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Genome instability & disease最新文献

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Accurate prediction of stomach adenocarcinomas of poorest and best prognosis with a combination of gene expression and clinical signatures 结合基因表达和临床特征准确预测胃腺癌最差和最佳预后
Genome instability & disease
Pub Date : 2022-08-19 DOI: 10.1007/s42764-022-00077-y
Lingyu Qiu, Huayu Kang, Jie-lin Yang, Yidong Zheng, Aiyue Chen, Chunlin Chen, Xinlong Wang, Qiongfang Fang, Weifang Zhu, Ou Sha, Yejun Wang
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引用次数: 0
Centrosome, microtubule and DNA damage response 中心体，微管和DNA损伤反应
Genome instability & disease
Pub Date : 2022-06-01 DOI: 10.1007/s42764-022-00068-z
Dingwei Li, Xiuwen Liu, Qiang Chen
{"title":"Centrosome, microtubule and DNA damage response","authors":"Dingwei Li, Xiuwen Liu, Qiang Chen","doi":"10.1007/s42764-022-00068-z","DOIUrl":"https://doi.org/10.1007/s42764-022-00068-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Genotoxicity testing and recent advances 基因毒性测试及其最新进展
Genome instability & disease
Pub Date : 2022-02-01 DOI: 10.1007/s42764-021-00058-7
Yang Luan, M. Honma
{"title":"Genotoxicity testing and recent advances","authors":"Yang Luan, M. Honma","doi":"10.1007/s42764-021-00058-7","DOIUrl":"https://doi.org/10.1007/s42764-021-00058-7","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The role of ral signaling and post translational modifications (PTMs) of Ras in cancer Ras的信号转导和翻译后修饰(PTMs)在癌症中的作用
Genome instability & disease
Pub Date : 2022-02-01 DOI: 10.1007/s42764-022-00059-0
Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi, Mahsa Keshavarz-Fathi, Mohammadmehdi Yousefi, N. Rezaei
{"title":"The role of ral signaling and post translational modifications (PTMs) of Ras in cancer","authors":"Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi, Mahsa Keshavarz-Fathi, Mohammadmehdi Yousefi, N. Rezaei","doi":"10.1007/s42764-022-00059-0","DOIUrl":"https://doi.org/10.1007/s42764-022-00059-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1. 在 WIP1 的调控下，UFM1 特异性肽酶 2 被动态招募到 DNA 双链断裂处。
Genome instability & disease
Pub Date : 2022-01-01 Epub Date: 2022-08-10 DOI: 10.1007/s42764-022-00076-z
Bo Qin, Jia Yu, Fei Zhao, Jinzhou Huang, Qin Zhou, Zhenkun Lou

The ufmylation ligase-UFL1 promotes ATM activation by monoufmylating H4 at K31 in a positive-feedback loop after double-strand breaks (DSB) occur, whereas UFM1 Specific Peptidase 2 (UfSP2) suppresses ATM activation, but the mechanism of recruitment of UfSP2 to the DSB finetuning DNA damage response is still not clear. Here, we report that UfSP2 foci formation is delayed compared to UFL1 foci formation following the radiation insult. Mechanistically, UfSP2 binds to the MRN complex in absence of DSB. Irradiation-induced phosphorylation of UfSP2 by ATM leads to the dissociation of UfSP2 from the MRN complex. This phosphorylation can be removed by the phosphatase WIP1, thereby UfSP2 is recruited to the DSBs, deufmylating H4 and suppressing ATM activation. In summary, we identify a mechanism of delicately negative modulation of ATM activation by UfSP2 and rewires ATM activation pathways.

双链断裂（DSB）发生后，ufmylation连接酶-UFL1通过在K31处对H4进行单ufmylation促进ATM活化，而UFM1特异性肽酶2（UfSP2）则抑制ATM活化，但UfSP2招募到DSB微调DNA损伤反应的机制仍不清楚。在这里，我们报告了与 UFL1 的形成相比，UfSP2 的形成在辐射损伤后会延迟。从机制上讲，UfSP2 在没有 DSB 的情况下与 MRN 复合物结合。辐照诱导的 ATM 对 UfSP2 的磷酸化导致 UfSP2 从 MRN 复合物中解离。这种磷酸化可被磷酸酶 WIP1 清除，从而使 UfSP2 被招募到 DSB，使 H4 去淀粉酰化并抑制 ATM 的活化。总之，我们发现了 UfSP2 对 ATM 激活的微妙负向调节机制，并重新构建了 ATM 激活途径。
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引用次数: 0
Correction to: Chromosome instability induced by mutations in TAD anchors leads to tumors 更正:由TAD锚点突变引起的染色体不稳定导致肿瘤
Genome instability & disease
Pub Date : 2021-12-01 DOI: 10.1007/s42764-021-00054-x
A. N. Luchnik
{"title":"Correction to: Chromosome instability induced by mutations in TAD anchors leads to tumors","authors":"A. N. Luchnik","doi":"10.1007/s42764-021-00054-x","DOIUrl":"https://doi.org/10.1007/s42764-021-00054-x","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43045507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity 修正:TIP60将SUV39H1招募到染色质上，以维持异染色质基因组的稳定性并抵抗过氧化氢诱导的细胞毒性
Genome instability & disease
Pub Date : 2021-08-01 DOI: 10.1007/s42764-020-00029-4
Bo Tu, Yantao Bao, Ming Tang, Qian Zhu, Xiaopeng Lu, Hui Wang, Tianyun Hou, Ying Zhao, Ping Zhang, Wei-Guo Zhu
{"title":"Correction to: TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity","authors":"Bo Tu, Yantao Bao, Ming Tang, Qian Zhu, Xiaopeng Lu, Hui Wang, Tianyun Hou, Ying Zhao, Ping Zhang, Wei-Guo Zhu","doi":"10.1007/s42764-020-00029-4","DOIUrl":"https://doi.org/10.1007/s42764-020-00029-4","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00029-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45688098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA SIRT7是核糖体RNA上n4 -乙酰胞苷的去乙酰化酶
Genome instability & disease
Pub Date : 2021-08-01 DOI: 10.1007/s42764-021-00046-x
Chenzhong Xu, Jin Zhang, Jie Zhang, Baohua Liu
{"title":"SIRT7 is a deacetylase of N4-acetylcytidine on ribosomal RNA","authors":"Chenzhong Xu, Jin Zhang, Jie Zhang, Baohua Liu","doi":"10.1007/s42764-021-00046-x","DOIUrl":"https://doi.org/10.1007/s42764-021-00046-x","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00046-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Microproteins: from behind the scenes to the spotlight 微蛋白:从幕后走向聚光灯下
Genome instability & disease
Pub Date : 2021-08-01 DOI: 10.1007/s42764-021-00040-3
Meiqian Jiang, H. Lou, Wenya Hou
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引用次数: 4
Role of NEDD8 and neddylation dynamics in DNA damage response NEDD8和类化修饰动力学在DNA损伤反应中的作用
Genome instability & disease
Pub Date : 2021-06-01 DOI: 10.1007/s42764-021-00044-z
Yifan Luo, Yang Su, Feng Rao
{"title":"Role of NEDD8 and neddylation dynamics in DNA damage response","authors":"Yifan Luo, Yang Su, Feng Rao","doi":"10.1007/s42764-021-00044-z","DOIUrl":"https://doi.org/10.1007/s42764-021-00044-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00044-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52772363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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