Pub Date : 2016-05-01DOI: 10.1177/0022034516639276
N P T Innes, J E Frencken, L Bjørndal, M Maltz, D J Manton, D Ricketts, K Van Landuyt, A Banerjee, G Campus, S Doméjean, M Fontana, S Leal, E Lo, V Machiulskiene, A Schulte, C Splieth, A Zandona, F Schwendicke
Variation in the terminology used to describe clinical management of carious lesions has contributed to a lack of clarity in the scientific literature and beyond. In this article, the International Caries Consensus Collaboration presents 1) issues around terminology, a scoping review of current words used in the literature for caries removal techniques, and 2) agreed terms and definitions, explaining how these were decided.Dental cariesis the name of the disease, and thecarious lesionis the consequence and manifestation of the disease-the signs or symptoms of the disease. The termdental caries managementshould be limited to situations involving control of the disease through preventive and noninvasive means at a patient level, whereascarious lesion managementcontrols the disease symptoms at the tooth level. While it is not possible to directly relate the visual appearance of carious lesions' clinical manifestations to the histopathology, we have based the terminology around the clinical consequences of disease (soft, leathery, firm, and hard dentine). Approaches to carious tissue removal are defined: 1)selective removal of carious tissue-includingselective removal to soft dentineandselective removal to firm dentine; 2)stepwise removal-including stage 1,selective removal to soft dentine, and stage 2,selective removal to firm dentine6 to 12 mo later; and 3)nonselective removal to hard dentine-formerly known ascomplete caries removal(technique no longer recommended). Adoption of these terms, around managing dental caries and its sequelae, will facilitate improved understanding and communication among researchers and within dental educators and the wider clinical dentistry community.
{"title":"Managing Carious Lesions: Consensus Recommendations on Terminology.","authors":"N P T Innes, J E Frencken, L Bjørndal, M Maltz, D J Manton, D Ricketts, K Van Landuyt, A Banerjee, G Campus, S Doméjean, M Fontana, S Leal, E Lo, V Machiulskiene, A Schulte, C Splieth, A Zandona, F Schwendicke","doi":"10.1177/0022034516639276","DOIUrl":"https://doi.org/10.1177/0022034516639276","url":null,"abstract":"<p><p>Variation in the terminology used to describe clinical management of carious lesions has contributed to a lack of clarity in the scientific literature and beyond. In this article, the International Caries Consensus Collaboration presents 1) issues around terminology, a scoping review of current words used in the literature for caries removal techniques, and 2) agreed terms and definitions, explaining how these were decided.Dental cariesis the name of the disease, and thecarious lesionis the consequence and manifestation of the disease-the signs or symptoms of the disease. The termdental caries managementshould be limited to situations involving control of the disease through preventive and noninvasive means at a patient level, whereascarious lesion managementcontrols the disease symptoms at the tooth level. While it is not possible to directly relate the visual appearance of carious lesions' clinical manifestations to the histopathology, we have based the terminology around the clinical consequences of disease (soft, leathery, firm, and hard dentine). Approaches to carious tissue removal are defined: 1)selective removal of carious tissue-includingselective removal to soft dentineandselective removal to firm dentine; 2)stepwise removal-including stage 1,selective removal to soft dentine, and stage 2,selective removal to firm dentine6 to 12 mo later; and 3)nonselective removal to hard dentine-formerly known ascomplete caries removal(technique no longer recommended). Adoption of these terms, around managing dental caries and its sequelae, will facilitate improved understanding and communication among researchers and within dental educators and the wider clinical dentistry community. </p>","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 2","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034516639276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34321377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-05-01DOI: 10.1177/0022034516639271
F Schwendicke, J E Frencken, L Bjørndal, M Maltz, D J Manton, D Ricketts, K Van Landuyt, A Banerjee, G Campus, S Doméjean, M Fontana, S Leal, E Lo, V Machiulskiene, A Schulte, C Splieth, A F Zandona, N P T Innes
The International Caries Consensus Collaboration undertook a consensus process and here presents clinical recommendations for carious tissue removal and managing cavitated carious lesions, including restoration, based on texture of demineralized dentine. Dentists should manage the disease dental caries and control activity of existing cavitated lesions to preserve hard tissues and retain teeth long-term. Entering the restorative cycle should be avoided as far as possible. Controlling the disease in cavitated carious lesions should be attempted using methods which are aimed at biofilm removal or control first. Only when cavitated carious lesions either are noncleansable or can no longer be sealed are restorative interventions indicated. When a restoration is indicated, the priorities are as follows: preserving healthy and remineralizable tissue, achieving a restorative seal, maintaining pulpal health, and maximizing restoration success. Carious tissue is removed purely to create conditions for long-lasting restorations. Bacterially contaminated or demineralized tissues close to the pulp do not need to be removed. In deeper lesions in teeth with sensible (vital) pulps, preserving pulpal health should be prioritized, while in shallow or moderately deep lesions, restoration longevity becomes more important. For teeth with shallow or moderately deep cavitated lesions, carious tissue removal is performed according toselective removal to firm dentine.In deep cavitated lesions in primary or permanent teeth,selective removal to soft dentineshould be performed, although in permanent teeth,stepwise removalis an option. The evidence and, therefore, these recommendations support less invasive carious lesion management, delaying entry to, and slowing down, the restorative cycle by preserving tooth tissue and retaining teeth long-term.
{"title":"Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal.","authors":"F Schwendicke, J E Frencken, L Bjørndal, M Maltz, D J Manton, D Ricketts, K Van Landuyt, A Banerjee, G Campus, S Doméjean, M Fontana, S Leal, E Lo, V Machiulskiene, A Schulte, C Splieth, A F Zandona, N P T Innes","doi":"10.1177/0022034516639271","DOIUrl":"https://doi.org/10.1177/0022034516639271","url":null,"abstract":"<p><p>The International Caries Consensus Collaboration undertook a consensus process and here presents clinical recommendations for carious tissue removal and managing cavitated carious lesions, including restoration, based on texture of demineralized dentine. Dentists should manage the disease dental caries and control activity of existing cavitated lesions to preserve hard tissues and retain teeth long-term. Entering the restorative cycle should be avoided as far as possible. Controlling the disease in cavitated carious lesions should be attempted using methods which are aimed at biofilm removal or control first. Only when cavitated carious lesions either are noncleansable or can no longer be sealed are restorative interventions indicated. When a restoration is indicated, the priorities are as follows: preserving healthy and remineralizable tissue, achieving a restorative seal, maintaining pulpal health, and maximizing restoration success. Carious tissue is removed purely to create conditions for long-lasting restorations. Bacterially contaminated or demineralized tissues close to the pulp do not need to be removed. In deeper lesions in teeth with sensible (vital) pulps, preserving pulpal health should be prioritized, while in shallow or moderately deep lesions, restoration longevity becomes more important. For teeth with shallow or moderately deep cavitated lesions, carious tissue removal is performed according toselective removal to firm dentine.In deep cavitated lesions in primary or permanent teeth,selective removal to soft dentineshould be performed, although in permanent teeth,stepwise removalis an option. The evidence and, therefore, these recommendations support less invasive carious lesion management, delaying entry to, and slowing down, the restorative cycle by preserving tooth tissue and retaining teeth long-term. </p>","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 2","pages":"58-67"},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034516639271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34321378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/0022034515624444
B. Boyan, A. Cheng, R. Olivares-Navarrete, Z. Schwartz
Changes in dental implant materials, structural design, and surface properties can all affect biological response. While bulk properties are important for mechanical stability of the implant, surface design ultimately contributes to osseointegration. This article reviews the surface parameters of dental implant materials that contribute to improved cell response and osseointegration. In particular, we focus on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage. Surface roughness has been largely studied at the microscale, but recent studies have highlighted the importance of hierarchical micron/submicron/nanosurface roughness, as well as surface roughness in combination with surface wettability. Integrins are transmembrane receptors that recognize changes in the surface and mediate downstream signaling pathways. Specifically, the noncanonical Wnt5a pathway has been implicated in osteoblastic differentiation of cells on titanium implant surfaces. However, much remains to be elucidated. Only recently have studies been conducted on the differences in biological response to implants based on sex, age, and clinical factors; these all point toward differences that advocate for patient-specific implant design. Finally, challenges in implant surface characterization must be addressed to optimize and compare data across studies. An understanding of both the science and the biology of the materials is crucial for developing novel dental implant materials and surface modifications for improved osseointegration.
{"title":"Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation","authors":"B. Boyan, A. Cheng, R. Olivares-Navarrete, Z. Schwartz","doi":"10.1177/0022034515624444","DOIUrl":"https://doi.org/10.1177/0022034515624444","url":null,"abstract":"Changes in dental implant materials, structural design, and surface properties can all affect biological response. While bulk properties are important for mechanical stability of the implant, surface design ultimately contributes to osseointegration. This article reviews the surface parameters of dental implant materials that contribute to improved cell response and osseointegration. In particular, we focus on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage. Surface roughness has been largely studied at the microscale, but recent studies have highlighted the importance of hierarchical micron/submicron/nanosurface roughness, as well as surface roughness in combination with surface wettability. Integrins are transmembrane receptors that recognize changes in the surface and mediate downstream signaling pathways. Specifically, the noncanonical Wnt5a pathway has been implicated in osteoblastic differentiation of cells on titanium implant surfaces. However, much remains to be elucidated. Only recently have studies been conducted on the differences in biological response to implants based on sex, age, and clinical factors; these all point toward differences that advocate for patient-specific implant design. Finally, challenges in implant surface characterization must be addressed to optimize and compare data across studies. An understanding of both the science and the biology of the materials is crucial for developing novel dental implant materials and surface modifications for improved osseointegration.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 1","pages":"10 - 17"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034515624444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64931383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/0022034515624443
M. Dard, S. Kuehne, M. Obrecht, M. Grandin, J. Helfenstein, B. Pippenger
Primary mechanical stability, as measured by maximum insertion torque and resonance frequency analysis, is generally considered to be positively associated with successful secondary stability and implant success. Primary implant stability can be affected by several factors, including the quality and quantity of available bone, the implant design, and the surgical procedure. The use of a tapered implant design, for instance, has been shown to result in good primary stability even in clinical scenarios where primary stability is otherwise difficult to achieve with traditional cylindrical implants—for example, in soft bone and for immediate placement in extraction sockets. In this study, bone-type specific drill procedures are presented for a novel Straumann bone level tapered implant that ensure maximum insertion torque values are kept within the range of 15 to 80 Ncm. The drill procedures are tested in vitro using polyurethane foam blocks of variable density, ex vivo on explanted porcine ribs (bone type 3), and finally in vivo on porcine mandibles (bone type 1). In each test site, adapted drill procedures are found to achieve a good primary stability. These results are further translated into a finite element analysis model capable of predicting primary stability of tapered implants. In conclusion, we have assessed the biomechanical behavior of a novel taper-walled implant in combination with a bone-type specific drill procedure in both synthetic and natural bone of various types, and we have developed an in silico model for predicting primary stability upon implantation.
{"title":"Integrative Performance Analysis of a Novel Bone Level Tapered Implant","authors":"M. Dard, S. Kuehne, M. Obrecht, M. Grandin, J. Helfenstein, B. Pippenger","doi":"10.1177/0022034515624443","DOIUrl":"https://doi.org/10.1177/0022034515624443","url":null,"abstract":"Primary mechanical stability, as measured by maximum insertion torque and resonance frequency analysis, is generally considered to be positively associated with successful secondary stability and implant success. Primary implant stability can be affected by several factors, including the quality and quantity of available bone, the implant design, and the surgical procedure. The use of a tapered implant design, for instance, has been shown to result in good primary stability even in clinical scenarios where primary stability is otherwise difficult to achieve with traditional cylindrical implants—for example, in soft bone and for immediate placement in extraction sockets. In this study, bone-type specific drill procedures are presented for a novel Straumann bone level tapered implant that ensure maximum insertion torque values are kept within the range of 15 to 80 Ncm. The drill procedures are tested in vitro using polyurethane foam blocks of variable density, ex vivo on explanted porcine ribs (bone type 3), and finally in vivo on porcine mandibles (bone type 1). In each test site, adapted drill procedures are found to achieve a good primary stability. These results are further translated into a finite element analysis model capable of predicting primary stability of tapered implants. In conclusion, we have assessed the biomechanical behavior of a novel taper-walled implant in combination with a bone-type specific drill procedure in both synthetic and natural bone of various types, and we have developed an in silico model for predicting primary stability upon implantation.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 1","pages":"28 - 33"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034515624443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64931373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/0022034515624445
E. Bonfante, Paulo G. Coelho, Paulo G. Coelho
The degree of interplay among variables in dental implant treatment presents a challenge to randomized clinical trials attempting to answer questions in a timely, unbiased, and economically feasible fashion. Further adding complexity to the different scenarios is the varied implant designs and related bone response, area of implantation, implant bulk material, restoration, abutments and related screws, fixation mode (screwed, fixed, or a combination), and horizontal implant-abutment matching geometry. This article critically appraises the most common mechanical testing methods used to characterize the implant-prostheses complex. It attempts to provide insight into the process of construction of an informed database of clinically relevant questions regarding preclinical evaluation of implant biomechanics and failure mechanisms. The use of single load to failure, fatigue life, fatigue limit, and step-stress accelerated life testing is discussed with emphasis on their deliverables, weaknesses, and strengths. Fractographic analysis and challenges in the correlation between laboratory- and in-service-produced failures of dental ceramics, resin composites, and titanium are introduced. In addition, examples are presented of mechanical characterization studies used in our laboratory to assess some implant-supported rehabilitation variables.
{"title":"A Critical Perspective on Mechanical Testing of Implants and Prostheses","authors":"E. Bonfante, Paulo G. Coelho, Paulo G. Coelho","doi":"10.1177/0022034515624445","DOIUrl":"https://doi.org/10.1177/0022034515624445","url":null,"abstract":"The degree of interplay among variables in dental implant treatment presents a challenge to randomized clinical trials attempting to answer questions in a timely, unbiased, and economically feasible fashion. Further adding complexity to the different scenarios is the varied implant designs and related bone response, area of implantation, implant bulk material, restoration, abutments and related screws, fixation mode (screwed, fixed, or a combination), and horizontal implant-abutment matching geometry. This article critically appraises the most common mechanical testing methods used to characterize the implant-prostheses complex. It attempts to provide insight into the process of construction of an informed database of clinically relevant questions regarding preclinical evaluation of implant biomechanics and failure mechanisms. The use of single load to failure, fatigue life, fatigue limit, and step-stress accelerated life testing is discussed with emphasis on their deliverables, weaknesses, and strengths. Fractographic analysis and challenges in the correlation between laboratory- and in-service-produced failures of dental ceramics, resin composites, and titanium are introduced. In addition, examples are presented of mechanical characterization studies used in our laboratory to assess some implant-supported rehabilitation variables.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 1","pages":"18 - 27"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034515624445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64931413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/0022034516630947
M. Dard
The topic “clinical relevance of integrated developmental research for dental implants” was initially addressed at a multidisciplinary symposium during the 93rd General Session & Exhibition of the International Association for Dental Research on March 11, 2015, in Boston, Massachusetts, USA. The objective of this meeting consisted in discussing the optimal workflow for the development of a dental implant from the initial bench design to in vivo implantation at the clinical level. As a study case, attendees decided to share views on and confer about a new tapered implant. This special issue of Advances in Dental Research reflects the multiple outcomes of the discussions that took place during the above symposium and the multiple exchanges and chats that followed. The opening publication consists in a narrative review. The authors of the first paper, relying on undisputed clinical experience, describe that the relationship that exists among implant surface, primary stability, thread configuration, body shape, and type of bony bed has to be considered to lessen treatment times by decreasing the healing period during which osseointegration is established (Wilson et al. 2016). From this discussion, the concept of initial stability, which incorporates all the aforementioned parameters (including primary stability), clearly emerges. Consequently the 2 subsequent papers by Boyan et al. (2016) and Bonfante and Coelho (2016) deepen, respectively, the significance of implant surface and mechanical properties on osseointegration and their long-term maintenance. Boyan et al. (2016) insist on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage, as recent studies have highlighted the importance of hierarchical micro-/nanosurface roughness, as well as surface roughness in combination with surface wettability. Cell surface receptors recognize topographic and biological changes in the surface and downstream signaling pathways accordingly (i.e., the noncanonical Wnt5a pathway, which has been implicated in osteoblastic differentiation on titanium implant surfaces). Moreover, recently conducted studies on the differences in biological responses to implants based on sex, age, and clinical factors advocate for patient-specific implant designs. Bonfante and Coelho (2016) identify the complexity of investigating varied implant designs, related bone response, area of implantation, implant bulk material, restoration, abutments and related screws, fixation mode (screwed, fixed, or a combination), and horizontal implant-abutment matching geometry. They are concerned by the number of and interplay among variables in dental implant treatment and outline that this presents a challenge to clinical trials attempting to answer questions in a timely, unbiased, and economically feasible fashion. Their manuscript critically appraises the most common mechanical testing methods used to characterize the implant-prosthesis complex. It atte
2015年3月11日,在美国马萨诸塞州波士顿举行的第93届国际牙科研究协会大会暨展览会上,多学科研讨会首次讨论了“牙科种植体综合发展研究的临床意义”这一主题。本次会议的目的是讨论牙科种植体从最初的工作台设计到临床水平的体内种植的最佳工作流程。作为一个研究案例,与会者决定就一种新的锥形种植体分享意见并进行讨论。这期《牙科研究进展》特刊反映了在上述研讨会期间进行的讨论以及随后的多次交流和聊天的多种结果。开篇是一篇叙述性评论。第一篇论文的作者根据无可争议的临床经验,描述了必须考虑种植体表面、初级稳定性、螺纹配置、身体形状和骨床类型之间的关系,通过缩短骨整合建立的愈合时间来减少治疗时间(Wilson等人,2016)。从这个讨论中,包含上述所有参数(包括初级稳定性)的初始稳定性概念清晰地出现了。因此,Boyan et al.(2016)和Bonfante and Coelho(2016)随后的两篇论文分别深化了种植体表面和力学性能对骨整合及其长期维护的重要性。Boyan等人(2016)坚持认为,表面设计如何影响间充质细胞的反应和向成骨细胞谱系的分化,因为最近的研究强调了层次微/纳米表面粗糙度的重要性,以及表面粗糙度与表面润湿性的结合。细胞表面受体相应识别表面和下游信号通路的地形和生物学变化(即非规范的Wnt5a通路,它与钛种植体表面的成骨细胞分化有关)。此外,最近开展的关于基于性别、年龄和临床因素的植入物生物学反应差异的研究提倡针对患者的植入物设计。Bonfante和Coelho(2016)指出了研究不同种植体设计、相关骨反应、种植面积、种植体体积材料、修复、基台和相关螺钉、固定模式(螺钉、固定或组合)以及水平种植体-基台匹配几何形状的复杂性。他们关注种植牙治疗中变量的数量和相互作用,并概述这对临床试验提出了挑战,试图以及时、公正和经济可行的方式回答问题。他们的手稿批判性地评估了最常用的机械测试方法,用于表征种植体-假体复合物。它试图提供深入了解关于临床前评估种植体生物力学和失效机制的临床相关问题的知情数据库的构建过程。对单载荷失效试验、疲劳寿命试验、疲劳极限试验和阶梯应力加速寿命试验等方法的应用进行了实际讨论,并着重分析了它们的优缺点。Dard等人(2016)发表的第四篇论文为应用于新型骨水平锥形植入物的综合性能分析概念进行了辩护。他们建议依次进行骨类型特定的钻孔程序,以确保通过最大插入扭矩和共振频率分析测量的最大插入扭矩值在15至80 N·cm范围内。锥形壁种植体的生物力学行为是通过结合不同类型的天然骨(猪肋骨和下颌骨)的骨类型特异性钻孔程序和使用可变密度聚氨酯泡沫块(骨类型1至4)的体外模型来评估的。该方法旨在预测种植后的初步稳定性。此外,作者表明,有限元分析支持针对给定种植体类型和骨质量合并优化钻孔程序的有效性。Stavropoulos和Cochran (Stavropoulos等人,2016)通过在临床前体内模型中评估,与标准方案相比,涉及种植体部位轻微准备不足的方案是否会对骨整合方面产生影响,并对种植体截骨的边缘方面进行记录和分析,从而提供了广泛的结论性贡献。一半的植入物立即被加载,其余的被淹没。标准钻井方案组630947 ADRXXX10记录的平均插入扭矩值明显较低。 中国口腔医学研究进展,牙种植体综合发展研究- 2016
{"title":"Clinical Relevance of Integrated Developmental Research for Dental Implants","authors":"M. Dard","doi":"10.1177/0022034516630947","DOIUrl":"https://doi.org/10.1177/0022034516630947","url":null,"abstract":"The topic “clinical relevance of integrated developmental research for dental implants” was initially addressed at a multidisciplinary symposium during the 93rd General Session & Exhibition of the International Association for Dental Research on March 11, 2015, in Boston, Massachusetts, USA. The objective of this meeting consisted in discussing the optimal workflow for the development of a dental implant from the initial bench design to in vivo implantation at the clinical level. As a study case, attendees decided to share views on and confer about a new tapered implant. This special issue of Advances in Dental Research reflects the multiple outcomes of the discussions that took place during the above symposium and the multiple exchanges and chats that followed. The opening publication consists in a narrative review. The authors of the first paper, relying on undisputed clinical experience, describe that the relationship that exists among implant surface, primary stability, thread configuration, body shape, and type of bony bed has to be considered to lessen treatment times by decreasing the healing period during which osseointegration is established (Wilson et al. 2016). From this discussion, the concept of initial stability, which incorporates all the aforementioned parameters (including primary stability), clearly emerges. Consequently the 2 subsequent papers by Boyan et al. (2016) and Bonfante and Coelho (2016) deepen, respectively, the significance of implant surface and mechanical properties on osseointegration and their long-term maintenance. Boyan et al. (2016) insist on how surface design affects mesenchymal cell response and differentiation into the osteoblast lineage, as recent studies have highlighted the importance of hierarchical micro-/nanosurface roughness, as well as surface roughness in combination with surface wettability. Cell surface receptors recognize topographic and biological changes in the surface and downstream signaling pathways accordingly (i.e., the noncanonical Wnt5a pathway, which has been implicated in osteoblastic differentiation on titanium implant surfaces). Moreover, recently conducted studies on the differences in biological responses to implants based on sex, age, and clinical factors advocate for patient-specific implant designs. Bonfante and Coelho (2016) identify the complexity of investigating varied implant designs, related bone response, area of implantation, implant bulk material, restoration, abutments and related screws, fixation mode (screwed, fixed, or a combination), and horizontal implant-abutment matching geometry. They are concerned by the number of and interplay among variables in dental implant treatment and outline that this presents a challenge to clinical trials attempting to answer questions in a timely, unbiased, and economically feasible fashion. Their manuscript critically appraises the most common mechanical testing methods used to characterize the implant-prosthesis complex. It atte","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 1","pages":"2 - 3"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034516630947","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64931043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01DOI: 10.1177/0022034515624446
Andreas Stavropoulos, David L. Cochran, M. Obrecht, B. Pippenger, Michel Dard
The aim of the present preclinical in vivo study was to evaluate whether a modified “drill-only” protocol, involving slight underpreparation of the implant site, may have an effect on aspects of osseointegration of a novel bone-level tapered implant, compared with the “standard drilling” protocol involving taping and profiling of the marginal aspect of the implant socket. In each side of the edentulated and completely healed mandible of 11 minipigs, 2 tapered implants (8 mm long × 4.1 mm Ø, BLT; Institut Straumann AG, Basel, Switzerland) were installed either with the drill-only or the standard drilling protocol. Significantly lower average insertion torque values were recorded for the standard drilling protocol group (52 ± 29 Ncm) compared with the drill-only group (70 ± 27 Ncm) (t test, P ≤ 0.05); no significant difference was observed between the 2 groups regarding implant stability, by means of resonance frequency analysis (75 ± 8 vs. 75 ± 6, respectively). Half of the implants were immediately loaded and the rest were submerged, providing observation times of 8 or 4 wk, respectively. Non-decalcified histological and histomorphometric analysis of the implants with surrounding tissues showed no significant differences between the 2 drilling protocols regarding the distance from the implant platform to the first coronal bone-to-implant contact (f-BIC), the total bone-to-implant contact (BIC) as a percentage of the total implant perimeter, and the bone density in an area extending 1 mm laterally from the implant (BATA) within 2 rectangular regions of interest (ROIs) 4 mm in height, representing the coronal (parallel-walled) and apical (tapered) aspect of the implant (ROI 1 and ROI 2, respectively) in non-submerged implants. In general, marginal peri-implant bone levels were at or slightly apical to the implant platform, and large amounts of bone-to-implant contact were observed. In contrast, immediately loaded implants placed with the drill-only protocol showed statistically significantly lower BIC values (66% ± 13.7%) compared with those installed with the standard drilling protocol (74.8% ± 11.2%) (P = 0.018). In addition, although marginal bone levels were in most of the immediately loaded implants at or slightly apical to the implant platform, some of the implants installed with the drill-only protocol showed marginal bone loss and crater formation. Thus, in this model system, even slight underpreparation of the implant socket appeared to compromise osseointegration of immediately loaded bone-level tapered implants.
{"title":"Effect of Osteotomy Preparation on Osseointegration of Immediately Loaded, Tapered Dental Implants","authors":"Andreas Stavropoulos, David L. Cochran, M. Obrecht, B. Pippenger, Michel Dard","doi":"10.1177/0022034515624446","DOIUrl":"https://doi.org/10.1177/0022034515624446","url":null,"abstract":"The aim of the present preclinical in vivo study was to evaluate whether a modified “drill-only” protocol, involving slight underpreparation of the implant site, may have an effect on aspects of osseointegration of a novel bone-level tapered implant, compared with the “standard drilling” protocol involving taping and profiling of the marginal aspect of the implant socket. In each side of the edentulated and completely healed mandible of 11 minipigs, 2 tapered implants (8 mm long × 4.1 mm Ø, BLT; Institut Straumann AG, Basel, Switzerland) were installed either with the drill-only or the standard drilling protocol. Significantly lower average insertion torque values were recorded for the standard drilling protocol group (52 ± 29 Ncm) compared with the drill-only group (70 ± 27 Ncm) (t test, P ≤ 0.05); no significant difference was observed between the 2 groups regarding implant stability, by means of resonance frequency analysis (75 ± 8 vs. 75 ± 6, respectively). Half of the implants were immediately loaded and the rest were submerged, providing observation times of 8 or 4 wk, respectively. Non-decalcified histological and histomorphometric analysis of the implants with surrounding tissues showed no significant differences between the 2 drilling protocols regarding the distance from the implant platform to the first coronal bone-to-implant contact (f-BIC), the total bone-to-implant contact (BIC) as a percentage of the total implant perimeter, and the bone density in an area extending 1 mm laterally from the implant (BATA) within 2 rectangular regions of interest (ROIs) 4 mm in height, representing the coronal (parallel-walled) and apical (tapered) aspect of the implant (ROI 1 and ROI 2, respectively) in non-submerged implants. In general, marginal peri-implant bone levels were at or slightly apical to the implant platform, and large amounts of bone-to-implant contact were observed. In contrast, immediately loaded implants placed with the drill-only protocol showed statistically significantly lower BIC values (66% ± 13.7%) compared with those installed with the standard drilling protocol (74.8% ± 11.2%) (P = 0.018). In addition, although marginal bone levels were in most of the immediately loaded implants at or slightly apical to the implant platform, some of the implants installed with the drill-only protocol showed marginal bone loss and crater formation. Thus, in this model system, even slight underpreparation of the implant socket appeared to compromise osseointegration of immediately loaded bone-level tapered implants.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 1","pages":"34 - 41"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034515624446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64931454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-29DOI: 10.1177/0022034516628868
T. G. Wilson, R. J. Miller, R. Trushkowsky, Michel Dard
The most common approach to lessen treatment times is by decreasing the healing period during which osseointegration is established. Implant design parameters such as implant surface, primary stability, thread configuration, body shape, and the type of bone have to be considered to obtain this objective. The relationship that exists between these components will define the initial stability of the implant. It is believed implant sites using a tapered design and surface modification can increase the primary stability in low-density bone. Furthermore, recent experimental preclinical work has shown the possibility of attaining primary stability of immediately loaded, tapered dental implants without compromising healing and rapid bone formation while minimizing the implant stability loss at compression sites. This may be of singular importance with immediate/early functional loading of single implants placed in poor-quality bone. The selection of an implant that will provide adequate stability in bone of poor quality is important. A tapered-screw implant design will provide adequate stability because it creates pressure on cortical bone in areas of reduced bone quality. Building on the success of traditional tapered implant therapy, newer tapered implant designs should aim to maximize the clinical outcome by implementing new technologies with adapted clinical workflows.
{"title":"Tapered Implants in Dentistry","authors":"T. G. Wilson, R. J. Miller, R. Trushkowsky, Michel Dard","doi":"10.1177/0022034516628868","DOIUrl":"https://doi.org/10.1177/0022034516628868","url":null,"abstract":"The most common approach to lessen treatment times is by decreasing the healing period during which osseointegration is established. Implant design parameters such as implant surface, primary stability, thread configuration, body shape, and the type of bone have to be considered to obtain this objective. The relationship that exists between these components will define the initial stability of the implant. It is believed implant sites using a tapered design and surface modification can increase the primary stability in low-density bone. Furthermore, recent experimental preclinical work has shown the possibility of attaining primary stability of immediately loaded, tapered dental implants without compromising healing and rapid bone formation while minimizing the implant stability loss at compression sites. This may be of singular importance with immediate/early functional loading of single implants placed in poor-quality bone. The selection of an implant that will provide adequate stability in bone of poor quality is important. A tapered-screw implant design will provide adequate stability because it creates pressure on cortical bone in areas of reduced bone quality. Building on the success of traditional tapered implant therapy, newer tapered implant designs should aim to maximize the clinical outcome by implementing new technologies with adapted clinical workflows.","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"28 1","pages":"4 - 9"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034516628868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64931472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1177/0022034515575540
A Sheiham, D M Williams
Dentistry is facing many serious challenges and threats. Addressing them will require major changes in strategy. This work outlines the extent of dental disease in the Africa and Middle East Region (AMER) and suggests strategies to reduce inequalities in oral health. The main oral health challenges in the AMER relate to controlling the relentless increase in caries with age. A very conservative estimate of population caries levels suggests that a 5-fold increase in dental personnel would be required just to treat current levels of caries. Hence, we argue that current approaches to control caries in the AMER are both ineffective and unaffordable, and a new model to promote oral health is needed. Unless determinants of noncommunicable diseases are addressed and access to evidence-based minimal intervention dental care is improved, the burden of dental disease will persist. The new oral health promotion model calls for an integrated intersectoral common risk factor approach, namely, "oral health in all policies" (OHiAP). An OHiAP framework will initiate high-level policy initiatives and intersectoral partnerships. Oral health professionals have an important advocacy role in securing the fundamental changes in health strategy needed to control the growing, unjust, and unaffordable burden of oral disease.
{"title":"Reducing Inequalities in Oral Health in the Africa and Middle East Region.","authors":"A Sheiham, D M Williams","doi":"10.1177/0022034515575540","DOIUrl":"https://doi.org/10.1177/0022034515575540","url":null,"abstract":"<p><p>Dentistry is facing many serious challenges and threats. Addressing them will require major changes in strategy. This work outlines the extent of dental disease in the Africa and Middle East Region (AMER) and suggests strategies to reduce inequalities in oral health. The main oral health challenges in the AMER relate to controlling the relentless increase in caries with age. A very conservative estimate of population caries levels suggests that a 5-fold increase in dental personnel would be required just to treat current levels of caries. Hence, we argue that current approaches to control caries in the AMER are both ineffective and unaffordable, and a new model to promote oral health is needed. Unless determinants of noncommunicable diseases are addressed and access to evidence-based minimal intervention dental care is improved, the burden of dental disease will persist. The new oral health promotion model calls for an integrated intersectoral common risk factor approach, namely, \"oral health in all policies\" (OHiAP). An OHiAP framework will initiate high-level policy initiatives and intersectoral partnerships. Oral health professionals have an important advocacy role in securing the fundamental changes in health strategy needed to control the growing, unjust, and unaffordable burden of oral disease. </p>","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"27 1","pages":"4-9"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034515575540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33286946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.1177/0022034515582062
A Abid, F Maatouk, L Berrezouga, C Azodo, O Uti, H El-Shamy, A Oginni
This review aims to determine the prevalence and severity of oral health diseases in the Africa and Middle East region (AMER). The profile of oral diseases is not homogeneous across the AMER. There are large disparities between groups. Reliable data are scarce. The prevalence and severity of oral diseases appear to be increasing in the African region, as does associated morbidity. There are substantial differences in inequalities in oral health. Dental caries prevalence is less severe in most African countries than in developed countries, but the high rate of untreated caries reflects the limited resources available and difficulties of access and affordability to essential oral health care services. The prevalence of gingival inflammation is very high in all age groups in several African countries. The prevalence of maxillofacial trauma has increased in many countries, with a wide variation of the incidence and high prevalence of traumatic dental injuries in primary and permanent teeth. Orofacial clefts are among the most common birth defects. Annual incidence of oral cancer is estimated as 25 cases per 100,000 people in Africa. Noma is a major public health problem for the Middle East and North African (MENA) region. Data about human immunodeficiency virus/AIDS are limited, particularly in the MENA region. According to the World Health Organization Regional Committee for Africa report, some fundamental key basic knowledge gaps need to be underlined. They include inequalities in oral health, low priority for oral health, lack of adequate funding, inadequate dental student training, obstacles to medical and dental research, and poor databases. There are very few effective public prevention and oral health promotion programs in the AMER. Universal health coverage is not achievable without scientific research on the effectiveness of health promotion interventions.
{"title":"Prevalence and Severity of Oral Diseases in the Africa and Middle East Region.","authors":"A Abid, F Maatouk, L Berrezouga, C Azodo, O Uti, H El-Shamy, A Oginni","doi":"10.1177/0022034515582062","DOIUrl":"https://doi.org/10.1177/0022034515582062","url":null,"abstract":"<p><p>This review aims to determine the prevalence and severity of oral health diseases in the Africa and Middle East region (AMER). The profile of oral diseases is not homogeneous across the AMER. There are large disparities between groups. Reliable data are scarce. The prevalence and severity of oral diseases appear to be increasing in the African region, as does associated morbidity. There are substantial differences in inequalities in oral health. Dental caries prevalence is less severe in most African countries than in developed countries, but the high rate of untreated caries reflects the limited resources available and difficulties of access and affordability to essential oral health care services. The prevalence of gingival inflammation is very high in all age groups in several African countries. The prevalence of maxillofacial trauma has increased in many countries, with a wide variation of the incidence and high prevalence of traumatic dental injuries in primary and permanent teeth. Orofacial clefts are among the most common birth defects. Annual incidence of oral cancer is estimated as 25 cases per 100,000 people in Africa. Noma is a major public health problem for the Middle East and North African (MENA) region. Data about human immunodeficiency virus/AIDS are limited, particularly in the MENA region. According to the World Health Organization Regional Committee for Africa report, some fundamental key basic knowledge gaps need to be underlined. They include inequalities in oral health, low priority for oral health, lack of adequate funding, inadequate dental student training, obstacles to medical and dental research, and poor databases. There are very few effective public prevention and oral health promotion programs in the AMER. Universal health coverage is not achievable without scientific research on the effectiveness of health promotion interventions. </p>","PeriodicalId":7300,"journal":{"name":"Advances in Dental Research","volume":"27 1","pages":"10-7"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0022034515582062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33286947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}