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A Transdisciplinary Program for Care of Veterans With Neurocognitive Disorders. 退伍军人神经认知障碍护理的跨学科项目。
Mario F Mendez, Rebecca A Melrose, Denise G Feil, Kelsey A Holiday, Marianne Hunt, Ali Najafian Jazi, Sukh L Lamba, Michael E Mahler, Daniel E Okobi, Hans F Von Walter

Background: Veterans face specific risk factors for neurocognitive disorders. Providing them with comprehensive care for dementia and related neurocognitive disorders is a challenge as the population ages. There is a need for family-centered interventions, specialized expertise, and collaboration among clinicians and caregivers. The literature suggests that application of a transdisciplinary care model can address these needs and provide effective dementia care.

Observations: The Veterans Affairs Greater Los Angeles Healthcare System has employed existing expertise to create a conference-centered transdisciplinary model that responds to the US Department of Veterans Affairs directive for a dementia system of care. This model involves direct participation of behavioral neurology, geriatric psychiatry, geriatrics, neuropsychology, nursing, and social work. In this model, the social worker serves as a dementia care manager and, along with the nurse specialist, assures long-term management through follow-up and monitoring. Transdisciplinary interactions occur in a clinical case conference where each discipline contributes to the veteran's care. The team generates a final report on treating these veterans, the caregiver's needs, referral for psychosocial services, and plans for monitoring and follow-up.

Conclusions: This model could be a template of a program for implementing the Dementia System of Care across Veteran Affairs medical centers.

背景:退伍军人面临神经认知障碍的特定危险因素。随着人口老龄化,为他们提供痴呆症和相关神经认知障碍的全面护理是一项挑战。需要以家庭为中心的干预措施、专业知识以及临床医生和护理人员之间的合作。文献表明,应用跨学科护理模式可以解决这些需求,并提供有效的痴呆症护理。观察结果:退伍军人事务部大洛杉矶医疗保健系统采用现有的专业知识创建了一个以会议为中心的跨学科模型,以响应美国退伍军人事务部关于痴呆症护理系统的指示。该模式涉及行为神经病学、老年精神病学、老年病学、神经心理学、护理学和社会工作的直接参与。在这种模式下,社会工作者作为痴呆症护理管理者,与护士专家一起,通过跟踪和监测来确保长期管理。跨学科的互动发生在临床病例会议上,每个学科都对退伍军人的护理有贡献。该小组就这些退伍军人的治疗、护理人员的需求、心理社会服务的转诊以及监测和随访计划生成一份最终报告。结论:该模型可以作为在退伍军人事务医疗中心实施痴呆症护理系统的程序模板。
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引用次数: 0
The Safety and Efficacy of AUC/MIC-Guided vs Trough-Guided Vancomycin Monitoring Among Veterans. 退伍军人在AUC/ mic引导下与凹槽引导下万古霉素监测的安全性和有效性。
Alyx Folkers, Rose Anderson, Jessica Harris, Courtney Rogen

Background: Vancomycin is a commonly used antibiotic for the treatment of methicillin-resistant Staphylococcus aureus (MRSA), which requires therapeutic drug monitoring (TDM). Guidelines recommend targeting an individualized area under the curve/minimum inhibitory concentration (AUC/MIC) ratio of 400 to 600 mg × h/L to maximize efficacy and minimize the risk of acute kidney injury (AKI). Before these guidelines, the accepted method of vancomycin TDM was using trough levels alone. To our knowledge, no studies of veterans have compared the difference in AKI incidence and time in the therapeutic range between monitoring strategies.

Methods: This single-site, retrospective, quasi-experimental study was conducted at the Sioux Falls Veterans Affairs Health Care System. The primary endpoint was the difference in vancomycin-induced AKI incidence between the 2 groups.

Results: This study included 97 patients with 43 in the AUC/MIC group and 54 in the trough-guided group. The incidence of vancomycin-induced AKI was 2% in the AUC/MIC group and 4% in the trough group (P = .10). The incidence of overall AKI for AUC/MIC-guided and trough-guided TDM was 23% and 15% (P = .29), respectively.

Conclusions: We did not find a significant difference in the incidence of vancomycin-induced or overall AKI between AUC/MIC- and trough-guided TDM. However, this study did indicate that AUC/MIC-guided TDM of vancomycin may be more effective than trough-guided TDM regarding a quicker time to and higher overall time in the therapeutic range. These findings support the recommendation to transition to the use of AUC/MIC-guided TDM of vancomycin in the veteran population.

背景:万古霉素是治疗耐甲氧西林金黄色葡萄球菌(MRSA)的常用抗生素,需要进行治疗性药物监测(TDM)。指南建议个体化的曲线下面积/最低抑制浓度(AUC/MIC)比为400 ~ 600 mg × h/L,以最大限度地提高疗效并降低急性肾损伤(AKI)的风险。在这些指南之前,万古霉素TDM的公认方法是单独使用谷水平。据我们所知,没有针对退伍军人的研究比较了不同监测策略在AKI发病率和治疗范围内的时间差异。方法:在苏福尔斯退伍军人事务卫生保健系统进行单点、回顾性、准实验研究。主要终点是两组万古霉素诱导AKI发生率的差异。结果:本研究纳入97例患者,其中AUC/MIC组43例,槽引导组54例。AUC/MIC组万古霉素诱发AKI的发生率为2%,低谷组为4% (P = 0.10)。AUC/ mic引导下和槽式引导下TDM的总AKI发生率分别为23%和15% (P = 0.29)。结论:我们没有发现在AUC/MIC-和通道引导TDM之间万古霉素诱导的AKI发生率或总体AKI发生率有显著差异。然而,本研究确实表明,在治疗范围内,AUC/ mic引导下的万古霉素TDM可能比低谷引导下的TDM更有效,达到时间更快,总时间更长。这些发现支持在退伍军人人群中过渡到使用AUC/ mic引导的万古霉素TDM的建议。
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引用次数: 0
When Patients Make Unexpected Medical Choices. 当病人做出意外的医疗选择时。
Grace Cullen
BackgroundIn the United States, about 500,000 patients are receiving maintenance dialysis for end-stage renal disease. The decision to discontinue dialysis and receive hospice care tends to be more difficult than to withhold or forego dialysis.ObservationsSupporting patient autonomy is an important health care priority that is recognized by most clinicians. However, some health care professionals are conflicted when patient autonomy varies from their treatment recommendations. This paper describes the case of a patient on kidney dialysis who chose to discontinue a potentially life-prolonging treatment.ConclusionsRespecting a patient's autonomy to make informed decisions about their end-of-life care is a fundamental ethical and legal principle. Medical opinion should not and cannot overrule the wishes of a competent patient who refuses treatment.
背景:在美国,约有50万名终末期肾病患者接受维持性透析治疗。决定停止透析并接受临终关怀往往比拒绝或放弃透析更困难。观察:支持病人自主是一个重要的卫生保健优先事项,是公认的大多数临床医生。然而,当患者的自主权与他们的治疗建议不同时,一些卫生保健专业人员感到矛盾。本文描述的情况下,病人肾透析谁选择停止一个潜在的延长生命的治疗。结论:尊重病人在知情的情况下做出临终关怀决定的自主权是一项基本的伦理和法律原则。医学意见不应该也不能推翻拒绝治疗的有能力的病人的意愿。
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引用次数: 0
Patient With Severe Headache After IV Immunoglobulin. 静脉注射免疫球蛋白后严重头痛患者。
Capt Christopher Russo, Lt Kenneth Dalton, Loran Grant, Noelle Enos, D Lt Andrew Evans
A 35-year-old woman with a history of hypothyroidism and idiopathic small fiber autonomic and sensory neuropathy presented to the emergency department (ED) 48 hours after IV immunoglobulin (IG) infusion with a severe headache, nausea, neck stiffness, photophobia, and episodes of intense positional eye pressure. The patient reported previous episodes of headaches post-IVIG infusion but not nearly as severe. On ED arrival, the patient was afebrile with vital signs within normal limits. Initial laboratory results were notable for levels within reference range parameters: 5.9 × 10/L white blood cell (WBC) count, 13.3 g/dL hemoglobin, 38.7% hematocrit, and 279 × 10/L platelet count; there were no abnormal urinalysis findings, and she was negative for human chorionic gonadotropin. Due to the patient’s symptoms concerning for an acute intracranial process, a brain computed tomography (CT) without contrast was ordered. The CT demonstrated no intracranial abnormalities, but the patient’s symptoms continued to worsen. The patient was started on IV fluids and 1 g IV acetaminophen and underwent a lumbar puncture (LP). Her opening pressure was elevated at 29 cm H 2O (reference range, 6-20 cm), and the fluid was notably clear. During the LP, 25 mL of cerebrospinal fluid (CSF) was collected for laboratory analysis to include a polymerase chain reaction (PCR) panel and cultures, and a closing pressure of 12 cm H 2 O was recorded at the end of the procedure with the patient reporting some relief of pressure. The patient was admitted to the medicine ward for further workup and observations. The patient’s meningitis/encephalitis PCR panel detected no pathogens in the CSF, but her WBC count was 84 × 10/L (reference range, 4-11) with 30 segmented neutrophils (reference range, 0-6) and red blood cell count of 24 (reference range, 0-1); her normal glucose at 60 mg/dL (reference range, 40-70) and protein of 33 mg/dL (reference range, 15-45) were within normal parameters. Brain magnetic resonance images with and without contrast was inconsistent with any acute intracranial pathology to include subarachnoid hemorrhage or central nervous system neoplasm (Figure 1). Bacterial and fungal cultures were negative.
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引用次数: 0
Oral Therapy for Aerococcus urinae Bacteremia and Thoracic Spondylodiscitis of Presumed Urinary Origin. 口服治疗尿气球菌菌血症和推定泌尿源性胸椎椎间盘炎。
Brandon Butcher, Echko Holman, James R Johnson, Aaron Boothby

Background: Aerococcus urinae (A urinae), considered a rare pathogen, has been identified with increasing frequency in urine cultures. Only 8 cases of spondylodiscitis due to A urinae have been reported. Optimal treatment for invasive A urinae infection is undefined. However, the reported cases were treated successfully with diverse antibiotic regimen combinations, all including a β-lactam and beginning with at least 2 weeks of IV antibiotics.

Case presentation: A 74-year-old man presented to the emergency department after 2 weeks of midthoracic back pain, lower extremity weakness, gait imbalance, fatigue, anorexia, rigors, and subjective fevers. The patient was presumed to have discitis secondary to a urinary tract infection with possible pyelonephritis and was given empiric vancomycin and ceftriaxone. Spinal magnetic resonance imaging with contrast supported spondylodiscitis. Preliminary results from the admission blood and urine cultures showed gram-positive cocci in clusters.

Conclusions: A urinae urinary tract infection in the absence of obvious predisposing factors should prompt evaluation for urinary outflow obstruction. We suspect a review of a US Department of Veterans Affairs population might uncover a higher incidence of A urinae infection than previously suspected.

背景:尿气球菌(A urinae)被认为是一种罕见的病原体,在尿液培养中发现的频率越来越高。仅报道了8例A型尿源性脊柱炎。侵袭性尿路A型感染的最佳治疗方法尚不明确。然而,报告的病例通过多种抗生素方案组合成功治疗,所有抗生素方案组合都包括β-内酰胺,并开始至少2周静脉注射抗生素。病例介绍:一名74岁男性患者,因胸中背部疼痛、下肢无力、步态不平衡、疲劳、厌食、僵直和主观发热2周后被送往急诊科。假定患者继发于尿路感染并发肾盂肾炎,给予经验万古霉素和头孢曲松治疗。脊柱磁共振成像与造影剂支持的脊椎椎间盘炎。入院血液和尿液培养的初步结果显示革兰氏阳性球菌呈聚集性。结论:无明显易感因素的尿路感染应及时评估尿出口梗阻。我们怀疑对美国退伍军人事务部人口的审查可能会发现a型尿感染的发生率比以前怀疑的要高。
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引用次数: 7
A Novel Text Message Protocol to Improve Bowel Preparation for Outpatient Colonoscopies in Veterans. 一种新的短信协议改善退伍军人门诊结肠镜检查的肠道准备。
Susan Lou, Morgan Freeman, Nicha Wongjarupong, Anders Westanmo, Amy Gravely, Shahnaz Sultan, Aasma Shaukat

Background: The current gold standard for screening for colorectal cancer is colonoscopy, a procedure that depends on the quality of bowel preparation. In 2016, the Veterans Health Administration introduced Annie, a text message service to improve health care communication with patients. The Minneapolis Veterans Affairs Medical Center conducted a prospective, single center study to measure the impact of Annie text messaging on patient satisfaction and quality of bowel preparation for patients undergoing outpatient colonoscopy.

Methods: Patients undergoing colonoscopy were divided into 2 groups. The control group received standardized patient education and a phone call prior to procedure. The intervention group, consisting of all patients who agreed to enroll, received a 6-day Annie text messaging protocol consisting of key bowel preparation steps that started 5 days prior to their scheduled procedure. Bowel preparation quality was measured using the Boston Bowel Preparation Scale (BBPS) score.

Results: During the study period, 688 veterans were scheduled for outpatient colonoscopy: 484 veterans were in the control group, 204 veterans were in the intervention group, and 126 were surveyed. Annie text messaging instructions were associated with a higher BBPS score (8.2) compared with usual care (7.8); P = .007 using independent t test, and P = .002 using parametric independent t test. Patients also reported satisfaction with the Annie text messaging service.

Conclusions: There was a statistically significant improvement in the average BBPS score in veterans receiving Annie text messages compared with the routine care control group for outpatient colonoscopies.

背景:目前筛查结直肠癌的金标准是结肠镜检查,这一程序取决于肠道准备的质量。2016年,退伍军人健康管理局推出了短信服务Annie,以改善与患者的医疗保健沟通。明尼阿波利斯退伍军人事务医疗中心进行了一项前瞻性单中心研究,以衡量Annie短信对门诊结肠镜检查患者满意度和肠道准备质量的影响。方法:将行结肠镜检查的患者分为两组。对照组在手术前接受标准化的患者教育和电话。干预组由所有同意入组的患者组成,在预定手术前5天开始接受为期6天的Annie短信协议,包括关键的肠道准备步骤。肠准备质量采用波士顿肠准备量表(BBPS)评分进行测量。结果:研究期间,688名退伍军人接受门诊结肠镜检查,其中对照组484名,干预组204名,调查126名。与常规护理(7.8)相比,安妮短信指示与更高的BBPS评分(8.2)相关;采用独立t检验P = .007,采用参数独立t检验P = .002。患者也对Annie的短信服务表示满意。结论:在门诊结肠镜检查中,与常规护理对照组相比,接受安妮短信的退伍军人的平均BBPS评分有统计学意义上的显著改善。
{"title":"A Novel Text Message Protocol to Improve Bowel Preparation for Outpatient Colonoscopies in Veterans.","authors":"Susan Lou,&nbsp;Morgan Freeman,&nbsp;Nicha Wongjarupong,&nbsp;Anders Westanmo,&nbsp;Amy Gravely,&nbsp;Shahnaz Sultan,&nbsp;Aasma Shaukat","doi":"10.12788/fp.0329","DOIUrl":"https://doi.org/10.12788/fp.0329","url":null,"abstract":"<p><strong>Background: </strong>The current gold standard for screening for colorectal cancer is colonoscopy, a procedure that depends on the quality of bowel preparation. In 2016, the Veterans Health Administration introduced Annie, a text message service to improve health care communication with patients. The Minneapolis Veterans Affairs Medical Center conducted a prospective, single center study to measure the impact of Annie text messaging on patient satisfaction and quality of bowel preparation for patients undergoing outpatient colonoscopy.</p><p><strong>Methods: </strong>Patients undergoing colonoscopy were divided into 2 groups. The control group received standardized patient education and a phone call prior to procedure. The intervention group, consisting of all patients who agreed to enroll, received a 6-day Annie text messaging protocol consisting of key bowel preparation steps that started 5 days prior to their scheduled procedure. Bowel preparation quality was measured using the Boston Bowel Preparation Scale (BBPS) score.</p><p><strong>Results: </strong>During the study period, 688 veterans were scheduled for outpatient colonoscopy: 484 veterans were in the control group, 204 veterans were in the intervention group, and 126 were surveyed. Annie text messaging instructions were associated with a higher BBPS score (8.2) compared with usual care (7.8); <i>P</i> = .007 using independent <i>t</i> test, and <i>P</i> = .002 using parametric independent <i>t</i> test. Patients also reported satisfaction with the Annie text messaging service.</p><p><strong>Conclusions: </strong>There was a statistically significant improvement in the average BBPS score in veterans receiving Annie text messages compared with the routine care control group for outpatient colonoscopies.</p>","PeriodicalId":73021,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"39 12","pages":"470-475"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071445/pdf/fp-39-12-470.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9259874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Patient Access to the My HealtheVet Electronic Patient Portal for Veterans. 改善退伍军人对My HealtheVet电子患者门户网站的访问。
Corinne Roberto, Melanie Keiffer, Melanie Black, Carol Williams-Suich, Karen Grunewald

Background: The US Department of Veterans Affairs My HealtheVet (MHV) patient portal is a secure online tool that provides patients access to personal health information. Although facilitators exist to encourage veteran registration, barriers to both adoption and use among veterans persist. This quality improvement project sought to improve veteran access to MHV.

Observations: Using Plan-Do-Study-Act (PDSA) methodology, we identified barriers to registration, evaluated processes for enrollment, and integrated a process improvement champion into a rural primary care clinic workflow. After 3 PDSA cycles, the integration of new processes resulted in increased enrollment and engagement with MHV. Fourteen veterans registered for MHV at the point-of-care in a 3-month time frame.

Conclusions: Use of a connected electronic health record platform and implementation of an MHV champion in the outpatient primary care setting improved rural veteran access to personal health information. Audit and feedback on processes that provide access to health information is an important strategy to narrow the gap between veterans who access patient portals and those who do not.

背景:美国退伍军人事务部My HealtheVet (MHV)患者门户网站是一个安全的在线工具,为患者提供个人健康信息。虽然存在鼓励退伍军人注册的促进者,但退伍军人采用和使用的障碍仍然存在。这一质量改进项目旨在改善退伍军人获得医疗保健服务的机会。观察:使用计划-执行-研究-行动(PDSA)方法,我们确定了注册障碍,评估了注册流程,并将流程改进champion整合到农村初级保健诊所工作流程中。在3个PDSA周期后,新流程的整合导致MHV的注册和参与增加。在3个月的时间框架内,14名退伍军人在医疗点注册了MHV。结论:在门诊初级保健设置中使用连接的电子健康记录平台和实施MHV冠军可以改善农村退伍军人对个人健康信息的获取。对提供卫生信息访问的程序进行审计和反馈是缩小访问患者门户和不访问患者门户的退伍军人之间差距的一项重要战略。
{"title":"Improving Patient Access to the My Health<i>e</i>Vet Electronic Patient Portal for Veterans.","authors":"Corinne Roberto,&nbsp;Melanie Keiffer,&nbsp;Melanie Black,&nbsp;Carol Williams-Suich,&nbsp;Karen Grunewald","doi":"10.17288/fp.0331","DOIUrl":"https://doi.org/10.17288/fp.0331","url":null,"abstract":"<p><strong>Background: </strong>The US Department of Veterans Affairs My Health<i>e</i>Vet (MHV) patient portal is a secure online tool that provides patients access to personal health information. Although facilitators exist to encourage veteran registration, barriers to both adoption and use among veterans persist. This quality improvement project sought to improve veteran access to MHV.</p><p><strong>Observations: </strong>Using Plan-Do-Study-Act (PDSA) methodology, we identified barriers to registration, evaluated processes for enrollment, and integrated a process improvement champion into a rural primary care clinic workflow. After 3 PDSA cycles, the integration of new processes resulted in increased enrollment and engagement with MHV. Fourteen veterans registered for MHV at the point-of-care in a 3-month time frame.</p><p><strong>Conclusions: </strong>Use of a connected electronic health record platform and implementation of an MHV champion in the outpatient primary care setting improved rural veteran access to personal health information. Audit and feedback on processes that provide access to health information is an important strategy to narrow the gap between veterans who access patient portals and those who do not.</p>","PeriodicalId":73021,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"39 12","pages":"476-481"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071446/pdf/fp-39-12-476.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9640139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doctors of Virtue and Vice: The Best and Worst of Federal Practice in 2023. 美德与邪恶的医生:2023年联邦实践的最佳和最差。
Cynthia Geppert
{"title":"Doctors of Virtue and Vice: The Best and Worst of Federal Practice in 2023.","authors":"Cynthia Geppert","doi":"10.12788/fp.0345","DOIUrl":"https://doi.org/10.12788/fp.0345","url":null,"abstract":"","PeriodicalId":73021,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"39 12","pages":"468-469"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071444/pdf/fp-39-12-468.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9258378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Patient Presenting With Shortness of Breath, Fever, and Eosinophilia. 1例患者表现为呼吸急促、发热和嗜酸性粒细胞增多。
Shawn Varghese, Marcus A Kouma, Donald F Storey, Reuben J Arasaratnam
{"title":"A Patient Presenting With Shortness of Breath, Fever, and Eosinophilia.","authors":"Shawn Varghese,&nbsp;Marcus A Kouma,&nbsp;Donald F Storey,&nbsp;Reuben J Arasaratnam","doi":"10.2788/fp.0336","DOIUrl":"https://doi.org/10.2788/fp.0336","url":null,"abstract":"","PeriodicalId":73021,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"39 11","pages":"445-447a"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794170/pdf/fp-39-11-445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10455649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes After Prolonged ICU Stays in Postoperative Cardiac Surgery Patients. 心脏手术后患者延长ICU治疗的结果。
Thomas F Curran, Bipin Sunkara, Aleda Leis, Adrian Lim, Jonathan Haft, Milo Engoren

Background: Prolonged postoperative intensive care unit (ICU) stays are common after cardiac surgery and are associated with poor outcomes. There are few studies evaluating how risk factors associated with mortality may change during prolonged ICU stays or how mortality may vary with length of stay. We evaluated operative and long-term mortality in post-cardiac surgery patients after prolonged ICU stays at 7, 14, 21, and 28 days and factors associated with mortality.

Methods: We included University of Michigan Medical Center cardiac surgery patients with ≥ 7 postoperative days in the ICU. We determined factors associated with hospital mortality at 7, 14, 21, and 28 days of ICU stay using logistic regression, and among hospital survivors, we determined the factors associated with long-term mortality using Cox regression.

Results: Of 8309 ICU admissions from cardiac surgery, 1174 (14%) had ICU stays > 7 days. Operative mortality was 11%, 18%, 22%, and 35% for the 7-, 14-, 21-, and 28-day groups, respectively. Mechanical ventilation on the day of assessment was associated with increased odds ratios of operative mortality in all models. Of the 1049 (89%) hospital survivors, 420 (40%) died by late follow-up. Median (IQR) Cox model survival was 10.7 (0.7) years. Longer ICU stays, postoperative pneumonia, and elevated discharge blood urea nitrogen were associated with increased hazard of dying; whereas higher discharge platelet count and cardiac transplant were protective.

Conclusions: Both operative and late mortality increased as the duration of a ICU stay increased after cardiac surgery.

背景:心脏手术后延长重症监护病房(ICU)住院时间是常见的,并与不良预后相关。很少有研究评估与死亡率相关的危险因素如何在延长ICU住院期间发生变化,或死亡率如何随住院时间变化。我们评估了心脏手术后患者在ICU长时间停留7、14、21和28天后的手术死亡率和长期死亡率,以及与死亡率相关的因素。方法:我们纳入了密歇根大学医学中心心脏手术患者术后在ICU≥7天。我们使用logistic回归确定了与ICU住院7、14、21和28天住院死亡率相关的因素,在住院幸存者中,我们使用Cox回归确定了与长期死亡率相关的因素。结果:8309例心脏外科住院患者中,1174例(14%)住院时间大于7天。7天、14天、21天和28天组的手术死亡率分别为11%、18%、22%和35%。在所有模型中,评估当天的机械通气与手术死亡率的优势比增加相关。在1049例(89%)医院幸存者中,420例(40%)在随访后期死亡。中位(IQR) Cox模型生存期为10.7(0.7)年。ICU住院时间延长、术后肺炎和排出血尿素氮升高与死亡风险增加相关;而较高的血小板计数和心脏移植具有保护作用。结论:随着心脏手术后ICU住院时间的延长,手术死亡率和晚期死亡率均增加。
{"title":"Outcomes After Prolonged ICU Stays in Postoperative Cardiac Surgery Patients.","authors":"Thomas F Curran,&nbsp;Bipin Sunkara,&nbsp;Aleda Leis,&nbsp;Adrian Lim,&nbsp;Jonathan Haft,&nbsp;Milo Engoren","doi":"10.12788/fp.0300","DOIUrl":"https://doi.org/10.12788/fp.0300","url":null,"abstract":"<p><strong>Background: </strong>Prolonged postoperative intensive care unit (ICU) stays are common after cardiac surgery and are associated with poor outcomes. There are few studies evaluating how risk factors associated with mortality may change during prolonged ICU stays or how mortality may vary with length of stay. We evaluated operative and long-term mortality in post-cardiac surgery patients after prolonged ICU stays at 7, 14, 21, and 28 days and factors associated with mortality.</p><p><strong>Methods: </strong>We included University of Michigan Medical Center cardiac surgery patients with ≥ 7 postoperative days in the ICU. We determined factors associated with hospital mortality at 7, 14, 21, and 28 days of ICU stay using logistic regression, and among hospital survivors, we determined the factors associated with long-term mortality using Cox regression.</p><p><strong>Results: </strong>Of 8309 ICU admissions from cardiac surgery, 1174 (14%) had ICU stays > 7 days. Operative mortality was 11%, 18%, 22%, and 35% for the 7-, 14-, 21-, and 28-day groups, respectively. Mechanical ventilation on the day of assessment was associated with increased odds ratios of operative mortality in all models. Of the 1049 (89%) hospital survivors, 420 (40%) died by late follow-up. Median (IQR) Cox model survival was 10.7 (0.7) years. Longer ICU stays, postoperative pneumonia, and elevated discharge blood urea nitrogen were associated with increased hazard of dying; whereas higher discharge platelet count and cardiac transplant were protective.</p><p><strong>Conclusions: </strong>Both operative and late mortality increased as the duration of a ICU stay increased after cardiac surgery.</p>","PeriodicalId":73021,"journal":{"name":"Federal practitioner : for the health care professionals of the VA, DoD, and PHS","volume":"39 Suppl 5","pages":"S6-S11c"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010497/pdf/fp-39-11s-s06.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Federal practitioner : for the health care professionals of the VA, DoD, and PHS
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