Pub Date : 2024-01-04DOI: 10.1007/s42764-023-00118-0
Longjiang Di, Weiguo Zhu
{"title":"The role of H3K27me3 methylation in cancer development","authors":"Longjiang Di, Weiguo Zhu","doi":"10.1007/s42764-023-00118-0","DOIUrl":"https://doi.org/10.1007/s42764-023-00118-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"57 17","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Protein arginine methylation, a post-translational modification (PTM), is fundamental in regulating protein function and stability. Among the nine protein methyl transferases (PRMT), PRMT5 plays a critical role in promoting oncogenic processes including tumor proliferation, invasiveness, immune escape and DNA damage repair through different signaling pathways. It is also a target in cancer therapy, with numerous inhibitors in clinical trial. In this review, we focus on the biological functions of PRMT5 in DNA damage repair and maintenance of genome stability in cancer, and summarize the development advance of PRMT5 inhibitors in cancer therapy.
{"title":"The role of protein arginine methylation 5 in DNA damage repair and cancer therapy","authors":"Qikun Gao, Ziyi Liu, Jinyang Liu, Xuyang Yan, Junfei Dai, Zixuan Zhang, Rongxiao Li, Shiva Basnet, Changzheng Du","doi":"10.1007/s42764-023-00111-7","DOIUrl":"https://doi.org/10.1007/s42764-023-00111-7","url":null,"abstract":"Abstract Protein arginine methylation, a post-translational modification (PTM), is fundamental in regulating protein function and stability. Among the nine protein methyl transferases (PRMT), PRMT5 plays a critical role in promoting oncogenic processes including tumor proliferation, invasiveness, immune escape and DNA damage repair through different signaling pathways. It is also a target in cancer therapy, with numerous inhibitors in clinical trial. In this review, we focus on the biological functions of PRMT5 in DNA damage repair and maintenance of genome stability in cancer, and summarize the development advance of PRMT5 inhibitors in cancer therapy.","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"101 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135390057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-06DOI: 10.1007/s42764-023-00110-8
Aishwarya Babu, Madhusoodanan Urulangodi
{"title":"Chemotherapy-induced neuronal DNA damage: an intriguing toolbox to elucidate DNA repair mechanisms in the brain","authors":"Aishwarya Babu, Madhusoodanan Urulangodi","doi":"10.1007/s42764-023-00110-8","DOIUrl":"https://doi.org/10.1007/s42764-023-00110-8","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"44 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135584770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.1007/s42764-023-00109-1
Qi Liu, Nan Zuo, Xinghan Li, Yongqiang Deng, Lanlan Wei, Lin Ma
{"title":"Novel insights into DNA damage repair defects in HPV-positive head and neck squamous cell carcinoma: from the molecular basis to therapeutic opportunities","authors":"Qi Liu, Nan Zuo, Xinghan Li, Yongqiang Deng, Lanlan Wei, Lin Ma","doi":"10.1007/s42764-023-00109-1","DOIUrl":"https://doi.org/10.1007/s42764-023-00109-1","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136063683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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