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Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus 夜间人造光以性别依赖的方式改变 II 型糖尿病小鼠模型中冷神经病变的进程
Pub Date : 2024-02-06 DOI: 10.3389/fphot.2024.1323539
Jacob R. Bumgarner, Rhett C. White, Jordan A. Brown, Randy J. Nelson
Artificial light at night (ALAN) is a pervasive circadian rhythm disruptor. Exposure to ALAN is associated with detrimental effects on physiology and behavior, including disrupted metabolism, immune function, endocrine function, and pain behavior. Given the detrimental effects of ALAN and other circadian rhythm disruptors on pain, we sought to understand how ALAN may alter the progression and severity of diabetic neuropathy. To do this, we used a previously reported high-fat diet and streptozotocin injection protocol to induce a type II diabetic phenotype in ∼8 week old female and male mice and then exposed the mice to either control or ALAN lighting conditions in 14:10 h light-dark cycles for 4 weeks. Male mice housed in control conditions exhibited reduced responsiveness to cold pain; in contrast, ALAN blunted this effect in male mice. ALAN exposure also elevated blood glucose and altered body mass loss in male mice. These effects were not present in female mice. The results of this study highlight the need to consider and study ALAN exposure and sex as a biological variable as risk factors in the treatment and mitigation of pain.
夜间人造光(ALAN)是一种普遍存在的昼夜节律干扰源。暴露于 ALAN 会对生理和行为产生有害影响,包括破坏新陈代谢、免疫功能、内分泌功能和疼痛行为。鉴于 ALAN 和其他昼夜节律干扰物对疼痛的有害影响,我们试图了解 ALAN 可能如何改变糖尿病神经病变的进展和严重程度。为此,我们使用了之前报道过的高脂饮食和链脲佐菌素注射方案,诱导 8 周大的雌性和雄性小鼠形成 II 型糖尿病表型,然后将小鼠置于 14:10 h 光暗循环的对照组或 ALAN 光照条件下 4 周。在对照组条件下饲养的雄性小鼠对冷痛的反应性降低;相反,ALAN 则削弱了雄性小鼠对冷痛的反应性。接触 ALAN 还会升高雄性小鼠的血糖,并改变其体重减轻的情况。雌性小鼠则没有这些影响。这项研究的结果突出表明,在治疗和减轻疼痛的过程中,有必要考虑和研究作为生物变量的 ALAN 暴露和性别风险因素。
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引用次数: 0
Advancements in microemulsion-based fabrication of upconversion-mediated multifunctional materials 基于微乳液制备上转换介导多功能材料的进展
Pub Date : 2024-02-02 DOI: 10.3389/fphot.2024.1363223
Yi Zhang, Qingsong Mei, Zhen Zhang
Upconversion nanoparticles (UCNPs) have experienced significant advancements, finding applications in diverse fields over the past decade. The growing demand for UCNP-based nanoplatforms with multifunctionality to address complex scenarios has led to the emergence of the microemulsion confined self-assembly method, which allows for the integration of different UCNPs or UCNPs with additional functional materials within a single entity, resulting in a nanoplatform that possesses a wide range of properties suitable for specific applications. This comprehensive review aimed to summarize recent developments in the design of UCNP assemblies using the microemulsion confined self-assembly method, which focused on exploring their applications in critical areas such as color encoding, bioimaging, and programmable therapeutics. Furthermore, the review acknowledged the existing limitations associated with the microemulsion confined self-assembly method and provided an in-depth discussion of potential solutions to overcome these challenges, aiming to foster further progress and innovation in the design and application of UCNP assemblies.
上转换纳米粒子(UCNPs)在过去十年中取得了长足的进步,并在多个领域得到了应用。人们越来越需要基于 UCNP 的多功能纳米平台来应对复杂的应用场景,因此出现了微乳液约束自组装方法,这种方法可以将不同的 UCNP 或 UCNP 与其他功能材料整合在一个单一实体中,从而形成一个具有多种特性的纳米平台,适用于特定应用。本综述旨在总结利用微乳液封闭自组装方法设计 UCNP 组合体的最新进展,重点探讨其在颜色编码、生物成像和可编程治疗等关键领域的应用。此外,综述还指出了微乳液封闭自组装方法的现有局限性,并深入探讨了克服这些挑战的潜在解决方案,旨在促进 UCNP 组合体设计和应用领域的进一步进步和创新。
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引用次数: 0
Advancements in microemulsion-based fabrication of upconversion-mediated multifunctional materials 基于微乳液制备上转换介导多功能材料的进展
Pub Date : 2024-02-02 DOI: 10.3389/fphot.2024.1363223
Yi Zhang, Qingsong Mei, Zhen Zhang
Upconversion nanoparticles (UCNPs) have experienced significant advancements, finding applications in diverse fields over the past decade. The growing demand for UCNP-based nanoplatforms with multifunctionality to address complex scenarios has led to the emergence of the microemulsion confined self-assembly method, which allows for the integration of different UCNPs or UCNPs with additional functional materials within a single entity, resulting in a nanoplatform that possesses a wide range of properties suitable for specific applications. This comprehensive review aimed to summarize recent developments in the design of UCNP assemblies using the microemulsion confined self-assembly method, which focused on exploring their applications in critical areas such as color encoding, bioimaging, and programmable therapeutics. Furthermore, the review acknowledged the existing limitations associated with the microemulsion confined self-assembly method and provided an in-depth discussion of potential solutions to overcome these challenges, aiming to foster further progress and innovation in the design and application of UCNP assemblies.
上转换纳米粒子(UCNPs)在过去十年中取得了长足的进步,并在多个领域得到了应用。人们越来越需要基于 UCNP 的多功能纳米平台来应对复杂的应用场景,因此出现了微乳液约束自组装方法,这种方法可以将不同的 UCNP 或 UCNP 与其他功能材料整合在一个单一实体中,从而形成一个具有多种特性的纳米平台,适用于特定应用。本综述旨在总结利用微乳液封闭自组装方法设计 UCNP 组合体的最新进展,重点探讨其在颜色编码、生物成像和可编程治疗等关键领域的应用。此外,综述还指出了微乳液封闭自组装方法的现有局限性,并深入探讨了克服这些挑战的潜在解决方案,旨在促进 UCNP 组合体设计和应用领域的进一步进步和创新。
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引用次数: 0
Grand challenges in neuromorphic photonics and photonic computing 神经形态光子学和光子计算的重大挑战
Pub Date : 2024-01-29 DOI: 10.3389/fphot.2023.1336510
Francesco Morichetti
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引用次数: 0
A review of defect mitigation strategies for UMG-Si wafers UMG-Si 晶圆缺陷缓解策略综述
Pub Date : 2024-01-10 DOI: 10.3389/fphot.2023.1331471
Rabin Basnet, Daniel Macdonald
This review focuses on the challenges and potential pathways for utilizing upgraded metallurgical-grade silicon (UMG-Si) in the silicon photovoltaic industry. UMG-Si is an attractive low-cost alternative silicon feedstock, but its bulk quality is compromised due to the presence of defects and impurities. The review begins by identifying and discussing the various defects and impurities commonly found in UMG-Si wafers, drawing insights from a literature survey. The detrimental effects of these defects on solar cell performance are highlighted. Next, the review provides a summary of defect mitigation strategies that have been employed to improve the bulk quality of UMG-Si wafers. These strategies include tabula rasa, impurity gettering, and defect/impurity passivation through hydrogenation. The effectiveness of these strategies is evaluated by considering carrier lifetimes and comparing them with those of conventional silicon wafers. The review then examines the reported open-circuit voltages and efficiencies of solar cells based on UMG-Si wafers. A comparison is made between the performance of UMG-Si solar cells and those fabricated on conventional silicon. The impact of defect mitigation strategies on the performance of UMG-Si solar cells is discussed, emphasizing the improvements achieved through these strategies.
本综述重点探讨在硅光伏产业中利用升级冶金级硅(UMG-Si)的挑战和潜在途径。UMG-Si 是一种极具吸引力的低成本替代硅原料,但由于存在缺陷和杂质,其块状质量受到影响。本综述首先从文献调查中汲取启示,识别并讨论了在超导锗硅晶片中常见的各种缺陷和杂质。文中强调了这些缺陷对太阳能电池性能的不利影响。接下来,综述概述了为改善 UMG-Si 硅片的块状质量而采用的缺陷缓解策略。这些策略包括钝化、杂质去除和通过氢化进行缺陷/杂质钝化。通过考虑载流子寿命并将其与传统硅晶片的载流子寿命进行比较,对这些策略的有效性进行了评估。然后,综述研究了所报道的基于 UMG-Si 硅片的太阳能电池的开路电压和效率。此外,还对 UMG-Si 太阳能电池和传统硅电池的性能进行了比较。讨论了缺陷缓解策略对超低分子量硅太阳能电池性能的影响,强调了通过这些策略实现的改进。
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引用次数: 0
Lipid quantification in living microalgal cultures with digital holographic microscopy 利用数字全息显微镜量化活体微藻培养物中的脂质
Pub Date : 2024-01-05 DOI: 10.3389/fphot.2023.1301708
C. Yourassowsky, Renaud Theunissen, Jérôme Dohet-Eraly, Frank Dubois
Large amounts of lipids are stored inside lipid droplets by some microalgae. Since these lipids can be used to produce nutraceuticals and biodiesel in a sustainable way, research is developing on fast non-destructive methods to quantify and monitor the amount of lipids within microalgal cultures. In this paper, we have developed with digital holographic microscopy a fast quantitative method to assess the evolution of the lipid content inside the diatom Phaeodactylum tricornutum living cells. The method uses a specific processing of recorded hologram sequences based on the refocusing capability in digital holographic microscopy. In representative samples of the culture, inside living cells, each lipid droplet volume is evaluated. In those experiments, for each sample, more than one thousand lipid droplets are automatically analysed from a sequence of one hundred recorded holograms. We have validated the method thanks to correlative quantitative phase contrast–fluorescence imaging and extrapolated it to larger calibrated spherical refractive particles, to demonstrate the flexibility of the method.
一些微藻的脂滴中储存着大量的脂质。由于这些脂质可用于以可持续的方式生产营养保健品和生物柴油,因此研究人员正在开发快速无损的方法来量化和监测微藻培养物中的脂质含量。在本文中,我们利用数字全息显微镜开发了一种快速定量方法,用于评估硅藻三尖杉活细胞内脂质含量的变化。该方法基于数字全息显微镜的重新聚焦功能,对记录的全息图序列进行特定处理。在活细胞内具有代表性的培养样本中,对每个脂滴体积进行评估。在这些实验中,对于每个样本,我们都从一百张全息图序列中自动分析了一千多个脂滴。我们通过相关的定量相衬-荧光成像验证了该方法,并将其推广到更大的校准球形折射颗粒,以证明该方法的灵活性。
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引用次数: 0
Fluorescence imaging for the anterior segment of the eye 眼球前段荧光成像技术
Pub Date : 2024-01-03 DOI: 10.3389/fphot.2023.1336541
Joshua M. Herzog, Volker Sick
Diagnostic technologies for the anterior segment of the eye, especially for hard-to-diagnose diseases such as microbial keratitis, are still lacking. Although in vivo confocal microscopy and optical coherence tomography are becoming more widely applicable to a variety of conditions, they are often prohibitively expensive, require specialized training and equipment, and are intrinsically insensitive to chemical changes. Here, ultraviolet-fluorescence imaging is proposed as a new technique to aid in investigation of the anterior segment. In this work, a novel two-color line-of-sight fluorescence imaging technique is described for imaging of the anterior segment. The technique is applied to seven ex vivo porcine eyes to illustrate the utility of the technique. The image data was used to estimate an effective fluorescence quantum yield of each eye at 370 nm. The eyes were then inoculated with bacteria to simulate microbial keratitis, a common sight-threatening infection, and the measurement was repeated. A simplified fluorescence-extinction model was developed to describe and analyze the relative intensities of the eye and biofilm fluorescence. Overall, the technique appears to have utility in clinical practice and with proper development may be suitable for detecting chemical changes in the eye, or the presence of foreign matter; however, further investigation is needed to develop the technique and analysis procedures into a quantitative diagnostic tool.
目前仍缺乏用于眼球前段的诊断技术,尤其是针对微生物性角膜炎等难以诊断的疾病的诊断技术。虽然体内共聚焦显微镜和光学相干断层扫描技术越来越广泛地应用于各种疾病,但它们往往过于昂贵,需要专门的培训和设备,而且对化学变化本质上并不敏感。在此,我们提出紫外荧光成像作为一种新技术,以帮助对眼前节进行研究。在这项工作中,描述了一种用于前节成像的新型双色视线荧光成像技术。该技术应用于七只活体猪眼,以说明该技术的实用性。图像数据用于估算每只眼睛在 370 纳米波长下的有效荧光量子产率。然后给眼睛接种细菌,模拟威胁视力的常见感染--微生物角膜炎,并重复测量。我们建立了一个简化的荧光消光模型来描述和分析眼睛和生物膜荧光的相对强度。总之,该技术在临床实践中似乎很有用,经过适当的开发,可能适用于检测眼睛的化学变化或异物的存在;但是,要将该技术和分析程序开发成定量诊断工具,还需要进一步的研究。
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引用次数: 0
Efficient and robust second-harmonic generation in thin-film lithium niobate using modal phase matching 利用模态相位匹配在薄膜铌酸锂中产生高效稳健的二次谐波
Pub Date : 2023-11-24 DOI: 10.3389/fphot.2023.1324648
M. T. Hansen, E. Ulsig, Fabien Labbe, Magnus L. Madsen, Yunhong Ding, Karsten Rottwitt, N. Volet
A double-ridge waveguide is designed for efficient and robust second-harmonic generation (SHG) using the thin-film lithium-niobate-on-insulator (LNOI) platform. Perfect phase matching (PhM) is achieved between the fundamental waveguide mode at 1,550 nm and a higher-order mode at the second harmonic. The fabrication tolerances of the PhM condition are simulated using a finite-difference method mode solver, and conversion efficiencies as high as 3.92 W−1 are obtained for a 1-cm long waveguide. This design allows access to the largest element of the second-order nonlinear susceptibility tensor, and represents a scalable alternative to waveguides based on periodically-poled lithium niobate (PPLN). The design has the potential for generating pairs of entangled photons in the infrared C-band by spontaneous parametric down-conversion (SPDC).
利用绝缘体上的铌酸锂薄膜(LNOI)平台设计了一种双脊波导,用于产生高效、稳定的二次谐波(SHG)。1550 纳米波导基波模式与二次谐波高阶模式之间实现了完美的相位匹配 (PhM)。利用有限差分法模式求解器模拟了 PhM 条件下的制造公差,1 厘米长波导的转换效率高达 3.92 W-1。这种设计允许访问二阶非线性感性张量的最大元素,是基于周期性铌酸锂电极(PPLN)的波导的一种可扩展替代方案。这种设计有可能通过自发参量下变频(SPDC)在红外 C 波段产生纠缠光子对。
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引用次数: 0
Lights should support circadian rhythms: evidence-based scientific consensus 灯光应该支持昼夜节律:基于证据的科学共识
Pub Date : 2023-10-04 DOI: 10.3389/fphot.2023.1272934
Martin Moore-Ede, David E. Blask, Sean W. Cain, Anneke Heitmann, Randy J. Nelson
For over a hundred years, the lighting industry has primarily been driven by illumination aesthetics, energy efficiency and product cost with little consideration of the effects of light on health. The recent widespread replacement of traditional light sources by blue-enriched LED lights has heightened concerns about the disruption of the blue-sensitive human circadian system by these LED lights and their impact on the multiple health disorders linked to circadian disruption. Despite these health concerns, less than 0.5% of the lighting sold today modifies spectral content and intensity between day and night. We report that 248 scientists, with a total of 2,697 peer-reviewed publications on light and circadian clocks since 2008, reached consensus on 25 statements about the impact of light on circadian rhythms and health based on accumulated scientific evidence, including support for the widespread introduction of circadian lighting and warning labels on blue-enriched LED lights indicating they “maybe harmful if used at night”.
一百多年来,照明行业主要由照明美学、能源效率和产品成本驱动,很少考虑光对健康的影响。最近,富含蓝色的LED灯广泛取代了传统光源,这加剧了人们对这些LED灯破坏对蓝色敏感的人类昼夜节律系统及其对与昼夜节律中断相关的多种健康疾病的影响的担忧。尽管存在这些健康问题,但目前销售的灯具中,只有不到0.5%的灯具能够改变白天和黑夜之间的光谱含量和强度。我们报告说,自2008年以来,248名科学家共发表了2697篇关于光和生物钟的同行评议出版物,根据积累的科学证据,就光对昼夜节律和健康的影响达成了25项共识,包括支持广泛引入昼夜节律照明,并在富含蓝色的LED灯上贴上警告标签,表明“夜间使用可能有害”。
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引用次数: 2
Editorial: Advances in plasmonics: a European collection 社论:等离子体的进展:欧洲收藏
Pub Date : 2023-08-24 DOI: 10.3389/fphot.2023.1270553
Michele Ortolani, C. Ciracì, M. Giordano, S. D’Agostino
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引用次数: 0
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Frontiers in photonics
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