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No benefit of hydrocortisone, ascorbic acid, and thiamine in reducing mortality in adult sepsis patients: a systematic review and meta-analysis 氢化可的松、抗坏血酸和硫胺素在降低成人败血症患者死亡率方面没有益处:一项系统回顾和荟萃分析
Pub Date : 2022-08-10 DOI: 10.1097/EC9.0000000000000036
Qing Zhao, Jian-guo Xiao, Huiyong Liu
Abstract Background Supplementation of corticosteroid, ascorbic acid and thiamine in adult septic patients remains controversial. We aimed to evaluate the efficacy and safety of hydrocortisone, ascorbic acid and thiamine (HAT) in adult septic patients. Methods Data search included Pumbed, EMBASE, and the Cochrane Library from inception to Sep, 2021. Only studies with classifications of sepsis and intravenous HAT treatment were included. Adult patients with sepsis (aged ≥18 years) were divided into 2 groups. The treatment group received HAT therapy, whereas the control group received standard care and/or intravenous hydrocortisone. The primary outcome was hospital mortality. Results Eleven studies including 4579 patients who fulfilled the predefined criteria were analyzed (6 randomized controlled trials [RCTs] and 5 clinical cohort studies). No hospital mortality reduction was demonstrated in patients treated with HAT when compared to the reference (OR: 0.99; 95% CI: 0.77 to 1.27; I2 = 39%) group. Sequential organ failure assessment (SOFA) score decrement at 72hours was more significant in HAT-treated patients (mean difference [MD]: –1.23; 95% CI: –1.94 to –0.53; I2 = 81%). There was no difference in the duration of vasopressor use between HAT-treated patients and controls (MD: –4.92; 95% CI: –24.38 to 14.53; I2 = 97%). Statistical heterogeneity was noted with no sign of significant publication bias. Conclusion In adult sepsis and septic shock patients, HAT treatment failed to reduce mortality or shorten vasopressor duration, but reduced SOFA scores.
摘要背景在成人脓毒症患者中补充皮质类固醇、抗坏血酸和硫胺素仍然存在争议。我们旨在评估氢化可的松、抗坏血酸和硫胺素(HAT)治疗成人败血症患者的疗效和安全性。方法从成立到2021年9月,数据检索包括Pumbed、EMBASE和Cochrane图书馆。仅包括败血症分类和静脉注射HAT治疗的研究。成年败血症患者(年龄≥18岁)分为2组。治疗组接受HAT治疗,而对照组接受标准护理和/或静脉注射氢化可的松。主要结果是住院死亡率。结果分析了11项研究,包括4579名符合预定义标准的患者(6项随机对照试验和5项临床队列研究)。与对照组相比,接受HAT治疗的患者的住院死亡率没有降低(OR:0.99;95%CI:0.77至1.27;I2=39%)。HAT治疗患者在72小时时的序贯器官衰竭评估(SOFA)评分下降更为显著(平均差异[MD]:-1.23;95%置信区间:-1.94至-0.53;I2=81%)。HAT治疗的患者和对照组使用血管升压药的持续时间没有差异(MD:–4.92;95%CI:–24.38至14.53;I2=97%)。统计异质性被注意到,没有显著的发表偏倚的迹象。结论在成人败血症和感染性休克患者中,HAT治疗未能降低死亡率或缩短血管升压药持续时间,但降低了SOFA评分。
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引用次数: 0
Dexmedetomidine-induced polyuria in the intensive care unit: a case report 右美托咪定在重症监护室诱发多尿:1例报告
Pub Date : 2022-06-22 DOI: 10.1097/EC9.0000000000000055
Nurcan Kutluer Karaca
Abstract Dexmedetomidine is an α2 agonist that is frequently used for sedation in intensive care units (ICUs). Hypotension and bradycardia are common adverse effects observed in clinical practice. In perioperative conditions, polyuria is a rare adverse effect with limited case reports after dexmedetomidine infusion. Similar to this situation, in ICU, there are rare cases. We present the case of a 59-year-old man who developed polyuria secondary to high-dose intravenous dexmedetomidine infusion in the medical ICU.
摘要右美托咪定是一种α2激动剂,经常用于重症监护室(ICU)的镇静。低血压和心动过缓是临床上常见的不良反应。在围手术期条件下,多尿是一种罕见的不良反应,右美托咪定输注后的病例报告有限。与这种情况类似,在重症监护室,也有罕见的病例。我们报告了一例59岁的男性患者,他在重症监护室因大剂量静脉输注右美托咪定而出现多尿。
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引用次数: 0
Congestive heart failure and sepsis: a retrospective study of hospitalization outcomes from a rural hospital in Southwest Missouri 充血性心力衰竭和败血症:密苏里州西南部一家农村医院住院结果的回顾性研究
Pub Date : 2022-06-10 DOI: 10.1097/EC9.0000000000000033
Alexandra Skovran, Mason B Hinke, S. N. Sloan, Greg Stahl, Kerry Johnson, S. Goade, R. Arnce
Abstract Background Sepsis is the leading cause of death in hospitalized patients and significant effort has been made to facilitate early diagnosis and management. However, aggressive treatment can have negative effects, especially in patients with unstable volume status, such as those with congestive heart failure. Methods We used electronic medical records to perform a retrospective study looking at hospital outcomes in patients from Southwest Missouri who were admitted with sepsis and had a comorbid diagnosis of hypertensive heart failure. Our primary outcome was in-hospital mortality. Results We studied a total of 184 patients with the diagnosis of hypertensive heart failure with sepsis, and 348 patients with the diagnosis of sepsis that served as the baseline group. There was a total of 37 (20%) deaths in the hypertensive heart failure group and a total of 94 (27%) deaths in the baseline group. Conclusion Our study showed no significant difference between the baseline group and those with hypertensive heart disease with heart failure.
摘要背景脓毒症是住院患者死亡的主要原因,为促进早期诊断和管理已做出了重大努力。然而,积极的治疗可能会产生负面影响,尤其是对容量不稳定的患者,如充血性心力衰竭患者。方法我们使用电子医疗记录进行了一项回顾性研究,观察密苏里州西南部因败血症入院并被诊断为高血压心力衰竭的患者的住院结果。我们的主要结果是住院死亡率。结果我们共研究了184例诊断为高血压心力衰竭伴败血症的患者,以及348例诊断为败血症的患者作为基线组。高血压心力衰竭组共有37人(20%)死亡,基线组共有94人(27%)死亡。结论我们的研究表明,基线组与高血压性心脏病合并心力衰竭组之间没有显著差异。
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引用次数: 0
The true global burden of trauma: a call for a comprehensive trauma research platform 创伤的真正全球负担:呼吁建立一个全面的创伤研究平台
Pub Date : 2022-06-01 DOI: 10.1097/ec9.0000000000000041
A. Ratnayake, Yonggang Li, A. Kushner
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引用次数: 0
Varied presentations, magnitude, and outcome of traumatic neck injuries at a level I trauma center 在一个一级创伤中心,外伤性颈部损伤的不同表现、程度和结果
Pub Date : 2022-06-01 DOI: 10.1097/EC9.0000000000000043
P. Dar, Jogendra Boddeda, Supreet Kaur, Pratyusha Priyadarshini, Abhinav Kumar, D. Bagaria, Narendra Choudhary, J. Alam, S. Sagar, Subodh Kumar, Amit Gupta, Biplab Mishra
Abstract Introduction: Traumatic neck injuries (TNIs) constitute 5%–10% of all trauma cases. These injuries can be caused by either penetrating or blunt trauma. Patients can have a varied presentation like cut injury over the neck, bleeding, neck swelling, breathing difficulty, dysphagia, etc. Methods: This was a retrospective observational study conducted at a level I trauma center in India from January 2016 to March 2020. One hundred thirty patients who required admission and intervention due to TNIs were included in this study. Results: One hundred thirty patients with neck injuries were included in this study. Males were predominant (91.5%) with the age ranging from 10 to 70 years. The most common mechanism of injury was physical assault (40.7%), followed by road traffic injury (23.8%) and self-inflicted injuries (18.4%). Penetrating trauma was predominant. Open neck wound with bleeding was the most common presenting symptom. Zone II injuries were more common (83.8%) followed by zone I (12.3%) and zone III (3.8%). Soft tissue injury including skin, platysma breach, and strap muscle injury was present in 46.9% of patients. Laryngopharyngeal injury was present in 13.8%, tracheal injury in 28.5%, vascular injury in 13.8%, and esophageal injury in 4.6% of patients. Conclusion: Penetrating neck trauma is more common than blunt in developing countries like India. Advanced Trauma Life Support (ATLS) protocol guides the initial management. The definitive management depends on the type and mechanism of injury, anatomical level, severity, and the organ injured.
摘要简介:外伤性颈部损伤(TNIs)占所有外伤病例的5%-10%。这些伤可能是由穿透性或钝性创伤造成的。患者可能有多种表现,如颈部割伤、出血、颈部肿胀、呼吸困难、吞咽困难等。方法:这是一项回顾性观察研究,于2016年1月至2020年3月在印度一级创伤中心进行。本研究纳入130例因tni而需要入院和干预的患者。结果:本研究纳入130例颈部损伤患者。男性居多(91.5%),年龄在10 ~ 70岁之间。最常见的伤害机制是人身伤害(40.7%),其次是道路交通伤害(23.8%)和自伤(18.4%)。以穿透性创伤为主。颈部开放性伤口出血是最常见的症状。II区损伤最常见(83.8%),其次是I区(12.3%)和III区(3.8%)。46.9%的患者存在软组织损伤,包括皮肤、颈阔肌破裂和带状肌损伤。喉部损伤占13.8%,气管损伤占28.5%,血管损伤占13.8%,食管损伤占4.6%。结论:在印度等发展中国家,穿透性颈部外伤比钝性颈部外伤更为常见。高级创伤生命支持(ATLS)方案指导初始管理。最终的治疗取决于损伤的类型和机制、解剖水平、严重程度和受损器官。
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引用次数: 0
Focused research in emergency medical systems in Asia: a necessity for trauma system advancement 亚洲急诊医疗系统的重点研究:创伤系统发展的必要性
Pub Date : 2022-06-01 DOI: 10.1097/EC9.0000000000000042
A. Ratnayake, S. Nakahara, D. Bagaria, Sohan De Silva, Sri Lal De Silva, April Llaneta, Ratrawee Pattanarattanamolee, Yonggang Li, Bui Hai Hoang
Abstract Since trauma is a growing health problem worldwide, emergency trauma care including emergency medical services (EMS) is becoming an integral part of the healthcare system. The optimal EMS which will improve access to trauma care, will be different in each country because of different healthcare systems, trauma etiology, and economic situations. To adopt models that have succeeded in developed countries is not always appropriate. In order to identify the optimal EMS model in developing countries, comparing the systems among many countries in detail and examining their advantages and disadvantages would be necessary. Therefore, this article tries to identify important elements of EMS to achieve mature EMS systems based on comparisons of 7 Asian countries, and discusses the need to conduct more detailed and extensive comparisons.
摘要由于创伤是一个日益严重的全球健康问题,包括紧急医疗服务(EMS)在内的紧急创伤护理正在成为医疗系统的一个组成部分。由于不同的医疗系统、创伤病因和经济状况,每个国家的最佳EMS将有所不同,这将改善创伤护理的可及性。采用在发达国家取得成功的模式并不总是合适的。为了确定发展中国家的最佳EMS模式,有必要详细比较许多国家的系统,并审查其优缺点。因此,本文试图在对7个亚洲国家进行比较的基础上,确定EMS的重要要素,以实现成熟的EMS系统,并讨论进行更详细和广泛比较的必要性。
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引用次数: 2
United States trauma system: Maryland focus 美国创伤系统:马里兰州为重点
Pub Date : 2022-06-01 DOI: 10.1097/ec9.0000000000000047
Shailvi Gupta, A. Tannous, Thomas Scalea
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引用次数: 0
Intrarenal pseudoaneurysm after percutaneous nephrolithotomy: a case report 经皮肾取石术后肾内假性动脉瘤1例
Pub Date : 2022-06-01 DOI: 10.1097/EC9.0000000000000037
M. Moussa, M. Chakra, A. Dellis, A. Papatsoris
ABSTRACT Background: Percutaneous nephrolithotomy (PNL) is the gold standard to treat large or complex renal stones. Intrarenal pseudoaneurysm is a rare, yet clinically significant, complication of PNL. Case summary: A 58-year-old man with a 3 cm calculus in the lower calyx of the left kidney was operated on by PNL 3 days before presentation to the emergency department. The patient presented with massive hematuria and dizziness. Upon presentation, the patient appeared uncomfortable and in distress. He was in hemorrhagic shock. The patient was resuscitated with intravenous fluids and blood transfusion. An urgent computed tomography scan showed multiple clots in the left renal pelvis and bladder with a retroperitoneal hematoma. The patient underwent angiography which revealed an inferior pole branch pseudoaneurysm. The pseudoaneurysm was treated by endovascular embolization with N-butyl-2-cyanoacrylate. No postoperative complications were seen. Conclusion: Selective renal artery embolization is an effective treatment for pseudoaneurysm post PNL with excellent outcomes.
摘要背景:经皮肾取石术(PNL)是治疗大型或复杂肾结石的金标准。肾内假性动脉瘤是PNL的一种罕见但具有临床意义的并发症。案例摘要:一名58岁男子 PNL3治疗左肾下肾盏cm结石 在急诊科就诊前几天。患者表现为大量血尿和头晕。在介绍时,患者表现出不舒服和痛苦。他处于失血性休克状态。病人通过静脉输液和输血进行了复苏。紧急计算机断层扫描显示左肾盂和膀胱有多个血块,并伴有腹膜后血肿。患者接受了血管造影术检查,发现一个下极支假性动脉瘤。用2-氰基丙烯酸正丁酯血管内栓塞治疗假性动脉瘤。未发现术后并发症。结论:选择性肾动脉栓塞是治疗PNL术后假性动脉瘤的有效方法,效果良好。
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引用次数: 0
The complexity of providing humanitarian surgical care in armed conflict: a framework to help categorize needs 武装冲突中提供人道主义外科护理的复杂性:帮助对需求进行分类的框架
Pub Date : 2022-06-01 DOI: 10.1097/EC9.0000000000000046
K. Gianaris, B. Stewart, S. Wren, A. Kushner
Abstract Armed conflicts are increasing globally due to political unrest and the broader effects of climate change. Without resources to provide quality surgical care, it becomes nearly impossible to provide quality emergency surgery and trauma care similar to that in high-income countries. To understand and help aid organizations provide resources and address the surgical needs of populations facing armed conflict, a matrix to identify variables and help with interventions was envisioned. A previously published global surgery matrix based on the PIPES (Personnel, Infrastructure, Procedures, Equipment and Supplies) surgical capacity tool was adapted to this context. The novel matrix incorporates 108 variables. These variables are grossly divided into local and international agency components to address the issue of who is providing care. Using a time continuum of pre-conflict, conflict, and post-conflict allows organizations to concentrate on when during the conflict to target their intervention. In addition to the previously used personnel, infrastructure, procedures, equipment, and supplies categories, a sixth category called standards was included that addresses the issues such as information technology, data systems, quality improvement programs, and patient safety. Pilot testing of this matrix to obtain feedback from end users is the next step in development. Ultimately, peri-conflict preparedness should increase and improve surgical outcomes and reduce in death and disabilities around the world.
摘要由于政治动荡和气候变化的广泛影响,全球武装冲突正在增加。如果没有资源提供高质量的外科护理,几乎不可能提供类似于高收入国家的高质量紧急手术和创伤护理。为了了解和帮助援助组织提供资源,解决面临武装冲突的人口的外科手术需求,设想了一个矩阵,以确定变量并帮助采取干预措施。先前发布的基于PIPES(人员、基础设施、程序、设备和用品)手术能力工具的全球手术矩阵适用于这种情况。新矩阵包含108个变量。这些变量大致分为地方和国际机构组成部分,以解决谁提供护理的问题。使用冲突前、冲突中和冲突后的时间连续体,可以让组织集中精力在冲突期间的什么时候进行干预。除了以前使用的人员、基础设施、程序、设备和用品类别外,还包括第六类标准,用于解决信息技术、数据系统、质量改进计划和患者安全等问题。对该矩阵进行试点测试以获得最终用户的反馈是开发的下一步。最终,冲突期间的准备工作应该增加和改善世界各地的手术结果,减少死亡和残疾。
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引用次数: 0
Management and outcome of pancreatic trauma: a 6-year experience at a level I trauma center 胰腺创伤的处理和结果:一级创伤中心6年的经验
Pub Date : 2022-04-15 DOI: 10.1097/EC9.0000000000000061
A. Anand, P. Dar, Preksha Rani, Supreet Kaur, J. James, J. Alam, Pratyusha Priyadarshini, Abhinav Kumar, D. Bagaria, Narendra Choudhary, Subodh Kumar, Amit Gupta, S. Sagar, Biplab Mishra
Abstract Background Pancreatic trauma (PT) accounts for less than 1% of all trauma admissions. Occasionally, PT is undetected during the primary survey and becomes apparent only when complications arise. It occurs in up to 5% of blunt abdominal trauma cases and 12% of individuals with penetrating abdominal injuries. Management is determined by the status of the main pancreatic duct and associated injuries. Methods This was an ambispective study conducted at the Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, from January 2015 to December 2017 (retrospective), and January 2019 to December 2020 (prospective). In total, 113 patients with PT were included in this study. Results We analyzed the data of 113 patients with PT included in this study, of which males predominated (93.7%). Blunt PT was present in 101 patients (89.4%) and penetrating PT in 12 patients (10.6%). Half of the patients (51.3%) had the American Association for the Surgery of Trauma grade III PT, followed by grade II (18.6%), and grade I (15%). Of the total 113 patients, 68 (60.2%) were treated with operative management, and 45 (39.8%) with nonoperative management. Distal pancreatectomy, with or without splenectomy, was the most common procedure performed in our study, followed by drainage. There were 27 mortalities (23.8%) during the study period, of which 7 were directly related to PT and 20 were due to other organ-related sepsis and hemorrhagic shock. Conclusion Pancreatic trauma is rare but challenging for trauma surgeons, with persistent management controversies. Early diagnosis is important for favorable results; however, a delay in diagnosis has been associated with higher morbidity and mortality. Low-grade pancreatic injuries can be successfully managed nonoperatively, whereas high-grade pancreatic injuries require surgical intervention.
摘要背景胰腺创伤(PT)占所有创伤入院人数的不到1%。有时,PT在初次调查中未被发现,只有在出现并发症时才变得明显。它发生在高达5%的钝性腹部创伤病例和12%的穿透性腹部损伤患者中。治疗由主胰管的状况和相关损伤决定。方法这是一项在新德里全印度医学科学研究所Jai Prakash Narayan Apex创伤中心进行的前瞻性研究,时间分别为2015年1月至2017年12月(回顾性)和2019年1月和2020年12月。本研究共纳入113例PT患者。结果我们分析了113例PT患者的数据,其中男性占主导地位(93.7%)。钝性PT有101例(89.4%),穿透性PT有12例(10.6%)。其中一半(51.3%)的患者具有美国创伤外科协会III级PT,其次是II级PT(18.6%)和I级PT(15%)。在总共113名患者中,68名(60.2%)接受了手术治疗,45名(39.8%)接受了非手术治疗。在我们的研究中,胰远端切除术,包括或不包括脾切除术,是最常见的手术,其次是引流。研究期间共有27例死亡(23.8%),其中7例与PT直接相关,20例死于其他器官相关的败血症和失血性休克。结论胰腺创伤是罕见的,但对创伤外科医生来说是具有挑战性的,其管理一直存在争议。早期诊断对取得良好结果很重要;然而,诊断的延迟与更高的发病率和死亡率有关。低级别胰腺损伤可以通过非手术成功治疗,而高级别胰腺损伤需要手术干预。
{"title":"Management and outcome of pancreatic trauma: a 6-year experience at a level I trauma center","authors":"A. Anand, P. Dar, Preksha Rani, Supreet Kaur, J. James, J. Alam, Pratyusha Priyadarshini, Abhinav Kumar, D. Bagaria, Narendra Choudhary, Subodh Kumar, Amit Gupta, S. Sagar, Biplab Mishra","doi":"10.1097/EC9.0000000000000061","DOIUrl":"https://doi.org/10.1097/EC9.0000000000000061","url":null,"abstract":"Abstract Background Pancreatic trauma (PT) accounts for less than 1% of all trauma admissions. Occasionally, PT is undetected during the primary survey and becomes apparent only when complications arise. It occurs in up to 5% of blunt abdominal trauma cases and 12% of individuals with penetrating abdominal injuries. Management is determined by the status of the main pancreatic duct and associated injuries. Methods This was an ambispective study conducted at the Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, from January 2015 to December 2017 (retrospective), and January 2019 to December 2020 (prospective). In total, 113 patients with PT were included in this study. Results We analyzed the data of 113 patients with PT included in this study, of which males predominated (93.7%). Blunt PT was present in 101 patients (89.4%) and penetrating PT in 12 patients (10.6%). Half of the patients (51.3%) had the American Association for the Surgery of Trauma grade III PT, followed by grade II (18.6%), and grade I (15%). Of the total 113 patients, 68 (60.2%) were treated with operative management, and 45 (39.8%) with nonoperative management. Distal pancreatectomy, with or without splenectomy, was the most common procedure performed in our study, followed by drainage. There were 27 mortalities (23.8%) during the study period, of which 7 were directly related to PT and 20 were due to other organ-related sepsis and hemorrhagic shock. Conclusion Pancreatic trauma is rare but challenging for trauma surgeons, with persistent management controversies. Early diagnosis is important for favorable results; however, a delay in diagnosis has been associated with higher morbidity and mortality. Low-grade pancreatic injuries can be successfully managed nonoperatively, whereas high-grade pancreatic injuries require surgical intervention.","PeriodicalId":72895,"journal":{"name":"Emergency and critical care medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42271288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Emergency and critical care medicine
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