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Titanium implants and type IV hypersensitivity reactions: A systematic literature review 钛植入物与IV型超敏反应:系统文献综述
Pub Date : 2025-10-09 DOI: 10.1016/j.fastrc.2025.100578
Susanna Oppong B.S. PMS-3, Amber del Rosario B.S. PMS-3, Steffi Casimir B.S. M.S. PMS-3, Jasmine Atri B.S. PMS-3, Dr. Mark Razzante DPM
This study investigates titanium (Ti) hypersensitivity in surgical implants, which can cause complications like implant failure and inflammation. The goal is to evaluate diagnostic methods, particularly skin patch testing versus the Memory Lymphocyte Immunostimulation Assay (MELISA), to improve outcomes for patients with metal sensitivities. A literature search using databases such as Google Scholar and PubMed identified 18 peer-reviewed studies from 2006 to 2024, focusing on titanium implant reactions. Inclusion criteria involved studies with clinical or experimental data on Ti hypersensitivity, excluding non-metallic implant failures and unrelated hypersensitivity reactions. Titanium hypersensitivity, though rare, can result in chronic inflammation and implant failure in foot and ankle surgeries. Patch testing often fails to detect deep tissue reactions, while MELISA testing shows greater accuracy. Alternative materials, such as ceramic or niobium, may be better for patients with metal allergies. MELISA testing is a more reliable tool for diagnosing metal hypersensitivity than patch testing. Surgeons should consider preoperative MELISA testing and alternative implants to reduce hypersensitivity risks, improving patient outcomes. Preoperative MELISA testing should be standard for titanium implant patients to minimize allergic reactions.
本研究探讨了外科植入物中钛(Ti)的超敏性,这可能导致植入物失败和炎症等并发症。目的是评估诊断方法,特别是皮肤贴片试验与记忆淋巴细胞免疫刺激试验(MELISA),以改善金属敏感性患者的预后。利用b谷歌Scholar和PubMed等数据库进行文献检索,确定了2006年至2024年期间18项同行评议的研究,重点关注钛植入物的反应。纳入标准包括有钛超敏性临床或实验数据的研究,不包括非金属植入失败和不相关的超敏性反应。钛过敏虽然罕见,但在足部和踝关节手术中会导致慢性炎症和植入失败。贴片测试通常无法检测到深层组织反应,而MELISA测试显示出更高的准确性。替代材料,如陶瓷或铌,可能对金属过敏的患者更好。MELISA测试是诊断金属过敏比贴片测试更可靠的工具。外科医生应考虑术前MELISA测试和替代植入物,以减少过敏风险,改善患者预后。术前MELISA检测应作为钛种植患者的标准,以减少过敏反应。
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引用次数: 0
Limb salvage with transverse tibial bone transport in a high-risk patient with a Chronic Achilles Tendon Ulcer: a case report 慢性跟腱溃疡高危患者用胫骨横骨运输保肢1例
Pub Date : 2025-10-01 DOI: 10.1016/j.fastrc.2025.100575
Lucian M. Feraru DPM, FACFAS , Mikhail Samchukov MD
Diabetic foot ulcers (DFUs), particularly in the Achilles region, pose significant challenges for limb salvage due to poor perfusion and high infection risk. Transverse tibial bone transport (TTBT), utilizing distraction osteogenesis, enhances local blood flow and promotes tissue regeneration(1, 2). This case report describes a high-risk 60- year-old female patient with a chronic Achilles tendon ulcer refractory to standard treatments who underwent TTBT. The procedure successfully resulted in complete wound healing and limb salvage, avoiding major amputation. This report discusses the clinical details and implications of TTBT as an effective intervention in managing recalcitrant diabetic foot ulcers.
Background: Diabetic foot ulcers at the posterior heel/Achilles are difficult to heal due to limited soft tissue, high stress, and microvascular disease, often ending in major amputation.
Purpose: To describe limb salvage using transverse tibial bone transport (TTBT) for a recalcitrant Achilles‑region ulcer in a high‑risk patient.
Study Design: Single‑patient case report.
Methods: A 60‑year‑old woman with type 2 diabetes, peripheral arterial disease, renal disease, and calcaneal osteomyelitis had a chronic 16 × 8 cm posterior heel/Achilles ulcer refractory to revascularization, antibiotics, and advanced wound care. After radical debridement, a circular external fixator was applied with a tibial corticotomy and TTBT module. Following a 7‑day latency, distraction was performed at 0.25 mm twice daily for 28 days, then compression 0.25 mm four times daily for 14 days until redocking. External fixation continued for consolidation.
Results: Granulation developed during distraction; ulcer dimensions decreased ∼50 % by frame removal. Complete epithelialization occurred by 20 weeks with infection control and limb preservation. Postoperative CT angiography showed a patent anterior tibial artery with collateral reconstitution of the peroneal and posterior tibial arteries, consistent with improved microcirculation. A superficial plantar heel ulcer related to calcaneal‑gait biomechanics after Achilles resection healed with offloading and local care. At 12‑month follow‑up the limb remained salvaged with functional recovery.
Conclusion: TTBT may augment local perfusion and support healing of intractable Achilles‑region diabetic ulcers in selected patients. When macro‑revascularization is insufficient or contraindicated, TTBT offers a driven limb‑salvage option that targets distal microcirculatory failure while avoiding free‑tissue transfer in compromised hosts.
糖尿病足溃疡(DFUs),特别是在跟腱区域,由于灌注不良和高感染风险,对肢体保留构成了重大挑战。胫骨横骨运输(TTBT),利用牵张成骨,增强局部血流量,促进组织再生(1,2)。这个病例报告描述了一个高风险的60岁女性患者慢性跟腱溃疡难治性标准治疗谁接受了TTBT。手术成功导致伤口完全愈合和肢体保留,避免了大面积截肢。本报告讨论了TTBT作为一种有效干预治疗顽固性糖尿病足溃疡的临床细节和意义。背景:糖尿病足后足跟/跟腱溃疡由于软组织受限、高应激和微血管疾病而难以愈合,通常以大截肢告终。目的:描述利用胫骨横骨运输(TTBT)治疗顽固性跟腱区溃疡的高危患者的肢体挽救。研究设计:单患者病例报告。方法:1例60岁女性,伴有2型糖尿病、外周动脉疾病、肾脏疾病和跟骨髓炎,并发慢性16 × 8 cm后跟/跟腱溃疡,对血运重建、抗生素治疗和后期伤口护理均难治。彻底清创后,使用圆形外固定架配合胫骨皮质切开术和TTBT模块。在7天的潜伏期后,每天两次0.25 mm的牵张,持续28天,然后每天四次0.25 mm的压迫,持续14天,直到重新对接。继续外固定以巩固。结果:牵张过程中出现肉芽;通过移除框架,溃疡尺寸减少了约50%。在感染控制和肢体保存的情况下,20周上皮完全形成。术后CT血管造影显示胫骨前动脉通畅,腓动脉和胫骨后动脉侧支重建,微循环改善。跟腱切除术后与跟骨-步态生物力学相关的浅表足底溃疡通过卸载和局部护理愈合。在12个月的随访中,肢体保留了功能恢复。结论:TTBT可增加顽固性跟腱区糖尿病溃疡患者的局部灌注,支持溃疡愈合。当宏观血运重建不足或有禁忌时,TTBT提供了一种驱动的肢体挽救选择,针对远端微循环衰竭,同时避免受损宿主的游离组织转移。
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引用次数: 0
Surgical correction of severe hallux abducto-valgus deformity with minimally invasive chevron akin osteotomy: A systematic review 微创切骨术矫正严重拇外展外翻畸形:系统回顾
Pub Date : 2025-09-27 DOI: 10.1016/j.fastrc.2025.100574
Levi Smith DPM , Hughes Ackom DPM , Rachel A Murphy MS , Andrew Elliott DPM, FACFAS

Background

With the increasing use of minimally invasive surgical (MIS) techniques in the field of hallux abductovalgus (HAV) correction, foot and ankle surgeons are utilizing third-generation techniques, such as the minimally invasive chevron Akin (MICA) osteotomy, to repair bunions ranging in severity from mild to severe. Literature identifying the correction of severe HAV deformities with MIS techniques is sparse.

Purpose

A systematic review is presented of peer-reviewed sources to analyze complications, pre- and postoperative radiographic analysis, and patient-reported outcomes in correction of severe HAV deformity with the MICA surgical approach.

Study Design/Methods

After review of multiple databases, 4 articles were obtained matching our inclusion criteria, with 236 total feet.

Results

Complication rates ranged from 18.8 % to 24.2 %, while recurrence rates ranged from 3.8 % to 7.5 %. Average intermetatarsal angle improved from 17.81 degrees to 6.59 degrees, and hallux valgus angle improved from 42.18 degrees to 8.94 degrees. Improvements in the two radiographic angles were statistically significant. Improvement in patient-reported outcomes was appreciated among studies but unable to be analyzed statistically owing to low sample size and heterogeneity in reporting.

Conclusion

Thissystematic review revealed that the use of the MICA technique to correct severe HAV deformity showed significant improvement of radiographic angles, acceptable patient-reported outcomes, and complication and recurrence rates similar to those reporting on less severe deformity correction.

Level of Evidence

Level 4
背景:随着微创外科(MIS)技术在拇外翻(HAV)矫正领域的应用越来越多,足部和踝关节外科医生正在使用第三代技术,如微创chevron Akin (MICA)切骨术,来修复从轻度到重度的拇外翻。用MIS技术矫正严重HAV畸形的文献很少。目的:对经同行评审的资料进行系统回顾,分析MICA手术入路矫正严重HAV畸形的并发症、术前和术后影像学分析以及患者报告的结果。研究设计/方法在对多个数据库进行审查后,获得符合我们纳入标准的4篇文章,总长度为236英尺。结果并发症发生率为18.8% ~ 24.2%,复发率为3.8% ~ 7.5%。平均跖间角由17.81°提高到6.59°,拇外翻角由42.18°提高到8.94°。两个x线摄影角度的改善具有统计学意义。患者报告结果的改善在研究中得到赞赏,但由于样本量小和报告的异质性,无法进行统计分析。结论:本系统综述显示,MICA技术矫正严重HAV畸形的影像学角度显著改善,患者报告的预后可接受,并发症和复发率与轻度畸形矫正相似。证据等级:4级
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引用次数: 0
Intramuscular corticosteroids combined with exercise for refractory midportion achilles tendinopathy: A case series 肌内皮质类固醇联合运动治疗难治性跟腱中段病变:一个病例系列
Pub Date : 2025-09-24 DOI: 10.1016/j.fastrc.2025.100573
Jan MA Mens MD, PhD

Background

Treatment of Achilles tendinopathy (AT) typically consists of progressive exercise, load management, and patient education. The use of paratendinous administration is controversial. Improvement with conventional measures is often insufficient, creating a need for alternative solutions.

Purpose

Purpose is to describe the outcomes of patients treated with intramuscular corticosteroid-injections in combination with exercises.

Study design

retrospective analysis of a case series.

Methods

Baseline data and short-term outcomes were collected from patient records treated in our clinic. Follow-up results were gathered by means of structured telephonic interviews. AT was defined as pain in the Achilles tendon during activities with at least two of the following criteria: pain on tiptoe standing, swelling and/or tenderness 2–7 cm above the insertion, ultrasound signs of tendinopathy.

Results

Ten patients were included. The median duration of symptoms was 12 months (IQR 23). Patients reported improvement after 5.6 days (SD 4.8).The treatment reached its maximum effect at 6.2 weeks (SD 3.4). At the end of the 2–12 week intervention, six patients felt completely recovered and four reported feeling much better. At follow-up (23 months, SD 17), seven patients felt completely recovered and three much better. The median NRS pain score changed from 8 at baseline to 0 (p = 0.002), and the mean VISA-A score from 37 to 95 (p < 0.0001). No major adverse events were observed.

Conclusion

one or two intramuscular corticosteroid injections combined with concentric–eccentric exercises may offer rapid and sustained relief for patients with midportion AT.

Level of Clinical Evidence

4
背景:跟腱病(AT)的治疗通常包括进行性运动、负荷管理和患者教育。辅助给药的使用是有争议的。常规措施的改进往往是不够的,因此需要替代解决方案。目的描述肌内注射皮质类固醇结合运动治疗的疗效。研究设计:对一系列病例进行回顾性分析。方法基线数据和短期结果收集于本诊所的患者记录。通过结构化的电话访谈收集随访结果。AT定义为活动时跟腱疼痛,且至少符合以下两项标准:站立时脚尖疼痛,止点上方2-7厘米处肿胀和/或压痛,超声显示肌腱病变迹象。结果纳入10例患者。中位症状持续时间为12个月(IQR 23)。患者在5.6天后报告改善(SD 4.8)。治疗在6.2周时达到最大效果(SD 3.4)。在2-12周的干预结束时,6名患者感觉完全恢复,4名患者报告感觉好多了。随访(23个月,SD 17), 7例患者感觉完全恢复,3例明显好转。NRS疼痛评分中位数从基线时的8分变为0分(p = 0.002), VISA-A评分中位数从37分变为95分(p < 0.0001)。未观察到重大不良事件。结论1 ~ 2次肌内皮质类固醇注射配合同心偏心运动可快速、持续缓解中段AT。临床证据水平
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引用次数: 0
Managing complex foot deformities in paraplegia: Outcomes of intramedullary hindfoot arthrodesis for spastic pes cavovarus; A case series review 截瘫患者复杂足畸形的治疗:痉挛性颈内翻后足髓内融合术的疗效案例系列回顾
Pub Date : 2025-09-23 DOI: 10.1016/j.fastrc.2025.100572
Gil Genuth , Martin Keith Ulrich , Markus Damrau , Lukas D Iselin

Background

Patients with spinal cord injury (SCI), particularly those with paraplegia, often develop rigid foot deformities such as spastic pes cavovarus due to unopposed muscle activity and chronic spasticity. These deformities compromise seating alignment, hinder passive standing programs, and significantly increase the risk of pressure ulcers (PUs), especially at the heel, lateral border, first metatarsal head, and lateral malleolus. Conservative treatments often fail in severe, fixed deformities, necessitating surgical intervention.
This study aimed to evaluate the clinical and radiographic outcomes of hindfoot arthrodesis using intramedullary nail (IMN) fixation in paraplegic patients with spastic foot deformities, focusing on fusion rates, PU recurrence, and improvements in wheelchair positioning.

Methods

This retrospective case series included eight paraplegic patients (mean age: 34 years) with fixed pes cavovarus deformities treated between 2015 and 2019. All underwent percutaneous soft tissue release and open hindfoot joint preparation, followed by IMN fixation using a hindfoot nail. Radiographic fusion was assessed at 3, 6, and 9 months via standard radiographs and selected CT scans. Clinical follow-up lasted at least 12 months.

Results

Radiographic fusion was achieved in 75 % of cases. All patients showed clinical improvement in seating alignment and tolerance to gravity-loading protocols. Two patients had asymptomatic non-union. Postoperative complications included two superficial infections, one new PU, and two cases of symptomatic screw protrusion requiring hardware removal.

Conclusion

Hindfoot arthrodesis using IMN offers a promising surgical option for SCI patients with rigid foot deformities. It enables plantigrade alignment, supports pressure redistribution, and improves functional seating. Despite a small sample size, the outcomes justify further prospective studies to confirm its role in this complex, underserved population.

Level of evidence

4
脊髓损伤(SCI)患者,特别是截瘫患者,由于肌肉活动不对抗和慢性痉挛,通常会发展为刚性足畸形,如痉挛性颈内翻。这些畸形损害了坐姿对齐,妨碍了被动站立计划,并显著增加了压疮(PUs)的风险,特别是在足跟、外侧缘、第一跖骨头和外踝。对于严重的、固定的畸形,保守治疗往往失败,需要手术干预。本研究旨在评估采用髓内钉(IMN)固定治疗痉挛性足畸形截瘫患者后足关节融合术的临床和影像学结果,重点关注融合率、PU复发和轮椅定位的改善。方法回顾性分析2015 - 2019年间收治的8例固定型颈内翻畸形截瘫患者(平均年龄34岁)。所有患者均行经皮软组织松解术和开放后足关节准备,随后用后足钉进行IMN固定。在3、6和9个月时通过标准x线片和选定的CT扫描评估放射学融合。临床随访至少12个月。结果影像学融合率达75%。所有患者在座椅对齐和对重力负荷方案的耐受性方面均表现出临床改善。2例患者无症状骨不连。术后并发症包括2例浅表感染,1例新发PU, 2例有症状的螺钉突出需要取出硬体。结论IMN后足关节融合术是治疗脊髓损伤伴刚性足畸形患者的一种有前景的手术选择。它可以实现plantigrade对齐,支持压力重新分配,并改善功能性座椅。尽管样本量小,但结果证明了进一步的前瞻性研究,以确认其在这一复杂的,服务不足的人群中的作用。证据水平4
{"title":"Managing complex foot deformities in paraplegia: Outcomes of intramedullary hindfoot arthrodesis for spastic pes cavovarus; A case series review","authors":"Gil Genuth ,&nbsp;Martin Keith Ulrich ,&nbsp;Markus Damrau ,&nbsp;Lukas D Iselin","doi":"10.1016/j.fastrc.2025.100572","DOIUrl":"10.1016/j.fastrc.2025.100572","url":null,"abstract":"<div><h3>Background</h3><div>Patients with spinal cord injury (SCI), particularly those with paraplegia, often develop rigid foot deformities such as spastic pes cavovarus due to unopposed muscle activity and chronic spasticity. These deformities compromise seating alignment, hinder passive standing programs, and significantly increase the risk of pressure ulcers (PUs), especially at the heel, lateral border, first metatarsal head, and lateral malleolus. Conservative treatments often fail in severe, fixed deformities, necessitating surgical intervention.</div><div>This study aimed to evaluate the clinical and radiographic outcomes of hindfoot arthrodesis using intramedullary nail (IMN) fixation in paraplegic patients with spastic foot deformities, focusing on fusion rates, PU recurrence, and improvements in wheelchair positioning.</div></div><div><h3>Methods</h3><div>This retrospective case series included eight paraplegic patients (mean age: 34 years) with fixed pes cavovarus deformities treated between 2015 and 2019. All underwent percutaneous soft tissue release and open hindfoot joint preparation, followed by IMN fixation using a hindfoot nail. Radiographic fusion was assessed at 3, 6, and 9 months via standard radiographs and selected CT scans. Clinical follow-up lasted at least 12 months.</div></div><div><h3>Results</h3><div>Radiographic fusion was achieved in 75 % of cases. All patients showed clinical improvement in seating alignment and tolerance to gravity-loading protocols. Two patients had asymptomatic non-union. Postoperative complications included two superficial infections, one new PU, and two cases of symptomatic screw protrusion requiring hardware removal.</div></div><div><h3>Conclusion</h3><div>Hindfoot arthrodesis using IMN offers a promising surgical option for SCI patients with rigid foot deformities. It enables plantigrade alignment, supports pressure redistribution, and improves functional seating. Despite a small sample size, the outcomes justify further prospective studies to confirm its role in this complex, underserved population.</div></div><div><h3>Level of evidence</h3><div>4</div></div>","PeriodicalId":73047,"journal":{"name":"Foot & ankle surgery (New York, N.Y.)","volume":"5 4","pages":"Article 100572"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gunshot wounds in the lower extremities: Treatment review 下肢枪伤:治疗回顾
Pub Date : 2025-09-20 DOI: 10.1016/j.fastrc.2025.100571
Michael A. Coyer DPM FACFAS , James C. Connors DPM FACFAS , Mark A. Hardy DPM FACFAS , Victoria Suggs BS , Kasra Karamlou DPM
A high number of gunshot injuries occur in the lower extremities, making it likely that foot and ankle surgeons will encounter these wounds when involved in lower extremity trauma care. Understanding current thought processes and standards of care regarding high and low velocity wounds is imperative for surgeons to appropriately manage these unique and challenging traumatic injuries. Additionally, it is crucial to consider legal ramifications related to evidence collection, interaction with law enforcement, and witness testimony. This article discusses treatment guidelines that are crucial for patient care as well as preservation of evidence and appropriate documentation for law enforcement.

Level of Evidence

5
大量的枪伤发生在下肢,这使得足部和踝关节外科医生在进行下肢创伤护理时很可能会遇到这些伤口。了解当前关于高速和低速创伤的思维过程和护理标准对于外科医生适当处理这些独特和具有挑战性的创伤性损伤是必不可少的。此外,考虑与证据收集、与执法部门的互动以及证人证词有关的法律后果也至关重要。本文讨论的治疗指南是至关重要的病人护理,以及保存证据和适当的文件执法。证据水平
{"title":"Gunshot wounds in the lower extremities: Treatment review","authors":"Michael A. Coyer DPM FACFAS ,&nbsp;James C. Connors DPM FACFAS ,&nbsp;Mark A. Hardy DPM FACFAS ,&nbsp;Victoria Suggs BS ,&nbsp;Kasra Karamlou DPM","doi":"10.1016/j.fastrc.2025.100571","DOIUrl":"10.1016/j.fastrc.2025.100571","url":null,"abstract":"<div><div>A high number of gunshot injuries occur in the lower extremities, making it likely that foot and ankle surgeons will encounter these wounds when involved in lower extremity trauma care. Understanding current thought processes and standards of care regarding high and low velocity wounds is imperative for surgeons to appropriately manage these unique and challenging traumatic injuries. Additionally, it is crucial to consider legal ramifications related to evidence collection, interaction with law enforcement, and witness testimony. This article discusses treatment guidelines that are crucial for patient care as well as preservation of evidence and appropriate documentation for law enforcement.</div></div><div><h3>Level of Evidence</h3><div>5</div></div>","PeriodicalId":73047,"journal":{"name":"Foot & ankle surgery (New York, N.Y.)","volume":"5 4","pages":"Article 100571"},"PeriodicalIF":0.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare presentation of an abductor hallucis soft tissue mass: A case report 罕见的外展幻觉软组织肿块一例报告
Pub Date : 2025-09-17 DOI: 10.1016/j.fastrc.2025.100570
Ksenja Llazar DPM , Nayab Khan DPM , Michael Loshigian DPM, FACFAS
Schwannomas can present as soft tissue masses in the foot and ankle that mimic other conditions. This report presents a rare case of schwannoma arising within the abductor hallucis muscle belly in a 53-year-old female with past medical history of rheumatoid arthritis. The patient presented with a year-long history of left foot pain and a slowly enlarging, palpable mass on the plantar medial aspect of the foot. Initial evaluation and imaging revealed a well-circumscribed soft tissue mass with internal vascularity. However, due to medical history and overlapping clinical and imaging features, the differential diagnosis, among others, included rheumatoid nodules. Surgical excision of the mass was performed, and histopathology confirmed the diagnosis of traditional schwannoma. This report underlines the diagnostic challenge of distinguishing schwannomas from rheumatoid nodules and other types of soft tissue masses, specifically in patients with autoimmune disease. We discuss the clinical, radiological, and pathological aspects of this rare tumor. Definitive diagnosis requires histological analysis, as imaging alone may be inconclusive.
神经鞘瘤可以表现为足部和踝关节的软组织肿块,类似于其他疾病。本文报告一例罕见的神经鞘瘤,发生于外展幻觉肌腹部,患者为53岁女性,既往有类风湿关节炎病史。患者表现为一年的左脚疼痛史和一个缓慢扩大,可触及的肿块在足底内侧。初步评估和影像学显示一个界限分明的软组织肿块,内有血管。然而,由于病史和重叠的临床和影像学特征,鉴别诊断包括类风湿结节。手术切除肿块,组织病理学证实了传统神经鞘瘤的诊断。本报告强调了区分神经鞘瘤与类风湿结节和其他类型软组织肿块的诊断挑战,特别是在自身免疫性疾病患者中。我们讨论临床,放射学和病理方面的这种罕见的肿瘤。明确的诊断需要组织学分析,因为单独的影像学可能是不确定的。
{"title":"A rare presentation of an abductor hallucis soft tissue mass: A case report","authors":"Ksenja Llazar DPM ,&nbsp;Nayab Khan DPM ,&nbsp;Michael Loshigian DPM, FACFAS","doi":"10.1016/j.fastrc.2025.100570","DOIUrl":"10.1016/j.fastrc.2025.100570","url":null,"abstract":"<div><div>Schwannomas can present as soft tissue masses in the foot and ankle that mimic other conditions. This report presents a rare case of schwannoma arising within the abductor hallucis muscle belly in a 53-year-old female with past medical history of rheumatoid arthritis. The patient presented with a year-long history of left foot pain and a slowly enlarging, palpable mass on the plantar medial aspect of the foot. Initial evaluation and imaging revealed a well-circumscribed soft tissue mass with internal vascularity. However, due to medical history and overlapping clinical and imaging features, the differential diagnosis, among others, included rheumatoid nodules. Surgical excision of the mass was performed, and histopathology confirmed the diagnosis of traditional schwannoma. This report underlines the diagnostic challenge of distinguishing schwannomas from rheumatoid nodules and other types of soft tissue masses, specifically in patients with autoimmune disease. We discuss the clinical, radiological, and pathological aspects of this rare tumor. Definitive diagnosis requires histological analysis, as imaging alone may be inconclusive.</div></div>","PeriodicalId":73047,"journal":{"name":"Foot & ankle surgery (New York, N.Y.)","volume":"5 4","pages":"Article 100570"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipofibromatosis-like neural tumor of the foot: A case study 足部脂肪纤维瘤样神经肿瘤一例研究
Pub Date : 2025-09-14 DOI: 10.1016/j.fastrc.2025.100568
Derek A. Swanson PMSIII , Robert Lee PMSIII , Annie Phan OMSIII, MA , Janna Kroleski DPM, MS
Lipofibromatosis-like neural tumors (LPF-NTs) are a rare form of mesenchymal tumors generally found in children and young adults1. LPF-NTs are a novel tumor type, only recently identified and named with the first case being <10 years ago2. These tumors tend to occur in the distal extremities, presenting as slow-growing benign non-metastatic masses. They display a lipofibromatosis-like structure with an immunophenotype positive for CD34/S100 and NTRK1 gene abnormalities2. Due to LPF-NTs rarity and a lack of pain until significant mass expansion, they are often challenging to diagnose making treatment options more challenging3. Conservative treatment will not stop tumor growth or pain long term, causing a need for surgical excision. LPF-NTs, if improperly excised, demonstrate a high rate of local recurrence2. The rarity and diagnostic difficulty of LPF-NTs complicate patient care and increase the risk of misdiagnosis. This case report details a successful surgical removal of an LPF-NT and reviews the literature to improve recognition, diagnosis, and treatment by explicitly focusing on key characteristics, common diagnostic failures, and optimal treatment approaches for an LPF-NT located in the foot.
脂肪纤维瘤样神经肿瘤(LPF-NTs)是一种罕见的间充质肿瘤,常见于儿童和青少年1。lpf - nt是一种新的肿瘤类型,直到最近才被发现并命名,第一例是在10年前。这些肿瘤往往发生在远端肢体,表现为缓慢生长的良性非转移性肿块。他们表现出脂肪纤维瘤样结构,CD34/S100和NTRK1基因异常免疫表型阳性2。由于lpf - nt的罕见性和在肿块显著扩大之前没有疼痛感,它们的诊断往往具有挑战性,这使得治疗选择更具挑战性。保守治疗不能长期阻止肿瘤生长或疼痛,因此需要手术切除。如果切除不当,lpf - nt的局部复发率很高。lpf - nt的罕见性和诊断难度使患者护理复杂化,并增加了误诊的风险。本病例报告详细介绍了一例成功手术切除LPF-NT的病例,并回顾了文献,通过明确关注足部LPF-NT的关键特征、常见诊断失败和最佳治疗方法,提高了对LPF-NT的识别、诊断和治疗。
{"title":"Lipofibromatosis-like neural tumor of the foot: A case study","authors":"Derek A. Swanson PMSIII ,&nbsp;Robert Lee PMSIII ,&nbsp;Annie Phan OMSIII, MA ,&nbsp;Janna Kroleski DPM, MS","doi":"10.1016/j.fastrc.2025.100568","DOIUrl":"10.1016/j.fastrc.2025.100568","url":null,"abstract":"<div><div>Lipofibromatosis-like neural tumors (LPF-NTs) are a rare form of mesenchymal tumors generally found in children and young adults<sup>1</sup>. LPF-NTs are a novel tumor type, only recently identified and named with the first case being &lt;10 years ago<sup>2</sup>. These tumors tend to occur in the distal extremities, presenting as slow-growing benign non-metastatic masses. They display a lipofibromatosis-like structure with an immunophenotype positive for CD34/S100 and NTRK1 gene abnormalities<sup>2</sup>. Due to LPF-NTs rarity and a lack of pain until significant mass expansion, they are often challenging to diagnose making treatment options more challenging<sup>3</sup>. Conservative treatment will not stop tumor growth or pain long term, causing a need for surgical excision. LPF-NTs, if improperly excised, demonstrate a high rate of local recurrence<sup>2</sup>. The rarity and diagnostic difficulty of LPF-NTs complicate patient care and increase the risk of misdiagnosis. This case report details a successful surgical removal of an LPF-NT and reviews the literature to improve recognition, diagnosis, and treatment by explicitly focusing on key characteristics, common diagnostic failures, and optimal treatment approaches for an LPF-NT located in the foot.</div></div>","PeriodicalId":73047,"journal":{"name":"Foot & ankle surgery (New York, N.Y.)","volume":"5 4","pages":"Article 100568"},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unexpected bony regrowth following partial hallux amputation in a diabetic neuropathic foot: A case report 糖尿病神经性足部部分拇截肢后意外骨再生1例报告
Pub Date : 2025-09-14 DOI: 10.1016/j.fastrc.2025.100569
Avvi Shabat DPM , Vinay Hosuru Siddappa MD , Sam Lai Huat Lo MD
Bony regrowth following digital amputation in adult diabetic patients is rarely observed. This case report presents a 60-year-old man with diabetes and peripheral neuropathy who underwent partial distal phalanx amputation of the hallux due to osteomyelitis. Radiographic imaging 15 months later revealed unexpected regeneration of approximately 1 cm of bone at the amputation site. We hypothesize that preserved periosteal structures and the patient’s physically active lifestyle contributed to osteogenesis. This case highlights the potential for spontaneous bone regeneration in adults under specific biomechanical and surgical conditions.
成人糖尿病患者手指截肢后骨再生是罕见的。这个病例报告提出了一个60岁的男性糖尿病和周围神经病变谁接受了部分远端指骨截肢拇骨髓炎。15个月后的x线影像显示在截肢部位意外再生了约1厘米的骨。我们假设保留的骨膜结构和患者积极的生活方式有助于成骨。这个病例强调了在特定的生物力学和外科条件下,成人骨再生的潜力。
{"title":"Unexpected bony regrowth following partial hallux amputation in a diabetic neuropathic foot: A case report","authors":"Avvi Shabat DPM ,&nbsp;Vinay Hosuru Siddappa MD ,&nbsp;Sam Lai Huat Lo MD","doi":"10.1016/j.fastrc.2025.100569","DOIUrl":"10.1016/j.fastrc.2025.100569","url":null,"abstract":"<div><div>Bony regrowth following digital amputation in adult diabetic patients is rarely observed. This case report presents a 60-year-old man with diabetes and peripheral neuropathy who underwent partial distal phalanx amputation of the hallux due to osteomyelitis. Radiographic imaging 15 months later revealed unexpected regeneration of approximately 1 cm of bone at the amputation site. We hypothesize that preserved periosteal structures and the patient’s physically active lifestyle contributed to osteogenesis. This case highlights the potential for spontaneous bone regeneration in adults under specific biomechanical and surgical conditions.</div></div>","PeriodicalId":73047,"journal":{"name":"Foot & ankle surgery (New York, N.Y.)","volume":"5 4","pages":"Article 100569"},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare presentation of synovial sarcoma in the foot: A case study 罕见的足部滑膜肉瘤一例
Pub Date : 2025-09-12 DOI: 10.1016/j.fastrc.2025.100566
Drishti Dhawan , Emily Pugh
Synovial sarcoma is a rare, high-grade soft tissue malignancy that most commonly affects the extremities of adolescents and young adults, with a predilection for the foot and ankle. We present the case of a 47-year-old male with a 12-month history of progressive left foot dorsal swelling and pain. Initial imaging suggested a soft tissue hemangioma; however, surgical excision and subsequent histopathologic and molecular analysis revealed a monophasic synovial sarcoma with SS18-SSX gene fusion. The patient underwent wide re-excision of the tumor bed in coordination with orthopedic oncology. Final pathology confirmed negative margins, and no metastatic disease was identified on PET or chest CT. Given the complete resection and absence of residual disease, adjuvant radiation therapy was deferred. The patient remains disease-free on surveillance imaging at follow-up. This case highlights the diagnostic challenges of synovial sarcoma in the foot and ankle and emphasizes the importance of early biopsy, multidisciplinary coordination, and adherence to oncologic principles for optimal outcomes. Malignancy should remain a consideration in the differential diagnosis of persistent soft tissue masses.
滑膜肉瘤是一种罕见的,高度的软组织恶性肿瘤,最常见于青少年和年轻人的四肢,以足部和踝关节为主。我们提出的情况下,一个47岁的男性与12个月的历史进行性左脚背部肿胀和疼痛。初步影像学提示软组织血管瘤;然而,手术切除和随后的组织病理学和分子分析显示为SS18-SSX基因融合的单相滑膜肉瘤。患者接受肿瘤床的广泛再切除配合骨科肿瘤学。最终病理证实阴性边缘,PET或胸部CT未发现转移性疾病。鉴于完全切除和无残留疾病,辅助放射治疗被推迟。在随访时的监测成像中,患者仍无疾病。本病例强调了足部和踝关节滑膜肉瘤的诊断挑战,并强调了早期活检、多学科协调和遵守肿瘤学原则的重要性,以获得最佳结果。恶性肿瘤仍应考虑在鉴别诊断持续性软组织肿块。
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引用次数: 0
期刊
Foot & ankle surgery (New York, N.Y.)
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