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The efficacy of augmentative anti-rotational plating plus decortication and autogenic bone grafting for aseptic nonunion after intramedullary nailing of femoral shaft fracture 增强型抗旋转钢板加自体骨移植治疗股骨干骨折髓内钉术后无菌性骨不连的疗效
Pub Date : 2021-12-07 DOI: 10.1097/EC9.0000000000000022
Yonggang Li, Hanbing Xing, X. Qi, Mingxing Liu, Zhiyong Wang, Xiguang Sang
Abstract Background: Femoral interlocking intramedullary (IM) nailing fixation is an effective method for the treatment of femoral shaft fractures. Aseptic nonunion of femoral shaft fracture after IM nailing is uncommon. Currently, the treatment for aseptic femoral shaft nonunion is controversial. The aim of this study was to investigate the clinical effect of augmentative antirotational plating plus decortication and autogenic bone grafting for aseptic femoral shaft nonunion after IM nailing failure. Methods: A retrospective study was conducted on 25 cases of aseptic femoral shaft fracture nonunion treated with IM nailing from January 2015 to August 2019. All patients were treated by leaving the nail in situ, debridement of nonunion sites, decortication, autogenous iliac bone grafting, and augmentative antirotational plating fixation. The time to fracture union and complications were recorded. Results: All patients were followed up for 12–18 months. The union rate after revision surgery was 100%. The average union time was 5.5 months (range, 4-10). Subjective pain symptoms had disappeared in all patients. There were no incision infections or internal fixator fatigue fractures. Average scores of the physical function and bodily pain components of the SF-36 were 95.5 (range, 91-98) and 94.1 (range, 90-97), respectively. No other obvious complications occurred postoperatively. Conclusion: Augmentative antirotational plating plus decortication and autogenic bone grafting is an excellent choice for treating femoral shaft fracture nonunion after IM nailing; this approach has an overall high union rate and few complications.
摘要背景:股骨交锁髓内钉内固定是治疗股骨干骨折的有效方法。IM钉内固定后股骨干骨折无菌性骨不连不常见。目前,无菌性股骨干骨不连的治疗方法存在争议。本研究的目的是探讨增强型抗旋转钢板加去骨和自体骨移植治疗IM钉失败后无菌性股骨干骨不连的临床效果。方法:回顾性分析2015年1月至2019年8月应用IM钉治疗无菌性股骨干骨折不连25例的临床资料。所有患者均采用原位留钉、骨不连部位清创、去骨、自体髂骨移植和增强型抗旋转钢板内固定治疗。记录骨折愈合时间及并发症。结果:所有患者随访12-18年 月。翻修手术后的愈合率为100%。平均愈合时间为5.5 月(范围4-10)。所有患者的主观疼痛症状均消失。没有切口感染或内固定器疲劳性骨折。SF-36的身体功能和身体疼痛成分的平均得分分别为95.5(范围91-98)和94.1(范围90-97)。术后无其他明显并发症发生。结论:增强型抗旋转钢板加自体骨移植是治疗IM钉内固定后股骨干骨折不愈合的良好选择;这种方法总体上具有较高的愈合率和较少的并发症。
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引用次数: 0
Roles of ribosomal proteins in hematologic disorders and cancers: a review 核糖体蛋白在血液系统疾病和癌症中的作用:综述
Pub Date : 2021-12-07 DOI: 10.1097/EC9.0000000000000014
Jie Wang, F. Yan
Abstract Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation. In addition, ribosomal proteins also perform extra-ribosomal functions, such as participating in DNA replication, transcription, and damage repair, regulating cell growth, proliferation, apoptosis, and transformation. In recent years, studies have shown that alterations in ribosomal protein synthesis or function can lead to various hematologic diseases, including Diamond-Blackfan anemia, 5q-syndrome, Shwachman-Diamond syndrome, and other blood system diseases. Moreover, abnormal expressions of specific ribosomal protein genes have been reported in many malignant tumors. In this review, we elaborated on the changes in ribosomal proteins in hepatocellular carcinoma and colorectal, prostate, gastric, esophageal, and other cancers and discussed the relationship between ribosomal proteins and the occurrence of hematologic disorders and cancers.
摘要核糖体是细胞合成蛋白质的重要细胞器。它们由核糖体核糖核酸和80多种核糖体蛋白质组成。众所周知,核糖体蛋白质的一个基本功能是参与蛋白质翻译。此外,核糖体蛋白还具有额外的核糖体功能,如参与DNA复制、转录和损伤修复,调节细胞生长、增殖、凋亡和转化。近年来,研究表明核糖体蛋白合成或功能的改变会导致各种血液系统疾病,包括Diamond Blackfan贫血、5q综合征、Shwachman-Diamond综合征和其他血液系统疾病。此外,在许多恶性肿瘤中已经报道了特定核糖体蛋白基因的异常表达。在这篇综述中,我们详细阐述了肝细胞癌、结直肠癌、前列腺癌、胃癌、食道癌和其他癌症中核糖体蛋白的变化,并讨论了核糖体蛋白与血液系统疾病和癌症发生的关系。
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引用次数: 0
Protection in the eye room 眼室保护
Pub Date : 2021-12-01 DOI: 10.1097/ec9.0000000000000023
Matthew M Wilson
Ocular examinations in the emergency department (ED) provide an increased risk of coronavirus disease 2019 (COVID-19) transmission due to the close-proximity to the patient and inability to physical distance. In this article, I discuss the appropriate personal protective wear when undertaking an ocular examination in the ED. Copyright © 2022 Shandong University, published by Wolters Kluwer, Inc.
在急诊科(ED)进行眼部检查会增加2019冠状病毒病(COVID-19)传播的风险,因为与患者的距离很近,无法保持身体距离。在这篇文章中,我讨论了在ED进行眼部检查时适当的个人防护服。版权所有©2022山东大学,威科集团出版。
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引用次数: 0
Probable lumbar acute noncompressive nucleus pulposus extrusion 可能是腰椎急性非压缩性髓核挤压
Pub Date : 2021-12-01 DOI: 10.1097/ec9.0000000000000008
Changjun Chen, Xianlei Gao, Hao Li, Xin Pan, Songgang Wang
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引用次数: 0
Outcome of bystander cardiopulmonary resuscitation after out-of-hospital cardiac arrest in Beijing 北京院外心脏骤停后旁观者心肺复苏的结果
Pub Date : 2021-12-01 DOI: 10.1097/EC9.0000000000000002
Xian-Yu Shi, Yang Wu, Haibin Li, S. Ma, Dou Li, Ding Gao, H. Cui, Changxiao Yu, Song Yang, Ziren Tang, Fei Shao
Abstract Aim: We aimed to investigate the association between bystander cardiopulmonary resuscitation (CPR) and survival of patients with out-of-hospital cardiac arrests (OHCA) in Beijing. Methods: This observational study analyzed adult patients with OHCA treated by the Beijing emergency medical service (EMS) from January 2013 to December 2017. Data were collected in a Utstein style with a 1-year follow-up and a primary outcome of survival to hospital discharge. Secondary outcomes were return of spontaneous circulation (ROSC), survival to admission, favorable neurological outcome at hospital discharge, and survival and favorable neurological outcomes of up to 1 year. Results: A total of 5016 patients with OHCA from Beijing's urban area were recorded by EMS, wherein 765 patients (15.25%) underwent bystander CPR. The data were propensity score-matched forage, sex, location, witness, aetiology, initial rhythm, and call to EMS arrival to compare the difference between the occurrence and nonoccurrence of bystander CPR. The survival upon the discharge of patients who experienced bystander CPR was superior to that of patients who did not receive bystander CPR (3.7% vs 1.2%, respectively; P < 0.001). Moreover, patients with OHCA resuscitated with bystander CPR achieved better outcomes of ROSC, survival to admission, favorable neurological outcome at hospital discharge, survival and favorable neurological outcome after 1 year compared with those who were not resuscitated with bystander CPR. Conclusion: Survival and neurological outcome of patients who underwent bystander CPR was better than those who underwent nonbystander CPR in Beijing. However, the rate of bystander CPR was low.
摘要目的:探讨北京市院外心脏骤停(OHCA)患者的旁观者心肺复苏(CPR)与生存率之间的关系。方法:本观察性研究分析了2013年1月至2017年12月在北京急救中心接受治疗的成人OHCA患者。数据以Utstein方式收集,随访1年,主要结果为出院后的生存率。次要结果是恢复自然循环(ROSC)、入院生存率、出院时良好的神经系统结果以及长达1年的生存率和良好的神经功能结果。结果:北京市区共有5016例OHCA患者接受了EMS记录,其中765例(15.25%)患者接受了旁观者心肺复苏术。数据是倾向评分匹配的饲料、性别、地点、目击者、病因、初始节律和EMS到达电话,以比较旁观者心肺复苏的发生和不发生之间的差异。经过旁观者心肺复苏术的患者出院后的存活率高于未接受旁观者心肺切除术的患者(分别为3.7%和1.2%;P < 0.001)。此外,与未使用旁观者心肺复苏术的患者相比,使用旁观者心复苏术复苏的OHCA患者在ROSC、入院生存率、出院时良好的神经系统结果、1年后的生存率和良好的神经系统结果方面取得了更好的结果。结论:在北京,采用旁观者心肺复苏术的患者的生存率和神经系统结果优于采用非旁观者心肺切除术的患者。然而,旁观者心肺复苏术的发生率很低。
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引用次数: 2
Emergency care for chest pain in China: the unmet challenges 中国胸痛急救:尚未解决的挑战
Pub Date : 2021-11-22 DOI: 10.1097/EC9.0000000000000012
Jiali Wang, F. Xu, J. Pang, W. Zheng, Yuguo Chen
Abstract Jiali Wang and colleagues discuss challenges owing to the assessment and management of patients presenting to emergency department with acute chest pain in China and effective strategies to lessen the pressure on health care systems and improve quality of care.
摘要王佳丽及其同事讨论了在中国对急诊科急性胸痛患者进行评估和管理所面临的挑战,以及减轻医疗保健系统压力和提高护理质量的有效策略。
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引用次数: 0
Expert consensus on the emergency diagnosis and therapy of acute chest pain (English version) 急性胸痛急诊诊疗专家共识(英文版)
Pub Date : 2021-11-17 DOI: 10.1097/ec9.0000000000000019
Yuguo Chen
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引用次数: 0
Effects of therapeutic plasma exchange on survival in patients with postoperative liver failure: a retrospective single-center study 治疗性血浆置换对术后肝功能衰竭患者生存率的影响:一项回顾性单中心研究
Pub Date : 2021-11-17 DOI: 10.1097/EC9.0000000000000015
Yoshiro Kobe, Y. Tateishi, S. Oda
Abstract Background: Recent decreases in the incidence of postoperative liver failure (POLF) have been attributed to advances in surgical techniques, critical care, and postoperative management. However, POLF management remains a challenge, and worsening POLF is a significant cause of morbidity and mortality. Therapeutic plasma exchange (TPE) is used as a salvage strategy for POLF in some countries, and several studies conducted between 1980 and 1990 have reported the use of TPE for POLF. We conducted this retrospective single-center study to investigate the outcomes of patients with POLF treated with TPE. Methods: We retrospectively reviewed the charts of patients with POLF admitted to the intensive care unit who underwent TPE between November 2010 and March 2017. POLF was defined as the presence of persistent hyperbilirubinemia. Data on patient demographics, Glasgow Coma Scale score, platelet count, prothrombin time, and serum total bilirubin level were collected, and their Sequential Organ Failure Assessment scores were calculated. The lengths of postoperative hospital stays, lengths of post-TPE hospital stays, and patient outcomes were also analyzed. Results: TPE was performed in 20 patients with POLF during the study period. TPE was initiated on the 49th postoperative day and was performed for a median of five sessions. TPE improved hyperbilirubinemia and coagulopathy but had no effect on neurological and clinical symptoms. All 20 patients treated with TPE died after the 36th day (median) from the initial TPE. Conclusions: Although TPE may improve laboratory values in patients with POLF, the current study suggests that it has no survival benefit.
摘要背景:最近术后肝功能衰竭(POLF)发生率的下降归因于手术技术、重症监护和术后管理的进步。然而,POLF的管理仍然是一个挑战,POLF恶化是发病率和死亡率的重要原因。在一些国家,治疗性血浆置换(TPE)被用作POLF的抢救策略,1980年至1990年间进行的几项研究报告了TPE对POLF的使用。我们进行了这项回顾性单中心研究,以调查接受TPE治疗的POLF患者的结果。方法:我们回顾性回顾了2010年11月至2017年3月期间入住重症监护室接受TPE的POLF患者的病历。POLF被定义为存在持续性高胆红素血症。收集患者人口统计数据、格拉斯哥昏迷量表评分、血小板计数、凝血酶原时间和血清总胆红素水平,并计算其序贯器官衰竭评估评分。还分析了术后住院时间、TPE后住院时间和患者结局。结果:在研究期间对20例POLF患者进行了TPE。TPE于术后第49天开始,平均进行了5次治疗。TPE改善了高胆红素血症和凝血障碍,但对神经和临床症状没有影响。所有接受TPE治疗的20名患者在首次TPE后第36天(中位数)死亡。结论:尽管TPE可以提高POLF患者的实验室价值,但目前的研究表明,它对生存没有益处。
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引用次数: 0
Candidates and allocation time for extracorporeal membrane oxygenation in patients with cardiogenic shock 心源性休克患者体外膜氧合的选择和分配时间
Pub Date : 2021-11-17 DOI: 10.1097/EC9.0000000000000020
Baotao Huang
Abstract Extracorporeal membrane oxygenation (ECMO) is a last resort life support in several patients with cardiogenic shock. However, appropriate candidates and optimal timing of ECMO initiation need to be established. The present report reviewed relevant literatures to refine the allocation of ECMO in patients with cardiogenic shock. The PubMed database was searched from inception to October 5, 2020, using the following search terms: “extracorporeal membrane oxygenation” or “mechanical circulatory support” AND “cardiogenic shock” or “cardiac arrest” or “myocardial infarction” or “fulminant myocarditis.” The etiology of cardiogenic shock, widened QRS duration, QTc interval prolongation, cardiac arrest, dynamic narrowing of pulse pressure, and speed of lactate accumulation per unit time can be associated with the course of cardiogenic shock, and typically warn that advanced medical circulatory support is required. In the critical moment when the circulatory status deteriorates sharply, an immediate physical examination combined with ready-to-use tools such as monitoring data or blood gas analysis results is crucial for assessing the appropriateness and timing of ECMO initiation.
摘要体外膜肺氧合(ECMO)是几例心源性休克患者的最后生命支持。然而,需要确定ECMO启动的适当候选者和最佳时机。本报告回顾了相关文献,以完善ECMO在心源性休克患者中的分配。PubMed数据库从开始到2020年10月5日进行搜索,使用以下搜索词:“体外膜肺氧合”或“机械循环支持”和“心源性休克”或“心脏骤停”或“心肌梗死”或“暴发性心肌炎”,脉压的动态变窄和每单位时间乳酸积累的速度可能与心源性休克的过程有关,并通常警告需要先进的医疗循环支持。在循环状态急剧恶化的关键时刻,立即进行身体检查,并结合监测数据或血气分析结果等现成工具,对于评估ECMO启动的适当性和时机至关重要。
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引用次数: 0
The PIEZO1 gene mutation (c.2005G>T) causes iron overload cardiomyopathy: a case report PIEZO1基因突变(c.2005G>T)引起铁超载心肌病1例报告
Pub Date : 2021-11-17 DOI: 10.1097/EC9.0000000000000018
Sumei Cui, Huixia Lu, Shujian Wei, Chuanbao Li, F. Xu, Yuguo Chen
Supplemental Digital Content is available in the text Abstract Background: Cardiomyopathy has a variety of etiologies. Here, we report a case of iron overload cardiomyopathy (IOC) in combination with hereditary stomatocytosis (HST) due to a rare mutation in the PIEZO1 gene. Case summary: A 31-year-old man presented to the clinic with a new onset of fatigue and abdominal distension. He had a history of 9-year cholelithiasis, 4-year hemolytic anemia, 7-month diabetes mellitus (DM), and 6-month low sex drive. The specific features of bronze skin, liver palms, yellow eyes, DM, and cardiomyopathy raised our suspicion of hemochromatosis, which was confirmed by an elevated serum ferritin concentration and high transferrin saturation. Echocardiography and cardiovascular magnetic resonance (CMR) imaging demonstrated dilation of all cardiac cavities with a left ventricular ejection fraction of 30%. CMR T2∗ mapping showed myocardial, hepatic, and pancreatic siderosis. Next-generation sequencing identified one missense variant in the PIEZO1 gene (c.2005G>T), which conferred HST and hyperferritinemia. We screened his close family members and identified his son as a heterozygous carrier of this variant, who had intermittent jaundice. Conclusion: In this case, the PIEZO1 c.2005G>T mutation conferred HST and IOC, complicated with cholelithiasis, DM, and low sex drive. Bronze skin, liver cirrhosis, cardiomyopathy, and DM are red flags, while magnetic resonance imaging T2∗ mapping, blood iron metabolism markers, and gene testing are valuable in the diagnosis.
摘要背景:心肌病有多种病因。在这里,我们报告了一例铁过载心肌病(IOC)合并遗传性口细胞增多症(HST),由于PIEZO1基因的罕见突变。病例总结:一名31岁男性以新发疲劳和腹胀就诊。患者有9年胆石症病史,4年溶血性贫血病史,7个月糖尿病病史,6个月性欲低下病史。古铜色皮肤、肝掌、黄眼、糖尿病和心肌病的具体特征使我们怀疑血色素沉着症,血清铁蛋白浓度升高和高转铁蛋白饱和度证实了这一点。超声心动图和心血管磁共振(CMR)成像显示所有心腔扩张,左心室射血分数为30%。CMR T2 *测图显示心肌、肝脏和胰腺黄素沉着。下一代测序鉴定出PIEZO1基因的一个错义变异(c.2005G>T),该变异导致HST和高铁蛋白血症。我们对他的近亲进行了筛查,发现他的儿子是这种变异的杂合携带者,患有间歇性黄疸。结论:在本病例中,piezo1c . 2005g >T突变导致HST和IOC,并伴有胆石症、糖尿病和性欲低下。青铜色皮肤、肝硬化、心肌病和糖尿病是危险信号,而磁共振成像T2 *作图、血铁代谢标记物和基因检测在诊断中是有价值的。
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引用次数: 0
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Emergency and critical care medicine
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