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Nitrous Oxide Analgesia in Dentistry: From Mechanism to Clinical Integration. 牙科氧化亚氮镇痛:从机制到临床整合。
Lynda Jiayi Wo, Aviv Ouanounou

A colorless, nonflammable, virtually odorless gas, nitrous oxide is widely used in medicine and dentistry for its anxiolytic, analgesic, and amnesic properties. In the dental setting, it is particularly valuable for its ability to reduce pain perception, alleviate anxiety, and induce a state of conscious sedation while maintaining patient cooperation and protective reflexes. Nitrous oxide exerts its effects rapidly and predictably, making it a versatile tool for managing patients with dental fear, special healthcare needs, or those undergoing lengthy or uncomfortable procedures. Its suggestive properties further enhance its utility by facilitating communication and trust between the patient and healthcare provider, often serving as an adjunct to behavioral management strategies. With its rapid onset and recovery, minimal systemic effects, and excellent safety attributes when administered appropriately, nitrous oxide is deemed one of the safest pharmacological agents for sedation in dental practice. The gas has an extensive history of clinical use, with well-established guidelines for its safe administration. Nevertheless, clinicians must remain vigilant to potential adverse effects, including nausea, diffusion hypoxia, or rare idiosyncratic reactions, and be equipped to manage emergencies should they arise. Proper patient selection, preparation, and monitoring are essential to ensuring effective and safe sedation outcomes. This article provides a comprehensive overview of nitrous oxide sedation, including its pharmacodynamics and pharmacokinetics, indications and contraindications, potential side effects, emergency protocols, and practical guidelines for administration. Clinical considerations relevant to dental practitioners are emphasized, offering an evidence-based approach to integrating nitrous oxide into routine dental care.

一氧化二氮是一种无色、不易燃、几乎没有气味的气体,因其抗焦虑、镇痛和健忘症的特性而广泛用于医学和牙科。在牙科治疗中,它特别有价值,因为它能够减少疼痛感知,减轻焦虑,并在保持患者合作和保护性反射的同时诱导有意识的镇静状态。一氧化二氮的作用迅速而可预测,使其成为一种万能的工具,用于治疗有牙科恐惧、特殊医疗需求或经历漫长或不舒服的手术的患者。它的暗示属性通过促进患者和医疗保健提供者之间的沟通和信任进一步增强了它的效用,通常作为行为管理策略的辅助手段。氧化亚氮起效快,恢复快,对全身的影响小,并且在适当使用时具有良好的安全性,被认为是牙科实践中最安全的镇静药物之一。该气体具有广泛的临床使用历史,具有完善的安全管理指南。然而,临床医生必须对潜在的不良反应保持警惕,包括恶心、弥漫性缺氧或罕见的特殊反应,并做好应对紧急情况的准备。适当的患者选择、准备和监测是确保有效和安全镇静结果的必要条件。这篇文章提供了一氧化二氮镇静的全面概述,包括其药效学和药代动力学,适应症和禁忌症,潜在的副作用,急救方案和实用的给药指南。临床考虑相关的牙科医生强调,提供了一个基于证据的方法,将一氧化二氮纳入常规牙科护理。
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引用次数: 0
Hypercementosis Progression With Evidence of Acquired Concrescence: A Case Report. 积血进展伴获得性愈合:1例报告。
Olysia Takla, Ashley L Madern, Karen Berrigan, Pili Peters

This case report highlights the importance of periodic dental examinations in identifying progressive hypercementosis and its rare complication, root concrescence, which can complicate future dental extractions. Hypercementosis may be idiopathic or secondary to either local factors or systemic disorders. However, evolution to concrescence raises questions about future treatment approaches should the involved teeth become nonrestorable and require extraction. This article presents a case of generalized hypercementosis affecting multiple quadrants with progression. The severe hypercementosis led to concrescence of Nos. 25/26 and 29/30 surrounded by one joint lamina dura. Generalized wear was noted on all occlusal and incisal surfaces of dentition with periodontal pocket depths of teeth Nos. 29 and 30 buccally of 3 mm and 2 mm and distally of 3 mm and 4 mm, respectively. Periapical radiographs from full-mouth series x-rays revealed that the roots of both teeth were grossly thickened, bulbous, and blunted. Because of a lack of contributory medical history, the presumptive diagnosis was hypercementosis sequela to occlusal trauma.

本病例报告强调了定期牙科检查的重要性,以确定进行性积血症及其罕见的并发症,牙根愈合,这可能会使未来的拔牙复杂化。充血症可能是特发性或继发于局部因素或全身性疾病。然而,进化到愈合提出了未来治疗方法的问题,如果涉及的牙齿变得不可修复和需要拔牙。这篇文章提出了一个病例的广泛性积血影响多个象限与进展。严重的积血导致25/26号和29/30号关节粘连,被一个关节硬膜包围。牙列咬合面和牙列切面均出现普遍磨损,29号和30号牙的牙周袋深度上颌分别为3 mm和2 mm,上颌为3 mm和4 mm。全口系列x光片显示两颗牙的牙根明显变厚,呈球根状,变钝。由于缺乏相关病史,推测诊断为咬合创伤所致积血过多。
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引用次数: 0
Full Rehabilitation in an Open-Bite Case Using Lithium Disilicate and Custom Digital Design. 使用二硅酸锂和定制数字设计的开咬病例的完全康复。
Oleksandr Tierientiev

This article presents a clinical case of a comprehensive full-mouth rehabilitation in a 26-year-old female patient with an anterior open bite and accompanying mild chronic generalized periodontitis. Contemporary digital methods involving diagnosis, modeling, and restoration fabrication were utilized. The case encompassed the use of CAD software, a Kois deprogrammer, extraction of impacted molars, cut-back technique, and artistic layering of ceramics on a lithium-disilicate framework. Significant improvements were demonstrated in both esthetics and function, with results remaining stable after 1 year of follow-up.

这篇文章提出了一个临床病例的全面全口康复在26岁的女性患者前开咬和伴随轻度慢性全身性牙周炎。现代数字化方法包括诊断、建模和修复制作。该案例包括使用CAD软件、Kois去编程器、拔牙、切牙技术和在二硅酸锂框架上艺术地分层陶瓷。美观和功能均有显著改善,随访1年后结果保持稳定。
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引用次数: 0
A 6-Month Randomized Controlled Trial to Measure the Efficacy of a Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) on Dental Plaque and Gingivitis. 一项为期 6 个月的随机对照试验,以衡量硝酸盐和磷酸盐稳定亚锡氟化物牙膏 (SNaP) 对牙菌斑和牙龈炎的疗效。
Sean Lee, Yiming Li, Luis R Mateo, Guofeng Xu, Carl P Myers, Divino Rajah, Nicky Li, Yun-Po Zhang

Background: The objective of this randomized controlled trial was the comparison of a stannous fluoride (SnF2) dentifrice stabilized with nitrate and phosphates (test) to a regular fluoride dentifrice (negative control) for the control of plaque and gingivitis over 6 months.

Methods: A total of 80 adult participants were enrolled in this study that was conducted in Loma Linda, California. After randomization and blinding of study personnel and patients, enrolled participants were provided instructions for the use of their assigned dentifrice. At three visits (0, 3, and 6 months), various gingival and plaque indices were collected to determine the clinical efficacy of the SnF2 stabilized dentifrice. These results were compared with the results of the negative control dentifrice.

Results: A total of 77 participants completed the study. The test dentifrice demonstrated statistically significant reductions versus baseline in all plaque and gingivitis indices after 3 and 6 months of product use. The negative control dentifrice demonstrated significant reductions versus baseline in all plaque indices, but not gingivitis indices, after 3 months of product use and in all plaque and gingivitis indices after 6 months of product use, with the exception of the interproximal gingivitis index, which did not reach statistical significance. The test SnF2 dentifrice showed statistically significant reductions in all plaque and gingivitis indices compared to baseline and with the negative control dentifrice (P less than .001) after 3 months and 6 months of product use.

Conclusions: The results of this clinical trial showed statistically significantly improved clinical outcomes for reduction of gingival inflammation and improvement in plaque control over 6 months when using a new SnF2 dentifrice stabilized with nitrate and phosphates as compared to the results from a regular fluoride dentifrice.

Practical implications: This newly formulated SnF2 dentifrice may be of benefit to patients who need help controlling plaque biofilm and in reducing gingivitis, leading to an improvement in overall oral health.

背景:这项随机对照试验的目的是比较一种用硝酸盐和磷酸盐稳定的亚锡氟化物(SnF2)牙膏(试验)和一种普通含氟牙膏(阴性对照)在6个月内对牙菌斑和牙龈炎的控制效果:这项研究在加利福尼亚州洛马琳达市进行,共有 80 名成人参加。在对研究人员和患者进行随机分组并设置盲区后,研究人员向参加者提供了指定牙膏的使用说明。在三次检查(0、3 和 6 个月)中,收集了各种牙龈和牙菌斑指数,以确定 SnF2 稳定型牙膏的临床疗效。这些结果与阴性对照牙膏的结果进行了比较:共有 77 位参与者完成了研究。使用 3 个月和 6 个月后,测试牙膏的所有牙菌斑和牙龈炎指数与基线相比均有统计学意义的显著降低。阴性对照牙膏在使用产品 3 个月后,所有牙菌斑指数与基线相比都有显著降低,但牙龈炎指数没有显著降低;在使用产品 6 个月后,所有牙菌斑和牙龈炎指数与基线相比都有显著降低,但边缘间牙龈炎指数除外,该指数没有达到统计学意义。在使用 SnF2 牙膏 3 个月和 6 个月后,与基线相比以及与阴性对照牙膏相比,试验用 SnF2 牙膏在所有牙菌斑和牙龈炎指数方面都有统计学意义的显著降低(P 小于 0.001):这项临床试验的结果表明,与普通含氟牙膏的结果相比,使用硝酸盐和磷酸盐稳定的新型 SnF2 牙膏 6 个月后,在减少牙龈炎症和改善牙菌斑控制方面的临床效果有明显的统计学改善:这种新配制的 SnF2 牙膏可能对需要帮助控制牙菌斑生物膜和减少牙龈炎的患者有益,从而改善整体口腔健康。
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引用次数: 0
Alpha Omega: Envisioning the Next Generation of Leaders. 阿尔法-欧米茄:展望下一代领导人。
Marc Rothman

The Alpha Omega International Dental Society represents around 5,000 active dentists and dental students across the United States, Canada, South America, Europe, Israel, South Africa, Australia, and New Zealand, with combined charitable contributions estimated at over $60 million. As the oldest international Jewish dental society in the world, Alpha Omega was founded in Baltimore, Maryland, in 1907, with a mission to combat the widespread anti-Semitism present in educational institutions and the broader dental community. From its inception, philanthropy has been central to its goals.

阿尔法-欧米茄国际牙科协会代表着美国、加拿大、南美、欧洲、以色列、南非、澳大利亚和新西兰约 5,000 名活跃的牙科医生和牙科学生,其慈善捐款总额估计超过 6,000 万美元。作为世界上历史最悠久的国际犹太牙科协会,阿尔法欧米茄于 1907 年在马里兰州巴尔的摩市成立,其使命是打击教育机构和广大牙科社区中普遍存在的反犹太主义。自成立以来,慈善事业一直是其目标的核心。
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引用次数: 0
Plasma Cell Gingivitis With Plasma Cell Cheilitis: A Diagnostic Challenge. 浆细胞性龈炎伴浆细胞性龈炎:诊断难题。
Lata Goyal, Shivani Bansal, Arshad Ernakulum, Manjit Kaur Rana

Plasma cell gingivitis and cheilitis are diagnostic challenges for dental practitioners. To the best of the authors' knowledge, concomitant plasma cell gingivitis and plasma cell cheilitis in the same patient has not been reported in the dental literature, although these conditions have been reported separately (on lips and gingiva) several times. Underreporting of these coexisting clinical conditions may be attributed to a lack of awareness of both conditions and underperformance of comprehensive histopathological examinations. This article describes a case of plasma cell gingivitis with plasma cell cheilitis in a 63-year-old female patient. Histopathology and immunohistochemistry evaluations confirmed the diagnosis. After being informed about her condition and educated about possible allergens, which could be present in certain toothpastes, foods, and other foreign substances, the patient responded well to the stoppage of the use of suspected allergens. Identification and elimination of causative allergens is considered the accepted treatment for these conditions.

浆细胞性牙龈炎和牙龈颊炎是牙科医生在诊断上面临的难题。据作者所知,牙科文献中从未报道过同一患者同时患有浆细胞性龈炎和浆细胞性咽颊炎的病例,尽管这两种病症已分别报道过多次(嘴唇和牙龈)。对这两种并存临床症状的报告不足可能是由于人们对这两种疾病缺乏认识,以及没有进行全面的组织病理学检查。本文描述了一例 63 岁女性患者浆细胞性龈炎合并浆细胞性咽颊炎的病例。组织病理学和免疫组化评估证实了这一诊断。在被告知病情并了解可能存在于某些牙膏、食物和其他外来物质中的过敏原后,患者对停止使用可疑过敏原反应良好。确定并消除致敏原被认为是治疗这些病症的公认方法。
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引用次数: 0
Digital Workflow for a Definitive Implant-Supported Hybrid Prosthesis. 确定性种植体支撑混合假体的数字化工作流程。
Julian Conejo, Alejandro Sanchez-Lara, Christina Rivet, Frank LaMar

Implant-supported hybrid prostheses have become popular solutions when treating patients with terminal dentitions or who are completely edentulous. Since the implementation of osseointegrated dental implants to treat edentulism, multiple prosthetic designs and materials have been used for full-arch fixed hybrid prostheses. While these restorations can be highly successful, the most common restorative failures are attributed to lack of prosthetic space or a framework without passive fit, consequently leading to possible chippings, delamination, and/or fractures. This article reviews the clinical and laboratory steps for fabrication of definitive implant-supported hybrid prostheses with the implementation of bone reduction guides, implant osteotomy guides, and immediate provisionalization using digital manufacturing technologies.

种植体支持的混合修复体已成为治疗末牙或全口无牙患者的常用解决方案。自从采用骨结合种植体治疗缺牙症以来,已有多种修复设计和材料被用于全牙弓固定混合修复体。虽然这些修复体可以非常成功,但最常见的修复失败是由于修复体空间不足或框架没有被动配合,因此可能导致崩裂、分层和/或骨折。本文回顾了使用数字化制造技术制作最终种植体支持混合修复体的临床和实验室步骤,包括骨缩小导板、种植体截骨导板和即刻临时修复。
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引用次数: 0
Advanced Oral Health Protection: A Multifunctional Dentifrice Designed to Prevent Oral Diseases and Conditions. 高级口腔健康保护:旨在预防口腔疾病和病症的多功能牙膏。
Cassiano Kuchenbecker Rösing

In 1948, the United Nations General Assembly in Paris declared that a standard of health was a universal human right.1 There is no reason to suggest that this affirmation should not include oral health as well. Oral health is a human right! Oral diseases are a public health problem that impair quality of life and generate increased costs and demands.2 The World Economic Forum reported this year that almost half the world's population suffers from oral diseases that impact daily life and subject the population to a higher risk of systemic health issues.3 It is time for radical policy action. Governments, industries, academic institutions, and scientific organizations must help change the burden of oral diseases.4 Concerned about the lack of attention to oral health, a historic resolution was adopted by the World Health Assembly in 2021 stating that oral health should be firmly embedded within the noncommunicable disease agenda and that oral healthcare interventions should be included in universal health coverage programs.5.

1948 年,巴黎联合国大会宣布,健康标准是一项普遍人权1 。口腔健康是一项人权!口腔疾病是一个公共卫生问题,损害生活质量,增加成本和需求。2 世界经 济论坛今年报告说,世界上几乎一半的人口患有口腔疾病,影响日常生活,并使 人口面临更高的系统性健康问题风险。4 出于对口腔健康缺乏关注的担忧,世界卫生大会于 2021 年通过了一项历史性决议,指出应将口腔健康牢牢纳入非传染性疾病议程,并将口腔保健干预措施纳入全民医保计划。
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引用次数: 0
Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) Reduces Oral Malodor: A Randomized Clinical Study. 硝酸盐和磷酸盐稳定亚锡氟化物牙膏(SNaP)可减少口腔异味:随机临床研究》。
Aileen Cabelly, Mania Bankova, Jason Darling, Tracy Bariexca, Catalina Monroy, Deyu Hu, Luis R Mateo, Pamela Monty, Robert D'Ambrogio, Maria Ryan, Yun-Po Zhang

Background: Oral malodor, whether from systemic disease, dietary sources, or bacteria in the oral cavity, can negatively impact patients' quality of life. Oral malodor due to bacteria in the oral cavity can be managed by mechanically or chemically removing bacteria. Dentifrices are ideal vehicles to deliver therapeutic active ingredients that promote and maintain oral health since most consumers brush their teeth daily. Consumer preference drives consistency in oral hygiene routine. This study first identified a favorite flavor via consumer flavor testing and then measured the clinical efficacy of the dentifrice with a new flavor formulation to reduce malodor.

Methods: Consumer testing was conducted via an online product evaluation questionnaire to gauge consumer flavor preferences for stannous fluoride toothpaste stabilized with nitrate and phosphates (SNaP). In a 3-week randomized, single-center, double-blind clinical study, the malodor reduction ability of SNaP was compared to the negative control toothpaste containing 0.76% sodium monofluorophosphate via the organoleptic method.

Results: Consumer testing was used to determine a winning flavor for the new flavor formulation of SNaP tested in the clinical study. In this study, after 3 weeks of product use, on average, malodor clinical trial subjects (n = 97) randomized into the SNaP group had a 32.7% malodor score reduction from baseline (P less than .001) 12 hours post-brushing compared to a 9.4% reduction in the negative control group. Relative to the negative control group, the SNaP group had a statistically significant reduction of 25.7% (P less than .001) in oral malodor via organoleptic scores.

Conclusions: SNaP toothpaste delivered superior malodor reduction 12 hours post-brushing when compared to a negative control toothpaste.

Practical implications: Incorporating therapeutic active ingredients like stannous fluoride into toothpaste is an effective way to deliver oral health benefits, such as caries prevention, reduction in gingivitis and dentin hypersensitivity, and protection against enamel erosion and bad breath.

背景:无论是全身性疾病、饮食来源还是口腔细菌引起的口腔异味,都会对患者的生活质量产生负面影响。口腔细菌引起的口腔异味可通过机械或化学方法清除细菌。由于大多数消费者每天都要刷牙,因此牙膏是提供促进和维护口腔健康的治疗活性成分的理想载体。消费者的偏好推动了口腔卫生常规的一致性。本研究首先通过消费者口味测试确定了消费者最喜欢的口味,然后测量了采用新口味配方的牙膏在减少口腔异味方面的临床疗效:方法:通过在线产品评估问卷进行消费者测试,以了解消费者对硝酸盐和磷酸盐稳定亚锡氟化物牙膏(SNaP)的口味偏好。在一项为期 3 周的随机、单中心、双盲临床研究中,通过感官法比较了 SNaP 与含有 0.76% 单氟磷酸钠的阴性对照牙膏的减少恶臭能力:通过消费者测试,确定了在临床研究中测试的 SNaP 新口味配方的优胜口味。在这项研究中,经过 3 周的产品使用后,随机分配到 SNaP 组的恶臭临床试验受试者(n = 97)在刷牙后 12 小时的恶臭评分与基线相比平均降低了 32.7%(P 小于 0.001),而阴性对照组则降低了 9.4%。与阴性对照组相比,SNaP 组通过感官评分获得的口腔异味评分在统计学上显著降低了 25.7%(P 小于 0.001):结论:与阴性对照牙膏相比,SNaP 牙膏能在刷牙后 12 小时内有效减少口腔异味:在牙膏中加入氟化亚锡等治疗活性成分是一种有效的口腔保健方法,可预防龋齿、减轻牙龈炎和牙本质过敏症、防止牙釉质侵蚀和口臭。
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引用次数: 0
Leveraging Digital Smile Design Technology in Esthetic Restorative Dentistry. 在牙科美容修复中利用数字微笑设计技术。
Macarena Rivera, Markus B Blatz

Digital smile design has transformed the approach to planning and executing esthetic dental treatments, allowing clinicians to digitally visualize and customize a patient's smile before taking any clinical interventions. By leveraging modern digital technologies, clinicians can streamline diagnostics and treatment planning while also improving accuracy in predicting the final results. This article explores the advantages of digital smile design in esthetic treatment planning along with the key principles of smile design and facial harmony that must be considered for a successful smile transformation.

数字微笑设计改变了牙科美容治疗的规划和执行方法,使临床医生能够在采取任何临床干预措施之前,以数字方式可视化和定制患者的微笑。通过利用现代数字技术,临床医生可以简化诊断和治疗计划,同时提高预测最终结果的准确性。本文探讨了数字化微笑设计在美容治疗规划中的优势,以及成功的微笑改造必须考虑的微笑设计和面部和谐的关键原则。
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引用次数: 0
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Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
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