Emerging trends in drugs, addictions, and health最新文献

Pathological gambling among students at the Joseph KI-ZERBO University in Ouagadougou, Burkina Faso: prevalence and associated factors 布基纳法索瓦加杜古Joseph KI-ZERBO大学学生的病态赌博：流行程度及相关因素

Emerging trends in drugs, addictions, and health

Pub Date : 2026-01-02 DOI: 10.1016/j.etdah.2025.100270

Boubacar BAGUE , Zeinabou CISSE , Konsam Cédric Christel SAWADOGO , Zoulkarnéini Cheick ZAN , Mahamane Mobarak SALIFOU ABDOU , DOGA Azize , Kady Tissalogo , Kapouné KARFO

Introduction

Pathological gambling, recognised as an addictive disorder, is increasingly affecting young people. Given the lack of data in Burkina Faso, this study explores its prevalence and associated factors among students at Joseph KI-ZERBO University, in order to better guide preventive action.

Method

This was a prospective, descriptive and analytical cross-sectional study conducted from September 2024 to March 2025, with data collection from January 14 to 22, 2025.

Results

A total of 439 students were included in our study. We found that 25.1% of students gambled. The average age of gambling students was 23.7 years. The prevalence of pathological gambling among UJKZ students was 30%, and 48.2% of students had a moderate risk of pathological gambling. We found that age, gender and religion were not significantly associated with pathological gambling among UJKZ students. However, family history of pathological gambling, initiation to gambling through the media and daily gambling were significantly associated with pathological gambling.

Conclusion

Our study highlights the extent of pathological gambling and the factors that might influence it. It is therefore necessary to implement collective and targeted preventive strategies to limit the spread of pathological gambling among this vulnerable population, i.e. students. It will also be important to conduct further research to gain a deeper understanding of the mechanisms underlying these behaviours, as well as their academic and social impact.

病态赌博，被认为是一种成瘾障碍，正越来越多地影响着年轻人。鉴于布基纳法索缺乏相关数据，本研究探讨了Joseph KI-ZERBO大学学生患此病的情况及其相关因素，以便更好地指导预防行动。方法采用前瞻性、描述性和分析性横断面研究，研究时间为2024年9月至2025年3月，数据收集时间为2025年1月14日至22日。结果共纳入439名学生。我们发现25.1%的学生赌博。赌博学生的平均年龄为23.7岁。UJKZ学生病态赌博患病率为30%，其中48.2%的学生有中度病态赌博风险。我们发现年龄、性别和宗教与UJKZ学生的病态赌博没有显著相关。然而，病态赌博家族史，通过媒体开始赌博和日常赌博与病态赌博显著相关。结论本研究突出了病态赌博的程度及其影响因素。因此，有必要实施集体和有针对性的预防战略，以限制病态赌博在这一弱势群体，即学生中的传播。开展进一步的研究以更深入地了解这些行为背后的机制以及它们的学术和社会影响也很重要。

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引用次数: 0

Development and Validation of Methods for Detection of New Psychoactive Substances (NPS) in Athletes 运动员新精神活性物质（NPS）检测方法的开发和验证

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100233

S. Khelifi, M. Al-Jaber, R. Kamal, K. Al-Kuwari, V. Mohamed-Ali, M. Al-Maadheed

Introduction

There is increasing evidence for the association between substance use disorders and mental health disorders in athletes. New Psychoactive Substances (NPS) pose an additional challenge, especially those prohibited by the World Anti-Doping Agency (WADA) and difficult to detect due to their rapidly evolving chemical structures and limited availability of reference standards. This project aims to develop and validate sensitive analytical methods for detecting selected NPS identified by local institutions in Qatar and investigate their presence in 500 samples destined for discard following routine analysis for known dopants at ADLQ.

Methods

LC-MS/MS and GC-MS/MS methods were developed and validated targeting NPS observed in Qatar. Development included optimizing sample preparation protocols (dilute and shoot, solid-phase extraction, liquid-liquid extraction) and mass spectrometric parameters. Validation was conducted following guidelines established by WADA and the International Standard for Laboratories (ISL), assessing selectivity, detection and identification limits, carry-over, recovery, and matrix effects. Retrospective analyses are being performed on previously negative urine samples from consenting athletes.

Results

This research will establish validated analytical methods for NPS detection and generate the first comprehensive prevalence data for NPS use among athletes.

Conclusions

The study addresses a gap in anti-doping research and supports global understanding of NPS in sport.

越来越多的证据表明运动员物质使用障碍与精神健康障碍之间存在关联。新的精神活性物质（NPS）带来了额外的挑战，特别是那些被世界反兴奋剂机构（WADA）禁止的物质，由于其快速变化的化学结构和有限的参考标准而难以检测。该项目旨在开发和验证检测卡塔尔当地机构确定的选定NPS的敏感分析方法，并在ADLQ对已知掺杂物进行常规分析后，在500个运往丢弃的样品中调查它们的存在。方法建立针对卡塔尔NPS的slc -MS/MS和GC-MS/MS方法并进行验证。开发包括优化样品制备方案（稀释和射击，固相萃取，液-液萃取）和质谱参数。验证是按照WADA和国际实验室标准（ISL）制定的指导方针进行的，评估选择性、检测和鉴定限度、结转、回收率和基质效应。正在对先前同意的运动员的阴性尿样进行回顾性分析。结果本研究将建立有效的NPS检测分析方法，并生成第一个NPS在运动员中使用的综合流行数据。该研究填补了反兴奋剂研究的空白，并支持全球对体育运动中NPS的理解。

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引用次数: 0

Changes in the Drug Market in Poland After the Introduction of Generic Legislation for the Control of NPS 引入控制NPS的通用立法后波兰药品市场的变化

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100201

B. Byrska

Introduction

In Poland, psychoactive substances are controlled under the Act on Counteracting Drug Addiction, which schedules traditional narcotics and psychotropics. The rise of new psychoactive substances (NPS) led to the introduction of generic legislation in 2018, allowing regulation of entire chemical groups based on structural and pharmacological similarity.

Methods

The results of analyses of samples submitted to the Institute of Forensic Research in Krakow between 2018 and 2025 were examined. GC-MS, UHPLC-PDA and LC-QTOF/MS were used to identify and quantify psychoactive substances.

Results

In recent years, 3-CMC and 4-CMC have been the most popular substances. In 2024, many numbers of samples containing mephedrone were also seized. Recently, the emergence of a new cathinone derivative – NEP has been observed. Semi-synthetic cannabinoids first appeared in 2022, followed by a marked increase in their prevalence and popularity among users in 2023 and 2024. Besides NPS, a significant number of seized samples contained amphetamine and MDMA.

Conclusions

Since 2018, the number of identified NPS has declined, with users returning to classical substances like amphetamine and MDMA. However, semi-synthetic cannabinoids may represent a new wave of NPS.

在波兰，精神活性物质受《反药物成瘾法》的管制，该法案对传统麻醉品和精神药物进行了管制。新精神活性物质（NPS）的兴起导致2018年引入了通用立法，允许根据结构和药理相似性对整个化学基团进行监管。方法对2018 - 2025年提交给克拉科夫法医研究所的样本进行分析。采用GC-MS、UHPLC-PDA和LC-QTOF/MS对精神活性物质进行鉴定和定量。结果近年来以3-CMC和4-CMC为主。2024年，还查获了大量含有甲氧麻黄酮的样本。最近，人们发现了一种新的卡西酮衍生物——NEP。半合成大麻素首次出现于2022年，随后在2023年和2024年，其在用户中的流行程度和受欢迎程度显著增加。除NPS外，大量检获样本亦含有安非他明及摇头丸。自2018年以来，NPS的数量有所下降，使用者重新使用安非他明和MDMA等经典物质。然而，半合成大麻素可能代表了新一波NPS。

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引用次数: 0

Analgesic Effects of 3-Methylmethcathinone (3-MMC) in Healthy Volunteers 3-甲基甲卡西酮（3-MMC）对健康志愿者的镇痛作用

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100257

E. Theunissen, J. Reckweg, N. Mason, K. Kuypers, S. Toennes, J. Ramaekers

Introduction

3-Methylmethcathinone (3-MMC) is a synthetic cathinone that has been banned in many countries after emerging as a “legal high”. Although synthetic cathinones currently lack approved medical applications, cathinone and other compounds structurally related to amphetamine have previously demonstrated analgesic effects.

Methods

This study evaluated the analgesic effects of low to moderate doses of 3-MMC (25, 50, and 100 mg) in a placebo-controlled, crossover trial involving 14 healthy volunteers. Participants were exposed to experimental pain using pressure pain threshold (PPT) and cold pressor test (CPT) paradigms for up to five hours after dosing.

Results

The results showed that 3-MMC produced dose-dependent increases in pain threshold and reductions in the subjective experience of pain and unpleasantness. These effects were most pronounced at the 50 and 100 mg doses and remained consistent throughout the 5-hour testing period. Notably, the doses used were low enough to avoid intense psychoactive effects and were associated with a relatively mild side effect profile.

Conclusions

These findings suggest that 3-MMC may have potential as a pain-relieving agent. Further research is warranted to explore its analgesic properties in clinical populations and to better understand its safety and efficacy in therapeutic contexts.

甲基卡西酮（3-MMC）是一种合成卡西酮，在成为“合法兴奋剂”后，在许多国家被禁止使用。虽然合成卡西酮目前缺乏批准的医疗应用，但卡西酮和其他结构上与安非他明相关的化合物以前已证明具有镇痛作用。方法本研究通过一项涉及14名健康志愿者的安慰剂对照交叉试验，评估了低至中剂量3-MMC（25、50和100 mg）的镇痛作用。在给药后，参与者使用压力疼痛阈值（PPT）和冷压力测试（CPT）范式暴露于实验性疼痛中长达5小时。结果3-MMC使痛觉阈值呈剂量依赖性增加，疼痛和不愉快的主观体验减少。这些影响在50和100毫克剂量时最为明显，并在整个5小时的测试期间保持一致。值得注意的是，使用的剂量足够低，避免了强烈的精神作用，并且副作用相对轻微。结论3-MMC可能具有镇痛作用。有必要进一步研究其在临床人群中的镇痛特性，并更好地了解其在治疗中的安全性和有效性。

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引用次数: 0

Development of an Integrated Drug Early Advisory System (IDEAS) to Collate Drug-Related Data in Aotearoa New Zealand 开发综合药物早期咨询系统（IDEAS）以整理新西兰奥特罗阿的药物相关数据

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100230

O. Johnson, W. Popplewell, M. Russell, D. Kappatos, M.-J. McCarthy

Introduction

The Institute of Environmental Science and Research (ESR) is developing the Integrated Drug Early Advisory System (IDEAS). ESR holds a unique position as the provider of forensic drug analysis for Aotearoa New Zealand, encompassing clandestine laboratory investigations, drug chemistry, toxicology, wastewater analysis, and border interceptions. IDEAS aims to integrate these data streams to detect novel or high-risk substances, monitor drug trends, and provide actionable temporal spatial intelligence.

Methods

Subject matter experts from drug-related teams are collaborating with business intelligence specialists to define system requirements, identify key data sources, and map critical functionalities for real-time alerts.

Results

Development is underway to build a unified, searchable repository that enables early detection of harmful substances and supports trend analysis. IDEAS will serve as an essential drug data management tool for ESR and external partners such as the National Drug Intelligence Bureau, Ministry of Health, licenced Drug Checking services, emergency medicine, and the justice system, supporting national harm reduction strategies.

Conclusions

By leveraging real-time laboratory data, IDEAS will enhance Aotearoa New Zealand’s ability to respond rapidly to emerging drug threats. This initiative will strengthen coordination across ESR and empower public health and enforcement agencies to act decisively, improving safety outcomes for communities.

环境科学与研究所（ESR）正在开发综合药物早期咨询系统（IDEAS）。ESR拥有独特的地位，为新西兰奥特罗阿提供法医药物分析，包括秘密实验室调查，药物化学，毒理学，废水分析和边境拦截。IDEAS旨在整合这些数据流，以检测新型或高风险物质，监测药物趋势，并提供可操作的时空情报。方法来自药物相关团队的主题专家与商业智能专家合作，定义系统需求，识别关键数据源，并绘制实时警报的关键功能。结果建立一个统一的、可搜索的储存库的工作正在进行中，该储存库能够早期发现有害物质并支持趋势分析。IDEAS将作为ESR和外部合作伙伴（如国家药物情报局、卫生部、许可药物检查服务、急诊医学和司法系统）的基本药物数据管理工具，支持国家减少危害战略。通过利用实时实验室数据，IDEAS将增强新西兰对新出现的药物威胁的快速反应能力。这一举措将加强整个ESR的协调，并授权公共卫生和执法机构采取果断行动，改善社区的安全成果。

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引用次数: 0

Design, Synthesis, and Binding Affinity of Novel N-Naphthyl-Substituted Phenethylamines as 5-HT2AR Agonists 新型n -萘取代苯乙胺作为5-HT2AR激动剂的设计、合成和结合亲和力

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100212

E.R.A. Desport

Introduction

Hundreds of new psychoactive substances (NPS) appear on the legal and illegal drug market each year, with serotonergic phenethylamines, such as 2C-B and derivatives, being some of the most common. Minor, easy-to-perform changes in their chemical structure can drastically change their pharmacology, especially at the 5-HT2A receptor (5-HT2AR). We therefore explored N-naphthyl substitutions on 2C-X/2C-X-Fly scaffolds for their potential enhanced affinity and bias signaling toward β-arrestin.

Methods

Ten analogues (including five not previously described) were synthesised and characterised by ¹H/¹³C NMR, HPLC, GC-MS, HR-MS, and melting point. Affinity for 5-HT2AR was measured in duplicate competitive [³H]-ketanserin binding assays using transfected CHO-K1 membranes; Ki values were calculated with the Cheng–Prusoff equation.

Results

N-naphthylation increased 5-HT2AR affinity by up to ∼600-fold relative to parent compounds. The most potent analogue, 2C-T N-1-Nap, exhibited Ki ≈ 6 nM (pKi = 8.23), comparable to ketanserin. Across the set, 1-naphthyl isomers consistently outperformed their 2-naphthyl counterparts, showing a clear positional effect. Structure–activity analysis suggests a steric clamp in the receptor pocket favoring the 1-orientation.

Conclusions

A single N-naphthyl substitution can transform low-potency phenethylamines into high-affinity, potentially β-arrestin-biased 5-HT2AR agonists. While their probable β-arrestin bias necessity further functional assays, it remains unclear how these compounds behave in humans. Nonetheless, they hold great potential for the appearance of non-hallucinogenic psychoplastogens on the drug market.

每年有数百种新的精神活性物质（NPS）出现在合法和非法药物市场上，其中最常见的是5 -羟色胺类苯乙胺，如2C-B及其衍生物。化学结构的微小、易于操作的改变可以极大地改变它们的药理学，特别是在5-HT2A受体（5-HT2AR）上。因此，我们探索了2C-X/2C-X- fly支架上的n -萘基取代，以获得其潜在的增强亲和力和对β-阻滞蛋白的偏倚信号。方法合成10个类似物（包括5个未描述的类似物），并通过¹H/¹³NMR、HPLC、GC-MS、HR-MS和熔点进行表征。使用转染CHO-K1膜，通过重复竞争[³H]-酮色蛋白结合测定对5-HT2AR的亲和力；用Cheng-Prusoff方程计算Ki值。结果n -萘化使5-HT2AR的亲和力比母体化合物提高了约600倍。最有效的类似物2C-T N-1-Nap的Ki≈6 nM (pKi = 8.23)，与酮色胺相当。在整个集合中，1-萘基异构体的表现始终优于2-萘基异构体，显示出明显的位置效应。结构-活性分析表明，受体口袋中存在有利于1取向的位阻夹。结论单次n-萘基取代可将低效苯乙胺转化为高亲和力、可能偏向β-阻滞蛋白的5-HT2AR激动剂。虽然他们可能的β抑制蛋白的偏见需要进一步的功能分析，但尚不清楚这些化合物在人体中的表现。尽管如此，它们在药物市场上是非致幻性精神质体的出现方面具有很大的潜力。

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引用次数: 0

Development and Validation of a Sensitive and Specific UV Spectrophotometric Method for Detection and Determination of Diphenhydramine in Urine for Forensic Analysis 一种灵敏特异紫外分光光度法检测和测定尿液中苯海拉明的方法的建立和验证

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100253

H. Saurabh, L. Gupta, N. Tomar, A. Kumar, K. Goyal, R.K. Sarin

Introduction

Diphenhydramine (DPH) is a first-generation H1-antihistaminic agent that is widely available in the Indian market under the brand name Benadryl. This pharmaceutical compound has been identified as an adulterant in seized samples of cocaine and heroin. Besides adding to the bulk, DPH also enhances the synergistic effects of the heroin. The current research presents a rapid and sensitive methodology for the detection and quantification of DPH in forensic samples, utilizing a UV-Spectrophotometer.

Methods

The drug was spiked into the urine samples and extracted at a basic pH using ethyl acetate. Various aliquots of the drug, ranging from 100 to 6.25 ppm, were prepared and analysed using a double-beam UV spectrophotometer (Lab India UV 3092).

Results

The presence of DPH was confirmed at ƛmax of 257 nm with a correlation coefficient of 0.9997. Conclusion: The developed method is sensitive, reproducible, rugged, stable (1 week of storage at ambient temperature), and precise (% RSD 1.72). The limit of detection was found to be 0.800 μg/mL, and the limit of quantitation was found to be 3.41 μg/mL. The developed method is a rapid tool for the routine analysis of DPH in forensic samples.

苯海拉明（DPH）是第一代h1抗组胺药，在印度市场上以Benadryl的品牌广泛销售。在缴获的可卡因和海洛因样本中，这种药物化合物被认定为掺杂物。DPH除能增加海洛因的体积外，还能增强海洛因的协同作用。目前的研究提出了一种快速和敏感的方法，用于检测和定量法医样品中的DPH，利用紫外分光光度计。方法将该药加入到尿样中，用乙酸乙酯在碱性pH下提取。用双光束紫外分光光度计（印度实验室UV 3092）制备和分析了100至6.25 ppm的不同比例的药物。结果在ƛmax （257 nm）处证实DPH存在，相关系数为0.9997。结论：该方法灵敏度高，重现性好，稳定性好（常温保存1周），精密度高（% RSD 1.72）。检测限为0.800 μg/mL，定量限为3.41 μg/mL。该方法是法医样品中DPH常规分析的快速工具。

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引用次数: 0

Web Outreach and NPS: Expanding Harm Reduction Through Online Engagement in St. Petersburg 网络外联和NPS：圣彼得堡通过在线参与扩大减少伤害

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100190

L. Aleksei

Introduction

The emergence of new psychoactive substances (NPS) and evolving drug markets in Russia necessitates innovative harm reduction strategies. The St. Petersburg Charitable Fund "Humanitarian Action" developed a pioneering web outreach program to engage people who use drugs (PWUD) online, particularly those who are not reached by traditional services.

Methods

Using online platforms, including Darknet forums and Telegram instant messenger, trained outreach workers engaged with PWUD to provide harm reduction information, counseling, and referrals. The project integrated peer-based strategies and maintained anonymity to build trust and accessibility. Data were collected on interactions, reach, and referrals.

Results

Between 2020 and 2022, the web outreach team contacted more than 2,000 individuals, with a significant share reporting NPS use. Online communication led to increased uptake of offline harm reduction services and improved knowledge of safer use practices. Engagement with harder-to-reach populations, such as those using synthetic cathinones, was especially notable.

Conclusions

Web outreach represents a vital expansion of harm reduction, especially in contexts of repressive drug policies and limited access to health services. The experience of "Humanitarian Action" underscores the potential of digital strategies to connect with marginalized PWUD and address emerging drug trends.

新的精神活性物质（NPS）的出现和俄罗斯不断发展的药物市场需要创新的减少危害战略。圣彼得堡慈善基金“人道主义行动”制定了一项开创性的网络外展计划，以在线吸引吸毒者，特别是那些传统服务无法接触到的人。方法利用在线平台，包括暗网论坛和Telegram即时通讯工具，培训外联工作人员与PWUD接触，提供减少伤害的信息，咨询和转介。该项目集成了基于对等的策略，并保持匿名，以建立信任和可访问性。收集了互动、覆盖面和推荐的数据。结果在2020年至2022年期间，网络推广团队联系了2000多人，其中很大一部分报告了NPS的使用情况。在线交流导致更多地采用线下减少伤害服务，并改进了对更安全使用做法的了解。与难以接触到的人群（例如使用合成卡西酮的人群）的接触尤其引人注目。结论：网络外展是减少危害的重要扩展，特别是在毒品管制政策和获得保健服务的机会有限的情况下。“人道主义行动”的经验强调了数字战略在与边缘化的PWUD联系和应对新出现的毒品趋势方面的潜力。

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引用次数: 0

The Role of Drug Checking in Identifying Novel Substances in Aotearoa New Zealand 药品检查在新西兰奥特罗阿新物质鉴定中的作用

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100229

O. Johnson, H. Partington, C. Trueman, J. George, J. Bown, E. Carroll, C. Spearin, E. Hughes, R. Ponton

Introduction

Aotearoa New Zealand was the first country to legalise Drug Checking in 2021, aiming to reduce drug-related harm by helping people who use drugs to make informed decisions. The service has grown significantly, evidenced by a near 300% increase in sample numbers. Samples associated with harm or that cannot be identified in-field are sent for laboratory analysis. Several samples have been found to contain novel psychoactive substances (NPS).

Methods

A review of samples submitted by Drug Checking Providers was undertaken to ascertain the prevalence of NPS and other dangerous substances.

Results

Synthetic cannabinoids, synthetic cathinones, benzodiazepines, nitazenes, and ketamine-analogues are the most detected groups of NPS, including the first reported detection of N-cyclohexyl-pentylone internationally. First detections in Aotearoa now often occur through Drug Checking, a shift from NPS detections in seized samples which was prevalent a few years ago.

Conclusions

Drug Checking provides an unparalleled insight into drug trends, the identification of NPS, and other potentially dangerous substances circulating in Aotearoa’s drug supply. This drug intelligence provides a community-level harm reduction benefit. Other jurisdictions should consider Drug Checking to gain a wider picture of the national drugscape than traditional methods of informing early warning systems from analysing seizures alone.

新西兰是第一个在2021年将毒品检查合法化的国家，旨在通过帮助吸毒者做出明智的决定来减少与毒品相关的伤害。这项服务有了显著的增长，样本数量增加了近300%。与危害有关或现场无法识别的样品送去实验室分析。一些样品被发现含有新型精神活性物质（NPS）。方法对药品检查机构提交的样品进行审查，确定NPS和其他危险物质的流行情况。结果合成大麻素、合成卡西酮类、苯二氮卓类、nitazene类和氯胺酮类似物是NPS检出最多的类群，其中n -环己基戊酮在国际上首次被检出。现在，奥特罗阿的首次检测通常是通过药物检查进行的，这与几年前在缉获样本中进行NPS检测的做法不同。结论药物检查提供了一个无与伦比的洞察药物趋势，NPS的识别，以及其他潜在的危险物质在Aotearoa的药物供应中流通。这种药物情报提供了社区一级的减少危害的好处。其他司法管辖区应考虑药物检查，以获得更广泛的全国毒品情况，而不是仅通过分析缉获量来通知预警系统的传统方法。

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引用次数: 0

Introducing Pooled Urine and Wastewater Samples Testing for Identification of Psychoactive Substances in the Northern Region of Russia 介绍在俄罗斯北部地区进行集中尿液和废水样本检测以鉴定精神活性物质

Emerging trends in drugs, addictions, and health

Pub Date : 2025-12-01 DOI: 10.1016/j.etdah.2025.100219

A. Gil

Introduction

Data provided by the Ministry of Internal Affairs based on seizures of psychoactive substances (PS) and by medical organizations conducting laboratory testing of biological samples sometimes provide an incomplete or contradictory picture of the PS availability and consumption.

Methods

An analysis was conducted of the concept developed and adopted for the implementation of testing pooled urine samples and wastewater samples for PS in the Russia’s Khanty-Mansi Autonomous Okrug-Yugra (KhMAO-Yugra).

Results

The implementation of the measures outlined in the concept will enable the following priority tasks to be achieved: 1) conducting PS community-wide surveillance, 2) obtaining data on PS use in real-time or near-real-time, 3) achieving a high level of impartiality of PS use assessments, 4) eliminating risks associated with invasive assessment methods, 5) identification of hidden or undetected PS use, 6) reduction of economic costs associated with PS surveillance, 7) monitoring of emerging trends and detecting novel substances, 8) providing a more nuanced understanding of drug use, helping policymakers tailor interventions more effectively.

Conclusions

It is expected that the implementation of the concept of introducing new methods for detecting psychoactive substances will lead to a more effective response to current changes in the drug situation in the region and to a reduction in morbidity and mortality attributable to psychoactive substances use.

内务部提供的关于精神活性物质缉获情况的数据和医疗组织对生物样本进行实验室测试的数据有时对精神活性物质的供应和消费情况提供了不完整或相互矛盾的情况。方法对在俄罗斯汉特-曼西自治区尤格拉（KhMAO-Yugra）开发和采用的集中尿液样本和废水样本检测PS的概念进行分析。结果实施概念内概述的措施，可达致以下优先工作：1)在社区范围内进行PS监测，2)实时或近实时获取PS使用数据，3)实现PS使用评估的高度公正性，4)消除与侵入性评估方法相关的风险，5)识别隐藏或未被发现的PS使用，6)降低与PS监测相关的经济成本，7)监测新趋势和检测新物质，8)提供对药物使用的更细致的了解。帮助政策制定者更有效地调整干预措施。结论：采用检测精神活性物质的新方法这一概念的实施预计将导致更有效地应对该区域目前药物状况的变化，并减少可归因于使用精神活性物质的发病率和死亡率。

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引用次数: 0