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Progress in Understanding Metabolic Syndrome and Knowledge of Its Complex Pathophysiology 代谢综合征及其复杂病理生理的研究进展
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-04-12 DOI: 10.3390/diabetology4020015
Birendra Kumar Jha, Mingma Lhamu Sherpa, Mohammad Imran, Yousuf Mohammed, Laxmi Akhileshwar Jha, Keshav Raj Paudel, Saurav Kumar Jha
The metabolic syndrome (MetS), first introduced by Haller in 1975, was sometimes also known as insulin resistance syndrome, syndrome X, and plurimetabolic syndrome. In 1989, it was rechristened by Kaplan as the “Deadly Quartet” based on a consolidation of central obesity, impaired glucose tolerance, dyslipidemia, and systemic hypertension. MetS is positively associated with a pro-inflammatory and pro-thrombotic state, attributed to increased pro-thrombotic and inflammatory marker activity. Moreover, MetS is frequently associated with increased atherosclerotic cardiovascular disease, impaired glucose tolerance, hyperuricemia, obstructive sleep apnea, and chronic kidney disease. Despite concerted endeavors worldwide, the complexity of the pathophysiology of metabolic syndrome still needs to be clearly understood. Currently, therapeutic possibilities are confined to individual therapy for hyperglycemia, hypertension, hypertriglyceridemia, hyperuricemia, regular physical exercise, and a restricted diet. In this review, progress regarding the understanding and pathophysiology of MetS; recent emerging technologies, such as metabolomics and proteomics; the relation of MetS with obesity, diabetes, and cardiovascular diseases; and the association of MetS with COVID-19 are discussed.
代谢综合征(MetS)于1975年由Haller首次提出,有时也被称为胰岛素抵抗综合征、X综合征和多代谢综合征。1989年,卡普兰将其重新命名为“致命四重奏”,其基础是中枢性肥胖、糖耐量受损、血脂异常和全身性高血压的合并。MetS与促炎和促血栓状态呈正相关,归因于促血栓和炎症标志物活性的增加。此外,MetS通常与动脉粥样硬化性心血管疾病增加、糖耐量受损、高尿酸血症、阻塞性睡眠呼吸暂停和慢性肾脏疾病有关。尽管世界范围内的共同努力,代谢综合征的病理生理学的复杂性仍然需要清楚地了解。目前,治疗可能性仅限于高血糖、高血压、高甘油三酯血症、高尿酸血症、定期体育锻炼和限制饮食的个体化治疗。本文综述了对MetS的认识和病理生理方面的进展;最近出现的技术,如代谢组学和蛋白质组学;MetS与肥胖、糖尿病、心血管疾病的关系;并讨论MetS与COVID-19的关系。
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引用次数: 1
Increasing the Representation of Women in Diabetes Research 增加女性在糖尿病研究中的代表性
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-30 DOI: 10.3390/diabetology4020014
K. Riches-Suman
Approximately half of all people with diabetes are women; however, the inclusion of women at all levels of research on diabetes is lacking. Clinical and pre-clinical trials do not have gender equity despite the differing progression of diabetes complications in women, and fewer women sit in academic or clinical leadership positions in diabetes than men. Whilst this scenario is not unique to diabetes, the purpose of this opinion article is to evaluate women’s position in diabetology and focus on why the drive for gender equity at all levels is important. This article serves as a preface to the upcoming Diabetology Women’s Special Issue Series, which aims to highlight and celebrate the achievements of women and people who identify as women in the hope of raising female voices in diabetes research and practice.
大约一半的糖尿病患者是女性;然而,在糖尿病的各级研究中,妇女的参与是缺乏的。尽管女性糖尿病并发症的进展不同,但临床和临床前试验并没有实现性别平等,而且在糖尿病的学术或临床领导职位上,女性比男性少。虽然这种情况并不是糖尿病所独有的,但这篇观点文章的目的是评估女性在糖尿病学中的地位,并关注为什么在各个层面上推动性别平等是重要的。这篇文章是即将出版的糖尿病女性特刊系列的序言,旨在强调和庆祝女性和女性的成就,希望在糖尿病研究和实践中提高女性的声音。
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引用次数: 0
Lipodystrophies from Insulin Injection: An Update of the Italian Consensus Statement of AMD-OSDI Study Group on Injection Technique 胰岛素注射引起的脂肪营养不良:AMD-OSDI研究组关于注射技术的意大利共识声明的更新
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-03 DOI: 10.3390/diabetology4010013
S. Gentile, E. Satta, G. Guarino, F. Strollo
The causes and metabolic consequences of lipohypertrophy (LH) from incorrect insulin injection techniques have been well-known for a long time and are the subject of countless publications. However, only some researchers propose structured research modalities for LH and programs to teach patients how to prevent them and minimize their effects, thus contributing to complete rehabilitation. Experts and scientific societies have produced consensus documents and recommendations to spread the culture of LH and its complications among clinicians. However, they should go deeper into LH detection methods. This short article analyzes the recent literature on the best way to explore and find more or less evident LH lesions by using a structured and validated clinical methodology to benefit the many clinicians without access to technological equipment such as ultrasonography. This text also aims to bring awareness that since the last published recommendations on injection techniques, new needles for insulin injection, more technologically advanced and suitable for specific populations, have come to market but still need a thorough evaluation.
由于不正确的胰岛素注射技术引起的脂肪肥大(LH)的原因和代谢后果已经众所周知了很长一段时间,并且是无数出版物的主题。然而,只有一些研究者提出了结构化的LH研究模式和方案,以指导患者如何预防和减少其影响,从而有助于完全康复。专家和科学协会已经产生了共识文件和建议,以传播黄体生成素文化及其并发症的临床医生。但是,他们应该更深入地研究LH的检测方法。这篇短文分析了最近的文献,通过使用结构化和经过验证的临床方法,探索和发现或多或少明显的LH病变的最佳方法,使许多没有超声检查等技术设备的临床医生受益。本文还旨在使人们认识到,自上次发表的注射技术建议以来,技术更先进、适合特定人群的胰岛素注射新针头已经上市,但仍需要进行彻底的评估。
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引用次数: 1
Diabetes Management in Danish Primary School: A Survey of Experiences of Parents of Children with Type 1 Diabetes 丹麦小学糖尿病管理:1型糖尿病儿童家长的经验调查
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-02 DOI: 10.3390/diabetology4010012
M. Iken, N. C. Mateu, L. Johansen, K. A. Pilgaard, A. K. Mouritsen, A. Schou, Line S. Høst, A. Ø. Nannsen, Kurt Kristensen, S. Hangaard, M. Madsen, D. Grabowski
Supporting diabetes self-care in school is important for optimal glycemic control and mental health. The aim of this study was to investigate parental experiences of diabetes management in Danish schools, with an emphasis on the importance of school staff support in self-care. This cross-sectional study surveyed parents of schoolchildren with type 1 diabetes aged 6 to 16 years in Denmark. The parents were identified among members of the Danish Diabetes Association and were invited to complete an online questionnaire. A total of 252 parents of schoolchildren with type 1 diabetes answered the questionnaire. Only 28% of the children had a designated staff member responsible for support in diabetes self-care during school hours. Having a designated staff member responsible for support in self-care was positively associated with parental experiences of better school–parent cooperation (p < 0.001), better experience of diabetes management in school (p < 0.001), and larger proportions of children and parents feeling comfortable in school (p = 0.022 and p = 0.049, respectively). School staff support was positively associated with better parental experience of diabetes management and with some parameters of mental health in schoolchildren with type 1 diabetes and their parents in Denmark.
在学校里支持糖尿病患者的自我护理对于最佳的血糖控制和心理健康非常重要。本研究的目的是调查丹麦学校糖尿病管理的家长经验,重点是学校工作人员在自我保健方面的支持的重要性。这项横断面研究调查了丹麦6至16岁1型糖尿病学童的父母。这些父母是丹麦糖尿病协会的成员,并被邀请完成一份在线问卷。共有252名1型糖尿病学童的家长回答了问卷。只有28%的儿童在上学期间有指定的工作人员负责糖尿病自我护理的支持。有指定的工作人员负责自我照顾的支持与家长体验到更好的学校-家长合作(p < 0.001),更好的学校糖尿病管理体验(p < 0.001),更大比例的孩子和家长在学校感到舒适(p = 0.022和p = 0.049分别)呈正相关。在丹麦,学校工作人员的支持与更好的家长糖尿病管理经验和1型糖尿病学童及其家长的一些心理健康参数呈正相关。
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引用次数: 1
Achieving Remission in the Era of Clinical Inertia: What Is Preventing Us from Treating Type 2 Diabetes? 在临床惰性时代实现缓解:是什么阻碍了我们治疗2型糖尿病?
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-02-24 DOI: 10.3390/diabetology4010011
A. Suits, Ridhi R. Gudoor, J. Shubrook
Despite evolution in treatment options and improved understanding of pathophysiology, the treatment of type 2 diabetes remains unsatisfactory. Current management guidelines complicated by clinical inertia have resulted in over half of patients failing to meet glycemic targets. Expert consensus has defined a state of diabetes remission whereby treatment can induce sustained normalization of glucose levels. Evidence suggests that metabolic surgery, intensive lifestyle modification, and pharmacologic approaches are each viable options for achieving remission when implemented early in the disease course. The authors review each of these strategies and include practical considerations to aid in the pursuit of remission.
尽管治疗方案的发展和对病理生理学的理解的提高,2型糖尿病的治疗仍然不令人满意。目前的管理指南因临床惯性而复杂化,导致超过一半的患者未能达到血糖目标。专家共识已经定义了糖尿病缓解状态,通过治疗可以诱导血糖水平持续正常化。有证据表明,代谢手术、强化生活方式改变和药物治疗方法都是在病程早期实现缓解的可行选择。作者回顾了这些策略,并包括实际考虑,以帮助追求缓解。
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引用次数: 0
Managing Hospitalized Patients Taking SGLT2 Inhibitors: Reducing the Risk of Euglycemic Diabetic Ketoacidosis 管理服用SGLT2抑制剂的住院患者:降低血糖型糖尿病酮症酸中毒的风险
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-02-21 DOI: 10.3390/diabetology4010010
Julia Selwyn, Ariana R. Pichardo-Lowden
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are emerging as an important therapy not only for type 2 diabetes (T2DM), but also for heart disease and kidney disease. As these medicines gain acceptance, the number of hospitalized patients receiving them is likely to rise. During clinical trials, SGLT2 inhibitors were noted to have a potential risk for diabetic ketoacidosis (DKA), particularly DKA with relatively normal blood glucose levels, ‘euglycemic DKA’. Similar to DKA that is not associated with SGLT2 inhibitors, most of these events seem to be related to acute illnesses or other changes in a patient’s medications or self-management circumstances. This creates a need among hospital providers to create strategies to prevent DKA in their hospitalized patient and guidance on monitoring and treating euglycemic DKA. Our combined experience concerning this phenomenon has given a great deal of insight into this problem and the knowledge needed to improve patient care, by augmenting patient education, inpatient surveillance, and early treatment for euglycemic DKA.
钠-葡萄糖共转运蛋白-2 (SGLT2)抑制剂不仅是2型糖尿病(T2DM)的重要治疗药物,也是心脏病和肾脏疾病的重要治疗药物。随着这些药物被接受,接受它们的住院患者数量可能会增加。在临床试验中,SGLT2抑制剂被注意到具有糖尿病酮症酸中毒(DKA)的潜在风险,特别是血糖水平相对正常的DKA,“血糖正常的DKA”。与与SGLT2抑制剂无关的DKA类似,这些事件中的大多数似乎与急性疾病或患者药物或自我管理环境的其他变化有关。这使得医院提供者需要制定预防住院患者DKA的策略,并指导监测和治疗血糖正常性DKA。我们对这一现象的综合经验使我们对这一问题有了深入的了解,并通过加强患者教育、住院监护和早期治疗血糖正常的DKA来改善患者护理所需的知识。
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引用次数: 3
Knowledge of Diabetes among Adults at High Risk for Type 2 Diabetes in the Trivandrum District of Kerala, India 印度喀拉拉邦Trivandrum地区2型糖尿病高危人群的糖尿病知识
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-02-16 DOI: 10.3390/diabetology4010009
T. Sathish, K. Thankappan, Jeemon Panniyammakal, B. Oldenburg
We aimed to study the knowledge of diabetes among individuals with a high risk for developing type 2 diabetes in the Trivandrum district of the Indian state of Kerala. The baseline data collected from 1007 participants of the Kerala Diabetes Prevention Program were analyzed. Diabetes knowledge was assessed using a scale adapted from a large nationwide study conducted in India. The composite score of the scale ranged from 0 to 8. The mean age of the participants was 46.0 (SD: 7.5) years, and 47.2% were women. The mean diabetes knowledge score was 6.9 (SD: 2.1), with 59.5% having the maximum possible score of 8. Of the 1007 participants, 968 (96.1%) had heard the term diabetes, and of them, 87.2% knew that the prevalence of diabetes is increasing, 92.9% knew at least one risk factor for diabetes, 79.6% knew that diabetes can cause complications in organs, and 75.9% knew that diabetes can be prevented. While the overall level of knowledge of diabetes about its risk factors, complications, and prevention was generally high, an alarmingly low proportion of participants knew that diabetes can affect key organs such as the eyes (24.0%), heart (20.1%), feet (10.2%), and nerves (2.9%), and nearly a quarter (24.1%) were not aware that diabetes can be prevented. It is essential to educate high-risk individuals about diabetes complications and the importance of and strategies for diabetes prevention in the Trivandrum district of Kerala.
我们的目的是研究印度喀拉拉邦Trivandrum地区2型糖尿病高危人群的糖尿病知识。从喀拉拉邦糖尿病预防计划的1007名参与者收集的基线数据进行了分析。糖尿病知识的评估使用的量表改编自在印度进行的一项大型全国性研究。量表的综合得分范围为0 ~ 8分。参与者的平均年龄为46.0 (SD: 7.5)岁,其中47.2%为女性。平均糖尿病知识得分为6.9分(SD: 2.1),其中59.5%的患者最高可能得分为8分。在1007名参与者中,968人(96.1%)听说过“糖尿病”一词,其中87.2%知道糖尿病的患病率正在上升,92.9%知道至少一种糖尿病的危险因素,79.6%知道糖尿病可引起器官并发症,75.9%知道糖尿病可以预防。虽然对糖尿病的危险因素、并发症和预防的总体知识水平普遍较高,但知道糖尿病会影响关键器官如眼睛(24.0%)、心脏(20.1%)、脚(10.2%)和神经(2.9%)的参与者比例低得惊人,近四分之一(24.1%)的参与者不知道糖尿病可以预防。在喀拉拉邦Trivandrum地区,教育高危人群糖尿病并发症以及糖尿病预防的重要性和策略是至关重要的。
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引用次数: 0
The Lipids and Volume in Satiation and Satiety (LIVES) Hypothesis: A Proposed Alternative Model for the Pathogenesis of Obesity 饱腹和饱腹的脂质和体积(LIVES)假说:肥胖发病机制的另一种建议模型
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-02-14 DOI: 10.3390/diabetology4010008
A. Warrilow, K. Pumpa, S. Somerset, N. Naumovski
Obesity is one of the most important factors responsible for the marked increase in both the incidence and prevalence of type 2 diabetes mellitus (T2DM) in recent decades. Addressing the lifestyle factors associated with the progression to T2DM would present a potential rational early prevention strategy. The current evidence suggests that excessive energy intake is mediated via dietary fat. Biochemical signals released in response to the ingestion of food require supportive signalling from the presence of food in the stomach. The degree of supportive volume signalling emanating from the stomach influences both the satiation and satiety phases. The Lipids and Volume in Satiation and Satiety (LIVES) Hypothesis proposes that the biological feedback from fat intake appears to be influenced by the other macronutrients with which it is consumed. By identifying the various possible macronutrient combinations with fat, it is possible to construct a matrix of food composition/volume scenarios, which may help elucidate dysfunction in the human food energy regulation system within the context of the modern food environment.
肥胖是近几十年来2型糖尿病(T2DM)发病率和患病率显著增加的最重要因素之一。解决与T2DM进展相关的生活方式因素可能是一种合理的早期预防策略。目前的证据表明,过量的能量摄入是通过膳食脂肪介导的。摄入食物后释放的生化信号需要胃中食物的支持信号。从胃发出的支持量信号的程度影响饱腹期和饱腹期。饱腹和饱腹中的脂质和体积(LIVES)假说提出,脂肪摄入的生物反馈似乎受到摄入脂肪的其他常量营养素的影响。通过识别各种可能的宏量营养素与脂肪的组合,有可能构建食物成分/体积情景矩阵,这可能有助于阐明现代食品环境下人类食物能量调节系统的功能障碍。
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引用次数: 1
Editorial to “Gender Differences in Diabetes” 《糖尿病的性别差异》社论
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-02-03 DOI: 10.3390/diabetology4010007
G. Tonolo
Welcome to this Special Issue of Diabetology entitled “Gender Difference in Diabetes” [...]
欢迎来到本期题为“糖尿病的性别差异”的糖尿病学特刊[…]
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引用次数: 0
Transitioning to Telehealth during COVID-19: Experiences and Insights from Diabetes Prevention and Management Program Providers in Los Angeles County 2019冠状病毒病期间向远程医疗过渡:洛杉矶县糖尿病预防和管理项目提供者的经验和见解
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-01-31 DOI: 10.3390/diabetology4010006
S. Bullock, Telma Menendez, Liz Schwarte, Lisa Craypo, Jennifer T. Mosst, Gabrielle Green, N. Barragan, T. Kuo
The onset of the COVID-19 pandemic in March 2020 accelerated the efforts of several organizations providing the National Diabetes Prevention Program (National DPP) and the Diabetes Self-Management Education and Support (DSMES) program to rapidly transition from in-person service delivery to program administration via telehealth. Semi-structured interviews were conducted with 35 National DPP and DSMES experts and providers in Los Angeles County to gain a better understanding of the challenges and benefits associated with this transition. Interviews were completed during June to October 2021. Thematic analyses were performed using the Social-Ecological Model as a guiding framework. The analyses revealed several factors that influenced the transition, including at the individual (e.g., technology and health behaviors), interpersonal (e.g., social connections and support), organizational (e.g., provider workload and program enrollment and retention), community (e.g., recruitment), and policy (e.g., government support and reimbursement for telehealth services) levels. Findings suggest that the transition to telehealth was challenging for most National DPP and DSMES providers. However, because of its lower cost, ability to reach long distances virtually, and potential efficiency when employed as part of a hybrid approach, this delivery modality remains viable, offering benefits beyond the traditional program models.
2020年3月,2019冠状病毒病大流行的爆发加快了提供国家糖尿病预防计划(National DPP)和糖尿病自我管理教育和支持计划(DSMES)的几个组织的努力,以便通过远程医疗迅速从亲自提供服务过渡到项目管理。我们对洛杉矶县的35位国家级DPP和DSMES专家和供应商进行了半结构化访谈,以更好地了解这一转型带来的挑战和好处。访谈于2021年6月至10月完成。以社会生态模型为指导框架进行专题分析。分析揭示了影响转型的几个因素,包括个人(如技术和健康行为)、人际(如社会联系和支持)、组织(如提供者工作量和项目注册和保留)、社区(如招聘)和政策(如政府支持和远程医疗服务报销)层面。调查结果表明,向远程医疗过渡对大多数国家DPP和DSMES提供者来说是具有挑战性的。然而,由于其成本较低,能够虚拟地达到长距离,以及作为混合方法的一部分使用时的潜在效率,这种交付模式仍然是可行的,提供了超越传统项目模式的好处。
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引用次数: 2
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Diabetology
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