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Functional MRI Assessment of Brain Activity During Hand Rehabilitation with an MR-Compatible Soft Glove in Chronic Stroke Patients: A Preliminary Study. 慢性脑卒中患者手部磁共振兼容软手套康复过程中大脑活动的MRI功能评估:一项初步研究。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304776
SeongHyeon Jo, Youngjo Song, Yechan Lee, Si-Hwan Heo, Sang Jin Jang, Yusung Kim, Joon-Ho Shin, Jaesung Jeong, Hyung-Soon Park

Brain plasticity plays a significant role in functional recovery after stroke, but the specific benefits of hand rehabilitation robot therapy remain unclear. Evaluating the specific effects of hand rehabilitation robot therapy is crucial in understanding how it impacts brain activity and its relationship to rehabilitation outcomes. This study aimed to investigate the brain activity pattern during hand rehabilitation exercise using functional magnetic resonance imaging (fMRI), and to compare it before and after 3-week hand rehabilitation robot training. To evaluate it, an fMRI experimental environment was constructed to facilitate the same hand posture used in rehabilitation robot therapy. Two stroke survivors participated and the conjunction analysis results from fMRI scans showed that patient 1 exhibited a significant improvement in activation profile after hand rehabilitation robot training, indicative of improved motor function in the bilateral motor cortex. However, activation profile of patient 2 exhibited a slight decrease, potentially due to habituation to the rehabilitation task. Clinical results supported these findings, with patient 1 experiencing a greater increase in FMA score than patient 2. These results suggest that hand rehabilitation robot therapy can induce different brain activity patterns in stroke survivors, which may be linked to patient-specific training outcomes. Further studies with larger sample sizes are necessary to confirm these findings.

脑可塑性在中风后的功能恢复中起着重要作用,但手部康复机器人治疗的具体益处尚不清楚。评估手部康复机器人治疗的具体效果对于了解它如何影响大脑活动及其与康复结果的关系至关重要。本研究旨在利用功能磁共振成像(fMRI)研究手部康复运动过程中的大脑活动模式,并在手部康复机器人训练3周前后进行比较。为了对其进行评估,构建了一个fMRI实验环境,以促进康复机器人治疗中使用的相同手部姿势。两名中风幸存者参与了研究,功能磁共振成像扫描的连接分析结果显示,患者1在手部康复机器人训练后表现出激活特征的显著改善,表明双侧运动皮层的运动功能有所改善。然而,患者2的激活特征表现出轻微下降,这可能是由于对康复任务的习惯。临床结果支持了这些发现,患者1的FMA评分比患者2的增加幅度更大。这些结果表明,手部康复机器人治疗可以在中风幸存者中诱导不同的大脑活动模式,这可能与患者特定的训练结果有关。有必要对更大的样本量进行进一步的研究来证实这些发现。
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引用次数: 0
Individualized Learning-Based Ground Reaction Force Estimation in People Post-Stroke Using Pressure Insoles. 使用压力鞋垫对中风后患者的基于个性化学习的地面反作用力估计。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304695
Gregoire Bergamo, Krithika Swaminathan, Daekyum Kim, Andrew Chin, Christopher Siviy, Ignacio Novillo, Teresa C Baker, Nicholas Wendel, Terry D Ellis, Conor J Walsh
Stroke is a leading cause of gait disability that leads to a loss of independence and overall quality of life. The field of clinical biomechanics aims to study how best to provide rehabilitation given an individual's impairments. However, there remains a disconnect between assessment tools used in biomechanical analysis and in clinics. In particular, 3-dimensional ground reaction forces (3D GRFs) are used to quantify key gait characteristics, but require lab-based equipment, such as force plates. Recent efforts have shown that wearable sensors, such as pressure insoles, can estimate GRFs in real-world environments. However, there is limited understanding of how these methods perform in people post-stroke, where gait is highly heterogeneous. Here, we evaluate three subject-specific machine learning approaches to estimate 3D GRFs with pressure insoles in people post-stroke across varying speeds. We find that a Convolutional Neural Network-based approach achieves the lowest estimation errors of 0.75 ± 0.24, 1.13 ± 0.54, and 4.79 ± 3.04 % bodyweight for the medio-lateral, antero-posterior, and vertical GRF components, respectively. Estimated force components were additionally strongly correlated with the ground truth measurements ($R^{2}> 0.85$). Finally, we show high estimation accuracy for three clinically relevant point metrics on the paretic limb. These results suggest the potential for an individualized machine learning approach to translate to real-world clinical applications.
中风是步态残疾的主要原因,导致丧失独立性和整体生活质量。临床生物力学领域旨在研究如何在个人损伤的情况下最好地提供康复。然而,生物力学分析和临床中使用的评估工具之间仍然存在脱节。特别是,三维地面反作用力(3D GRF)用于量化关键步态特征,但需要基于实验室的设备,如力板。最近的研究表明,压力鞋垫等可穿戴传感器可以估计真实世界环境中的GRF。然而,对这些方法在中风后步态高度异质的人群中的表现了解有限。在这里,我们评估了三种特定于主题的机器学习方法,以评估不同速度的中风后患者使用压力鞋垫的3D GRF。我们发现,基于卷积神经网络的方法对内侧、前后和垂直GRF分量的估计误差最低,分别为0.75±0.24、1.13±0.54和4.79±3.04%。此外,估计的分力与地面实况测量值密切相关()。最后,我们展示了瘫痪肢体上三个临床相关点度量的高估计精度。这些结果表明,个性化机器学习方法有可能转化为现实世界的临床应用。
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引用次数: 0
Investigating the Effect of Novel Gamified Stepper on Lower Limb Biomechanics in Seated Healthy Subjects. 研究新型游戏化步进器对坐着的健康受试者下肢生物力学的影响。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304715
Beycan Emre, Ofori Seyram, L W R Joshua, Weihao Zhao, Haoyong Yu

The present study introduces a new gamified stepper device designed for bilateral lower limb rehabilitation, which is combined with a 3-D exergame. To the best of our knowledge, this is the initial study to utilize the stepping exercise for seated lower limb rehabilitation. The device comprises a stepping mechanism and a magnetic encoder. The modified stepper facilitates the bilateral training in the lower limb within its workspace. The magnetic encoder provides real-time rotational angle data during the exercise. A task-specific exergame platform was created and integrated with the device to enhance user compliance and engagement with the exercise. Experiments were conducted with ten healthy individuals with no history of lower limb injury to evaluate the system's feasibility for providing bilateral training and the effectiveness of the exergame platform. Participants were asked to perform bilateral lower limb exercise with a metronome and gamified stepper device in a seated position. Lower limb range of motion (ROM) and EMG activations were recorded during the exercises. The results indicate that the device was capable of providing cyclical ROM training with reduced muscle activation of the lower limb, and the exergame platform increased motivation to continue the exercises. This study can serve as the foundation for developing a robotic version of the proposed stepper device.

本研究介绍了一种用于双侧下肢康复的新型游戏化步进装置,该装置与三维运动游戏相结合。据我们所知,这是利用步进运动进行坐姿下肢康复的初步研究。该装置包括一个步进机构和一个磁性编码器。改进的步进器便于在其工作空间内进行下肢的双侧训练。磁性编码器在运动过程中提供实时旋转角度数据。创建了一个特定任务的运动游戏平台,并与该设备集成,以增强用户对运动的依从性和参与度。对10名没有下肢损伤史的健康人进行了实验,以评估该系统提供双边训练的可行性和运动游戏平台的有效性。参与者被要求用节拍器和游戏化的步进装置进行双侧下肢运动。在训练过程中记录下肢活动范围(ROM)和肌电图激活。结果表明,该设备能够在减少下肢肌肉激活的情况下提供周期性ROM训练,并且运动游戏平台增加了继续锻炼的动力。这项研究可以作为开发所提出的步进装置的机器人版本的基础。
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引用次数: 0
Modelling Physical Human-Robot Interface with Different Users, Cuffs, and Strapping Pressures: A Case Study. 具有不同用户、袖带和捆绑压力的物理人机界面建模:一个案例研究。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304754
Mingrui Sun, Tomislav Bacek, Dana Kulic, Jennifer McGinley, Denny Oetomo, Ying Tan

Assisting persons during physical therapy or augmenting their performance often requires precise delivery of an intervention. Robotic devices are perfectly placed to do so, but their intervention highly depends on the physical human-robot connection. The inherent compliance in the connection leads to delays and losses in bi-directional power transmission and can lead to human-robot joint axes misalignment. This is often neglected in the literature by assuming a rigid connection and has a negative impact on the intervention's effectiveness and robustness. This paper presents the preliminary results of a study that aims to close that gap. The study investigates what model forms and parameters best capture human-robot connection dynamics across different persons, connection designs (cuffs), and cuff strapping pressures. The results show that the linear spring-damper model is the best compromise, but its parameters must be adjusted for each individual and different conditions separately.

在物理治疗期间帮助患者或提高他们的表现通常需要精确的干预。机器人设备的位置非常合适,但它们的干预在很大程度上取决于人与机器人的物理连接。连接中固有的顺应性导致双向电力传输的延迟和损失,并可能导致人类-机器人关节轴错位。这在文献中经常被忽视,因为假设存在刚性联系,并对干预的有效性和稳健性产生负面影响。本文介绍了一项旨在缩小这一差距的研究的初步结果。该研究调查了什么样的模型形式和参数最能捕捉不同人之间的人机连接动态、连接设计(袖带)和袖带捆扎压力。结果表明,线性弹簧阻尼器模型是最好的折衷方案,但其参数必须分别针对每个单独和不同的条件进行调整。
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引用次数: 0
Control of a Back-Support Exoskeleton to Assist Carrying Activities. 背部支撑外骨骼的控制,以协助携带活动。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304691
Maria Lazzaroni, Giorgia Chini, Francesco Draicchio, Christian Di Natali, Darwin G Caldwell, Jesus Ortiz

Back-support exoskeletons are commonly used in the workplace to reduce low back pain risk for workers performing demanding activities. However, for the assistance of tasks differing from lifting, back-support exoskeletons potential has not been exploited extensively. This work focuses on the use of an active back-support exoskeleton to assist carrying. A control strategy is designed that modulates the exoskeleton torques to comply with the task assistance requirements. In particular, two gait phase detection frameworks are exploited to adapt the exoskeleton assistance according to the legs' motion. The control strategy is assessed through an experimental analysis on ten subjects. Carrying task is performed without and with the exoskeleton assistance. Results prove the potential of the presented control in assisting the task without hindering the gait movement and improving the usability experienced by users. Moreover, the exoskeleton assistance significantly reduces the lumbar load associated with the task, demonstrating its promising use for risk mitigation in the workplace.

背部支撑外骨骼通常用于工作场所,以降低从事高要求活动的工人的腰痛风险。然而,对于不同于举重的任务,背部支撑外骨骼的潜力尚未得到广泛开发。这项工作的重点是使用主动背部支撑外骨骼来帮助携带。设计了一种控制策略,该策略调节外骨骼扭矩以符合任务辅助要求。特别地,利用两个步态相位检测框架来根据腿的运动调整外骨骼辅助。通过对10名受试者的实验分析来评估控制策略。搬运任务是在没有外骨骼辅助的情况下进行的。结果证明了所提出的控制在不妨碍步态运动和提高用户体验的可用性的情况下辅助任务的潜力。此外,外骨骼辅助显著降低了与任务相关的腰部负荷,证明了其在工作场所缓解风险方面的良好应用前景。
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引用次数: 0
Feasibility and Validation of a Robotic-Based Multisensory Integration Assessment in Healthy Controls and a Stroke Patient. 基于机器人的多传感器集成评估在健康对照和中风患者中的可行性和验证。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304735
Erick Carranza, Tommaso Bertoni, Giulio Mastria, Amy Boos, Michela Bassolino, Andrea Serino, Elvira Pirondini

After experiencing brain damage, stroke patients commonly suffer from motor and sensory impairments that impact their ability to perform volitional movements. Visuo-proprioceptive integration is a critical component of voluntary movement, allowing for accurate movements and a sense of ownership over one's body. While recent studies have increased our understanding of the balance between visual compensation and proprioceptive deficits in stroke patients, quantitative methods for studying multisensory integration are still lacking. This study aimed to evaluate the feasibility of adapting a 3D visuo-proprioceptive disparity (VPD) task into a 2D setting using an upper-limb robotic platform for moderate to severe chronic stroke patients. To assess the implementation of the 2D task, a cohort of unimpaired healthy participants performed the VPD task in both a 3D and 2D environment. We used a computational Bayesian model to predict errors in visuo-proprioceptive integration and compared the model's predictions to real behavioral data. Our findings indicated that the behavioral trends observed in the 2D and 3D tasks were similar, and the model accurately predicted behavior. We then evaluated the feasibility of our task to assess post-stroke deficits in a patient with severe motor and sensory deficits. Ultimately, this work may help to improve our understanding of the significance of visuo-proprioceptive integration and aid in the development of better rehabilitation therapies for improving sensorimotor outcomes in stroke patients.

中风患者在经历脑损伤后,通常会出现运动和感觉障碍,影响他们进行意志运动的能力。Visuo本体感觉整合是自主运动的关键组成部分,可以实现准确的运动和对身体的所有权感。尽管最近的研究增加了我们对中风患者视觉补偿和本体感觉缺陷之间平衡的理解,但研究多感觉整合的定量方法仍然缺乏。本研究旨在评估使用上肢机器人平台将3D视觉本体感觉差异(VPD)任务适应于2D环境的可行性,用于中重度慢性中风患者。为了评估2D任务的实施情况,一组未受损的健康参与者在3D和2D环境中执行VPD任务。我们使用计算贝叶斯模型来预测视觉本体感觉整合的误差,并将该模型的预测与真实的行为数据进行比较。我们的研究结果表明,在2D和3D任务中观察到的行为趋势相似,该模型准确地预测了行为。然后,我们评估了我们的任务评估严重运动和感觉缺陷患者卒中后缺陷的可行性。最终,这项工作可能有助于提高我们对视本体感觉整合重要性的理解,并有助于开发更好的康复疗法,以改善中风患者的感觉运动结果。
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引用次数: 0
Optimizing Trajectories and Inverse Kinematics for Biomechanical Analysis of Markerless Motion Capture Data. 用于无标记运动捕捉数据生物力学分析的轨迹优化和反向运动学。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304683
R James Cotton, Allison DeLillo, Anthony Cimorelli, Kunal Shah, J D Peiffer, Shawana Anarwala, Kayan Abdou, Tasos Karakostas

Markerless motion capture using computer vision and human pose estimation (HPE) has the potential to expand access to precise movement analysis. This could greatly benefit rehabilitation by enabling more accurate tracking of outcomes and providing more sensitive tools for research. There are numerous steps between obtaining videos to extracting accurate biomechanical results and limited research to guide many critical design decisions in these pipelines. In this work, we analyze several of these steps including the algorithm used to detect keypoints and the keypoint set, the approach to reconstructing trajectories for biomechanical inverse kinematics and optimizing the IK process. Several features we find important are: 1) using a recent algorithm trained on many datasets that produces a dense set of biomechanically-motivated keypoints, 2) using an implicit representation to reconstruct smooth, anatomically constrained marker trajectories for IK, 3) iteratively optimizing the biomechanical model to match the dense markers, 4) appropriate regularization of the IK process. Our pipeline makes it easy to obtain accurate biomechanical estimates of movement in a rehabilitation hospital.

使用计算机视觉和人体姿态估计(HPE)的无标记运动捕捉有可能扩大精确运动分析的范围。这可以通过更准确地跟踪结果和提供更敏感的研究工具,极大地有利于康复。从获得视频到提取准确的生物力学结果,再到指导这些管道中许多关键设计决策的有限研究,需要许多步骤。在这项工作中,我们分析了其中的几个步骤,包括用于检测关键点和关键点集的算法、重建生物力学逆运动学轨迹的方法以及优化IK过程。我们发现几个重要的特征是:1)使用在许多数据集上训练的最新算法,该算法生成一组密集的生物力学驱动关键点,2)使用隐式表示来重建IK的平滑、解剖学约束的标记轨迹,3)迭代优化生物力学模型以匹配密集的标记,4)IK过程的适当正则化。我们的管道可以很容易地在康复医院获得准确的运动生物力学估计。
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引用次数: 0
Spatial and Temporal Analysis of Normal and Shear Forces During Grasping, Manipulation and Social Activities. 抓取、操纵和社交活动过程中法向力和剪切力的时空分析。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304717
Theophil Spiegeler Castaneda, Joana Matos, Patricia Capsi-Morales, Cristina Piazza

Extensive research has established and widely acknowledged the important contribution of human hand sensory receptors in providing tactile feedback. The absence of these receptors results in a poor perception of the environment, impairing our efficient manipulation skills. Although the literature emphasizes the significance of normal forces in human grasping, further investigations should point toward the role of shear forces in this process. This paper presents an analysis of human everyday grasping activities through the use of 20 three-axis magnetic soft skin force sensors, in the form of rings and bands, that measure both normal and shear forces. Our study includes twelve tasks that cover various grasping requirements. Results highlight the importance of spatial information and the usefulness of shear forces in the prediction of unexpected changes that can not be always observed in normal forces. Tactile sensing can ultimately be integrated into prosthetic and rehabilitation devices for improved control and potentially provide sensory feedback to the user.

广泛的研究已经确立并广泛承认人类手部感觉受体在提供触觉反馈方面的重要贡献。缺乏这些受体会导致对环境的感知能力差,削弱我们的有效操作技能。尽管文献强调了法向力在人类抓握中的重要性,但进一步的研究应该指向剪切力在这一过程中的作用。本文通过使用20个三轴磁性软皮肤力传感器来分析人类的日常抓握活动,这些传感器以环和带的形式测量法向力和剪切力。我们的研究包括十二项任务,涵盖了不同的抓握要求。结果强调了空间信息的重要性以及剪切力在预测法向力中无法始终观察到的意外变化方面的有用性。触觉传感最终可以集成到假肢和康复设备中,以改善控制,并可能向用户提供感官反馈。
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引用次数: 0
The Use of Kinematic Features in Evaluating Upper Limb Motor Function Learning Progress Based on Machine Learning. 运动学特征在评估基于机器学习的上肢运动功能学习进展中的应用。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304807
Shuhao Dong, Justin Gallagher, Andrew Jackson, Martin Levesley

Evaluating progress throughout a patient's rehabilitation process helps choose effective treatment and formulate personalised and evidence-based rehabilitation interventions. The evaluation process is difficult due to the limitations of current clinical assessments. They lack the ability to reflect sensitive changes continuously throughout the rehabilitation process. Kinematic features have been extracted from individual's movement to address this problem due to their sensitivity and continuity. However, choosing appropriate kinematic features for rehabilitation evaluation has always been challenging. This paper exploits the application of kinematic features to classify movement patterns and movement qualities. 12 kinematic features were firstly extracted from a 7-segment triangle pattern of motion to monitor the learning progress with more numbers of drawing attempts. A statistical analysis was then conducted to compare the selected kinematic features with the clinically validated normalised jerk. Two supervised machine learning models were finally developed to classify movement patterns and movement qualities based on the selected kinematic features. The study was based on data recorded from 14 participants using a single position sensor. 6 kinematic features were able to reflect sensitive changes during the experiment and all kinematic features contributed to the classification tasks. Consistent with the literature, the results indicated that features based on movement velocity were the most beneficial in the classification tasks.

评估患者康复过程中的进展有助于选择有效的治疗方法,并制定个性化和循证的康复干预措施。由于目前临床评估的局限性,评估过程很困难。他们缺乏在整个康复过程中持续反映敏感变化的能力。由于其敏感性和连续性,已经从个人的运动中提取了运动学特征来解决这个问题。然而,选择合适的运动学特征进行康复评估一直是一项挑战。本文利用运动学特征对运动模式和运动质量进行分类。首先从一个7段三角形运动模式中提取了12个运动学特征,以监测更多绘图次数的学习进度。然后进行统计分析,将选定的运动学特征与临床验证的标准化急动进行比较。最后开发了两个有监督的机器学习模型,根据所选的运动学特征对运动模式和运动质量进行分类。该研究基于14名参与者使用单个位置传感器记录的数据。6个运动学特征能够反映实验过程中的敏感变化,所有运动学特征都有助于分类任务。与文献一致,结果表明,基于运动速度的特征在分类任务中是最有益的。
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引用次数: 0
Influence of Robotic Therapy on Severe Stroke Patients. 机器人治疗对严重脑卒中患者的影响。
Pub Date : 2023-09-01 DOI: 10.1109/ICORR58425.2023.10304780
Yolanda Vales, Jose M Catalan, Arturo Bertomeu-Motos, Jose V Garcia-Perez, Luis D Lledo, Andrea Blanco-Ivorra, Camila A Marzo, Gemma Mas, Nicolas Garcia-Aracil

Robotic rehabilitation has emerged as a promising approach to enhance motor recovery after stroke, but there is limited knowledge about its efficacy in individuals who have experienced severe stroke. The study presented in this paper aims to analyze the effect of robotic therapy on the recovery of patients with severe stroke when combined with conventional rehabilitation therapies, and we want to observe whether there is a relationship between the clinical assessment provided by the therapist and the data recorded by the robotic device. Participants were divided into an experimental group and a control group, both receiving 15 sessions of conventional therapy in three consecutive weeks, but the experimental group underwent three out of five sessions per week with a robotic device. Both groups were evaluated using clinical scales, and in addition the experimental group was evaluated using an assessment game incorporated in the robotic device that provides session data such as the level of assistance needed by each user to complete the activity, or the score obtained in the game. These preliminary results showed that patients who received robot-assisted therapy had better motor function recovery compared to those who only received conventional therapy. In addition, it is also observed that the robot assistance needed by patients in the experimental group decreased as the sessions progressed, suggesting that robot-assisted therapy could be an effective tool for severe stroke patients.

机器人康复已成为增强中风后运动恢复的一种很有前途的方法,但对其在严重中风患者中的疗效知之甚少。本文提出的研究旨在分析机器人治疗与传统康复治疗相结合对严重中风患者康复的影响,我们希望观察治疗师提供的临床评估与机器人设备记录的数据之间是否存在关系。参与者被分为实验组和对照组,两组在连续三周内接受了15次常规治疗,但实验组每周使用机器人设备进行五次治疗中的三次。两组均使用临床量表进行评估,此外,实验组还使用机器人设备中包含的评估游戏进行评估,该游戏提供会话数据,如每个用户完成活动所需的辅助水平或游戏中获得的分数。这些初步结果表明,与只接受常规治疗的患者相比,接受机器人辅助治疗的患者运动功能恢复更好。此外,还观察到,实验组患者所需的机器人辅助随着疗程的进行而减少,这表明机器人辅助治疗可能是治疗严重中风患者的有效工具。
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引用次数: 0
期刊
IEEE ... International Conference on Rehabilitation Robotics : [proceedings]
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