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The role of ACE2 cause of death between COVID-19 and various complications COVID-19 和各种并发症之间 ACE2 死因的作用
Pub Date : 2024-07-09 DOI: 10.29333/ejeph/14790
Maryam Nourbakhsh
The COVID-19 pandemic has affected millions of people worldwide. While the virus primarily targets the respiratory system, it also affects other organs in the body, leading to multiple organ dysfunction syndrome (MODS) and death. Recent studies have shown that angiotensin-converting enzyme 2 (ACE2) plays a crucial role in pathogenesis of COVID-19 and development of MODS.Since its discovery in 2000, ACE2 has garnered widespread attention for its multiple physiological roles, leading to subsequent interest in the influence of the Renin-angiotensin system (RAS) on SARS-CoV-2 infection and COVID-19 during the pandemic.ACE2 is both an enzyme and a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells. Recent research has highlighted the multifaceted impact of the virus on various organs, showcasing its ability to induce severe multi-organ injuries. Understanding the intricate interplay between ACE2, RAS, and the pathophysiological changes associated with COVID-19 is crucial for the development of effective treatment strategies and preventative measures.This study investigates the differences in causes of death related to COVID-19 and its complications. Data from cumulative records for all age groups across the 50 states of the USA and the District of Columbia was retrospectively analyzed. The results revealed significant differences in the incidence of COVID-19 deaths associated with various medical conditions, with respiratory complications showing notably higher incidence compared to other medical conditions besides COVID-19, circulatory, and diabetes.
COVID-19 大流行已影响到全球数百万人。虽然该病毒主要针对呼吸系统,但也会影响身体的其他器官,导致多器官功能障碍综合征(MODS)和死亡。最近的研究表明,血管紧张素转换酶 2(ACE2)在 COVID-19 的发病机制和 MODS 的发展中起着至关重要的作用。自 2000 年发现血管紧张素转换酶 2 以来,它的多种生理作用引起了广泛关注,从而引发了人们对肾素-血管紧张素系统(RAS)在大流行期间对 SARS-CoV-2 感染和 COVID-19 的影响的兴趣。最近的研究突显了病毒对各器官的多方面影响,显示了它诱发严重的多器官损伤的能力。了解 ACE2、RAS 和与 COVID-19 相关的病理生理变化之间错综复杂的相互作用对于制定有效的治疗策略和预防措施至关重要。本研究调查了与 COVID-19 及其并发症有关的死亡原因的差异。研究人员对美国 50 个州和哥伦比亚特区所有年龄组的累积记录数据进行了回顾性分析。结果显示,COVID-19 与各种疾病相关的死亡发生率存在明显差异,除 COVID-19、循环系统和糖尿病外,呼吸系统并发症的发生率明显高于其他疾病。
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引用次数: 0
Defluoridation of drinking water by using low cost point of use treatment technologies: A review 利用低成本的使用点处理技术对饮用水进行脱氟处理:综述
Pub Date : 2024-07-01 DOI: 10.29333/ejeph/14739
Sadaf Tagar, Muhammad Rizwan, N. A. Qambrani
Fluoride is an anionic pollutant found in surface or ground water in large quantities due to various human activities, for examples, disposal of industrial wastewater or geochemical reactions. The presence of fluoride in drinking water above certain limits has intense effects on human health. It strengthens the tooth enamel to a small level (1.0-1.5 mg/L). In drinking water, the presence of fluoride in the range of 1.5 to 4.0 mg/L may give rise to dental fluorosis at initial the stage, while the continuous exposure to high fluoride concentrations (4.0-10.0 mg/L) leads to skeletal fluorosis. In many countries of the world, including Pakistan, fluoride exists in ground water in high concentration, reaching above 30.0 mg/L on a large scale. The objective of writing this article is to offer accurate information on the efforts of a number of scholars who worked on fluoride removal from drinking water. The fluoride removal techniques have been categorized into two parts dealing with coagulation/precipitation and adsorption. Lime and alum (Nalgonda technique) and chitin have been discussed under coagulation technologies, while adsorption deals with a number of adsorbents, i.e., activated carbon, activated alumina, saw dust, bone char, rice husk ash, bauxite, tea-ash, and kaolin. Each technique discussed can remove fluoride under certain conditions. Each treatment technology has its limitations, and since there is no technology that can achieve its purpose in diverse conditions, the choice of fluoride removal techniques should be according to a specific site, depending on fundamental conditions and the needs of the local area.
氟是一种阴离子污染物,由于人类的各种活动,例如工业废水的处理或地球化学反应,大量存在于地表水或地下水中。饮用水中的氟含量超过一定限度会对人体健康产生严重影响。它能在很小程度上(1.0-1.5 毫克/升)强化牙釉质。饮用水中的氟含量在 1.5 至 4.0 毫克/升之间时,可能会导致初期氟斑牙,而持续接触高浓度氟(4.0-10.0 毫克/升)则会导致氟骨症。在包括巴基斯坦在内的世界许多国家,地下水中的氟浓度都很高,大范围超过 30.0 毫克/升。撰写这篇文章的目的是提供准确的信息,介绍一些致力于从饮用水中去除氟化物的学者所做的努力。除氟技术分为混凝/沉淀和吸附两部分。混凝技术中讨论了石灰和明矾(纳尔贡达技术)以及甲壳素,而吸附技术则涉及多种吸附剂,即活性炭、活性氧化铝、锯末、骨炭、稻壳灰、铝矾土、茶叶灰和高岭土。所讨论的每种技术都能在特定条件下去除氟化物。每种处理技术都有其局限性,由于没有一种技术可以在各种条件下都能达到目的,因此应根据具体地点的基本条件和当地的需要来选择除氟技术。
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引用次数: 0
Exploring medical students’ perspectives on online education in medical education 探索医学生对医学教育中在线教育的看法
Pub Date : 2024-05-14 DOI: 10.29333/ejeph/14622
Ahmet Kaya, S. Bostan, Yasemin Kaya, Esra Demir, Nur Abdullah, Samet Yesil
Aim: Medical education has traditionally been a face-to-face and hands-on field of education. Recently, the development of educational technologies, epidemics, and disasters have made it necessary to use online education method in addition to the traditional method in medical education. The purpose of this study is to evaluate medical students’ perspectives on online medical education.Methods: This study was carried out as a descriptive, cross-sectional and cohort research with the participation of 906 medical faculty students in Türkiye. Data were collected with “distance education evaluation scale for medical faculty students” scale. Descriptive statistics and significance tests (t-test, ANOVA, and Tukey tests) were used to analyze the data.Results: Medical students stated that online education was economically and time-efficient, that they had difficulty in following the courses, and that they could not manage patients with the knowledge and skills they would gain through online education.Conclusions: Medical students do not recommend that medical education should be done only through online education. However, it was evaluated that online education should also be utilized, in other words, it would be beneficial to develop hybrid education models.
目的:医学教育历来是一种面对面的实践教育。近年来,随着教育技术的发展、流行病和灾难的发生,在传统的医学教育方法之外,有必要使用在线教育方法。本研究旨在评估医学生对在线医学教育的看法:本研究以描述性、横断面和队列研究的形式进行,共有 906 名土耳其医学系学生参与。数据采用 "医学院学生远程教育评价量表 "收集。数据分析采用了描述性统计和显著性检验(t 检验、方差分析和 Tukey 检验):结果:医学生表示,在线教育既经济又省时,但他们在学习课程时遇到困难,而且他们无法通过在线教育获得的知识和技能管理病人:结论:医学生并不建议只通过在线教育进行医学教育。结论:医学生并不建议医学教育只通过在线教育来进行,但他们认为也应利用在线教育,换句话说,发展混合教育模式将是有益的。
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引用次数: 0
Understanding depression and suicide rates in the UK in comparison to Pakistan 了解英国与巴基斯坦抑郁症和自杀率的比较
Pub Date : 2024-04-17 DOI: 10.29333/ejeph/14470
Aneesa Arshad, Mohammed Taiyyib
This review compares depression and suicide rates in the UK and Pakistan, highlighting disparities and challenges in mental health care. While depression affects one in six individuals in the UK, limited resources, stigma, and funding constraints in Pakistan result in a shortage of mental health professionals, particularly in rural areas. The complex relationship between depression and suicide is explored, emphasizing the need for multifaceted intervention strategies. Disparities in suicide rates underscore socio-cultural and healthcare system differences. While the UK implements comprehensive prevention strategies, Pakistan struggles with underreporting, stigma, and limited access to care. Notably, Thar Desert Region in Pakistan has seen a surge in suicides, reflecting socio-economic challenges. Globally, the World Health Organization’s (WHO) mental health gap action program aims to address treatment gaps, yet disparities persist. Collaborative efforts are needed to invest in mental health infrastructure, reduce stigma, and increase awareness, promoting mental well-being globally.
这篇综述比较了英国和巴基斯坦的抑郁症和自杀率,突出强调了心理健康护理方面的差异和挑战。在英国,每六人中就有一人受到抑郁症的影响,而在巴基斯坦,有限的资源、耻辱感和资金限制导致了心理健康专业人员的短缺,尤其是在农村地区。报告探讨了抑郁症与自杀之间的复杂关系,强调了多方面干预策略的必要性。自杀率的差异凸显了社会文化和医疗系统的不同。英国实施了全面的预防策略,而巴基斯坦却在报告不足、耻辱感和有限的医疗途径等问题上苦苦挣扎。值得注意的是,巴基斯坦塔尔沙漠地区的自杀人数激增,反映了社会经济方面的挑战。在全球范围内,世界卫生组织(WHO)的心理健康差距行动方案旨在解决治疗差距问题,但差距依然存在。需要共同努力,投资心理健康基础设施,减少耻辱感,提高认识,在全球范围内促进心理健康。
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引用次数: 0
Life-event-induced changes in daily routines: Their association with the manifestation of dysphoric emotions 由生活事件引发的日常生活变化:它们与焦虑情绪表现的关联
Pub Date : 2024-04-03 DOI: 10.29333/ejeph/14431
Vasiliki Brouskeli, Kyriaki Nikolaidou
Life events are usually followed by significant changes in the everyday routines of the affected individuals. In this study, we investigated the association of the changes in daily activities caused by the strict COVID-19 lockdown measures adopted in Greece to people’s psycho-emotional adjustment. A new measure, the everyday life change index (ELCI), was administered to 853 adults, while their psychological distress was measured with the depression-anxiety-stress scale (DASS-21). Results showed that the greater the changes a person experienced in their daily life due to lockdown, the higher the symptoms of depression, anxiety, and stress they manifested. We suggest that life-event-induced changes in routine activities could be a meaningful measure for clinical practice.
生活事件发生后,受影响者的日常生活通常会发生重大变化。在这项研究中,我们调查了希腊采取的严格 COVID-19 封锁措施所导致的日常活动变化与人们的心理情绪适应之间的关系。我们对 853 名成年人进行了新的测量,即日常生活变化指数(ELCI),并使用抑郁-焦虑-压力量表(DASS-21)测量了他们的心理压力。结果表明,封锁给人们日常生活带来的变化越大,他们表现出的抑郁、焦虑和压力症状就越严重。我们认为,由生活事件引起的日常活动的变化可以成为临床实践中一个有意义的测量指标。
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引用次数: 0
Digital health literacy and quality of life association with perceptions about the disease COVID-19 in public health services 数字健康知识和生活质量与公共卫生服务机构对 COVID-19 疾病的认知相关联
Pub Date : 2024-01-25 DOI: 10.29333/ejeph/14150
Ioannis Pantelis Adamopoulos, A. Bardavouras
Background: Digital health literacy and quality of life association with perceptions about the disease COVID-19 in public health services may have been little studied to date to examine socio-demographic parameters.Materials & methods: This research was conducted using self-report about digital health literacy, and quality of life questionnaires to participants attending in the Hippocrates Hospital Athens Greece (n=167). Initially, participants were asked to answer questions regarding the impact of the COVID-19 pandemic. The data of the study were analyzed using SPSS 26 IBM.Results: Study’s findings from has to do with the role of age. People who are younger in age seem to be more likely to think that quality of life is just a flu-like illness and generally harmless. In addition, the stronger the perceived impact of the pandemic, the higher the digital health literacy of the participants.Conclusions: The findings of this study regarding the relationship between socio-demographic variables and the examined parameters are in line with previous literature. Moreover, this study highlights the central role of digital health literacy in relation to the perception of the severity of the situation during quality of life associated with pandemic.
背景:数字健康素养和生活质量与公共卫生服务机构对 COVID-19 疾病的看法有关,但迄今为止,有关社会人口学参数的研究可能很少:本研究采用自我报告数字健康素养和生活质量问卷的方式,对希腊雅典希波克拉底医院(Hippocrates Hospital)的就诊者(n=167)进行调查。最初,参与者被要求回答有关 COVID-19 大流行影响的问题。研究数据使用 SPSS 26 IBM 进行分析:研究结果与年龄的作用有关。年龄较小的人似乎更倾向于认为生活质量只是一种类似流感的疾病,一般不会造成危害。此外,大流行病的影响感知越强,参与者的数字健康素养就越高:本研究关于社会人口变量与所研究参数之间关系的结论与以往的文献一致。此外,本研究还强调了数字健康素养在与大流行病相关的生活质量期间对情况严重程度的感知方面所起的核心作用。
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引用次数: 0
Integrating clinical psychology and neuropsychology: Advancing insights and interventions in mind-brain disorders 整合临床心理学和神经心理学:提高对心脑疾病的认识和干预措施
Pub Date : 2024-01-16 DOI: 10.29333/ejeph/14126
Maria Theodoratou
The intricate interplay between the mind and the brain underpins the complexities of mental health disorders. Clinical psychology and neuropsychology, as distinct yet interrelated disciplines, offer valuable insights into unraveling this interplay. This paper aims to explore the synergies between clinical psychology and neuropsychology, emphasizing their complementary roles in understanding and intervening in mind-brain disorders. By examining their shared principles, distinctive approaches, and collaborative potential, this paper seeks to illuminate how the integration of these disciplines can contribute to a holistic approach to mental health assessment and treatment. The primary aim of this paper is to elucidate the interconnections and collaborations between clinical psychology and neuropsychology in the context of mind-brain disorders. By examining their shared tenets, distinctive methodologies, and potential integration, this paper seeks to highlight how these disciplines can collectively enhance our comprehension of mental health disorders and optimize interventions.
心理和大脑之间错综复杂的相互作用是心理健康疾病复杂性的基础。临床心理学和神经心理学作为不同但又相互关联的学科,为揭示这种相互作用提供了宝贵的见解。本文旨在探讨临床心理学和神经心理学之间的协同作用,强调它们在理解和干预心脑障碍方面的互补作用。通过研究它们的共同原则、独特方法和合作潜力,本文试图阐明这些学科的整合如何有助于心理健康评估和治疗的整体方法。本文的主要目的是阐明临床心理学和神经心理学在心脑障碍方面的相互联系与合作。通过研究它们共同的信条、独特的方法论以及潜在的整合,本文旨在强调这些学科如何共同提高我们对心理健康疾病的理解并优化干预措施。
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引用次数: 0
Self-care practices in decision-making: How nutrition and habits may affect decision in business 决策中的自我保健实践:营养和习惯如何影响商业决策
Pub Date : 2024-01-16 DOI: 10.29333/ejeph/14128
Georgios Lountzis
Decision-making process (DMP), our everyday most frequent action, has attracted the attention of a wide range of disciplines aiming to identify and analyze its determinants, encompassing specific steps. This paper intends to investigate whether nutrition and habits of managers/employees–via hormone levels–might statistically influence DMP in the business field. Some groups of food could encourage the secretion of specific hormones, which in turn influence the brain’s function that may in turn affect humans’ behavior and emotional status, and hence, their decision. To explore the set hypothesis, fieldwork was undertaken to an extensive random sample, from Greek companies/organizations, using appropriately designed questionnaire to select and statistically analyze related quantitative and qualitative information. The questionnaire was distributed to the employees/managers (n=242) of Greek companies. The findings confirm this hypothesis (statistical significance, p<0.05) and indicate that DMP is influenced by nutrition and habits in interaction with body mass index.
决策过程(DMP)是我们日常生活中最常见的行为,吸引了众多学科的关注,这些学科旨在确定和分析其决定因素,包括具体步骤。本文旨在研究管理人员/员工的营养和习惯是否会通过激素水平对商业领域的决策过程产生统计学影响。某些食物会促进特定荷尔蒙的分泌,进而影响大脑功能,进而影响人的行为和情绪状态,进而影响人的决策。为探讨设定的假设,研究人员从希腊的公司/组织中随机抽取了大量样本进行实地调查,并使用适当设计的调查问卷来选择和统计分析相关的定量和定性信息。问卷发放给希腊公司的员工/管理人员(n=242)。研究结果证实了这一假设(统计显著性,P<0.05),并表明 DMP 受营养和习惯与体重指数相互作用的影响。
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引用次数: 0
Malaria incidence and prevalence: An ecological analysis through Six Sigma approach 疟疾发病率和流行率:通过六西格玛方法进行生态分析
Pub Date : 2024-01-16 DOI: 10.29333/ejeph/14127
Md. Al-Amin, Kesava Chandran Vijaya Bhaskar, Walaa Enab, Reza Kamali Miab, Jennifer Slavin, Nigar Sultana
Malaria is the leading cause of death globally, especially in sub-Saharan African countries claiming over 400,000 deaths globally each year, underscoring the critical need for continued efforts to combat this preventable and treatable disease. The objective of this study is to provide statistical guidance on the optimal preventive and control measures against malaria. Data have been collected from reliable sources, such as World Health Organization, UNICEF, Our World in Data, and STATcompiler. Data were categorized according to the factors and sub-factors related to deaths caused by malaria. These factors and sub-factors were determined based on root cause analysis and data sources. Using JMP 16 Pro software, both linear and multiple linear regression were conducted to analyze the data. The analyses aimed to establish a linear relationship between the dependent variable (malaria deaths in the overall population) and independent variables, such as life expectancy, malaria prevalence in children, net usage, indoor residual spraying usage, literate population, and population with inadequate sanitation in each selected sample country. The statistical analysis revealed that using insecticide treated nets (ITNs) by children and individuals significantly decreased the death count, as 1,000 individuals sleeping under ITNs could reduce the death count by eight. Based on the statistical analysis, this study suggests more rigorous research on the usage of ITNs.
疟疾是导致全球死亡的主要原因,尤其是在撒哈拉以南非洲国家,每年全球有 40 多万人死于疟疾,这说明我们亟需继续努力防治这种可防可治的疾病。本研究旨在为疟疾的最佳预防和控制措施提供统计指导。数据收集自世界卫生组织、联合国儿童基金会、Our World in Data 和 STATcompiler 等可靠来源。数据根据与疟疾导致的死亡有关的因素和子因素进行分类。这些因素和子因素是根据根本原因分析和数据来源确定的。使用 JMP 16 Pro 软件对数据进行了线性和多元线性回归分析。这些分析旨在建立因变量(总人口中的疟疾死亡人数)与自变量之间的线性关系,这些自变量包括每个选定样本国家的预期寿命、儿童疟疾流行率、蚊帐使用率、室内滞留喷洒使用率、识字人口以及卫生条件不足的人口。统计分析显示,儿童和个人使用驱虫蚊帐可显著减少死亡人数,因为 1 000 人睡在驱虫蚊帐内可减少 8 人死亡。根据统计分析,本研究建议对驱虫蚊帐的使用进行更严格的研究。
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引用次数: 0
Evaluation of awareness, knowledge, and attitudes level of sustainable nutrition in different age groups: A cross-sectional study 评估不同年龄组可持续营养的意识、知识和态度水平:一项横断面研究
Pub Date : 2023-10-01 DOI: 10.29333/ejeph/13390
Nilüfer Acar Tek, M. Ş. Karaçil Ermumcu, Nazlıcan Erdoğan Gövez, Merve Esra Çıtar Dazıroğlu
Sustainable nutrition have become widespread throughout the world. It was aimed to question the awareness, knowledge and the attitude of sustainable nutrition in individuals in wide age range. This cross-sectional study was conducted with 3,498 volunteers (1,575 male and 1,923 female) between the ages of 18-95. The questionnaire form was by face to face interview method. The concept of sustainable nutrition was heard higher in women (22.7%), those living in urban areas (22.8%) and in the 18-24 age group (26.6%) (p<0.05). Almost half (49.1%) of the individuals aged 65+ had no idea about the best practice about sustainable nutrition and as the age of the group increased, the knowledge decreased (p<0.05). Only %6 of the individuals heard about the food mile, while the most heard concept was the carbon footprint (28%). There are differences in the attitudes of individuals regarding sustainable nutrition according to gender, age and region of residence.
可持续营养已经在世界范围内普及。它的目的是质疑可持续营养的认识,知识和态度的个人在广泛的年龄范围。这项横断面研究对年龄在18-95岁之间的3498名志愿者(1575名男性和1923名女性)进行了研究。问卷形式采用面对面访谈法。女性(22.7%)、城市居民(22.8%)和18-24岁年龄组(26.6%)对可持续营养概念的了解程度较高(p<0.05)。近一半(49.1%)的65岁以上个体不了解可持续营养最佳实践,随着年龄的增长,知识水平下降(p<0.05)。只有6%的人听说过“食物里程”,而听到最多的概念是碳足迹(28%)。个人对可持续营养的态度因性别、年龄和居住地区而异。
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引用次数: 0
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European journal of environment and public health
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