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Patent data-driven analysis of literature associations with changing innovation trends. 专利数据驱动的文献关联分析与不断变化的创新趋势。
Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI: 10.3389/frma.2024.1432673
Adrian Sven Geissler, Jan Gorodkin, Stefan Ernst Seemann

Patents are essential for transferring scientific discoveries to meaningful products that benefit societies. While the academic community focuses on the number of citations to rank scholarly works according to their "scientific merit," the number of citations is unrelated to the relevance for patentable innovation. To explore associations between patents and scholarly works in publicly available patent data, we propose to utilize statistical methods that are commonly used in biology to determine gene-disease associations. We illustrate their usage on patents related to biotechnological trends of high relevance for food safety and ecology, namely the CRISPR-based gene editing technology (>60,000 patents) and cyanobacterial biotechnology (>33,000 patents). Innovation trends are found through their unexpected large changes of patent numbers in a time-series analysis. From the total set of scholarly works referenced by all investigated patents (~254,000 publications), we identified ~1,000 scholarly works that are statistical significantly over-represented in the references of patents from changing innovation trends that concern immunology, agricultural plant genomics, and biotechnological engineering methods. The detected associations are consistent with the technical requirements of the respective innovations. In summary, the presented data-driven analysis workflow can identify scholarly works that were required for changes in innovation trends, and, therefore, is of interest for researches that would like to evaluate the relevance of publications beyond the number of citations.

专利对于将科学发现转化为造福社会的有意义产品至关重要。虽然学术界注重引用次数,根据 "科学价值 "对学术著作进行排名,但引用次数与专利创新的相关性无关。为了探索公开专利数据中专利与学术著作之间的关联,我们建议使用生物学中常用的统计方法来确定基因与疾病之间的关联。我们将在与食品安全和生态学高度相关的生物技术趋势相关的专利(即基于 CRISPR 的基因编辑技术(>60,000 项专利)和蓝藻生物技术(>33,000 项专利))中说明其用法。创新趋势是通过时间序列分析中专利数量的意外大幅变化发现的。从所有被调查专利所引用的学术著作(约 254,000 篇出版物)中,我们发现约 1,000 篇学术著作在不断变化的创新趋势专利的引用中明显过多,这些创新趋势涉及免疫学、农业植物基因组学和生物技术工程方法。所发现的关联与相关创新的技术要求是一致的。总之,所介绍的数据驱动分析工作流程可以识别创新趋势变化所需的学术著作,因此,对于希望评估出版物相关性(而非被引用次数)的研究人员来说很有意义。
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引用次数: 0
Politicizing science funding undermines public trust in science, academic freedom, and the unbiased generation of knowledge 将科学资助政治化有损公众对科学的信任、学术自由和不偏不倚的知识创造
Pub Date : 2024-07-23 DOI: 10.3389/frma.2024.1418065
Igor R. Efimov, Jeffrey S. Flier, Robert P. George, Anna I. Krylov, Luana S. Maroja, Julia Schaletzky, Jay Tanzman, Abigail Thompson
This commentary documents how federal funding agencies are changing the criteria by which they distribute taxpayer money intended for scientific research. Increasingly, STEMM (Science, Technology, Engineering, Mathematics, and Medicine) funding agencies are requiring applicants for funding to include a plan to advance DEI (“Diversity, Equity, and Inclusion”) in their proposals and to dedicate a part of the research budget to its implementation. These mandates undermine the academic freedom of researchers and the unbiased generation of knowledge needed for a well-functioning democracy. Maintaining excellence in science is fundamental to the continuation of the U.S. as a global economic leader. Science provides a basis for solving important global challenges such as security, energy, climate, and health. Diverting funding from science into activities unrelated to the production of knowledge undermines science's ability to serve humankind. When funding agencies politicize science by using their power to further a particular ideological agenda, they contribute to public mistrust in science. Hijacking science funding to promote DEI is thus a threat to our society.
本评论记录了联邦资助机构如何改变其分配纳税人用于科学研究的资金的标准。越来越多的 STEMM(科学、技术、工程、数学和医学)资助机构要求资金申请者在其提案中纳入推进 DEI("多样性、公平性和包容性")的计划,并将一部分研究预算用于实施该计划。这些规定损害了研究人员的学术自由和民主制度良好运作所需的不偏不倚的知识生成。保持科学的卓越性是美国继续作为全球经济领导者的根本。科学为解决安全、能源、气候和健康等重要的全球性挑战奠定了基础。将科学资金转用于与知识生产无关的活动,会削弱科学为人类服务的能力。当资助机构利用其权力推进特定的意识形态议程,将科学政治化时,就会助长公众对科学的不信任。因此,劫持科学资金来促进 DEI 是对我们社会的威胁。
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引用次数: 0
The H-index is an unreliable research metric for evaluating the publication impact of experimental scientists H 指数是评估实验科学家出版影响力的不可靠研究指标
Pub Date : 2024-07-19 DOI: 10.3389/frma.2024.1385080
M. K. Akhtar
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引用次数: 0
The Method of Everything vs. Experimenter Bias of Loophole-Free Bell Experiments 万有方法与无漏洞贝尔实验的实验者偏差
Pub Date : 2024-07-11 DOI: 10.3389/frma.2024.1404371
Manuel S. Morales
Experimenter bias compromises the integrity and advancement of science, especially when awarded as such. For example, the 2022 Nobel Prize in Physics awarded for the loophole-free experiments that tested physicist John S. Bell's inequality theorem. These experiments employed the logic of conducting local experiments to obtain local evidence that contradicted local realistic theories of nature, thereby validating quantum mechanics as a fundamental non-local theory. However, there was one loophole that was wittingly not tested by the Nobel laureates. The notable exception was Bell's “super-deterministic” loophole, which was validated (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) (2009) (2010) (2011) (2012) non-locally, thus compromising the subsequent Nobel Prize. More importantly, the discovery of two mutually exclusive and jointly exhaustive non-local hidden variables revealed why local scientific methods obtain false-positive and false-negative results. With knowledge of this fundamental omission, the inclusion of the non-local hidden variables in the local methods used in science can then advance it to be a complete study of nature.
实验者的偏见损害了科学的完整性和进步性,尤其是在以这种方式颁奖时。例如,2022 年诺贝尔物理学奖授予了检验物理学家约翰-贝尔不等式定理的无漏洞实验。这些实验运用了进行局部实验的逻辑,获得了与局部现实自然理论相矛盾的局部证据,从而验证了量子力学是一种基本的非局部理论。然而,有一个漏洞却被诺贝尔奖获得者们有意地忽略了。值得注意的例外是贝尔的 "超决定论 "漏洞,它得到了(2000 年)(2001 年)(2002 年)(2003 年)(2004 年)(2005 年)(2006 年)(2007 年)(2008 年)(2009 年)(2010 年)(2011 年)(2012 年)非局域的验证,从而影响了后来的诺贝尔奖。更重要的是,两个互斥且共同穷尽的非局部隐藏变量的发现揭示了局部科学方法获得假阳性和假阴性结果的原因。有了对这一根本性遗漏的认识,将非局部隐变量纳入科学所用的局部方法,就能推动科学成为对自然的完整研究。
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引用次数: 0
Addressing researcher fraud: retrospective, real-time, and preventive strategies-including legal points and data management that prevents fraud. 解决研究人员欺诈问题:回顾、实时和预防战略--包括法律要点和防止欺诈的数据管理。
Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.3389/frma.2024.1397649
James E Kennedy

Researcher fraud is often easy and enticing in academic research, with little risk of detection. Cases of extensive fraud continue to occur. The amount of fraud that goes undetected is unknown and may be substantial. Three strategies for addressing researcher fraud are (a) retrospective investigations after allegations of fraud have been made, (b) sting operations that provide conclusive evidence of fraud as it occurs, and (c) data management practices that prevent the occurrence of fraud. Institutional and regulatory efforts to address researcher fraud have focused almost exclusively on the retrospective strategy. The retrospective approach is subject to controversy due to the limitations of post-hoc evidence in science, the difficulty in establishing who actually committed the fraud in some cases, the application of a legal standard of evidence that is much lower than the usual standards of evidence in science, and the lack of legal expertise by scientists investigating fraud. The retrospective strategy may be reliably effective primarily in cases of extensive, careless fraud. Sting operations can overcome these limitations and controversies, but are not feasible in many situations. Data management practices that are effective at preventing researcher fraud and unintentional errors are well-established in clinical trials regulated by government agencies, but appear to be largely unknown or unimplemented in most academic research. Established data management practices include: archiving secure copies of the raw data, audit trails, restricted access to the data and data collection processes, software validation, quality control checks, blinding, preregistration of data processing and analysis programs, and research audits that directly address fraud. Current discussions about data management in academic research focus on sharing data with little attention to practices that prevent intentional and unintentional errors. A designation or badge such as error-controlled data management could be established to indicate research that was conducted with data management practices that effectively address intentional and unintentional errors.

在学术研究中,研究人员的欺诈行为往往很容易被发现,而且诱惑力很大。大量欺诈案件仍在发生。未被发现的欺诈数量尚不清楚,但可能相当可观。解决研究人员欺诈问题的三项策略是:(a) 在提出欺诈指控后进行追溯调查;(b) 在欺诈发生时采取刺探行动,提供确凿证据;(c) 采取数据管理措施,防止欺诈发生。机构和监管部门为解决研究人员欺诈问题所做的努力几乎都集中在追溯策略上。由于事后证据在科学领域的局限性、在某些情况下难以确定欺诈行为的实际实施者、适用的法律证据标准远低于科学领域的通常证据标准,以及调查欺诈行为的科学家缺乏法律专业知识,追溯法备受争议。追溯策略可能主要在大范围、粗心大意的欺诈案件中可靠有效。刺探行动可以克服这些限制和争议,但在许多情况下并不可行。在由政府机构监管的临床试验中,有效防止研究人员欺诈和无意失误的数据管理方法已经非常成熟,但在大多数学术研究中,这些方法似乎大多不为人知或未得到实施。成熟的数据管理实践包括:原始数据的安全副本归档、审计跟踪、限制访问数据和数据收集过程、软件验证、质量控制检查、盲法、数据处理和分析程序的预先注册,以及直接针对欺诈行为的研究审计。目前有关学术研究数据管理的讨论主要集中在数据共享方面,而很少关注防止有意和无意错误的做法。可以设立一个称号或徽章,如 "错误可控数据管理",以表明研究是在有效解决有意和无意错误的数据管理实践中进行的。
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引用次数: 0
Technical-scientific production and knowledge networks about medicinal plants and herbal medicines in the Amazon 亚马逊地区药用植物和草药的技术科学生产和知识网络
Pub Date : 2024-06-12 DOI: 10.3389/frma.2024.1396472
Nadja Lepsch-Cunha, Vinicius Muraro, Henrique Eduardo Mendonça Nascimento, A. Mazoni, Cecília Verónica Nunez, M. B. Bonacelli
This paper explores the role of Brazilian research institutions in the global and national context of study of medicinal plants. Most of these plants have ethnopharmacological use and herbal medicines related to the Amazon. It highlights Brazil's position in scientific production and the importance of Amazonian resources in developing phytomedicines. The study aims to provide an overview of the technical-scientific production of medicinal plants and herbal medicines related to the Amazon, focusing on scientific impact, collaboration, Technology Readiness Level (TRL) of scientific production, and innovation system maturity.The study employs a comprehensive methodological approach, including data collection from Scopus covering the period from 2002 to 2022. The data was cleaned and analyzed using bibliometric and network analysis techniques. Advanced natural language processing techniques, such as Latent Dirichlet Allocation and Jaccard distance measure, were used for TRL classification.The findings reveal a predominant contribution from Brazilian institutions and authors, with 1,850 publications analyzed. Key areas identified include Pharmacology, Toxicology, Pharmaceuticals, Medicine, and Biochemistry. The study also uncovers various collaborative networks and technological maturity levels, with a significant focus on early-stage development phases.The research concludes that Brazilian institutions, particularly those in the Amazon region, play a significant role in the scientific exploration and development of medicinal plants and herbal medicines. Despite this, countries like the USA were proportionally more productive in clinical trial research. The study underscores the potential of Brazil's rich biodiversity and traditional knowledge in the pharmaceutical industry, particularly for neglected diseases. It suggests the need for stronger research systems and international collaboration to leverage these resources for global health benefits.
本文探讨了巴西研究机构在全球和国家药用植物研究中的作用。这些植物大多与亚马逊地区的民族药学用途和草药有关。它强调了巴西在科学生产方面的地位以及亚马逊资源在开发植物药方面的重要性。本研究旨在概述与亚马逊有关的药用植物和草药的技术科学生产情况,重点关注科学影响、合作、科学生产的技术准备水平(TRL)以及创新体系的成熟度。本研究采用了综合方法论,包括从 Scopus 收集数据,时间跨度为 2002 年至 2022 年。研究采用了全面的方法,包括从 Scopus 收集 2002 年至 2022 年期间的数据,并使用文献计量学和网络分析技术对数据进行清理和分析。研究结果显示,巴西机构和作者的贡献占主导地位,共分析了 1,850 篇出版物。发现的主要领域包括药理学、毒理学、药物学、医学和生物化学。研究还发现了各种合作网络和技术成熟度,其中早期开发阶段是重点。研究得出结论,巴西机构,尤其是亚马逊地区的机构,在药用植物和草药的科学探索和开发方面发挥着重要作用。尽管如此,像美国这样的国家在临床试验研究方面的成果比例更高。这项研究强调了巴西丰富的生物多样性和传统知识在制药业中的潜力,尤其是在被忽视疾病方面。研究表明,需要加强研究系统和国际合作,利用这些资源造福全球健康。
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引用次数: 0
Pedagogical implications of pragmatic HRM research 实用人力资源管理研究的教学意义
Pub Date : 2024-06-11 DOI: 10.3389/frma.2024.1374628
Dieu Hack‐Polay
This chapter examines the interplay between human resource management theory and human resource management practice. It advocates that effective human resource management practice and theory are intrinsically intertwined, and this indispensable link ought to be central to the pedagogy of management research methods. Through greater embeddedness of the institutional and societal context in research method teaching, students can develop as scholars who understand their roles as facilitators of dialogue between researchers and a significant part of their audience (practitioners). The chapter conceptualizes this perspective as a collaborative model in human resource management research, which then must hold centrality in the teaching of research methods in our university and college classrooms.
本章探讨了人力资源管理理论与人力资源管理实践之间的相互作用。本章主张,有效的人力资源管理实践与理论之间存在内在联系,这种不可或缺的联系应成为管理研究方法教学的核心。通过在研究方法教学中更多地嵌入制度和社会背景,学生可以发展成为学者,理解自己作为研究人员与重要受众(实践者)之间对话的促进者的角色。本章将这一视角概念化为人力资源管理研究中的合作模式,因此必须将其作为大学和学院课堂研究方法教学的核心。
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引用次数: 0
The needed link between open science and science diplomacy—A Latin American perspective 开放科学与科学外交之间的必要联系--拉丁美洲视角
Pub Date : 2024-06-06 DOI: 10.3389/frma.2024.1355393
Reina Camacho Toro, Luz M. Cumba Garcia, Laura A. Galvis, L. F. Echeverría-King, B. Pantović, Claudia Alarcón-López, Verónica Rossana Suárez, Pedro Figueroa, Ivonne Torres-Atencio, Claudia Widmaier, Tatiana Rodrigues Fraga, Susan Benavides
The relevance of science diplomacy and open science in today's world is undeniable. Science diplomacy enables countries to jointly address pressing global challenges, such as climate change, pandemics, and food security. Open science, promoting accessible and transparent research, plays a pivotal role in this context. Nevertheless, the degree of openness is subject to specific circumstances, contingent upon varying factors, including local knowledge and resources. Latin America has not only been at the forefront of pioneering open access strategies, making it an interesting case to study, but it has also shown a tangible interest in using science diplomacy. Our research employs a mixed-methods approach, incorporating a quantitative survey involving 50 organizations and initiatives dedicated to promoting open science in Latin America, along with two qualitative focus group studies. Our primary objective is to assess if and how these entities use science diplomacy to achieve their objectives. Non-policy entities were prioritized due to their institutional stability in the region. We highlight successful strategies and delve into the existing barriers hindering the full implementation of open science principles. Our research aims to enhance collaboration between these organizations and policy and decision-makers by providing a set of recommendations in that direction. By shedding light on the current landscape and dynamics of open science in Latin America, we aspire to focus on science diplomacy, facilitate informed decision-making, and formulate policies that further propel the region along the path of openness, collaboration, and innovation in scientific research.
科学外交和开放科学在当今世界的现实意义毋庸置疑。科学外交使各国能够共同应对气候变化、大流行病和粮食安全等紧迫的全球挑战。在此背景下,促进可获取和透明研究的开放科学发挥着关键作用。然而,开放程度取决于具体情况,取决于各种因素,包括当地知识和资源。拉丁美洲不仅走在开放式获取战略的前沿,使其成为一个有趣的研究案例,而且在利用科学外交方面也表现出了切实的兴趣。我们的研究采用了混合方法,包括一项涉及 50 个致力于促进拉丁美洲开放科学的组织和倡议的定量调查,以及两项定性焦点小组研究。我们的主要目标是评估这些实体是否以及如何利用科学外交来实现其目标。非政策性实体因其在该地区的机构稳定性而被优先考虑。我们强调了成功的战略,并深入探讨了阻碍全面实施开放科学原则的现有障碍。我们的研究旨在通过提供一系列建议,加强这些组织与政策和决策者之间的合作。通过揭示拉丁美洲开放科学的现状和动态,我们希望关注科学外交,促进知情决策,并制定政策,进一步推动该地区沿着开放、合作和创新的道路开展科学研究。
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引用次数: 0
Bringing rigor in contextual objectivity: lessons from applying feminist lens in scoping the evidence on girlhood studies in Indonesia. 在客观背景中体现严谨性:在印度尼西亚女童研究中运用女权主义视角的经验教训。
Pub Date : 2024-05-30 eCollection Date: 2024-01-01 DOI: 10.3389/frma.2024.1339651
Santi Kusumaningrum, Shaila Tieken, Andrea Andjaringtyas Adhi, Siti Ainun Nisa, Widi Laras Sari, Annisa R Beta

This perspective paper contemplates the nuances of engaging with literature ethically in conducting a scoping review based on the researchers' project on girlhood studies in Indonesia. We assert that the ethical perspective extends beyond conventional primary data collection from human participants, further emphasizing the essence of a feminist methodology in this scholarly investigation. We discuss the interplay between the role of rigor and the dynamics of power relations in research, shedding light on reconciling between the pursuit of facts and acknowledgment of biases in knowledge production. This reflection offers insights into the methodological process and the researcher's role, contributing to the broader discourse on how research can effectively address issues of gender equity and social inclusion. Through this paper, we underscore the necessity of an intentional approach in unifying the domains of science and advocacy because only then can we truly catalyze transformative change. In doing so, we seek to foster a more comprehensive, objective, and empathetic understanding of the researched: in this case, the experiences of girls and young women -and, by extension, marginalized individuals in Indonesia and beyond.

本视角论文以研究人员在印度尼西亚开展的女童研究项目为基础,探讨了在进行范围综述时如何从伦理角度参与文献研究的细微差别。我们认为,伦理视角超越了传统的从人类参与者那里收集原始数据的范围,进一步强调了这一学术调查中女性主义方法论的本质。我们讨论了研究中严谨性的作用与权力关系动态之间的相互作用,揭示了在知识生产中追求事实与承认偏见之间的协调。这种思考为研究方法过程和研究人员的角色提供了见解,有助于更广泛地讨论研究如何有效解决性别平等和社会包容问题。通过本文,我们强调了有意识地将科学与宣传领域统一起来的必要性,因为只有这样,我们才能真正推动变革。在此过程中,我们力图促进对被研究者更全面、更客观、更感同身受的理解:在本案例中,被研究者是女孩和年轻女性--进而是印度尼西亚及其他国家的边缘化个人--的经历。
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引用次数: 0
Mapping social movements momentum: unveiling networks in the movement for the right to abortion in Mexico 绘制社会运动势头图:揭示墨西哥堕胎权运动的网络
Pub Date : 2024-05-24 DOI: 10.3389/frma.2024.1294495
Cesángari López Martínez, Allison Sambo, Diana Medina González
In this case study, we propose a network analysis approach to map social movements through an intersectional feminist lens. We aim to gain a more in-depth understanding of movements' network structures to examine the roles and relationships of movement actors, the flow of resources between them, and potential areas of collaboration and conflict. By incorporating Social Network Analysis (SNA) techniques and visually mapping dynamics within social movements, this approach can assess the significance of small actors in creating change and stresses the need for their perspectives to be heard. Furthermore, our methodology adopts a feminist intersectional framework that recognizes the role of different identities in shaping the movement and its actors. To demonstrate the practical application of this approach, we examined the movement for the right to abortion in Mexico between September and December 2021. Our multi-step process included (1) designing a survey tool adapted to the context of the movement, (2) collecting and analyzing survey responses on movement actors' relationships and interactions, including their priorities, activities, needs, risks, and challenges, (3) visualizing the network using SNA techniques that account for the complexity and diversity of the movement, (4) interpreting the findings through insights collected in semi-structured interviews and validation meetings with key movement actors, and (5) implementing safety and security guidelines to safeguard the identity of individuals whose activities could put them at risk of suffering institutional, emotional, and physical violence. Our case study offers valuable insights that not only encourage the integration of feminist and intersectional perspectives into data collection processes but also provide a roadmap for accompanying social movements and supporting meaningful and contextually responsive activities.
在本案例研究中,我们提出了一种网络分析方法,通过交叉女权主义视角来绘制社会运动地图。我们的目标是更深入地了解运动的网络结构,研究运动参与者的角色和关系、他们之间的资源流动以及潜在的合作和冲突领域。通过采用社会网络分析(SNA)技术和直观映射社会运动内部的动态,这种方法可以评估小行动者在创造变革中的重要性,并强调需要听取他们的观点。此外,我们的方法采用了女权主义交叉框架,承认不同身份在塑造运动及其参与者方面的作用。为了展示这种方法的实际应用,我们考察了 2021 年 9 月至 12 月间墨西哥的堕胎权运动。我们的多步骤过程包括:(1) 设计一个适合运动背景的调查工具;(2) 收集和分析关于运动参与者关系和互动的调查回复,包括他们的优先事项、活动、需求、风险和挑战;(3) 使用考虑到运动复杂性和多样性的国民账户体系(SNA)技术将网络可视化;(4) 通过与主要运动参与者进行半结构式访谈和验证会议所收集的见解来解释调查结果;(5) 实施安全和安保准则,以保护其活动可能使其面临遭受制度、情感和身体暴力风险的个人的身份。我们的案例研究提供了宝贵的见解,这些见解不仅鼓励将女权主义和交叉视角纳入数据收集过程,而且还为陪伴社会运动、支持有意义且符合实际情况的活动提供了路线图。
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引用次数: 0
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