Suppl 3","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}