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Global practices in AT provision: considerations for a national assistive technology policy for health in India. 提供辅助医疗技术的全球做法:对印度国家卫生辅助技术政策的考虑。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-11-10 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1664118
Rakesh K Srivastava, Hitesh K Sharma, Ashoo Grover, Ruchir Malik, Ravinder Singh

Functional impairment refers to limitations in performing basic activities necessary for independent living, mobility, communication or social participation. Meeting the needs of people with functional impairments is an essential part of strengthening India's health system. Present article is an attempt to cover the individuals with functional impairments under proposed Health Policy on AT, which otherwise have inadequate attention in existing public health policies, acts, and laws. Assistive technologies (AT), such as wheelchairs, white canes, hearing aids, spectacles, prosthetic limbs, communication boards, memory aids, adapted writing tools, and self-care devices, play a vital role in improving functionality, enhancing quality of life, and enabling participation in education, employment, and community activities. Based on wide range of articles reviewed from the countries with best provisioning models on AT, present health policy article proposes recommendations for a comprehensive inclusive National AT Policy for India. The policy considerations emphasize legal entitlements, sustainable financing, equitable access, integration into health systems, digital inclusion, localized manufacturing, and cross-sector collaboration. Implementing assistive technology policy is not only essential to improve public health outcomes, but also for achieving the Sustainable Development Goals by 2030 and realizing India's vision of "Viksit Bharat" by 2047.

功能障碍是指在进行独立生活、行动、交流或社会参与所需的基本活动方面受到限制。满足功能障碍者的需求是加强印度卫生系统的重要组成部分。在现有的公共卫生政策、法案和法律中,功能障碍患者没有得到足够的重视,本文试图将这些患者纳入拟议的AT卫生政策中。辅助技术(AT),如轮椅、白手杖、助听器、眼镜、假肢、通讯板、记忆辅助工具、适应性书写工具和自我护理设备,在改善功能、提高生活质量以及促进参与教育、就业和社区活动方面发挥着至关重要的作用。本卫生政策文章在审查了具有最佳反兴奋剂供应模式的国家的广泛文章的基础上,为印度制定全面包容的反兴奋剂国家政策提出了建议。政策考虑强调法律权利、可持续融资、公平获取、融入卫生系统、数字包容、本地化制造和跨部门合作。实施辅助技术政策不仅对改善公共卫生成果至关重要,而且对到2030年实现可持续发展目标和到2047年实现印度“Viksit Bharat”愿景至关重要。
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引用次数: 0
Construct validity of self-reported and interview-guided administration methods of the Danish version of the post-COVID-19 functional Status scale. 构建丹麦版covid -19后功能状态量表自我报告和访谈指导管理方法的效度。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-11-10 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1690892
Lotte Sørensen, Jane Agergaard, Trine Brøns Nielsen, Berit Schiøttz-Christensen, Cecilia Hee Laursen, Steffen Leth, Claus Vinther Nielsen, Lisa Gregersen Oestergaard

Introduction: The Post-COVID-19 Functional Status (PCFS) scale was quickly adopted into COVID-19 research and clinical practice worldwide to monitor functional status and recovery. The scale has been translated into Danish, and three different administration methods have been employed. However, clinicians have expressed concerns about the scale's ability to capture work-related functional limitations. Therefore, the purpose of this study was to evaluate the construct validity of three different administration methods of the Danish version of the PCFS scale.

Methods: This cross-sectional study included patients with long COVID who completed three versions of the PCFS scale: a questionnaire-based version, a flowchart-based version, and an interview-based version. The construct validity was evaluated following the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines by testing predefined hypotheses that compared the PCFS scale with sick leave and EuroQoL Five-dimensions Five level (EQ-5D-5l).

Results: A total of 437 patients, with a mean age 48 years, 75% female, and 59% on sick leave, were included in this study. Statistically significant differences between the three administration methods were found. Of the 234 patients on sick leave, only 50%-54% had a PCFS grade ≥3 which was below our predefined hypothesis. Furthermore, correlations between the PCFS scale and EQ-5D-5l was lower than hypothesized.

Conclusion: None of the three administration methods effectively captured work-related functional limitations associated with being on part-time or full-time sick leave. Additionally, correlations with quality of life were lower than expected. Overall, the construct validity of the PCFS scale was only partially supported.

PCFS (Post-COVID-19 Functional Status)量表在全球范围内迅速应用于COVID-19研究和临床实践,用于监测功能状态和恢复情况。该比额表已翻译成丹麦文,并采用了三种不同的管理方法。然而,临床医生对该量表能否捕捉与工作相关的功能限制表示担忧。因此,本研究的目的是评估丹麦版PCFS量表三种不同给药方法的构念效度。方法:本横断面研究纳入了完成三种版本PCFS量表的长COVID患者:基于问卷的版本,基于流程图的版本和基于访谈的版本。根据基于共识的健康测量工具选择标准(COSMIN)指南,通过测试预先设定的假设,将PCFS量表与病假和EuroQoL五维度五水平(EQ-5D-5l)进行比较,评估结构效度。结果:共纳入437例患者,平均年龄48岁,75%为女性,59%为病假。三种给药方法间差异有统计学意义。在234例请病假的患者中,只有50%-54%的PCFS评分≥3,低于我们预先设定的假设。此外,PCFS量表与EQ-5D-5l之间的相关性低于假设。结论:三种管理方法均不能有效捕获与兼职或全职病假相关的工作功能限制。此外,与生活质量的相关性低于预期。总体而言,PCFS量表的构念效度仅得到部分支持。
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引用次数: 0
Early positive approaches to support for family carers of young children with developmental disabilities: adaptation and piloting in Quebec public services. 支持有发育障碍幼儿的家庭照顾者的早期积极办法:魁北克公共服务的适应和试点。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-11-07 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1627502
Mélina Rivard, Mélina Boulé, Marjorie Morin, Nadia Abouzeid, Céline Chatenoud, Diane Morin, Catherine Mello, Nick Gore, Jill Bradshaw, Richard Hastings

Background: This paper presents the participative research undertaken to adapt and pilot the Early Positive Approaches to Support (E-PAtS) program, originally developed and evaluated in English for use in the United-Kingdom, for implementation within Québec's public health and social services. E-PAtS supports family carers of young children with developmental disabilities by promoting their well-being and adjustment early in their services trajectory.

Method: The program was translated into French and iteratively adapted based on feedback from six pilot cohorts conducted across four diverse clinical settings: a rural service center, an urban center, a specialized pediatric hospital, and a diagnostic clinic. These sites were selected to ensure demographic and geographic representativity of Québec's population, and participating families also reflected a range of backgrounds. The adaptation process was grounded in community-based participatory research principles, actively involving parents, practitioners, managers, and researchers. Changes to the program's content and delivery were made according to partner recommendations. Evaluation focused on social validity, effectiveness, feasibility, and fidelity of implementation.

Results: Participating parents completed questionnaires and interviews, reporting improved well-being and greater confidence in self-care, indicating the program's relevance and positive impact. Fidelity of implementation was assessed using the E-PAtS fidelity checklist, and feasibility was evaluated through session attendance logs. Both indicators were considered strong, despite the challenges posed by the COVID-19 pandemic.

Conclusion: Findings support the adapted E-PAtS program's suitability for Québec's public services, with further refinements recommended for broader dissemination. This study highlights the value of participatory approaches in adapting evidence-based interventions across cultural and service delivery contexts.

背景:本文介绍了为适应和试点早期积极支助办法(E-PAtS)方案而进行的参与性研究,该方案最初是用英语制定和评估的,供联合王国使用,以便在qusamube的公共卫生和社会服务部门实施。E-PAtS为有发展障碍幼儿的家庭照顾者提供支援,促进他们在服务初期的福祉和适应。方法:该计划被翻译成法语,并根据在四个不同的临床环境中进行的六个试点队列的反馈进行迭代调整:农村服务中心、城市中心、儿科专科医院和诊断诊所。选择这些地点是为了确保在人口统计和地理上具有代表性,参与的家庭也反映了各种背景。适应过程以社区参与研究原则为基础,家长、从业人员、管理人员和研究人员积极参与。根据合作伙伴的建议,对项目的内容和交付方式进行了更改。评估的重点是社会效度、有效性、可行性和实施的保真度。结果:参与的父母完成了问卷调查和访谈,报告说他们的幸福感得到了提高,自我照顾的信心也增强了,这表明了该计划的相关性和积极影响。使用E-PAtS保真度检查表评估实施的保真度,并通过会话出席日志评估可行性。尽管COVID-19大流行带来了挑战,但这两项指标都被认为是强劲的。结论:研究结果支持改编后的E-PAtS项目适用于quemail的公共服务,并建议进一步改进以进行更广泛的推广。本研究强调了参与式方法在跨文化和服务提供环境调整基于证据的干预措施方面的价值。
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引用次数: 0
Clinical and engagement efficacy of a virtual musculoskeletal integrated practice unit in health system employees: aggregate and comparative results from two employers. 虚拟肌肉骨骼综合实践单元在卫生系统雇员中的临床和参与效能:来自两个雇主的汇总和比较结果。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-11-05 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1541508
Austin G Cross, Usmaan Zunnu Rain, Eric C Makhni, Emily N Schnettler, Prakash Jayakumar, Sameer Berry, Jeff Vandenboom, Courtland Keteyian, Russell Day, Daniel Verhagen, Michael Schumacher, Joseph Kucksdorf, Bruce Muma

Introduction: Integrated Practice Units are whole-person models of care designed to deliver a comprehensive range of treatment strategies centered around a patient's preferences, values, and needs. The purpose of this study was to assess the efficacy of a virtual IPU (V-IPU) for employees of two large health systems experiencing back, neck or joint pain. Specifically, we evaluated improvements in pain interference, physical health, and user satisfaction/experience.

Methods: This was a prospective cohort study with a total of 167 employees from two health systems who were recruited through e-mail outreach and completed a brief health assessment, including patient reported outcome measures (PROMs) for physical, emotional, and pain health. Upon sign-up, employees began a 12-week multidisciplinary program consisting of musculoskeletal (MSK) physician telehealth treatment and oversight, supervised one-to-one physical therapy, registered dietitian counseling, health coaching, and platform to in-person specialty services when clinically appropriate. National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS) scores for physical health, mental health, and pain interference were assessed at intake, 6-weeks, and 12-weeks after program initiation. Net promoter score (NPS) was measured to evaluate participant experience and satisfaction with the program.

Results: The average age was 50.56 years, and a large majority of responders were female (89.2%). There were clinically meaningful improvements for PROMIS measures of physical health, mental health and pain interference (5.6, 4.4 and 6.9 points, respectively). The Net Promoter Score was 85 for engaged individuals. Additionally, the V-IPU was successful in connecting employees to additional surgical-avoiding services offered by the employer and which complemented the digital participation of the V-IPU.

Conclusion: The V-IPU improves health outcomes and care coordination for health system employees. These findings support the use of virtual multidisciplinary models to enhance access and outcomes in employer-based health initiatives.

简介:综合实践单位是全人的护理模式,旨在提供全面的治疗策略,以患者的偏好、价值观和需求为中心。本研究的目的是评估虚拟IPU (V-IPU)对两个大型卫生系统中出现背部、颈部或关节疼痛的员工的疗效。具体来说,我们评估了疼痛干扰、身体健康和用户满意度/体验方面的改进。方法:这是一项前瞻性队列研究,共有167名员工来自两个卫生系统,他们通过电子邮件外联招募,并完成了简短的健康评估,包括患者报告的身体、情绪和疼痛健康结果测量(PROMs)。注册后,员工开始了为期12周的多学科项目,包括肌肉骨骼(MSK)医生远程医疗治疗和监督,监督一对一物理治疗,注册营养师咨询,健康指导,以及在临床需要时亲自提供专业服务的平台。美国国立卫生研究院(NIH)患者报告结果测量信息系统(PROMIS)的身体健康、心理健康和疼痛干扰评分在项目开始后的摄入、6周和12周进行评估。净推荐值(NPS)被测量来评估参与者的经验和满意度的计划。结果:患者平均年龄为50.56岁,以女性为主(89.2%)。在身体健康、心理健康和疼痛干扰的PROMIS测量方面有临床意义的改善(分别为5.6、4.4和6.9分)。参与个人的净推荐值为85。此外,V-IPU成功地将员工与雇主提供的额外手术避免服务联系起来,并补充了V-IPU的数字参与。结论:V-IPU改善了卫生系统员工的健康结果和护理协调。这些发现支持使用虚拟多学科模型来提高基于雇主的卫生倡议的可及性和成果。
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引用次数: 0
Intratissue percutaneous electrolysis and deep dry needling compared to a standard physiotherapy protocol in the treatment of whiplash syndrome: study protocol for a randomized controlled trial. 组织内经皮电解和深度干针与标准物理治疗方案在治疗鞭打综合征中的比较:随机对照试验的研究方案。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-11-03 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1670603
Rocío Fernández-Navarro, María Benito-de-Pedro, Francisco-Manuel Navarro Reyes, Jorge Moreno-López, María-José Estebanez-Pérez, José-Manuel Pastora-Bernal

Background: Whiplash syndrome is one of the most frequent consequences of traumatic pathology caused traffic accidents. The acceleration-deceleration mechanism of energy transmitted to the neck causes abnormal maneuvers in the area and muscle pain. The most common form of muscle pain in the neck and head is myofascial pain syndrome, caused by myofascial trigger points, these being clinically defined as painful, sensitive and hyperirritable nodules that are located on tense muscle bands. These painful nodules are treated with different physiotherapy techniques, there being no international consensus regarding their diagnosis and recommended interventions.

Objective: The primary objective of this study is to evaluate the effectiveness of percutaneous intratissue electrolysis (EPI) on intrafibrillar blood flow and muscle fiber elasticity compared to deep dry needling (DN) and standard physiotherapy. Secondary objectives include the assessment of perceived pain, disability, and clinical outcomes at follow-up.

Methods: This single-blind randomized clinical trial will be conducted in patients residing in Melilla with whiplash syndrome due to traffic accidents. Participants will receive interventions targeting the sternocleidomastoid and/or levator scapulae muscles. Assessments will be conducted at baseline, after four weeks of intervention, and at three months post-intervention to evaluate medium-term effects. Our hypothesis is that EPI will produce greater improvements in the study variables compared to DN and standard physiotherapy.

Discussion: Percutaneous electrolysis has shown positive clinical effects in various musculoskeletal pathologies; however, its impact on intrafibrillar blood flow and muscle fiber elasticity remains unexplored. This study aims to provide reference clinical data on these physiological outcomes and compare the effects of invasive vs. standard physiotherapy interventions, supporting the development of evidence-based protocols for whiplash-associated disorders.

Clinical trial registration: NCT06938425.

背景:鞭臼综合征是交通事故创伤病理引起的最常见的后果之一。能量传递到颈部的加速-减速机制导致该区域的异常动作和肌肉疼痛。颈部和头部肌肉疼痛最常见的形式是肌筋膜疼痛综合征,由肌筋膜触发点引起,这些在临床上被定义为位于紧张肌肉带上的疼痛、敏感和高激惹结节。这些疼痛的结节采用不同的物理治疗技术进行治疗,对于其诊断和推荐的干预措施尚无国际共识。目的:本研究的主要目的是评估经皮组织内电解(EPI)对纤维内血流和肌纤维弹性的影响,并与深干针(DN)和标准物理治疗进行比较。次要目的包括评估感知疼痛、残疾和随访时的临床结果。方法:本单盲随机临床试验将在居住在梅利利亚的因交通事故引起的颈部扭伤综合征患者中进行。参与者将接受针对胸锁乳突肌和/或肩胛提肌的干预。评估将在基线、干预4周后和干预后3个月进行,以评估中期效果。我们的假设是,与DN和标准物理治疗相比,EPI将在研究变量方面产生更大的改善。讨论:经皮电解法在各种肌肉骨骼病变中显示出积极的临床效果;然而,其对纤维内血流和肌纤维弹性的影响仍未被研究。本研究旨在为这些生理结果提供参考临床数据,并比较侵入性与标准物理治疗干预的效果,支持基于证据的鞭打相关疾病方案的发展。临床试验注册:NCT06938425。
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引用次数: 0
The effect of pulmonary rehabilitation for post-acute sequelae of SARS-CoV-2 infection in patients: a systematic review and meta-analysis. 肺部康复治疗对SARS-CoV-2感染急性后后遗症的影响:系统综述和荟萃分析
IF 1.9 Q3 REHABILITATION Pub Date : 2025-10-31 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1634351
Yinghua Yue, Xinyi Han, Qiming Chen, Lirong Dai, Qingjuan Ai, Zhigang Zhang, Fangli Ma, Jing Gao

Background: Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID, are characterized by persistent symptoms such as fatigue, dyspnea, and reduced functional capacity. Pulmonary rehabilitation (PR) is recommended for chronic respiratory conditions, but its effectiveness in PASC, particularly across different delivery modes, remains uncertain.

Objective: To assess the impact of PR, including telerehabilitation and in-person modalities, on physical function, dyspnea, pulmonary function, fatigue, and quality of life in patients with PASC.

Methods: We conducted a systematic search of PubMed, Embase, the Cochrane Library, and Web of Science from inception to March 25 for controlled clinical trials assessing the effects of PR in PASC patients. Two independent reviewers performed study selection and data extraction. The risk of bias was assessed using the Cochrane Risk of Bias Tool, and data were analyzed using Review Manager (RevMan) 5.4.1. Effect sizes were reported as mean differences (MD) or standardized mean differences (SMD) with 95% confidence intervals (CI).

Results: Ten randomized controlled trials involving 673 participants were included. Most studies were judged to have a moderate risk of bias. Compared with usual care, PR significantly improved six-minute walk distance (MD: 76.85 meters; 95% CI: 57.35-96.36; p < 0.001), maximal inspiratory pressure (MD: 17.63 cmH₂O; 95% CI: 4.50-30.76; p = 0.009), fatigue (SMD: -1.15; 95% CI: -1.83 to -0.48; p < 0.001), and quality of life (SMD: 1.73; 95% CI: 0.56-2.91; p = 0.004). No statistically significant improvement was found for dyspnea (MD: -0.41; 95% CI: -1.51 to -0.68; p = 0.46). Subgroup analyses showed no significant differences between telerehabilitation and in-person PR across all outcomes, including exercise capacity (p = 0.84), dyspnea (p = 0.86), fatigue (p = 0.93), and quality of life (p = 0.44).

Conclusions: PR improves physical and functional outcomes in patients with PASC. Telerehabilitation offers a clinically equivalent alternative to in-person PR, supporting its broader implementation.

背景:SARS-CoV-2感染急性后后遗症(PASC),也称为长COVID,其特征是持续症状,如疲劳、呼吸困难和功能下降。肺康复(PR)被推荐用于慢性呼吸系统疾病,但其在PASC中的有效性,特别是在不同的交付模式下,仍不确定。目的:评估PR(包括远程康复和面对面治疗)对PASC患者身体功能、呼吸困难、肺功能、疲劳和生活质量的影响。方法:我们对PubMed、Embase、Cochrane图书馆和Web of Science进行了系统的检索,从开始到3月25日,进行了评估PR对PASC患者影响的对照临床试验。两名独立审稿人进行研究选择和数据提取。使用Cochrane风险偏倚工具评估偏倚风险,使用Review Manager (RevMan) 5.4.1对数据进行分析。效应量以95%置信区间(CI)的平均差异(MD)或标准化平均差异(SMD)报告。结果:纳入10项随机对照试验,673名受试者。大多数研究被认为有中等偏倚风险。与常规护理相比,PR显著改善了6分钟步行距离(MD: 76.85米;95% CI: 57.35 ~ 96.36; p = 0.009)和疲劳(SMD: -1.15; 95% CI: -1.83 ~ -0.48; p = 0.004)。呼吸困难无统计学显著改善(MD: -0.41; 95% CI: -1.51 ~ -0.68; p = 0.46)。亚组分析显示远程康复和现场PR在所有结果上没有显著差异,包括运动能力(p = 0.84)、呼吸困难(p = 0.86)、疲劳(p = 0.93)和生活质量(p = 0.44)。结论:PR改善PASC患者的身体和功能预后。远程康复提供了一种临床等效的面对面PR替代方案,支持其更广泛的实施。
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引用次数: 0
Operationalising Article 13 of the Convention on the Rights of Persons with Disabilities the role of assistive technology in ensuring access to justice. 实施《残疾人权利公约》第13条、辅助技术在确保诉诸司法方面的作用。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-10-30 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1650487
Joanne McVeigh

Access to justice is a determinant of the realisation of all other rights, including the right to health, employment, and education. As persons with disabilities experience increased discrimination and social exclusion and are at higher risk of violence than people without disabilities, it is crucial to ensure access to justice in both the civil and criminal legal spheres for people with disabilities. However, persons with disabilities experience multiple barriers at the macro/structural and individual levels to accessing justice. In light of the significance of access to justice for people with disabilities, and the multiple barriers to accessing justice experienced by those with disabilities, this perspective examines the importance of assistive technology in fulfilling the right to access justice. To fulfill the right of access to the justice system, assistive technologies must be more effectively harnessed to provide equitable access to justice for persons with disabilities.

获得司法救助是实现包括健康权、就业权和教育权在内的所有其他权利的决定因素。由于残疾人遭受的歧视和社会排斥比正常人更多,遭受暴力的风险也更高,因此确保残疾人在民事和刑事法律领域获得司法救助至关重要。然而,残疾人在获得司法公正方面在宏观/结构和个人层面面临多重障碍。鉴于残疾人获得司法救助的重要性,以及残疾人在获得司法救助方面遇到的多重障碍,本视角探讨了辅助技术在实现获得司法救助权利方面的重要性。为了实现利用司法系统的权利,必须更有效地利用辅助技术,为残疾人提供公平的司法机会。
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引用次数: 0
A novel multimodal pharmacologic approach using guanfacine, N-acetylcysteine, and donepezil in severe TBI: a case series. 一种使用胍法辛、n -乙酰半胱氨酸和多奈哌齐治疗严重脑外伤的新型多模式药理学方法:一个病例系列。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-10-24 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1648002
Arman Fesharaki-Zadeh, Timothy Belliveau, Robert H Pietrzak, Amy Arnsten

Traumatic brain injury (TBI) remains a leading cause of long-term morbidity and disability worldwide. Individuals with moderate to severe TBI often experience persistent neurocognitive deficits, including short-term memory loss, executive dysfunction, and slowed cognitive processing for which there are currently no FDA-approved treatments. This case series investigates the synergistic use of guanfacine, N-acetylcysteine (NAC), and donepezil (GND) administered alongside ongoing cognitive rehabilitation, with treatment effects evaluated through pre- and post-intervention Montreal Cognitive Assessment (MoCA) scores. The guanfacine/NAC combination has previously been reported to improve working memory and executive function in individuals with mild TBI, suggesting its potential applicability to more severe TBI cases. Guanfacine, an alpha-2A agonist approved for ADHD, enhances prefrontal cortical function; Donepezil, a cholinesterase inhibitor, is widely used to treat cognitive symptoms in mild cognitive impairment and early dementia; and NAC, a potent antioxidant and glutamate modulator, has demonstrated neuroprotective effects across a range of clinical contexts, including TBI. Each of these agents has a well-established safety profile. The encouraging outcomes observed in this case series underscore the potential of the GND regimen as a multimodal pharmacologic approach to target the complex neurochemical disruptions following TBI. These preliminary findings warrant further investigation in larger, placebo-controlled trials in order to more rigorously assess the safety, efficacy, and translational potential of this intervention for mitigating chronic cognitive sequelae in individuals with moderate to severe TBI.

外伤性脑损伤(TBI)仍然是世界范围内长期发病和残疾的主要原因。中度至重度脑外伤患者通常会经历持续的神经认知缺陷,包括短期记忆丧失、执行功能障碍和认知处理减慢,目前尚无fda批准的治疗方法。本病例系列研究了胍法新、n -乙酰半胱氨酸(NAC)和多奈哌齐(GND)与持续认知康复的协同使用,并通过干预前和干预后的蒙特利尔认知评估(MoCA)评分评估治疗效果。此前有报道称,胍法辛/NAC联合用药可改善轻度TBI患者的工作记忆和执行功能,这表明其可能适用于更严重的TBI病例。胍法辛,一种被批准用于多动症的α - 2a激动剂,增强前额皮质功能;多奈哌齐是一种胆碱酯酶抑制剂,广泛用于治疗轻度认知障碍和早期痴呆的认知症状;NAC是一种有效的抗氧化剂和谷氨酸调节剂,已在包括创伤性脑损伤在内的一系列临床情况下显示出神经保护作用。每一种药物都有良好的安全性。在这个病例系列中观察到的令人鼓舞的结果强调了GND方案作为针对TBI后复杂神经化学破坏的多模式药理学方法的潜力。这些初步发现值得在更大规模的安慰剂对照试验中进一步研究,以更严格地评估这种干预措施在缓解中度至重度TBI患者慢性认知后遗症方面的安全性、有效性和转化潜力。
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引用次数: 0
Does body weight support improve neural and biomechanical measures during treadmill gait in children with unilateral cerebral palsy? 体重支持是否能改善单侧脑瘫儿童跑步机步态时的神经和生物力学指标?
IF 1.9 Q3 REHABILITATION Pub Date : 2025-10-23 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1607515
Rajit Banerjee, Yushin Kim, Thomas C Bulea, Diane L Damiano

Introduction: Body weight support (BWS) treadmill training, commonly utilized to improve gait, has inconsistent evidence of effectiveness across disorders.

Methods: We aimed to comprehensively evaluate its scientific rationale by comparing immediate effects of two weight support levels (20%, 40%) to unsupported (0%) treadmill walking on neural and biomechanical measures in children with unilateral cerebral palsy (CP) and typical development (TD). We hypothesized BWS would demonstrate positive effects only in CP. Participants included 10 with TD and 8 with CP (mean age = 14.6 and 15.4 years, respectively).

Results: Minimal or no group differences or BWS effects were found for synergy number, structure or Walk-DMC, whereas the Gait Deviation Index (GDI) showed a significant interaction with 20% BWS where the dominant side in CP improved with 20% BWS while both sides in TD worsened. Beta band EEG activation from 0% to 20% BWS showed a significant triple interaction increasing in the non-dominant and decreasing in the dominant hemisphere in TD, while increasing in both in CP. A worsening trend was seen with 40% BWS in all measures except z scores.

Conclusion: BWS has beneficial effects on kinematics in CP supporting the basic premise for use in neurorehabilitation at the body structure level.

体重支持(BWS)跑步机训练,通常用于改善步态,对疾病的有效性证据不一致。方法:通过比较两种体重支撑水平(20%、40%)和无支撑(0%)跑步机行走对单侧脑瘫(CP)和典型发育(TD)患儿神经和生物力学指标的直接影响,综合评价其科学依据。我们假设BWS仅对CP有积极作用。参与者包括10名TD患者和8名CP患者(平均年龄分别为14.6岁和15.4岁)。结果:协同数、结构或Walk-DMC的组间差异很小或没有BWS效应,而步态偏差指数(GDI)与20% BWS有显著的相互作用,其中CP的优势侧随着20% BWS而改善,而TD的两侧则恶化。从0%到20%脑ws的β带激活显示出显著的三重相互作用,在TD中,非优势半球增加,优势半球减少,而在CP中,两个半球都增加。在40%脑ws时,除z分数外,所有测量都有恶化趋势。结论:BWS对CP的运动学有有益的影响,为在机体结构水平上应用于神经康复提供了基本前提。
{"title":"Does body weight support improve neural and biomechanical measures during treadmill gait in children with unilateral cerebral palsy?","authors":"Rajit Banerjee, Yushin Kim, Thomas C Bulea, Diane L Damiano","doi":"10.3389/fresc.2025.1607515","DOIUrl":"10.3389/fresc.2025.1607515","url":null,"abstract":"<p><strong>Introduction: </strong>Body weight support (BWS) treadmill training, commonly utilized to improve gait, has inconsistent evidence of effectiveness across disorders.</p><p><strong>Methods: </strong>We aimed to comprehensively evaluate its scientific rationale by comparing immediate effects of two weight support levels (20%, 40%) to unsupported (0%) treadmill walking on neural and biomechanical measures in children with unilateral cerebral palsy (CP) and typical development (TD). We hypothesized BWS would demonstrate positive effects only in CP. Participants included 10 with TD and 8 with CP (mean age = 14.6 and 15.4 years, respectively).</p><p><strong>Results: </strong>Minimal or no group differences or BWS effects were found for synergy number, structure or Walk-DMC, whereas the Gait Deviation Index (GDI) showed a significant interaction with 20% BWS where the dominant side in CP improved with 20% BWS while both sides in TD worsened. Beta band EEG activation from 0% to 20% BWS showed a significant triple interaction increasing in the non-dominant and decreasing in the dominant hemisphere in TD, while increasing in both in CP. A worsening trend was seen with 40% BWS in all measures except z scores.</p><p><strong>Conclusion: </strong>BWS has beneficial effects on kinematics in CP supporting the basic premise for use in neurorehabilitation at the body structure level.</p>","PeriodicalId":73102,"journal":{"name":"Frontiers in rehabilitation sciences","volume":"6 ","pages":"1607515"},"PeriodicalIF":1.9,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12588987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A longitudinal qualitative study on the care needs journey map of primary caregivers of patients undergoing total knee arthroplasty. 全膝关节置换术患者主要护理人员护理需求旅程图的纵向定性研究。
IF 1.9 Q3 REHABILITATION Pub Date : 2025-10-23 eCollection Date: 2025-01-01 DOI: 10.3389/fresc.2025.1623623
Jingru Hu, Guanglei Dong, Dongfang Liu, Dongyang Wang

Background: Total knee arthroplasty (TKA) is a common and effective treatment for advanced knee osteoarthritis, yet it imposes significant demands on primary caregivers throughout the perioperative and rehabilitation phases. Understanding caregivers' evolving needs is critical for optimizing patient outcomes and sustaining caregiver well-being. This study aimed to explore the dynamic care experiences and changing needs of primary caregivers of TKA patients across three distinct phases: the diagnosis period, discharge transition, and rehabilitation phase, and to construct a comprehensive journey map of caregiving needs.

Methods: A longitudinal qualitative study was conducted using purposive sampling. Sixteen primary caregivers of patients undergoing unilateral TKA were recruited from a tertiary hospital in Henan, China. Semi-structured interviews were conducted at three time points: preoperative (T1), pre-discharge (T2), and one month post-discharge (T3), resulting in 43 interviews. Data were analyzed using content analysis and synchronized temporal mapping to identify themes and subthemes along the caregiving timeline.

Results: Four major themes and 27 subthemes were identified: care tasks, emotional experiences, caregiving barriers, and support systems. Caregivers' responsibilities evolved from pre-surgical information gathering to intensive post-surgical care and long-term rehabilitation support. Emotional burdens shifted from anxiety and helplessness to fatigue and psychological strain. Major barriers included knowledge deficits, skill limitations, and inadequate systemic support. The caregiver support network transitioned from hospital-based to community and family-based systems over time. A visual journey map was developed to represent these findings.

Conclusion: Primary caregivers of TKA patients face complex and changing needs across different stages of care. A caregiver-centered, multidisciplinary, and phase-specific support framework is essential to improve the quality of postoperative care and reduce caregiver burden.

背景:全膝关节置换术(TKA)是晚期膝关节骨性关节炎的一种常见且有效的治疗方法,但在围手术期和康复阶段对主要护理人员提出了很高的要求。了解护理人员不断变化的需求对于优化患者结果和维持护理人员的健康至关重要。本研究旨在探讨TKA患者主要照顾者在诊断期、出院过渡期和康复期三个不同阶段的动态护理体验和变化需求,并构建全面的护理需求旅程图。方法:采用有目的抽样进行纵向定性研究。从河南省某三级医院招募了16名单侧TKA患者的主要护理人员。在术前(T1)、出院前(T2)和出院后1个月(T3)三个时间点进行半结构化访谈,共访谈43次。使用内容分析和同步时间映射来分析数据,以确定护理时间轴上的主题和子主题。结果:确定了四个主要主题和27个次要主题:护理任务、情感体验、护理障碍和支持系统。护理人员的职责从术前信息收集演变为术后强化护理和长期康复支持。情绪负担从焦虑和无助转变为疲劳和心理紧张。主要障碍包括知识不足、技能限制和系统支持不足。随着时间的推移,护理人员支持网络从以医院为基础的系统转变为以社区和家庭为基础的系统。一幅可视化的旅程地图被开发出来以表示这些发现。结论:TKA患者初级护理人员在不同护理阶段的需求复杂多变。一个以护理人员为中心、多学科和特定阶段的支持框架对于提高术后护理质量和减轻护理人员负担至关重要。
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引用次数: 0
期刊
Frontiers in rehabilitation sciences
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