{"title":"[Various types of malignant lymphomas].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"18 ","pages":"151-66"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11978113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1976-01-01DOI: 10.1007/978-3-642-87524-3_34
P H Duesberg, L H Wang, K Beemon, S Kawai, H Hanafusa
A procedure has been developed to map the genetic elements of avian tumor virus RNA, which has a molecular weight of about 3 X 10(6) daltons and a poly(A) sequence at the 3' end. For this purpose, about 30 RNase T1-resistant oligonucleotides were ordered relative to the 3'-poly(A) terminus of the RNA, to construct an oligonucleotide map of viral RNAs. A cluster of seven envelope gene (env)-specific oligonucleotides, identified by their absence from the otherwise very similar oligonucleotide map of an envelope-defective deletion mutant (which lacks the major viral glycoprotein), mapped at a distance of 0.9 to 1.6 X 10(6) daltons from the poly(A) end of sarcoma virus RNA. A cluster of three sarcoma gene (src)-specific oligonucleotides, identified by their absence from the otherwise nearly identical oligonucleotide map of a transformation-defective deletion mutant mapped at a distance of 0.2 to 0.6 X 10(6) daltons from the poly(A) end of sarcoma virus RNA. The oligonucleotide maps of sarcoma viruses and of related deletion mutants were the same from the poly(A) end up to 0.2 X 10(6) daltons and included one terminal oligonucleotide, termed C, which is found in all avian tumor viruses tested so far. Preliminary mapping experiments ordering the src-specific and env-specific oligonucleotides of recombinants, selected for sarcoma and envelope genes of different parents, agree with those obtained by comparing maps of wild type viruses and deletion mutants. A partial genetic map consistent with these results suggests that the src gene maps between the env gene and the 3'-poly(A) end of viral RNA. This map reads: poly(A)-src-env-(pol, gag).
禽肿瘤病毒RNA分子量约为3 × 10(6)道尔顿，在3′端有一个聚(A)序列。为此，在RNA的3'-poly(A)端排序了大约30个RNase t1抗性寡核苷酸，构建了病毒RNA的寡核苷酸图谱。一个由7个包膜基因(env)特异性寡核苷酸组成的簇，在一个包膜缺陷缺失突变体(缺乏主要的病毒糖蛋白)的非常相似的寡核苷酸图谱中缺失，在距离肉瘤病毒RNA的聚(A)端0.9至1.6 X 10(6)道尔顿处被定位。一个由三个肉瘤基因(src)特异性寡核苷酸组成的簇，通过在距离肉瘤病毒RNA多聚(A)端0.2至0.6 X 10(6)道尔顿的转化缺陷缺失突变体的几乎相同的寡核苷酸图谱中缺失它们而被识别。肉瘤病毒和相关缺失突变体的寡核苷酸图谱从多聚(A)端到0.2 X 10(6)道尔顿都是相同的，并且包括一个末端寡核苷酸，称为C，这是迄今为止在所有禽类肿瘤病毒中发现的。对不同亲本的肉瘤和包膜基因所选择的重组体的src特异性和env特异性寡核苷酸排序的初步作图实验与野生型病毒和缺失突变体作图的比较结果一致。与这些结果一致的部分遗传图谱表明，src基因定位在env基因和病毒RNA的3'-poly(A)端之间。这张图是:poly(A)-src-env-(pol, gag)。
{"title":"Sequences and functions of Rous sarcoma virus RNA.","authors":"P H Duesberg, L H Wang, K Beemon, S Kawai, H Hanafusa","doi":"10.1007/978-3-642-87524-3_34","DOIUrl":"https://doi.org/10.1007/978-3-642-87524-3_34","url":null,"abstract":"<p><p>A procedure has been developed to map the genetic elements of avian tumor virus RNA, which has a molecular weight of about 3 X 10(6) daltons and a poly(A) sequence at the 3' end. For this purpose, about 30 RNase T1-resistant oligonucleotides were ordered relative to the 3'-poly(A) terminus of the RNA, to construct an oligonucleotide map of viral RNAs. A cluster of seven envelope gene (env)-specific oligonucleotides, identified by their absence from the otherwise very similar oligonucleotide map of an envelope-defective deletion mutant (which lacks the major viral glycoprotein), mapped at a distance of 0.9 to 1.6 X 10(6) daltons from the poly(A) end of sarcoma virus RNA. A cluster of three sarcoma gene (src)-specific oligonucleotides, identified by their absence from the otherwise nearly identical oligonucleotide map of a transformation-defective deletion mutant mapped at a distance of 0.2 to 0.6 X 10(6) daltons from the poly(A) end of sarcoma virus RNA. The oligonucleotide maps of sarcoma viruses and of related deletion mutants were the same from the poly(A) end up to 0.2 X 10(6) daltons and included one terminal oligonucleotide, termed C, which is found in all avian tumor viruses tested so far. Preliminary mapping experiments ordering the src-specific and env-specific oligonucleotides of recombinants, selected for sarcoma and envelope genes of different parents, agree with those obtained by comparing maps of wild type viruses and deletion mutants. A partial genetic map consistent with these results suggests that the src gene maps between the env gene and the 3'-poly(A) end of viral RNA. This map reads: poly(A)-src-env-(pol, gag).</p>","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"19 ","pages":"327-40"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11405647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1976-01-01DOI: 10.1007/978-3-642-87524-3_4
J E Till, T W Mak, G B Price, J S Senn, E A McCulloch
Cellular organization and communication in leukemic hemopoiesis may be compared with its counterpart in normal hemopoiesis. Results obtained using cell culture methods have provided some support for the view that leukemic hemopoiesis, like normla hemopoiesis, may involve 3 levels of differentiation: leukemic stem cells, committed leukemic progenitors, and more mature cells. Evidence is also beginning to emerge that leukemic populations may be regulated by messages from the environment in a manner analogous to normal hemopoiesis. The apparent similarities between leukemic and normal hemopoiesis raise, the possibility that the target cell for leukemic transformation is the normal pluripotent stem cell. The development of culture methods for the production of leukovirus-like particles from human leukemic cells provides a possible first step toward the direct identification of leukemic target cells.
{"title":"Cellular subclasses in human leukemic hemopoiesis.","authors":"J E Till, T W Mak, G B Price, J S Senn, E A McCulloch","doi":"10.1007/978-3-642-87524-3_4","DOIUrl":"https://doi.org/10.1007/978-3-642-87524-3_4","url":null,"abstract":"<p><p>Cellular organization and communication in leukemic hemopoiesis may be compared with its counterpart in normal hemopoiesis. Results obtained using cell culture methods have provided some support for the view that leukemic hemopoiesis, like normla hemopoiesis, may involve 3 levels of differentiation: leukemic stem cells, committed leukemic progenitors, and more mature cells. Evidence is also beginning to emerge that leukemic populations may be regulated by messages from the environment in a manner analogous to normal hemopoiesis. The apparent similarities between leukemic and normal hemopoiesis raise, the possibility that the target cell for leukemic transformation is the normal pluripotent stem cell. The development of culture methods for the production of leukovirus-like particles from human leukemic cells provides a possible first step toward the direct identification of leukemic target cells.</p>","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"19 ","pages":"33-45"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11286088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1976-01-01DOI: 10.1007/978-3-642-87524-3_30
P Höcker, E Pittermann, D Lutz, A Stacher
{"title":"Aids in the management of leukemia (cellremoval by continuous flow leukapheresis and impulsecytophotometry).","authors":"P Höcker, E Pittermann, D Lutz, A Stacher","doi":"10.1007/978-3-642-87524-3_30","DOIUrl":"https://doi.org/10.1007/978-3-642-87524-3_30","url":null,"abstract":"","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"19 ","pages":"285-95"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12251195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1976-01-01DOI: 10.1007/978-3-642-87524-3_10
M R Parwaresch, H K Müller-Hermelink, K Lennert
Naphthol AS-D chloroacetatesterase activity in peripheral blood granulocytes is confined to neutrophils which are all positive and to a minor part of monocytes. Its occurance in eosinophils and basophils indicate a myeloproliferative disease. This chemical property can reliably be applied to separate neoplastic from reactive forms of quantitative and qualitative leukocyte alterations. The developmental line of this specific myeloid cellular attribut has been presented to elucidate its diagnostic significance and its validity as proof for existence of a common promyelocyte from which neutrophils, monocytes, basophils and eosinophils originate.
{"title":"Leukemic anaplasias reflecting physiologic cytogenesis of myeloid system.","authors":"M R Parwaresch, H K Müller-Hermelink, K Lennert","doi":"10.1007/978-3-642-87524-3_10","DOIUrl":"https://doi.org/10.1007/978-3-642-87524-3_10","url":null,"abstract":"<p><p>Naphthol AS-D chloroacetatesterase activity in peripheral blood granulocytes is confined to neutrophils which are all positive and to a minor part of monocytes. Its occurance in eosinophils and basophils indicate a myeloproliferative disease. This chemical property can reliably be applied to separate neoplastic from reactive forms of quantitative and qualitative leukocyte alterations. The developmental line of this specific myeloid cellular attribut has been presented to elucidate its diagnostic significance and its validity as proof for existence of a common promyelocyte from which neutrophils, monocytes, basophils and eosinophils originate.</p>","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"19 ","pages":"95-9"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12251199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Electron microscopy findings in non-Hodgkin's-lymphomas].","authors":"E Kaiserling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"18 ","pages":"185-209"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12266081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Radiotherapy of Hodgkin's disease].","authors":"K Musshoff","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"18 ","pages":"119-34"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Histologic classification and pathologic anatomy of lymphogranulomatosis].","authors":"R Fischer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"18 ","pages":"63-79"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12146399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Immunologic phenomena in lymphogranulomatosis: key to etiology and pathogenesis?].","authors":"W M Gallmeier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73191,"journal":{"name":"Hamatologie und Bluttransfusion","volume":"18 ","pages":"81-7"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11978117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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