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[Postdural puncture headache in a 9-year-old female patient: treatment options and trajectory]. [1例9岁女性患者的硬脊膜后穿刺头痛:治疗方案和治疗轨迹]。
IF 1 Pub Date : 2026-01-12 DOI: 10.1007/s00101-025-01632-4
Michael Niedermair, Maria Rabl, Christiane Lentes, Bernhard Zelle, Eva Neuhierl, Bernhard Furtner, Lennar Riesinger, Uwe Wintergerst, Florian Neuhierl
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引用次数: 0
Desflurane, sustainability and the diversity of the anesthesiological armamentarium. 地氟醚,麻醉设备的可持续性和多样性。
IF 1 Pub Date : 2026-01-12 DOI: 10.1007/s00101-025-01638-y
Martin Schuster
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引用次数: 0
[A 4-year-old girl with traumatic carotid artery dissection and subsequent infarction of the middle cerebral artery]. [1例4岁女童外伤性颈动脉夹层并继发大脑中动脉梗死]。
IF 1 Pub Date : 2026-01-09 DOI: 10.1007/s00101-025-01634-2
Thorsten Walter, Mareike Schimmel, Stefan Siegert, Lars Behrens
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引用次数: 0
Operationalizing the 2025 S3 sepsis update in the ICU: three immediate auditable practice levers for safer, faster care. 在ICU实施2025年S3脓毒症更新:三个即时可审计的实践杠杆,以实现更安全、更快速的护理。
IF 1 Pub Date : 2026-01-09 DOI: 10.1007/s00101-025-01633-3
M Vijayasimha
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引用次数: 0
[Placement of central venous catheters in pediatric anesthesia : Indications, techniques and complications]. 【小儿麻醉中心静脉置管:指征、技术及并发症】。
IF 1 Pub Date : 2026-01-09 DOI: 10.1007/s00101-025-01628-0
Josefin Grabert, Ehrenfried Schindler

Even experienced anesthesiologists can be challenged when establishing a central venous catheter in children. In addition to the classical indications, a difficult peripheral vein access represents a relevant indication for a central venous catheter to avoid repeated traumatic puncture attempts. The size of the catheter utilized depends on the body weight and the vein diameter to prevent thrombotic complications. Irrespective of the chosen vein, the puncture should be performed under direct sonographic visualization of the needle tip and subsequently the wire. The internal jugular vein is the vessel of choice for the site of puncture due to its accessibility for sonography, ease of catheter placement and management as well as valuable hemodynamic information. To avoid exposure to ionizing radiation, the catheter tip positioning should be verified using sonography (transthoracic echocardiography, TTE) or intracavitary electrocardiography (ECG). The indications and dwell time should be critically assessed for all catheter placements to avoid complications such as catheter-associated bloodstream infections and thrombosis.

即使是经验丰富的麻醉师在为儿童建立中心静脉导管时也会受到挑战。除了经典适应症外,外周静脉通路困难是中心静脉导管的相关适应症,以避免重复的创伤性穿刺尝试。使用导管的大小取决于体重和静脉直径,以防止血栓并发症。无论选择何种静脉,穿刺应在直接超声显像下进行,针尖随后是导线。颈内静脉是穿刺部位的首选血管,因为它便于超声检查,易于导管放置和管理,以及有价值的血流动力学信息。为避免暴露于电离辐射,应使用超声(经胸超声心动图,TTE)或腔内心电图(ECG)验证导管尖端定位。应严格评估所有导管置入的适应症和停留时间,以避免导管相关血流感染和血栓形成等并发症。
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引用次数: 0
Anesthetic diversity: a pillar of healthcare system resilience and a strategic imperative in an era of uncertainty. 麻醉药多样性:医疗保健系统弹性的支柱和不确定时代的战略要求。
IF 1 Pub Date : 2026-01-08 DOI: 10.1007/s00101-025-01639-x
Peter Kranke, Robert Kleinberg, Patrick Meybohm, Beverly K Philip, Laurentiu Marin, Kai Zacharowski
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引用次数: 0
Antioxidative Spenderkonditionierung mit Dopamin zur Verbesserung der Transplantatfunktion nach Nierentransplantation. 多巴胺抗氧化供体调节以改善肾移植后的移植功能。
IF 1 Pub Date : 2026-01-08 DOI: 10.1007/s00101-025-01625-3
Peter Schnuelle, Benito Yard
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引用次数: 0
[Desflurane, sustainability and the diversity of the anaesthesiological armamentarium]. [地氟醚、麻醉设备的可持续性和多样性]。
IF 1 Pub Date : 2026-01-08 DOI: 10.1007/s00101-025-01637-z
Martin Schuster
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引用次数: 0
[Aerosol therapy in spontaneously breathing tracheostomized patients: an in vitro study]. 气雾剂治疗气管造口术患者自主呼吸的体外研究
IF 1 Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1007/s00101-025-01618-2
Y Kropp, K Barthel, G Beck, M Thiel, C Tsagogiorgas, M Otto
<p><strong>Background: </strong>Aerosol therapy is widely used in tracheostomized patients, particularly during prolonged weaning, to improve mucociliary clearance and manage bronchoconstriction; however, there is a lack of standardized guidelines to optimize nebulization therapy in this patient population. Different nebulizer types and interfaces can affect the efficiency of drug deposition, thereby affecting the therapeutic efficacy. Understanding these differences is essential to improve aerosol delivery strategies in clinical practice.</p><p><strong>Objective: </strong>This in vitro study aimed to evaluate the drug deposition rates of different aerosol generators and interfaces to determine the most effective combination for spontaneously breathing tracheostomized patients. Specifically, we compared the performance of a jet nebulizer and a vibrating mesh nebulizer in combination with different delivery interfaces: a face mask, a tracheostomy mask and a T-piece connected directly to the tracheostomy tube.</p><p><strong>Material and methods: </strong>The study used an in vitro model simulating a spontaneously breathing tracheostomized patient. Drug deposition rates were measured using a jet nebulizer (Cirrus™ 2, Intersurgical Beatmungsgeräte GmbH, Sankt Augustin, Germany) and a vibrating mesh nebulizer (Aerogen® Solo, Aerogen Ltd., Galway, Ireland). The aerosol was delivered with the help of a face mask, a tracheal mask and a T-piece. The lung deposition rate was quantified gravimetrically by analyzing salbutamol deposition in a filter placed at the simulated airway.</p><p><strong>Results: </strong>The vibrating mesh nebulizer demonstrated the highest drug deposition rate (19.32 ± 4.29%) when used with a T-piece, significantly outperforming the jet nebulizer, which achieved its highest deposition rate (12.33 ± 1.38%) with a face mask (p = 0.008). The mesh nebulizer also achieved a higher deposition rate than the jet nebulizer when a tracheostomy mask was used (p = 0.023 with 1 l O<sub>2</sub>/min supplementary flow, p < 0.001 with 8 l O<sub>2</sub>/min).</p><p><strong>Conclusion: </strong>The results suggest that the use of a vibrating mesh nebulizer connected directly to the tracheostomy tube via a T-piece can improve aerosol delivery efficiency in spontaneously breathing tracheostomized patients. The T‑piece functions as a small reservoir when a vibrating mesh nebulizer is used without additional oxygen supply, improving the deposition efficiency. Conversely, jet nebulizers require a continuous oxygen/air flow for operation; this can result in significant drug loss when used with a T-piece due to the continuous release of aerosol through the distal T‑piece opening. These findings are consistent with previous studies highlighting the benefits of mesh nebulizers in mechanically ventilated patients but extend this knowledge to spontaneously breathing tracheostomized individuals. Further clinical research is required to validate these in vitro re
背景:气雾疗法被广泛应用于气管造口术患者,特别是在长时间脱机期间,以改善纤毛粘液清除和控制支气管收缩;然而,缺乏标准化的指导方针来优化这类患者的雾化治疗。不同的雾化器类型和界面会影响药物沉积的效率,从而影响治疗效果。了解这些差异对于改善临床实践中的气溶胶输送策略至关重要。目的:评价不同气溶胶发生器和界面的药物沉积速率,以确定气管造口患者自主呼吸的最有效组合。具体来说,我们比较了喷射喷雾器和振动网状喷雾器在不同输送接口下的性能:面罩、气管造口面罩和直接连接气管造口管的t片。材料与方法:采用体外模型模拟气管造口术患者的自主呼吸。使用喷射喷雾器(Cirrus™2,Intersurgical Beatmungsgeräte GmbH,圣奥古斯丁,德国)和振动网状喷雾器(Aerogen®Solo, Aerogen Ltd., Galway,爱尔兰)测量药物沉积率。气溶胶是在面罩、气管面罩和t形罩的帮助下输送的。肺沉积率是通过分析沙丁胺醇沉积在一个过滤器放置在模拟气道的重量量化。结果:振动网状雾化器与t片配合使用时药物沉积率最高(19.32 ±4.29%),显著优于面罩配合使用时的喷射雾化器(12.33 ±1.38%)(p = 0.008)。使用气管造口面罩时,网状雾化器的沉积速率也高于喷射雾化器(p = 0.023,补充流量为1 1 O2/min, p 2/min)。结论:在气管造口患者中,使用振动网状雾化器通过t片直接连接气管造口管,可以提高气雾剂的输送效率。当使用振动网雾化器时,T片可作为小型储气罐,无需额外供氧,提高沉积效率。相反,喷射喷雾器需要连续的氧气/空气流动才能运行;当使用T片时,由于气溶胶通过远端T片开口不断释放,这可能导致显着的药物损失。这些发现与先前的研究一致,强调网状雾化器在机械通气患者中的益处,但将这一知识扩展到气管造口术患者的自发呼吸。需要进一步的临床研究来验证这些体外结果,并评估它们对患者结局、分泌物清除率和现实环境中治疗效果的影响。
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引用次数: 0
Effect of topical vibration on pain during scalp block injections in awake craniotomy and deep brain stimulation surgery : Analgesic effects of vibratory stimulation during scalp blocks. 局部振动对清醒开颅和深部脑刺激手术中头皮阻滞注射疼痛的影响:头皮阻滞时振动刺激的镇痛作用。
IF 1 Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI: 10.1007/s00101-025-01604-8
Nur Yilmaz, Ceyda Ozhan Caparlar, Aylin Kilincarslan, Fatma Ozkan Sipahioglu, Derya Ozkan, Caner Unluer

Background and aim: Awake craniotomy and deep brain stimulation (DBS) procedures require the patient to be awake and adequate anesthesia conditions are typically achieved using a scalp block. These procedures inherently involve some degree of pain from local anesthetic injections during scalp block administration. We aimed to reduce the injection pain in scalp blocks using a vibration stimulus.

Methods: A total of 56 patients aged between 18 and 75 years undergoing awake craniotomy and DBS procedures were enrolled in the study. All patients received a loading dose of dexmedetomidine before scalp block administration. Local anesthetic injections were applied sequentially to the identically named nerves on the right and left sides of the head. A vibration device was used during injections on one side, while injections on the other side were performed without vibration. The numeric rating scale (NRS) score and hemodynamic measurements during each injection, including heart rate and mean arterial pressure were compared between vibration and nonvibration sides.

Results: The NRS scores were lower on the side where vibration was used during scalp block injections (P < 0.001). Additionally, there was a decrease in heart rate and mean arterial pressure on the side where vibration was used compared to the baseline value (P < 0.005).

Conclusion: The study showed that using topical vibration during a scalp block can decrease the pain of a local anesthetic injection and maintain hemodynamic stability.

Trial registration: ClinicalTrials.gov (NCT06038825).

背景和目的:清醒开颅术和深部脑刺激(DBS)手术需要患者保持清醒,并且通常使用头皮阻滞来实现足够的麻醉条件。这些手术本身就涉及到头皮阻滞给药过程中局部麻醉注射带来的一定程度的疼痛。我们的目标是使用振动刺激来减少头皮块的注射疼痛。方法:56例年龄在18 ~ 75岁之间的患者接受清醒开颅和DBS手术。所有患者在头皮阻滞前均接受右美托咪定负荷剂量。局部麻醉注射依次应用于头部左右侧相同命名的神经。一侧注射时使用振动装置,另一侧注射时不振动。比较振动侧和非振动侧每次注射时的数值评定量表(NRS)评分和血流动力学测量,包括心率和平均动脉压。结果:头皮阻滞注射时使用振动的一侧NRS评分较低(P )结论:研究表明,头皮阻滞注射时使用局部振动可以减轻局麻注射的疼痛,保持血流动力学的稳定性。试验注册:ClinicalTrials.gov (NCT06038825)。
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Die Anaesthesiologie
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