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The Evolution of Colgate Total®: A New Era Stabilized by Nitrate and Phosphates. 高露洁全效®的演变:硝酸盐和磷酸盐稳定的新时代。
Lisa M Manus, Carl P Myers, Robert D'Ambrogio, Gokul V Govindaraju, Guofeng Xu, Yun-Po Zhang, James G Masters

Effective and accessible oral care strategies, like the use of a multi-benefit, antimicrobial toothpaste, are a key tool in preventive public health. For over 30 years, Colgate Total toothpastes have represented a gold standard in multi-benefit toothpastes to help fight bacteria and provide whole-mouth care. This review introduces the next generation of Colgate's research and development featuring stannous fluoride (SnF2) stabilized by nitrate and phosphates. The uniqueness of this engine is detailed through a review of SnF2 oral benefits, the historic challenges associated with SnF2 toothpastes, and the advantages that this chemistry can bring to patients seeking multi-benefit oral care. With this novel technology, a new balance in efficacy, stability, and streamlined design enables flexible formulation and customized user experiences inspired by key therapeutic areas.

有效、方便的口腔护理策略,如使用多功效抗菌牙膏,是预防性公共卫生的重要工具。30 多年来,高露洁全效牙膏一直代表着多重功效牙膏的黄金标准,有助于对抗细菌并提供全口护理。本评论介绍了高露洁研发的下一代产品,其特点是由硝酸盐和磷酸盐稳定的亚锡氟化物(SnF2)。通过对 SnF2 的口腔益处、与 SnF2 牙膏相关的历史挑战以及这种化学成分可为寻求多重益处口腔护理的患者带来的优势的回顾,详细介绍了这种引擎的独特性。有了这项新技术,就能在功效、稳定性和简化设计之间取得新的平衡,从而实现灵活的配方和受关键治疗领域启发而定制的用户体验。
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引用次数: 0
Efficacy of a Novel Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) in Extrinsic Tooth Stain Removal: A Randomized Controlled Trial. 新型硝酸盐和磷酸盐稳定亚锡氟化物牙膏(SNaP)去除外源性牙渍的功效:随机对照试验。
Augusto R Elías-Boneta, Luis R Mateo, Robert D'Ambrogio, Guofeng Xu, Carl P Myers, Yun-Po Zhang, Bayardo García-Godoy

Background: This study compared the extrinsic tooth stain removal efficacy of a 0.454% stannous fluoride dentifrice stabilized with nitrate and phosphates (SNaP) versus a non-whitening regular fluoride dentifrice (negative control) after 3 and 6 weeks of product use.

Methods: This phase III, double-blind, randomized, two-cell, parallel-group study was conducted on 80 healthy adults in Puerto Rico. After a baseline tooth stain assessment and oral examinations, study participants were randomly assigned to either the SNaP (test) group or a negative control group. Participants brushed their teeth twice daily for 2 minutes for the 6-week duration. The efficacy for extrinsic tooth stain removal was assessed via Lobene composite stain index, stain area index, and stain intensity index scores for each treatment group at baseline, 3 weeks, and 6 weeks.

Results: Seventy-eight participants completed the 6-week study. The SNaP dentifrice provided more stain removal relative to baseline tooth stain scores (3-week: 24.4%; 6-week: 35.6%; P less than .001) and more stain removal relative to the regular fluoride dentifrice (3-week: 24.3%; 6-week: 39.1%; P less than .001).

Conclusion: The results indicate that the SNaP toothpaste provides a greater level of efficacy in the removal of extrinsic tooth stain as compared to a regular fluoride toothpaste when used twice a day, as measured with Lobene stain index at 3 weeks and 6 weeks.

Practical implications: A new stannous fluoride dentifrice stabilized with nitrate and phosphates offers greater efficacy in removing extrinsic tooth stain as compared to regular fluoride toothpaste.

研究背景本研究比较了使用硝酸盐和磷酸盐稳定的0.454%亚锡氟化物牙膏(SNaP)与非美白普通氟化物牙膏(阴性对照)3周和6周后的外源性牙齿去污效果:这项 III 期、双盲、随机、两组平行研究是在波多黎各的 80 名健康成年人中进行的。在进行基线牙渍评估和口腔检查后,研究参与者被随机分配到 SNaP(测试)组或阴性对照组。在为期 6 周的时间里,参与者每天刷牙两次,每次 2 分钟。在基线、3 周和 6 周时,通过对每个治疗组的 Lobene 复合染色指数、染色面积指数和染色强度指数评分来评估外源性牙渍去除效果:78 名参与者完成了为期 6 周的研究。与基线牙渍评分相比,SNaP牙膏的去渍效果更好(3周:24.4%;6周:35.6%;P小于0.001),与普通含氟牙膏相比,SNaP牙膏的去渍效果更好(3周:24.3%;6周:39.1%;P小于0.001):结果表明,与普通含氟牙膏相比,每天使用两次的 SNaP 牙膏在去除牙齿外源性污渍方面具有更高的功效,3 周和 6 周时的 Lobene 染色指数即为证明:实际意义:与普通含氟牙膏相比,用硝酸盐和磷酸盐稳定的新型含锡氟化物牙膏具有更强的去除外源性牙渍的功效。
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引用次数: 0
A Conservative Restorative Approach for a Patient With Cleft Palate: Replacing a Lateral Incisor and Enhancing Esthetics. 腭裂患者的保守修复方法:替换侧切牙并提高美观度
Sergio R Arias, Barry I Matza

Young patients often times are poor candidates for implant-supported restorations due to ongoing jawbone development. This case report describes a viable restorative option for a 16-year-old patient who had a large cleft defect and a hopeless prognosis for the right lateral incisor. The clinician utilized a combination of a fixed bonded ceramic restoration to replace tooth No. 7 and direct composite resin, including pink composite resin, to restore the symmetry and gingival level of tooth No. 8. This conservative approach allowed for an esthetic outcome while providing the patient a stable and functional restoration.

由于颌骨正在发育,年轻患者通常不适合种植体支持修复。本病例报告描述了一名 16 岁患者的可行修复方案,该患者的右侧切牙有较大的裂隙缺损,预后无望。临床医生采用固定粘结陶瓷修复体替代 7 号牙,并使用直接复合树脂(包括粉色复合树脂)恢复 8 号牙的对称性和牙龈水平。这种保守的方法既能达到美观的效果,又能为患者提供稳定的功能性修复体。
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引用次数: 0
The Core of Digital Dentistry: Intraoral Scanners. 数字牙科的核心:口内扫描仪
Florin Eggmann, Markus B Blatz

Intraoral scanners (IOSs) have transformed digital dentistry by enabling the capture of detailed intraoral optical impressions, resulting in high-precision virtual models. This article provides an overview of the technological advancements and emerging applications of IOSs in various dental specialties. Recent innovations have improved IOS speed, resolution, and functionality, eliminating the need for scanning powder and allowing for seamless integration with other digital tools. IOSs are widely used in restorative dentistry for computer-aided design/computer-aided manufacturing of dental restorations, offering accuracy comparable to traditional methods. Additionally, IOSs play critical roles in prosthodontics, orthodontics, and oral and maxillofacial surgery. Automated tooth segmentation and orthodontic landmarking have become more efficient due to advancements in machine learning. However, although IOSs are highly accurate for most dental procedures, they face limitations in edentulous areas and full-arch implant impressions. Efforts to expand their diagnostic capabilities-such as caries detection and the monitoring of soft-tissue levels and tooth wear-are underway, aided by advancements in imaging technologies. As research continues, future developments in IOS technology, including better integration with other digital tools and teledentistry applications, should further enhance its utility in dental care. This article highlights the pivotal role IOSs play in modern dentistry while acknowledging ongoing challenges.

口内扫描仪(IOS)通过采集详细的口内光学印模,产生高精度的虚拟模型,从而改变了数字化牙科。本文概述了口内扫描仪在各牙科专业的技术进步和新兴应用。最新的创新技术提高了口内光学印模的速度、分辨率和功能,无需使用扫描粉,并可与其他数字工具无缝集成。在牙科修复领域,IOS 被广泛用于牙科修复的计算机辅助设计/计算机辅助制造,其精确度可与传统方法相媲美。此外,IOS 还在义齿修复、牙齿矫正和口腔颌面外科中发挥着重要作用。由于机器学习的进步,自动牙齿分割和正畸标记变得更加高效。然而,尽管 IOS 在大多数牙科手术中都非常准确,但在无牙区和全牙弓种植体印模中却面临着局限性。在成像技术进步的帮助下,人们正在努力扩展其诊断功能,如龋齿检测、软组织水平和牙齿磨损监测等。随着研究的不断深入,IOS 技术的未来发展,包括与其他数字工具和远程牙科应用的更好整合,将进一步提高其在牙科护理中的实用性。本文强调了 IOS 在现代牙科中发挥的关键作用,同时也承认了目前面临的挑战。
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引用次数: 0
The Use of Nanoceramic Hybrid Material and Digital Light Processing Technology for 3D Printing of an Implant-Supported FP3 Restoration: A Case Report. 使用纳米陶瓷混合材料和数字光处理技术三维打印种植体支持的 FP3 修复体:病例报告。
Marianthi Papaioannou, Howard P Fraiman, Harold S Baumgarten, Michael Bergler

The advancement of digital technologies, including 3-dimensional (3D) imaging and computer-aided design/computer-aided manufacturing (CAD/CAM), and material science has significantly transformed dentistry. Current CAD/CAM techniques incorporate both subtractive and additive (eg, 3D printing) manufacturing methods, with 3D printing offering such benefits as reduced material waste and the ability to produce complex geometries. Much research has focused on the development of hybrid materials that merge the esthetics and durability of ceramics with the high flexural strength, low abrasiveness, and intraoral repairability characteristics of resin composites. Most hybrid ceramics, however, have been optimized for subtractive manufacturing methods, and only a few 3D-printed hybrid materials are available for permanent dental restorations. This case report documents the clinical application of digital technologies in the full-arch rehabilitation of a patient with terminal dentition, highlighting the use of 3D-printed nanoceramic hybrid materials for long-term provisionalization and as a potential permanent solution in the subsequent transition to definitive restorations. The article describes the clinical steps used in the fabrication of the 3D-printed implant-supported restoration, which was clinically tested over 1 year.

数字技术(包括三维(3D)成像和计算机辅助设计/计算机辅助制造(CAD/CAM))以及材料科学的发展极大地改变了牙科。目前的计算机辅助设计/计算机辅助制造(CAD/CAM)技术结合了减法和加法(如三维打印)制造方法,其中三维打印具有减少材料浪费和制造复杂几何形状的能力等优点。许多研究都集中在混合材料的开发上,这种材料既有陶瓷的美观和耐用性,又有树脂复合材料的高抗折强度、低磨损性和口内可修复性等特点。然而,大多数混合陶瓷已针对减材制造方法进行了优化,只有少数三维打印混合材料可用于永久性牙科修复。本病例报告记录了数字化技术在一名末牙患者全牙列修复中的临床应用,重点介绍了三维打印纳米陶瓷混合材料在长期临时修复中的应用,以及在随后过渡到永久性修复中作为潜在永久性解决方案的应用。文章介绍了制作三维打印种植体支持修复体的临床步骤,并对该修复体进行了为期一年的临床测试。
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引用次数: 0
Antibacterial Effects of a Novel Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP): In Vitro Study and Randomized Controlled Trial. 用硝酸盐和磷酸盐稳定的新型氟化亚锡牙膏 (SNaP) 的抗菌效果:体外研究和随机对照试验。
Brinta Chakraborty, Dutmanee Seriwatanachai, Terdphong Triratana, Luis R Mateo, Robert D'Ambrogio, Guofeng Xu, Maria Ryan, Yun-Po Zhang
<p><strong>Background: </strong>Stannous fluoride has long been an effective antibacterial, anticaries, antisensitivity, and antigingivitis addition to toothpaste formulas. However, in the past its chemical properties in aqueous solution have made it difficult to stabilize with desirable results. The recent development of a novel formulation of 0.454% stannous fluoride stabilized with nitrate and phosphates (SNaP) has resulted in prolonged therapeutic effect without compromising product experience and esthetics.</p><p><strong>Methods: </strong>Dentifrice antibacterial performance in vitro was determined through bacterial bioenergetics measured via rate of oxygen consumption and extracellular acidification in real-time comparing the SNaP toothpaste, a stannous fluoride positive control toothpaste, a non-antibacterial negative control toothpaste, and no treatment. Also, a single- center, randomized, controlled, double-blinded, clinical investigation of 98 subjects was performed to analyze dentifrice antibacterial performance in vivo following twice daily treatment with SNaP toothpaste (n = 48) and non-antibacterial control toothpaste (n = 50). Oral microenvironments, including plaque, tongue, cheek, gum, and saliva, of study participants 12 hours post-brushing were analyzed for bacterial load at baseline, 2 weeks, and 4 weeks.</p><p><strong>Results: </strong>In vitro treatment of biofilms with SNaP toothpaste resulted in significant suppression of bacterial respiration and glycolysis compared to a positive control, negative control, and no treatment. In the clinical trial, treatment with SNaP toothpaste showed significantly lower bacterial load in all oral microenvironments 12 hours post-brushing after 2 weeks (all: P less than .01) and 4 weeks (all: P less than .05) compared to non-antibacterial negative control toothpaste. Compared to baseline, SNaP toothpaste significantly reduced bacteria from tongue (P = .007) and saliva (P less than .001) at week 2, and from all microenvironments by week 4 (all: P ≤ .001).</p><p><strong>Conclusions: </strong>SNaP toothpaste provided significantly greater and more sustained antibacterial effects than other tested toothpastes. Stannous fluoride, when stabilized in the SNaP formulation, effectively inhibited bacterial respiration and glycolysis in saliva-derived in vitro biofilms. The specific stabilization strategy used in SNaP toothpaste is critical for the antibacterial performance of stannous fluoride, as this formulation was more effective at reducing bacterial metabolic activity than a toothpaste containing the same amount of stannous fluoride stabilized with gluconate. The clinical study supports the in vitro findings by showing that the regular use of SNaP toothpaste leads to a significant and prolonged reduction in viable bacterial counts of five oral microenvironments.</p><p><strong>Practical implications: </strong>The highly stabilized stannous ion in SNaP toothpaste confers potent, sustained antibact
背景:长期以来,氟化亚锡一直是牙膏配方中有效的抗菌、抗龋、抗敏感和抗牙龈炎添加剂。然而,由于氟化亚锡在水溶液中的化学性质,过去很难将其稳定在水溶液中并获得理想的效果。最近开发出了一种用硝酸盐和磷酸盐(SNaP)稳定的 0.454% 氟化亚锡的新型配方,可在不影响产品体验和美观的情况下延长治疗效果:牙膏的体外抗菌性能是通过细菌生物能实时测量耗氧率和细胞外酸化来确定的,并对 SNaP 牙膏、氟化亚锡阳性对照牙膏、非抗菌阴性对照牙膏和无处理牙膏进行了比较。此外,还对 98 名受试者进行了一项单中心、随机对照、双盲临床调查,分析每天两次使用 SNaP 牙膏(48 人)和非抗菌对照牙膏(50 人)后牙膏的体内抗菌性能。研究人员对刷牙后 12 小时的口腔微环境(包括牙菌斑、舌、颊、牙龈和唾液)进行了分析,以了解基线、2 周和 4 周时的细菌负荷情况:结果:使用 SNaP 牙膏对生物膜进行体外处理后,与阳性对照组、阴性对照组和未处理组相比,细菌的呼吸作用和糖酵解作用均受到显著抑制。在临床试验中,与非抗菌阴性对照牙膏相比,使用 SNaP 牙膏治疗后,刷牙后 12 小时内所有口腔微环境中的细菌量都明显降低(均小于 0.01),4 周后也明显降低(均小于 0.05)。与基线相比,SNaP牙膏在第2周时显著减少了舌头(P = .007)和唾液(P小于.001)中的细菌,在第4周时显著减少了所有微环境中的细菌(均:P小于.001):结论:与其他测试过的牙膏相比,SNaP 牙膏的抗菌效果明显更强、更持久。氟化亚锡在 SNaP 配方中稳定后,可有效抑制唾液衍生的体外生物膜中的细菌呼吸和糖酵解。SNaP牙膏中使用的特定稳定策略对氟化亚锡的抗菌性能至关重要,因为这种配方比使用葡萄糖酸盐稳定的含相同数量氟化亚锡的牙膏更能有效降低细菌的代谢活动。临床研究支持体外研究结果,表明定期使用 SNaP 牙膏可显著、持久地减少五种口腔微环境中的存活细菌数量:实际意义:SNaP 牙膏中高度稳定的亚锡离子具有强效、持久的抗菌活性,有助于改善口腔卫生,并有可能降低蛀牙、早期牙龈疾病、牙结石和口臭的风险,而这些疾病都与口腔细菌有关。
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引用次数: 0
Position, Angulation, and Sink Depth: Aspects of Therapy Used to Avoid and Modify Suboptimal Implant Placement. 位置、角度和下沉深度:用于避免和改变不理想种植体植入的治疗方法。
John Cavallaro, Gary Greenstein

Careful treatment planning, both clinically and radiographically, and when needed, utilization of a surgical guide, are prerequisites for proper implant placement. Accurate implant insertions with respect to position, angulation, and sink depth facilitate successful fabrication of prosthetic constructs. However, non-optimally located fixtures concerning these three facets of therapy can create biologic and prosthetic complications. This article discusses guidelines for correct implant insertions and for adjustments to surgical and prosthetic protocols to diminish problems associated with suboptimal implant placements.

在临床和影像学上仔细制定治疗计划,并在必要时使用手术导板,是正确植入种植体的先决条件。准确的种植体植入位置、角度和植入深度有助于修复体的成功制作。然而,如果这三个方面的固定位置不理想,就会造成生物和修复并发症。本文讨论了正确植入种植体以及调整手术和修复方案的指导原则,以减少因种植体植入不理想而引起的问题。
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引用次数: 0
Diagnosis and Nonsurgical Treatment of Periodontitis: Pragmatic Utilization of Contemporary Knowledge. 牙周炎的诊断和非手术治疗:实用当代知识。
Gary Greenstein, Sultan Albeshri

When treating patients with periodontitis, clinicians need to consider a number of diagnostic issues in light of contemporary knowledge. Such factors include the etiology of periodontal diseases, patterns of disease progression, interpretations of bleeding on probing, hypermobility, radiographs, and probing assessments. Root planing should be limited to areas that are inflamed or have calculus to avoid removal of cementum and inducing root sensitivity. Periodic professional maintenance visits should be based on the patient's periodontal status and ability to comply with maintenance protocols.

在治疗牙周炎患者时,临床医生需要根据现代知识考虑一系列诊断问题。这些因素包括牙周疾病的病因、疾病进展的模式、探诊出血的解释、活动度过大、X 光片和探诊评估。根面平整应仅限于发炎或有牙结石的区域,以避免去除骨水泥和引起牙根敏感。应根据患者的牙周状况和遵守维护方案的能力定期进行专业维护检查。
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引用次数: 0
Oral Health and Cognitive Decline in an Aging Population. 老龄人口的口腔健康和认知能力下降。
Sonu Acharya, Sheetal Acharya

As the global population ages, there is a growing recognition of the multifaceted impact of aging on various aspects of health and well-being. Oral ailments and conditions linked to the aging process increase the demand for preventive, restorative, and periodontal dental interventions. This holds particularly true for individuals aged 65 and above, specifically those facing economic disadvantages, belonging to racial or ethnic minority communities, or residing in institutions, experiencing disabilities, or being confined to their homes.1.

随着全球人口的老龄化,人们越来越认识到老龄化对健康和福祉的多方面影响。与老龄化进程相关的口腔疾病和状况增加了对预防、修复和牙周牙科干预的需求。这对于 65 岁及以上的人来说尤其如此,特别是那些面临经济困境、属于少数种族或少数族裔社区、或居住在机构中、身患残疾或被限制在家中的人。
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引用次数: 0
The Evolution of Adhesives Leads to Current Innovations. 粘合剂的演变引发了当前的创新。
Macarena Rivera, Markus B Blatz

Adhesive dentistry represents a crucial aspect of daily clinical practice. Occasionally, the introduction of a new material or technique triggers a significant shift in this field. Over the decades, from the largely ineffective systems of the late 1970s and early 1980s to the relatively successful total-etch and self-etch systems of today, the evolution of adhesive systems has been driven by a quest for simplicity, efficiency, and reliability in clinical practice procedures to achieve durable direct and indirect restorations.1.

粘接牙科是日常临床实践的一个重要方面。偶尔,一种新材料或新技术的引入会引发这一领域的重大转变。几十年来,从 20 世纪 70 年代末和 80 年代初基本无效的粘接剂系统到如今相对成功的全酸蚀和自酸蚀系统,粘接剂系统的演变一直是由临床实践程序中对简单、高效和可靠的追求所推动的,以实现持久的直接和间接修复。
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引用次数: 0
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Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
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