Pub Date : 2024-04-27DOI: 10.1007/s11101-024-09964-6
Bruno M. F. Gonçalves, Noélia Duarte, Cátia Ramalhete, Filipa Barbosa, Ana Margarida Madureira, Maria-José U. Ferreira
Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical diversity associated with significant biological properties. Among these, terpenoid indole alkaloids are the largest group of secondary metabolites. Tabernaemontana species (Apocynaceae) are widely distributed in tropical and subtropical regions of the world and used in traditional medicine to treat a variety of illnesses, including tumours. These species biosynthesize large quantities of structurally complex monoterpene indole and bisindole alkaloids. Given the compelling biological properties of indole alkaloids, the phytochemical study of Tabernaemontana species has been widely addressed to identify potential anticancer compounds. Several indole alkaloids have shown antiproliferative effect due to different mechanisms, namely by inducing apoptosis or arresting cell cycle, in diverse cancer cell lines, including multidrug-resistant phenotypes. This review primarily aims to underscore the anticancer activity of indole and bisindole alkaloids isolated from several Tabernaemontana species. Moreover, our recent contributions to the field are also highlighted, focusing on the study of Tabernaemontana elegans. The anticancer evaluation, namely the reversion of P-glycoprotein-mediated multidrug resistance, of two sets of monoterpene indole alkaloid derivatives, obtained by modification of some functional groups of two major monoterpene indole alkaloids, is reviewed, as well as the results obtained for a derivative that targeted homologous recombination DNA repair defects.
吲哚生物碱主要存在于植物中,是一大类天然产物衍生化合物,具有显著的化学多样性和重要的生物特性。其中,萜类吲哚生物碱是次生代谢产物中最大的一类。Tabernaemontana(天胡荽科)物种广泛分布于世界热带和亚热带地区,在传统医学中用于治疗包括肿瘤在内的多种疾病。这些物种可生物合成大量结构复杂的单萜吲哚和双吲哚生物碱。鉴于吲哚生物碱具有令人信服的生物特性,人们广泛对 Tabernaemontana 树种进行植物化学研究,以确定潜在的抗癌化合物。一些吲哚生物碱通过不同的机制,即通过诱导细胞凋亡或阻止细胞周期,在不同的癌细胞系(包括耐多药表型)中显示出抗增殖作用。本综述的主要目的是强调从几种 Tabernaemontana 物种中分离出的吲哚和双吲哚生物碱的抗癌活性。此外,还着重介绍了我们最近在该领域的贡献,重点是对 Tabernaemontana elegans 的研究。综述了通过修饰两种主要单萜吲哚生物碱的一些官能团而获得的两组单萜吲哚生物碱衍生物的抗癌评价,即逆转 P 糖蛋白介导的多药耐药性,以及针对同源重组 DNA 修复缺陷的衍生物所取得的成果。
{"title":"Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species","authors":"Bruno M. F. Gonçalves, Noélia Duarte, Cátia Ramalhete, Filipa Barbosa, Ana Margarida Madureira, Maria-José U. Ferreira","doi":"10.1007/s11101-024-09964-6","DOIUrl":"https://doi.org/10.1007/s11101-024-09964-6","url":null,"abstract":"<p>Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical diversity associated with significant biological properties. Among these, terpenoid indole alkaloids are the largest group of secondary metabolites. <i>Tabernaemontana</i> species (Apocynaceae) are widely distributed in tropical and subtropical regions of the world and used in traditional medicine to treat a variety of illnesses, including tumours. These species biosynthesize large quantities of structurally complex monoterpene indole and bisindole alkaloids. Given the compelling biological properties of indole alkaloids, the phytochemical study of <i>Tabernaemontana</i> species has been widely addressed to identify potential anticancer compounds. Several indole alkaloids have shown antiproliferative effect due to different mechanisms, namely by inducing apoptosis or arresting cell cycle, in diverse cancer cell lines, including multidrug-resistant phenotypes. This review primarily aims to underscore the anticancer activity of indole and bisindole alkaloids isolated from several <i>Tabernaemontana</i> species. Moreover, our recent contributions to the field are also highlighted, focusing on the study of <i>Tabernaemontana elegans</i>. The anticancer evaluation, namely the reversion of P-glycoprotein-mediated multidrug resistance, of two sets of monoterpene indole alkaloid derivatives, obtained by modification of some functional groups of two major monoterpene indole alkaloids, is reviewed, as well as the results obtained for a derivative that targeted homologous recombination DNA repair defects.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140802486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-27DOI: 10.1007/s11101-024-09965-5
Anja Klančnik, Ajda Kunčič, Sonja Smole Možina, Franz Bucar
The challenge of antimicrobial resistance requires new solutions, and Rhodiola sp. is a promising candidate due to its rich medicinal history. This review focuses on Rhodiola sp., especially R. rosea, highlighting its phytochemical constituents, such as salidroside, rosavins, and other phenolics, and their antimicrobial potential. We investigate the efficacy of Rhodiola sp. against various pathogenic bacteria, suggesting their value in combating antimicrobial resistance. Additionally, Rhodiola compounds are being investigated both as direct antimicrobials and as resistance modifiers that increase the efficacy of antibiotics. Rhodiola extracts and salidroside modulate gut microbiota, thereby affecting health and physiological and metabolic disorders. This illustrates the comprehensive therapeutic potential of Rhodiola sp. We emphasize the importance of understanding the complex interactions between Rhodiola phytochemicals, their antimicrobial effects, and their effects on gut microbiota as well as the need for in-depth research. Further studies will be crucial for the development of holistic treatment approaches. Finally, Rhodiola sp. is highlighted as an important natural resource in the fight against microbial pathogens and antibiotic resistance. Research on Rhodiola sp. should continue to further unravel pharmacological and health-promoting potential and thus address an important public health challenge.
{"title":"The antibacterial potential and effects of Rhodiola sp. on gut microbiota","authors":"Anja Klančnik, Ajda Kunčič, Sonja Smole Možina, Franz Bucar","doi":"10.1007/s11101-024-09965-5","DOIUrl":"https://doi.org/10.1007/s11101-024-09965-5","url":null,"abstract":"<p>The challenge of antimicrobial resistance requires new solutions, and <i>Rhodiola</i> sp. is a promising candidate due to its rich medicinal history. This review focuses on <i>Rhodiola</i> sp., especially <i>R. rosea</i>, highlighting its phytochemical constituents, such as salidroside, rosavins, and other phenolics, and their antimicrobial potential. We investigate the efficacy of <i>Rhodiola</i> sp. against various pathogenic bacteria, suggesting their value in combating antimicrobial resistance. Additionally, <i>Rhodiola</i> compounds are being investigated both as direct antimicrobials and as resistance modifiers that increase the efficacy of antibiotics. <i>Rhodiola</i> extracts and salidroside modulate gut microbiota, thereby affecting health and physiological and metabolic disorders. This illustrates the comprehensive therapeutic potential of <i>Rhodiola</i> sp. We emphasize the importance of understanding the complex interactions between <i>Rhodiola</i> phytochemicals, their antimicrobial effects, and their effects on gut microbiota as well as the need for in-depth research. Further studies will be crucial for the development of holistic treatment approaches. Finally, <i>Rhodiola</i> sp. is highlighted as an important natural resource in the fight against microbial pathogens and antibiotic resistance. Research on <i>Rhodiola</i> sp. should continue to further unravel pharmacological and health-promoting potential and thus address an important public health challenge.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140802428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-24DOI: 10.1007/s11101-024-09957-5
Iman Abdelhady Elshnoudy, A. M. Elkhouly, Mira Masoud, Hanin A. Rabea, F. Mansour
{"title":"Medicinal plants cultivated in Egypt with anticancer potential; a systematic review","authors":"Iman Abdelhady Elshnoudy, A. M. Elkhouly, Mira Masoud, Hanin A. Rabea, F. Mansour","doi":"10.1007/s11101-024-09957-5","DOIUrl":"https://doi.org/10.1007/s11101-024-09957-5","url":null,"abstract":"","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1007/s11101-024-09955-7
Sara F. Vieira, Rui L. Reis, Helena Ferreira, Nuno M. Neves
The immune system is a complex and fundamental network for organism protection. A minimal unbalance in the host defense system homeostasis can originate severe repercussions in human health. Fundamentally, immune-related diseases can arise from its compromise (immunodeficiency diseases), overactivation against itself (autoimmune diseases) or harmless substances (allergies), and failure of eliminating the harmful agent (chronic inflammation). The notable advances and achievements in the immune system diseases pathophysiology have been allowing for a dramatic improvement of the available treatments. Nevertheless, they present some drawbacks, including the inappropriate benefit/risk ratio. Therefore, there is a strong and urgent need to develop effective therapeutic strategies. Nature is a valuable source of bioactive compounds that can be explored for the development of new drugs. Particularly, plants produce a broad spectrum of secondary metabolites that can be potential prototypes for innovative therapeutic agents. This review describes the immune system and the inflammatory response and examines the current knowledge of eight plants traditionally used as immunomodulatory medicines (Boswellia serrata, Echinacea purpurea, Laurus nobilis, Lavandula angustifolia, Olea europaea, Salvia officinalis, Salvia rosmarinus, and Taraxacum officinale). Moreover, the issues responsible for possible biologic readout inconsistencies (plant species, age, selected organ, developmental stage, growth conditions, geographical location, drying methods, storage conditions, solvent of extraction, and extraction method) will also be discussed. Furthermore, a detailed list of the chemical composition and the immunomodulatory mechanism of action of the bioactive compounds of the selected plant extracts are presented. This review also includes future perspectives and proposes potential new avenues for further investigation.
{"title":"Plant-derived bioactive compounds as key players in the modulation of immune-related conditions","authors":"Sara F. Vieira, Rui L. Reis, Helena Ferreira, Nuno M. Neves","doi":"10.1007/s11101-024-09955-7","DOIUrl":"https://doi.org/10.1007/s11101-024-09955-7","url":null,"abstract":"<p>The immune system is a complex and fundamental network for organism protection. A minimal unbalance in the host defense system homeostasis can originate severe repercussions in human health. Fundamentally, immune-related diseases can arise from its compromise (immunodeficiency diseases), overactivation against itself (autoimmune diseases) or harmless substances (allergies), and failure of eliminating the harmful agent (chronic inflammation). The notable advances and achievements in the immune system diseases pathophysiology have been allowing for a dramatic improvement of the available treatments. Nevertheless, they present some drawbacks, including the inappropriate benefit/risk ratio. Therefore, there is a strong and urgent need to develop effective therapeutic strategies. Nature is a valuable source of bioactive compounds that can be explored for the development of new drugs. Particularly, plants produce a broad spectrum of secondary metabolites that can be potential prototypes for innovative therapeutic agents. This review describes the immune system and the inflammatory response and examines the current knowledge of eight plants traditionally used as immunomodulatory medicines (<i>Boswellia serrata</i>, <i>Echinacea purpurea</i>, <i>Laurus nobilis</i>, <i>Lavandula angustifolia</i>, <i>Olea europaea</i>, <i>Salvia officinalis</i>, <i>Salvia rosmarinus</i>, and <i>Taraxacum officinale</i>). Moreover, the issues responsible for possible biologic readout inconsistencies (plant species, age, selected organ, developmental stage, growth conditions, geographical location, drying methods, storage conditions, solvent of extraction, and extraction method) will also be discussed. Furthermore, a detailed list of the chemical composition and the immunomodulatory mechanism of action of the bioactive compounds of the selected plant extracts are presented. This review also includes future perspectives and proposes potential new avenues for further investigation.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140608933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1007/s11101-024-09958-4
Blandine Marant, Jérôme Crouzet, Amandine L. Flourat, Philippe Jeandet, Aziz Aziz, Eric Courot
Polyphenols are a large class of plant specialized metabolites with interesting biological properties. Among them, the stilbene phytoalexins are particularly abundant in grapevine gaining considerable applications in the cosmetic and nutraceutical industry. The well-studied stilbene biosynthetic pathway uses phenylalanine to generate resveratrol, the primary stilbene core synthetized in grapevine. A set of enzymes further metabolize resveratrol producing a diversity of stilbenes with different properties, activities and stabilities. In grapevine, 13 enzymes have been identified with the ability to use resveratrol as a substrate, including ten peroxidases, two glycosyltransferases and one O-methyltransferase. Peroxidases and methyltransferases are the most studied enzymes in grapevine, especially under stress conditions while the role of plant laccases and hydroxylases in stilbene metabolism is still poorly described. This article provides an overview of the key enzymes involved in the synthesis of resveratrol-based derivatives in Vitis spp. Perspectives to identify new enzymes are discussed, which could be further used for stilbene bioproduction using biotechnologies.
{"title":"Key-enzymes involved in the biosynthesis of resveratrol-based stilbenes in Vitis spp.: a review","authors":"Blandine Marant, Jérôme Crouzet, Amandine L. Flourat, Philippe Jeandet, Aziz Aziz, Eric Courot","doi":"10.1007/s11101-024-09958-4","DOIUrl":"https://doi.org/10.1007/s11101-024-09958-4","url":null,"abstract":"<p>Polyphenols are a large class of plant specialized metabolites with interesting biological properties. Among them, the stilbene phytoalexins are particularly abundant in grapevine gaining considerable applications in the cosmetic and nutraceutical industry. The well-studied stilbene biosynthetic pathway uses phenylalanine to generate resveratrol, the primary stilbene core synthetized in grapevine. A set of enzymes further metabolize resveratrol producing a diversity of stilbenes with different properties, activities and stabilities. In grapevine, 13 enzymes have been identified with the ability to use resveratrol as a substrate, including ten peroxidases, two glycosyltransferases and one <i>O</i>-methyltransferase. Peroxidases and methyltransferases are the most studied enzymes in grapevine, especially under stress conditions while the role of plant laccases and hydroxylases in stilbene metabolism is still poorly described. This article provides an overview of the key enzymes involved in the synthesis of resveratrol-based derivatives in <i>Vitis</i> spp. Perspectives to identify new enzymes are discussed, which could be further used for stilbene bioproduction using biotechnologies.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.1007/s11101-024-09959-3
Surbhi Sharma, Aushmita Das, Abha Kumari, Manju M. Gupta
In our comprehensive review, we delve into the critical steps of isolation of lutein and zeaxanthin from marigold flowers focusing on several pre-treatment technologies for marigold flower hydrolysis, non-green and green solvent-based extraction techniques of hydrolyzed solid biomass, and saponification of oleoresin while addressing the associated challenges and limitations. The review highlights the varying effects of different pre-treatments on the degradation of pectin, lignin, cellulose, and hemicellulose as well as on lutein and zeaxanthin ester yield. Notably, the enzymatic pre-treatment emerges as the most efficacious approach, despite its reliance on costly commercial enzymes. Based on the literature review, it is determined that supercritical fluid extraction, combined with ultrasound and various co-solvents gives off better yields of lutein as compared to the other extraction methods. This review also covers the saponification, purification, and recovery process. The applications of marigold flowers and lutein are also summarized.
{"title":"Technological insights into lutein isolation from marigold flower and their diverse applications: a compendious review","authors":"Surbhi Sharma, Aushmita Das, Abha Kumari, Manju M. Gupta","doi":"10.1007/s11101-024-09959-3","DOIUrl":"https://doi.org/10.1007/s11101-024-09959-3","url":null,"abstract":"<p>In our comprehensive review, we delve into the critical steps of isolation of lutein and zeaxanthin from marigold flowers focusing on several pre-treatment technologies for marigold flower hydrolysis, non-green and green solvent-based extraction techniques of hydrolyzed solid biomass, and saponification of oleoresin while addressing the associated challenges and limitations. The review highlights the varying effects of different pre-treatments on the degradation of pectin, lignin, cellulose, and hemicellulose as well as on lutein and zeaxanthin ester yield. Notably, the enzymatic pre-treatment emerges as the most efficacious approach, despite its reliance on costly commercial enzymes. Based on the literature review, it is determined that supercritical fluid extraction, combined with ultrasound and various co-solvents gives off better yields of lutein as compared to the other extraction methods. This review also covers the saponification, purification, and recovery process. The applications of marigold flowers and lutein are also summarized.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1007/s11101-024-09961-9
Claude Y. Hamany Djande, Ian A. Dubery
Hydroxycinnamoylamides are specialised metabolites widely distributed in the plant kingdom. These are phenolic moieties covalently linked to mono- or polyamines through amide bonds. Their oxidative coupling (dimerisation) leads to neolignanamides, a group of compounds showing high chemical, structural and functional diversity. Typical to barley, dehydro dimers of hydroxycinnamoylagmatines, hordatines are primarily found in germinated seeds and at the seedling stage. The first step in the biosynthesis of hordatines is catalysed by acyl-coenzyme A-dependent N-hydroxycinnamoyltransferases, and lead to the formation of hydroxycinnamoylagmatines (HCAgms). The oxidative homo- or hetero-dimerisation of the latter results in different hordatines (A, B, C or D). Hordatines can also undergo various types of conjugation and form hydroxylated, methylated or glycosylated derivatives. Although the research on the bioactivities of the hordatines is still nascent, the in planta antifungal properties have long been recognised. While hordatines are naturally and uniquely synthesised in barley plants, these molecules or lead compounds derived therefrom, also exhibit medicinal and pharmaceutical uses important for human health, stimulating research into the utilisation of biotechnology in alternative production hosts and to enhance agricultural yields and value-added production. This review summarises the older and recent knowledge about hordatines and derivatives and may serve as a springboard for future research on this intriguing class of secondary plant metabolites.
羟基肉桂酰亚胺是一种特殊的代谢物,广泛分布于植物界。它们是通过酰胺键与单胺或多胺共价连接的酚分子。它们的氧化偶联(二聚化)会产生新木犀草酰胺,这是一类具有高度化学、结构和功能多样性的化合物。以大麦为典型,羟基肉桂酰巴马汀的脱氢二聚体、霍达汀主要存在于发芽的种子和幼苗阶段。大麦芽碱生物合成的第一步是由依赖于酰基辅酶 A 的 N-羟基肉桂酰转移酶催化,形成羟基肉桂酰巴马汀(HCAgms)。后者的氧化同源或异源二聚化会产生不同的大麦芽碱(A、B、C 或 D)。大麦芽碱还会发生各种共轭作用,形成羟基化、甲基化或糖基化衍生物。尽管对大麦芽碱生物活性的研究仍处于起步阶段,但其植物抗真菌特性早已得到认可。虽然大麦碱是在大麦植物中自然合成的独特物质,但这些分子或由其衍生的先导化合物也具有对人类健康非常重要的药用和医药用途,从而促进了在替代生产主机中利用生物技术的研究,并提高了农业产量和生产附加值。本综述总结了有关大麦异黄酮及其衍生物的最新和较早的知识,可作为今后研究这类引人入胜的植物次生代谢物的跳板。
{"title":"Hordatines, dimerised hydroxycinnamoylagmatine conjugates of barley (Hordeum vulgare L.): an appraisal of the biosynthesis, chemistry, identification and bioactivities","authors":"Claude Y. Hamany Djande, Ian A. Dubery","doi":"10.1007/s11101-024-09961-9","DOIUrl":"https://doi.org/10.1007/s11101-024-09961-9","url":null,"abstract":"<p>Hydroxycinnamoylamides are specialised metabolites widely distributed in the plant kingdom. These are phenolic moieties covalently linked to mono- or polyamines through amide bonds. Their oxidative coupling (dimerisation) leads to neolignanamides, a group of compounds showing high chemical, structural and functional diversity. Typical to barley, dehydro dimers of hydroxycinnamoylagmatines, hordatines are primarily found in germinated seeds and at the seedling stage. The first step in the biosynthesis of hordatines is catalysed by acyl-coenzyme A-dependent N-hydroxycinnamoyltransferases, and lead to the formation of hydroxycinnamoylagmatines (HCAgms). The oxidative homo- or hetero-dimerisation of the latter results in different hordatines (A, B, C or D). Hordatines can also undergo various types of conjugation and form hydroxylated, methylated or glycosylated derivatives. Although the research on the bioactivities of the hordatines is still nascent, the <i>in planta</i> antifungal properties have long been recognised. While hordatines are naturally and uniquely synthesised in barley plants, these molecules or lead compounds derived therefrom, also exhibit medicinal and pharmaceutical uses important for human health, stimulating research into the utilisation of biotechnology in alternative production hosts and to enhance agricultural yields and value-added production. This review summarises the older and recent knowledge about hordatines and derivatives and may serve as a springboard for future research on this intriguing class of secondary plant metabolites.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quercus, an essential genus within the Fagaceae family, comprises roughly 500 plant species. Over the past 5 years (2019–2023), there has been a noticeable increase in the production of high-quality research papers focusing on this genus, marking it as an emerging research area of interest. However, despite this growing body of work, there has yet to be a comprehensive and systematic review addressing the metabolites, pharmacological effects, and underlying mechanisms associated with Quercus. To bridge this knowledge gap, the current study performed an exhaustive literature review. A total of 64 relevant papers published in high-impact journals (classified as JCR Q1–Q3) between January 2019 and April 2023 were meticulously selected through comprehensive searches of the ACS, PubMed, Web of Science, and Science Direct databases. The chemical analysis encompassed the identification of 217 compounds, spanning categories like terpenoids, flavonoids, tannins, and phenols, among others. Within this set, 11 previously undisclosed compounds emerged, comprising 6 terpenoids and 5 esters. The study primarily delved into the internal and external pharmacological properties of 23 distinct plant species, including antioxidant, antibacterial, anti-inflammatory, antidiabetic effects, and even the assessment of its potential for mitigating the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This paper offers a comprehensive evaluation of the findings and provides insightful recommendations for guiding future research on this plant genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of Quercus spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.
{"title":"The genus Quercus: metabolites, biological activity and mechanisms of action","authors":"Lulu Jiang, Shuanghui Yin, Guangyue Wang, Xinting Shao, Ye Wang, Yong Li, Yuling Ding","doi":"10.1007/s11101-024-09935-x","DOIUrl":"https://doi.org/10.1007/s11101-024-09935-x","url":null,"abstract":"<p><i>Quercus</i>, an essential genus within the Fagaceae family, comprises roughly 500 plant species. Over the past 5 years (2019–2023), there has been a noticeable increase in the production of high-quality research papers focusing on this genus, marking it as an emerging research area of interest. However, despite this growing body of work, there has yet to be a comprehensive and systematic review addressing the metabolites, pharmacological effects, and underlying mechanisms associated with <i>Quercus</i>. To bridge this knowledge gap, the current study performed an exhaustive literature review. A total of 64 relevant papers published in high-impact journals (classified as JCR Q1–Q3) between January 2019 and April 2023 were meticulously selected through comprehensive searches of the ACS, PubMed, Web of Science, and Science Direct databases. The chemical analysis encompassed the identification of 217 compounds, spanning categories like terpenoids, flavonoids, tannins, and phenols, among others. Within this set, 11 previously undisclosed compounds emerged, comprising 6 terpenoids and 5 esters. The study primarily delved into the internal and external pharmacological properties of 23 distinct plant species, including antioxidant, antibacterial, anti-inflammatory, antidiabetic effects, and even the assessment of its potential for mitigating the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This paper offers a comprehensive evaluation of the findings and provides insightful recommendations for guiding future research on this plant genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of <i>Quercus</i> spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-08DOI: 10.1007/s11101-024-09932-0
Deepak M. Kasote, Malik Adil Nawaz, Kamal Usman, Najeeb Ullah, Mohammed Alsafran
In Qatar, three main species of Pulicaria (from Asteraceae) such as Pulicaria undulata (L.) C.A.Mey, Pulicaria gnaphalodes (Vent.) Boiss. and Pulicaria sicula (L.) Moris are reported. Traditionally, these species have almost the same ethnomedical uses, including their use as herbal tea. This could be because of morphological similarities among some of these species, which also results in taxonomic ambiguity. Altogether, this indicates that these species need to be reviewed comparatively, to understand the phytochemical uniqueness and therapeutic significance of each species individually, including species differentiation at the subspecies level. Hence, this review aims to comparatively review the available literature about traditional uses, phytochemistry, and bio-activities of these species. Being aromatic plants, the chemical composition of essential oils of these species has been extensively studied and reported over 300 volatile organic compounds. Among these, oxygenated monoterpenes and sesquiterpenes are dominant. The diverse and distinguishable composition of essential oils can differentiate P. undulata and Pulicaria crispa (Forssk.) Oliv. (Synonyme: Pulicaria undulata subsp. undulata). Likewise, flavonoids and sesquiterpenes are the most reported classes of compounds in non-essential oil fractions. Various biological and pharmacological activities are reported to the essential oils, crude extracts, and their fractions, or isolated compounds of these species. Among these, antimicrobial, anticancer, and anti-oxidant activities were mostly investigated, mainly under in vitro conditions. Several distinguishable compounds are listed for each species that can potentially be used as chemical markers while characterizing these species. Most of the traditional claims of these species are validated in recent scientific studies. However, further detailed in vivo clinical interventions are needed for their potential use as therapeutic agents.
{"title":"A critical review on Pulicaria species occurring in Qatar: traditional uses, phytochemistry and biological activities","authors":"Deepak M. Kasote, Malik Adil Nawaz, Kamal Usman, Najeeb Ullah, Mohammed Alsafran","doi":"10.1007/s11101-024-09932-0","DOIUrl":"https://doi.org/10.1007/s11101-024-09932-0","url":null,"abstract":"<p>In Qatar, three main species of <i>Pulicaria</i> (from Asteraceae) such as <i>Pulicaria undulata</i> (L.) C.A.Mey, <i>Pulicaria gnaphalodes</i> (Vent.) Boiss. and <i>Pulicaria sicula</i> (L.) Moris are reported. Traditionally, these species have almost the same ethnomedical uses, including their use as herbal tea. This could be because of morphological similarities among some of these species, which also results in taxonomic ambiguity. Altogether, this indicates that these species need to be reviewed comparatively, to understand the phytochemical uniqueness and therapeutic significance of each species individually, including species differentiation at the subspecies level. Hence, this review aims to comparatively review the available literature about traditional uses, phytochemistry, and bio-activities of these species. Being aromatic plants, the chemical composition of essential oils of these species has been extensively studied and reported over 300 volatile organic compounds. Among these, oxygenated monoterpenes and sesquiterpenes are dominant. The diverse and distinguishable composition of essential oils can differentiate <i>P. undulata</i> and <i>Pulicaria crispa</i> (Forssk.) Oliv. (Synonyme: <i>Pulicaria undulata</i> subsp. <i>undulata</i>). Likewise, flavonoids and sesquiterpenes are the most reported classes of compounds in non-essential oil fractions. Various biological and pharmacological activities are reported to the essential oils, crude extracts, and their fractions, or isolated compounds of these species. Among these, antimicrobial, anticancer, and anti-oxidant activities were mostly investigated, mainly under in vitro conditions. Several distinguishable compounds are listed for each species that can potentially be used as chemical markers while characterizing these species. Most of the traditional claims of these species are validated in recent scientific studies. However, further detailed in vivo clinical interventions are needed for their potential use as therapeutic agents.</p>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}