{"title":"Accurate prediction of stomach adenocarcinomas of poorest and best prognosis with a combination of gene expression and clinical signatures","authors":"Lingyu Qiu, Huayu Kang, Jie-lin Yang, Yidong Zheng, Aiyue Chen, Chunlin Chen, Xinlong Wang, Qiongfang Fang, Weifang Zhu, Ou Sha, Yejun Wang","doi":"10.1007/s42764-022-00077-y","DOIUrl":"https://doi.org/10.1007/s42764-022-00077-y","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"3 1","pages":"227-237"},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43653131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-01DOI: 10.1007/s42764-022-00059-0
Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi, Mahsa Keshavarz-Fathi, Mohammadmehdi Yousefi, N. Rezaei
{"title":"The role of ral signaling and post translational modifications (PTMs) of Ras in cancer","authors":"Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi, Mahsa Keshavarz-Fathi, Mohammadmehdi Yousefi, N. Rezaei","doi":"10.1007/s42764-022-00059-0","DOIUrl":"https://doi.org/10.1007/s42764-022-00059-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"3 1","pages":"22-32"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The ufmylation ligase-UFL1 promotes ATM activation by monoufmylating H4 at K31 in a positive-feedback loop after double-strand breaks (DSB) occur, whereas UFM1 Specific Peptidase 2 (UfSP2) suppresses ATM activation, but the mechanism of recruitment of UfSP2 to the DSB finetuning DNA damage response is still not clear. Here, we report that UfSP2 foci formation is delayed compared to UFL1 foci formation following the radiation insult. Mechanistically, UfSP2 binds to the MRN complex in absence of DSB. Irradiation-induced phosphorylation of UfSP2 by ATM leads to the dissociation of UfSP2 from the MRN complex. This phosphorylation can be removed by the phosphatase WIP1, thereby UfSP2 is recruited to the DSBs, deufmylating H4 and suppressing ATM activation. In summary, we identify a mechanism of delicately negative modulation of ATM activation by UfSP2 and rewires ATM activation pathways.
{"title":"Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1.","authors":"Bo Qin, Jia Yu, Fei Zhao, Jinzhou Huang, Qin Zhou, Zhenkun Lou","doi":"10.1007/s42764-022-00076-z","DOIUrl":"10.1007/s42764-022-00076-z","url":null,"abstract":"<p><p>The ufmylation ligase-UFL1 promotes ATM activation by monoufmylating H4 at K31 in a positive-feedback loop after double-strand breaks (DSB) occur, whereas UFM1 Specific Peptidase 2 (UfSP2) suppresses ATM activation, but the mechanism of recruitment of UfSP2 to the DSB finetuning DNA damage response is still not clear. Here, we report that UfSP2 foci formation is delayed compared to UFL1 foci formation following the radiation insult. Mechanistically, UfSP2 binds to the MRN complex in absence of DSB. Irradiation-induced phosphorylation of UfSP2 by ATM leads to the dissociation of UfSP2 from the MRN complex. This phosphorylation can be removed by the phosphatase WIP1, thereby UfSP2 is recruited to the DSBs, deufmylating H4 and suppressing ATM activation. In summary, we identify a mechanism of delicately negative modulation of ATM activation by UfSP2 and rewires ATM activation pathways.</p>","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"3 4","pages":"217-226"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.1007/s42764-021-00054-x
A. N. Luchnik
{"title":"Correction to: Chromosome instability induced by mutations in TAD anchors leads to tumors","authors":"A. N. Luchnik","doi":"10.1007/s42764-021-00054-x","DOIUrl":"https://doi.org/10.1007/s42764-021-00054-x","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"2 1","pages":"330"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43045507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.1007/s42764-021-00046-x
Chenzhong Xu, Jin Zhang, Jie Zhang, Baohua Liu
{"title":"SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA","authors":"Chenzhong Xu, Jin Zhang, Jie Zhang, Baohua Liu","doi":"10.1007/s42764-021-00046-x","DOIUrl":"https://doi.org/10.1007/s42764-021-00046-x","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"2 1","pages":"253-260"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00046-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.1007/s42764-021-00040-3
Meiqian Jiang, H. Lou, Wenya Hou
{"title":"Microproteins: from behind the scenes to the spotlight","authors":"Meiqian Jiang, H. Lou, Wenya Hou","doi":"10.1007/s42764-021-00040-3","DOIUrl":"https://doi.org/10.1007/s42764-021-00040-3","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"2 1","pages":"225-239"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00040-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.1007/s42764-021-00044-z
Yifan Luo, Yang Su, Feng Rao
{"title":"Role of NEDD8 and neddylation dynamics in DNA damage response","authors":"Yifan Luo, Yang Su, Feng Rao","doi":"10.1007/s42764-021-00044-z","DOIUrl":"https://doi.org/10.1007/s42764-021-00044-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"2 1","pages":"139-149"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00044-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}