Butt Fouziah, Stephenson Laura, Agnelli Luca, Villalobos Xenia, Carter Louise, Chown Rachel, De Filippo, Damian Silvia, Dienstmann Rodrigo, Formica Elisabetta, Garralda Elena, M. Donna, Graley Andrew, Landers Dónal, O'Regan Paul, Patil Akshita, Regan Aoife, K. Jennifer, Stevenson Julie, Walker Alison, Dive Caroline, H. Andrew
Digitalizing clinical trials provide an opportunity to address challenges faced in the Phase I trial settings, where near real-time data capture and data interpretation are prerequisites for iterative decision-making to rapidly adapt trial designs based on emerging insights. Although digital technologies have driven significant improvements in many businesses and organizations, the adoption of digital technologies in clinical trials has been slow. In recognition of this lag, the UpSMART consortium, a 5-year funded program (2020–2024), has been established in Europe between the UK, Spain, and Italy to embrace digital technologies and drive benefits to patients. The consortium, led by the Cancer Research UK Manchester Institute Cancer Biomarker Centre, aims to 'digitalize' Experimental Cancer Medicine Centres in the UK and Early Drug Development Units in Spain and Italy by open-sourcing and sharing digital healthcare products between participating centers across the consortium. The goal is to optimize data capture and interpretation thus accelerating Phase I clinical research to ultimately benefit patients by allowing faster access to tomorrow's medicines.
{"title":"The UpSMART Accelerator: driving digital innovation to change the conduct of early phase cancer medicine trials","authors":"Butt Fouziah, Stephenson Laura, Agnelli Luca, Villalobos Xenia, Carter Louise, Chown Rachel, De Filippo, Damian Silvia, Dienstmann Rodrigo, Formica Elisabetta, Garralda Elena, M. Donna, Graley Andrew, Landers Dónal, O'Regan Paul, Patil Akshita, Regan Aoife, K. Jennifer, Stevenson Julie, Walker Alison, Dive Caroline, H. Andrew","doi":"10.4103/digm.digm_3_21","DOIUrl":"https://doi.org/10.4103/digm.digm_3_21","url":null,"abstract":"Digitalizing clinical trials provide an opportunity to address challenges faced in the Phase I trial settings, where near real-time data capture and data interpretation are prerequisites for iterative decision-making to rapidly adapt trial designs based on emerging insights. Although digital technologies have driven significant improvements in many businesses and organizations, the adoption of digital technologies in clinical trials has been slow. In recognition of this lag, the UpSMART consortium, a 5-year funded program (2020–2024), has been established in Europe between the UK, Spain, and Italy to embrace digital technologies and drive benefits to patients. The consortium, led by the Cancer Research UK Manchester Institute Cancer Biomarker Centre, aims to 'digitalize' Experimental Cancer Medicine Centres in the UK and Early Drug Development Units in Spain and Italy by open-sourcing and sharing digital healthcare products between participating centers across the consortium. The goal is to optimize data capture and interpretation thus accelerating Phase I clinical research to ultimately benefit patients by allowing faster access to tomorrow's medicines.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"8 1","pages":"7 - 7"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuepeng Chen, Qianming Chen, Tingwu Su, Hongqi Zhang, Ting Kang, Mengqi Zhou, Jie Han, Nan Ning, Hai Lin
{"title":"Application progress of three-dimensional printing technology in orthodontics","authors":"Xuepeng Chen, Qianming Chen, Tingwu Su, Hongqi Zhang, Ting Kang, Mengqi Zhou, Jie Han, Nan Ning, Hai Lin","doi":"10.4103/digm.digm_36_22","DOIUrl":"https://doi.org/10.4103/digm.digm_36_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of models for predicting the objective response of immune checkpoint inhibitor therapy in patients with nonsmall-cell lung cancer","authors":"Jianguo Sun, Qiao Yang, Lin Cui, Yu Gao, Xiu Yang","doi":"10.4103/digm.digm_20_22","DOIUrl":"https://doi.org/10.4103/digm.digm_20_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The efficacy and safety of trifluridine/tipiracil plus bevacizumab compared with trifluridine/tipiracil monotherapy for metastatic colorectal cancer: A meta-analysis","authors":"D. Gu, Xiaowei Wei, Yutong Ge","doi":"10.4103/digm.digm_44_21","DOIUrl":"https://doi.org/10.4103/digm.digm_44_21","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70713173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Q. Yao, Pengfei Zheng, Jun Hu, Yiwei Wang, Minjie Fan
{"title":"The comparison of properties of Ti-6Aluminum-4Vanadium porous scaffolds fabricated through low-power selective laser Melting and electron beam melting","authors":"Q. Yao, Pengfei Zheng, Jun Hu, Yiwei Wang, Minjie Fan","doi":"10.4103/digm.digm_46_21","DOIUrl":"https://doi.org/10.4103/digm.digm_46_21","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70713677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new approach to Maslach Burnout Inventory: Measuring burnout syndrome in health-care staff with fuzzy conjoint analysis","authors":"Guney Gursel, Ömer Turunç","doi":"10.4103/digm.digm_2_22","DOIUrl":"https://doi.org/10.4103/digm.digm_2_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Telepresence robots to support telehealth during pandemics","authors":"Mingzhong Wang, Chongdan Pan, P. Ray","doi":"10.4103/digm.digm_15_22","DOIUrl":"https://doi.org/10.4103/digm.digm_15_22","url":null,"abstract":"","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70712115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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