Frontiers in sleep最新文献

{"title":"Psychobiological risk factors for insomnia and depressed mood among hospital female nurses working shifts","authors":"Kochav Bennaroch, Tamar Shochat","doi":"10.3389/frsle.2023.1206101","DOIUrl":"https://doi.org/10.3389/frsle.2023.1206101","url":null,"abstract":"Introduction Despite a vast body of knowledge on the associations between insomnia and depression, and although women and shift workers are at high risk for each of these conditions separately, common psychobiological risk factors for developing insomnia and depressed mood concomitantly in high-functioning shift-working female nurses have yet to be investigated within a comprehensive framework. This study examines the contribution of shift work (disruption of circadian rhythms), stress, analytical rumination, and morningness-eveningness on the development of insomnia and depressed mood among female hospital nurses. Objectives We sought to assess the severity and prevalence of insomnia symptoms and depressed mood among hospital shift-working compared with day-working nurses; to examine associations between psychobiological risk factors with insomnia and depressed mood; and to develop a conceptual psychobiological model to describe their co-occurrence among hospital nurses. Methods Using a cross-sectional design, we recruited female hospital nurses, shift workers (SW) and day workers (DW: only morning shifts), and assessed them for insomnia, depressed mood, stress, analytical rumination, and morningness-eveningness through validated self-administered questionnaires delivered online. Using structural equation modeling (SEM), we assessed common pathways between psychobiological factors affecting insomnia and depressed mood. Results 448 nurses completed electronic questionnaires. SW nurses ( n = 358) compared with DW nurses ( n = 90) had significantly higher rates of insomnia and depressed mood. SW nurses also reported significantly higher severity of insomnia, depressed mood, stress, and a tendency to eveningness compared with DW nurses. A positive linear relationship was found between insomnia and depressed mood in both SW and DW nurses. SEM showed that shift work contributed directly to insomnia and indirectly to depressed mood. The overall model showed a good fit between the empirical and the conceptual psychobiological model proposed in the study [χ (1) = 0.16, p = 0.69, CFI = 0.99, RMSEA = 0.0001]. Discussion We found that SW nurses who reported high levels of stress and eveningness are at significantly greater risk for both insomnia symptoms and depressed mood. Findings provide the groundwork in creating a conceptual psychobiological model to examine the co-occurrence of insomnia and depressed mood phenomena in hospital nurses. This research is an important first step toward the development of interventions aimed at improving nurses' health, wellbeing and quality of life by preventing the mental burden associated with insomnia and depressed mood.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135678819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new approach to streamline obstructive sleep apnea therapy access using peripheral arterial tone-based home sleep test devices","authors":"Ding Zou, Steven Vits, Carlos Egea, Daniela Ehrsam-Tosi, Florent Lavergne, Mikel Azpiazu, Ingo Fietze","doi":"10.3389/frsle.2023.1256078","DOIUrl":"https://doi.org/10.3389/frsle.2023.1256078","url":null,"abstract":"Obstructive sleep apnea (OSA) is a prevalent condition that negatively impacts cardiovascular, metabolic and mental health. A high proportion of individuals with OSA remain undiagnosed and incur significant healthcare costs. The gold standard OSA diagnostic is in-lab polysomnography, but this is costly and time-consuming. Home sleep apnea tests (HSATs), including cardiorespiratory polygraphy and peripheral artery tonometry technology, provide an alternative. Advances in HSAT technology include non-invasive, easy-to-use medical devices that could allow unobtrusive, accessible, multi-night, cost-effective diagnosis and management of sleep-disordered breathing. One type of these devices is based on determination of peripheral arterial tone, and use photoplethysmography signals from the finger (oxygen saturation, pulse wave amplitude and pulse rate). The devices contain algorithms that use these data to generate the traditional metrics required by the American Academy of Sleep Medicine. They can be used to record sleep parameters over multiple nights at home, and can also provide information on total sleep time (TST) and sleep stages (including time spent in rapid eye movement sleep). The combination of objective measures (apnea-hypopnea index, oxygen desaturation index, respiratory disturbance index, TST) and subjective measures (symptoms and other patient-reported outcome measures) could facilitate the development of a personalized therapeutic plan for OSA patients. It is anticipated that the streamlined digital pathway facilitated by new peripheral artery tone-based technology could contribute to reducing the underdiagnosis of OSA, accelerating access to appropriate treatment, and the optimization of OSA therapy.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135679803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Current issues in sleep in children with neurodisability","authors":"J. Chawla, Laurie McLay, Moya Vandeleur","doi":"10.3389/frsle.2023.1317714","DOIUrl":"https://doi.org/10.3389/frsle.2023.1317714","url":null,"abstract":"","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139306654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated REM sleep behavior disorder is associated with altered 24-h rest-activity measures","authors":"Joseph R. Winer, Renske Lok, Adrian Ekelmans, Flavia Bueno, Kathleen L. Poston, Jamie M. Zeitzer, Emmanuel H. During","doi":"10.3389/frsle.2023.1286124","DOIUrl":"https://doi.org/10.3389/frsle.2023.1286124","url":null,"abstract":"Introduction Isolated REM sleep behavior disorder (iRBD), the loss of motor inhibition during REM sleep, is a symptom of prodromal Lewy body disease, with over 80% of iRBD patients progressing to Parkinson's disease or dementia with Lewy bodies. Disruption of rest-activity patterns, an established predictor of Parkinson's disease, has not been well characterized in patients with iRBD. Here, we tested the hypothesis that accelerometer-based measures of 24-h activity would indicate greater fragmentation and variability in patients with iRBD relative to matched healthy controls. Materials and methods Patients with iRBD ( N = 38) had 24-h activity monitored for (mean ± SD) 24.6 ± 8.8 days using an Axivity wrist-worn accelerometer. Age, sex, and body mass index matched healthy older adults ( N = 119) were selected as controls. Raw accelerometer data were processed and nonparametric and cosinor measures of 24-h activity were calculated. Functional principal component analyses (fPCA) were applied to detect differences in 24-h activity patterns. Results Compared to matched controls, individuals with iRBD had significantly lower cosine amplitude, mesor, and activity during their most active 10 hours, reflecting overall lower levels of activity and disrupted activity. They also had significantly increased movement during the night (L5). FPCA indicated that decreased daytime and increased nighttime activity may explain overall differences observed in iRBD. Conclusion Multiple metrics of rest-activity rhythms support the hypothesis that 24-h activity measures are altered in iRBD. This dysfunction may reflect degeneration of sleep-wake regulating circuits, representing a symptom of iRBD and indicating the early stages of Lewy body disease.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136067613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of outdoor light exposure is associated with sleep-wake consolidation in community-dwelling older men","authors":"Renske Lok, Sonia Ancoli-Israel, Kristine E. Ensrud, Susan Redline, Katie L. Stone, Jamie M. Zeitzer","doi":"10.3389/frsle.2023.1268379","DOIUrl":"https://doi.org/10.3389/frsle.2023.1268379","url":null,"abstract":"Introduction A consolidated sleep-wake pattern is essential for maintaining healthy cognition in older individuals, but many suffer from sleep fragmentation that exacerbates age-related cognitive decline and worsens overall mental and physical health. Timed light exposure (light therapy) has been explored as a countermeasure, but mixed results have been obtained. To determine whether the timing of light exposure is important for sleep-wake consolidation, we analyzed the natural light diets of a cohort of community-dwelling older men. Methods The degree of sleep-wake fragmentation and light exposure patterns were obtained over a week using wrist actigraphy. Correlations between fragmentation, light patterns, and various physical and mental health measures were examined ( n = 877). Results Our findings revealed that higher sleep-wake fragmentation correlated with poorer physical and mental health and reduced cognition. Moreover, reduced daytime light exposure was associated with increased sleep-wake fragmentation. Interestingly, morning and evening light exposure (>1,000 lux) were not useful in distinguishing between low and high sleep-wake fragmentation scores, while increased afternoon light exposure showed much better discrimination. Specifically, optimal discrimination between low and high fragmentation occurred 6.7 h after habitual sleep offset. This suggests that afternoon light therapy might be more efficient in consolidating sleep and wake in older adults, particularly in those with low-amplitude circadian rhythms. Discussion This study highlights the significance of properly-timed light exposure in promoting consolidated sleep and cognitive health among older individuals. Tailored light-based strategies may have the potential to enhance physical, mental, and cognitive well-being in the aging population.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sleep and circadian disruption in shift work and perpetration of interpersonal violence","authors":"Rosalie B. Flinn, Rebecca M. C. Spencer","doi":"10.3389/frsle.2023.1220056","DOIUrl":"https://doi.org/10.3389/frsle.2023.1220056","url":null,"abstract":"Research has uncovered substantial consequences of shift work on health outcomes through disruption of sleep and circadian rhythms. Less explored is how the effects of shift work on sleep and circadian rhythms can facilitate interpersonal aggression and violence within the home (i.e., intimate partner violence, child abuse). Given challenges in direct studies on this topic, integration across related literature is critical. In this narrative review, we identify compounding variables centered around sleep and circadian rhythms that place shift workers at an increased risk of perpetrating interpersonal violence. Shift workers have impaired sleep and altered circadian rhythms. Associated alternations in executive functioning, stress, and alcohol use provide pathways to increase risk for interpersonal violence. A model of interactions facilitating the relationship between shift work and interpersonal violence is proposed to promote prevention efforts and motivate policy change.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modulation of emotional memory consolidation by dream affect","authors":"Liëtte du Plessis, Gosia Lipinska","doi":"10.3389/frsle.2023.1239530","DOIUrl":"https://doi.org/10.3389/frsle.2023.1239530","url":null,"abstract":"Introduction Research in the field of cognitive neuroscience has focused on the role of sleep in various neurocognitive processes such as memory consolidation. However, an area that has not been adequately researched is the role of dreaming in this memory process. This study aimed to determine the relationship between affect experienced in dreams and emotional memory consolidation. Considering that REM dreams are laden with emotion and that emotion enhances memory, one possibility is that dream affect could also play a role in emotional memory consolidation. We hypothesised that greater dream-related affect would be associated with greater memory retention of emotional but not neutral information. Methods 126 healthy participants, aged 18–35, were recruited for the online study, of which 103 participants had valid data (female: n =73). On the night of the study, participants viewed a series of pictures from the South African Affective Picture System (SA-APS) in an online session. Afterwards, they verbally recalled as many pictures as possible. The following morning, they were asked to recall any dreams and rate the emotional intensity of their dreams. Participants then again verbally recalled all the pictures that they could remember from the previous night. Results Contrary to the prediction, dream-related affect, regardless of valence, did not predict memory consolidation of positive or negative information. Instead, increases in dream-related affect, and especially anxiety were predictive of better memory retention of all information. The findings also showed that an increase in negative affect in dreams predicted better memory retention of negative information. Discussion Our results suggest that dream affect is an important modulator of memory consolidation processes occurring during sleep. Furthermore, increased negative affect may indicate which experiences are salient and require consolidation to form long-lasting memories that can guide future behaviour. Conclusion These findings have implications for psychiatric disorders, such as major depression, which is characterised by negative affect and increased memory sensitivity to negative stimuli.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136210724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing intervention components for sleep promotion in children in the context of obesity prevention: the SLEEPY 2.0 study protocol","authors":"Maddy Fair, Jessica Decker, Alexander G. Fiks, Stephanie Mayne, Knashawn H. Morales, Ariel A. Williamson, Jonathan A. Mitchell","doi":"10.3389/frsle.2023.1264532","DOIUrl":"https://doi.org/10.3389/frsle.2023.1264532","url":null,"abstract":"Background Insufficient sleep duration is highly prevalent in childhood and is associated with obesity, especially among middle school-aged children. The primary care setting has enormous potential to promote sleep, but limited time and sleep resources at in person appointments are key barriers. Digital health innovations offer solutions to these barriers. Mobile health platforms can be developed to deliver behavioral sleep promotion remotely in the home setting, with tailoring to individual and contextual factors to help ensure equitable effectiveness across sociodemographic groups. This paper presents the protocol for a randomized optimization trial using the Multiphase Optimization Strategy (MOST) to develop a mobile health platform for the pediatric care setting to promote longer sleep duration for childhood obesity prevention. Methods This is a single-site study being conducted at the Children's Hospital of Philadelphia. We will randomize 325 children, aged 8–12 y, with a body mass index (BMI) between the 50th−95th percentile, and who sleep <8.5 h per night. The Way to Health mobile platform will facilitate remote communication and data collection. A sleep tracker will estimate sleep patterns for 12-months (2-week run-in; 6-month intervention; ≈5.5-month follow-up). A randomized 2 4 factorial design will assess four components: sleep goal (≥9 h or ≥30 min above baseline sleep duration), digital guidance (active or active with virtual study visits), caregiver incentive (inactive or active), and performance feedback (inactive or active). Fat mass will be measured at baseline, 6-, and 12-months using dual energy X-ray absorptiometry. Total energy intake and the timing and composition of meals will be measured using 24-h dietary recalls at baseline, 6-, and 12-months. Sociodemographic data (e.g., sex, race, ethnicity) will be measured using self-report and home addresses will be geocoded for geospatial analyses. Discussion We anticipate that this innovative optimization trial will identify optimal component settings for sleep promotion in children, with clinically meaningful improvements in fat mass trajectories. Importantly, the platform will have broad impact by promoting sleep health equity across sociodemographic groups. With the optimal settings identified, we will be able to determine the effectiveness of the final intervention package under the evaluation phase of the MOST framework in a future randomized controlled trial. Our proposed research will greatly advance the field of behavioral sleep medicine and reimagine how insufficient sleep duration and obesity are prevented in pediatric healthcare. Trial registration ClinicalTrials.gov NCT05703347 registered on 30 January 2023.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135591631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced expiratory rebreathing space for high loop gain sleep apnea treatment","authors":"Thomas Quinn, Robert Joseph Thomas, Eric James Heckman","doi":"10.3389/frsle.2023.1248371","DOIUrl":"https://doi.org/10.3389/frsle.2023.1248371","url":null,"abstract":"The pathophysiology of sleep apnea goes beyond anatomic predisposition to airway collapse and includes additional factors such as arousal threshold and loop gain. High loop gain is a prominent feature in central and complex sleep apnea (with a mixture of obstructive and central features) where relative hypocapnia can lead to respiratory instability and periodic breathing. Existing therapies, including continuous positive airway pressure (CPAP) and adaptive servo-ventilators, often inadequately treat sleep apnea with high loop gain features. Enhanced expiratory rebreathing space (EERS) targets prevention of the hypocapnia that triggers central events in sleep by increasing dead space in amounts less than typical tidal volumes. This is accomplished by covering traditional exhalation ports on positive airway pressure masks and adding small additional tubing with distal exhalation and safety valves. This technique reduces carbon dioxide (CO 2 ) blow-off during arousals and the associated large recovery breaths, typically producing a maximal increase in resting CO 2 by 1–2 mmHg, thus increasing the CO 2 reserve and making it less likely to encounter the hypocapnic apneic threshold. Typically, the amount of EERS is titrated in response to central events and periodic breathing rather than aiming for a goal CO 2 level. Ideally CO 2 monitoring is used during titration of EERS and the technique is avoided in the setting of baseline hypercapnia. This method has been used in clinical practice at our sleep center for over 15 years, and retrospective data suggests an excellent safety profile and high rates of successful therapy including in patients who have previously failed CPAP therapy. Limitations include decreased effectiveness in the setting of leak and decreased tolerance of the bulkier circuit. EERS represents a simple, affordable modification of existing positive airway pressure modalities for treatment of central and complex sleep apnea. Areas of future study include randomized controlled trials of the technique and study of use of EERS in combination with adaptive ventilation, and pharmacologic adjuncts targeting high loop gain physiology.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135193451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nap consolidates generalized perceptual learning","authors":"Katherine S. Reis, Shannon Heald, Sophia Uddin, Kimberly M. Fenn, Howard C. Nusbaum","doi":"10.3389/frsle.2023.1168511","DOIUrl":"https://doi.org/10.3389/frsle.2023.1168511","url":null,"abstract":"Previous research has demonstrated that a night's sleep can consolidate rote and generalized perceptual learning. Over a waking retention period following training, performance gains from learning significantly decline, but sleep can restore performance to levels found immediately after learning. Furthermore, when sleep precedes a waking retention period following training, performance is protected against loss. Other research demonstrating that rote learning can be consolidated by a night's sleep has shown that a relatively brief nap can consolidate rote learning. This suggests that short periods of sleep can produce consolidation, indicating that consolidation may not require successive sleep cycles over an entire night to emerge. However, previous research has demonstrated that there can be differences in sleep-dependent consolidation for rote and generalized learning. In this study, we investigated whether an opportunity for a 90-min midday nap was sufficient to consolidate generalized perceptual learning of synthetic speech. We recruited 75 participants from the University of Chicago community (mean age of 20.83) who completed a pretest, training, and posttest in the morning on perception of synthetic speech. Training and testing in this manner are known to result in substantial generalized learning of synthetic speech. Participants then returned in the afternoon and were either given an opportunity for a 90-min nap or remained awake for 90-min. Participants were then given another posttest later that evening, never hearing the same words twice during the experiment. Results demonstrated that participants who did not nap showed significant loss of learning at the evening posttest. In contrast, individuals who napped retained what they learned, and did not show loss of learning at the evening posttest. These results are consistent with the view that an opportunity for a 90-min midday nap can consolidate generalized learning, as only individuals with consolidated learning should be able to retain what they learned despite an intervening waking retention period. This is the first demonstration that generalized skill learning is subject to sleep-dependent consolidation in short durations of sleep and does not require a full night of sleep. This work has implications for understanding the basic neural mechanisms that operate to stabilize short-term learning experiences.","PeriodicalId":73106,"journal":{"name":"Frontiers in sleep","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}