JCSM clinical reports最新文献_第5页

Body composition, sarcopenia, and quality of life in patients with oesophageal cancer before resection surgery and at follow-up: a cohort study 食管癌患者切除术前和随访时的身体成分、肌肉减少症和生活质量:一项队列研究

JCSM clinical reports

Pub Date : 2020-02-14 DOI: 10.1002/crt2.9

Jan Persson, Monika Fagevik Olsén, Britt-Marie Iresjö, Ulrika Smedh

Aims

Oesophageal cancer is associated with dysphagia and reduced caloric intake. Body composition and prevalence of sarcopenia in patients with oesophageal cancer before and after surgery are not well known. The aims were to (i) describe body composition and sarcopenia, physical performance, and quality of life (QoL) in a cohort of patients with oesophageal cancer before surgery with curative intent; (ii) investigate alterations in body composition as a consequence of the surgery at 1 and 3 months post-operatively; and (iii) investigate if pre-operative measures are correlated to morbidity, length of stay, QoL, or mortality.

Methods and results

An observational study was performed in 76 consecutive patients with oesophageal cancer planned for open surgery with curative intent. Data were collected from the patient history database. QoL data were derived from the European Organization for Research and Treatment of Cancer QLQ-OES18 questionnaire. Pre-operatively, the patients displayed normal body mass index despite that almost 20% were sarcopenic, 86% had a lowered physical performance level, and 37% of the patients were severely malnourished. All body composition variables except fat mass declined up to 3 months after surgery. No pre-operative biometric measure or QoL item correlated with risk for complications. High physical performance, female sex, and high global QoL score positively predicted overall survival.

Conclusions

Severe malnourishment was common in patients judged suitable for surgery in spite of normal body mass index. Neither pre-operative malnutrition nor sarcopenia was independent risk factor for morbidity or overall mortality. Oesophageal surgery causes long-lasting catabolic effects, highlighting the importance of optimal peri-operative and post-operative nutrition.

食管癌与吞咽困难和热量摄入减少有关。食管癌患者手术前后的身体成分和肌肉减少症患病率尚不清楚。目的是(i)描述一组食管癌患者手术前的身体组成和肌肉减少症、身体表现和生活质量(QoL);(ii)在术后1个月和3个月调查手术对身体成分的影响;(iii)调查术前措施是否与发病率、住院时间、生活质量或死亡率相关。

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引用次数: 0

Ultrasound imaging for measuring muscle and subcutaneous fat tissue thickness of the anterior thigh: a 2 year longitudinal study in middle age 超声成像测量大腿前部肌肉和皮下脂肪组织厚度:一项为期2年的中年人纵向研究

JCSM clinical reports

Pub Date : 2020-01-14 DOI: 10.1002/crt2.7

Filippo Mechelli, Lars Arendt-Nielsen, Maria Stokes, Sandra Agyapong-Badu

Background

Ultrasound (US) imaging technique is widely used in research and clinical settings to assess the morphology and morphometry of neuromusculoskeletal structures. The technique has reported validity and reliability in measuring the size of various muscles under controlled conditions. The aim of the present study was to assess anterior thigh thickness using US imaging, in a healthy cohort of middle-aged older adults.

Methods

Participants included 17 healthy older adults involved in regular moderate-vigorous activities (age range 39–66 years). US imaging scans of the anterior thighs 2 years since baseline measurements were performed. Images were analysed offline to compare US imaging measurements of muscle thickness and subcutaneous fat (SF) of the anterior thigh taken at baseline and after 2 years.

Results

There was no significant difference between muscle thickness measurements taken at baseline and after 2 years (mean, standard deviation; baseline = 2.80 ± 0.71 cm; follow-up = 2.77 ± 0.72 cm, P = 0.33). There was also no significant change in SF thickness (baseline = 1.04 ± 0.41 cm; follow-up = 1.06 ± 0.40, P = 0.33).

Conclusions

The results show that there was no decline in anterior thigh muscle thickness or increase in SF in the healthy cohort studied using US imaging over a 2 year period. These findings demonstrate the robustness of US imaging measurements over time.

超声(US)成像技术广泛应用于研究和临床环境，以评估神经肌肉骨骼结构的形态和形态计量学。据报道，该技术在控制条件下测量各种肌肉大小的有效性和可靠性。本研究的目的是在一个健康的中年老年人队列中使用超声成像评估大腿前部厚度。

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引用次数: 3

Management of anorexia prevents skeletal muscle wasting during cisplatin-based chemotherapy for thoracic malignancies 在以顺铂为基础的胸部恶性肿瘤化疗中，厌食症的治疗可防止骨骼肌萎缩

JCSM clinical reports

Pub Date : 2020-01-13 DOI: 10.1002/crt2.8

Eriko Miyawaki, Tateaki Naito, Kazuhisa Nakashima, Taichi Miyawaki, Nobuaki Mamesaya, Takahisa Kawamura, Haruki Kobayashi, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Keita Mori, Toshiaki Takahashi

Background

Cancer-associated skeletal muscle loss often occurs in patients with advanced lung cancer who are receiving chemotherapy. This study aimed to elucidate the impact of chemotherapy-induced nausea and vomiting (CINV) or anorexia on muscle wasting.

Methods

In this post-hoc analysis of a phase II clinical trial of antiemetic agents, chemotherapy-naïve Japanese patients with thoracic malignancies were prospectively recruited between May and October 2015. Total control of CINV was defined as the absence of nausea and vomiting without rescue therapy 0–120 h after each course of chemotherapy. Non-anorexia was defined as having no anorexia or having an anorexia grade no higher than ‘1’ during the 3 month period following chemotherapy initiation. Skeletal muscle mass was measured by computed tomography, and lumbar skeletal muscle index (LSMI) was calculated.

Results

Among 29 patients, CINV was totally controlled in 7 (24%) and grade 2 or 3 anorexia was observed in 10 (34%). The LSMI significantly decreased across the entire cohort (mean ± standard error of the mean: −3.1 ± 0.6 cm²/m², P < 0.01); this reduction was similar among patients with and without total control of CINV (−4.1 ± 1.3 vs. −2.8 ± 0.7 cm²/m², P = 0.38). Patients with anorexia experienced a larger decrease in LSMI than did those without anorexia during the study period (−5.4 ± 0.9 vs. −1.9 ± 0.7 cm²/m², P < 0.01).

Conclusions

Significant skeletal muscle mass depletion was observed despite well-controlled CINV. Continuous oral food intake may be required throughout the course of cisplatin-based chemotherapy.

癌症相关的骨骼肌损失通常发生在接受化疗的晚期癌症患者中。本研究旨在阐明化疗诱导的恶心呕吐（CINV）或厌食症对肌肉萎缩的影响。

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引用次数: 5

Ultrasound imaging for measuring muscle and subcutaneous fat tissue thickness of the anterior thigh: A two-year longitudinal study in middle age 超声成像测量大腿前部肌肉和皮下脂肪组织厚度：一项为期两年的中年纵向研究

JCSM clinical reports

Pub Date : 2019-08-21 DOI: 10.17987/JCSM-CR.V4I2.94

Filippo Mechelli

Background Ultrasound (US) imaging technique is widely used in research and clinical settings to assess the morphology and morphometry of neuromusculoskeletal structures. The technique has reported validity and reliability in measuring the size of various muscles under controlled conditions. The aim of the present study was to assess anterior thigh thickness using US imaging, in a healthy cohort of middle-aged older adults.Methods Participants included seventeen healthy older adults involved in regular moderate-vigorous activities (age range 39-66 years). US imaging scans of the anterior thighs two years since baseline measurements were performed. Images were analyzed off-line to compare US imaging measurements of muscle thickness and subcutaneous fat (SF) of the anterior thigh taken at baseline and after two years.Results There was no significant difference between muscle thickness measurements taken at baseline and after two years (Mean, standard deviation; baseline=2.80±0.71cm; follow-up=2.77±0.72cm, p=0.33). There was also no significant change in SF thickness (baseline=1.04±0.41cm; follow-up=1.06±0.40, p=0.33).Conclusions The results show there was no decline in anterior thigh muscle thickness or increase in SF in the healthy cohort studied using US imaging over a two-year period. These findings demonstrate the robustness of US imaging measurements over time.

背景超声（US）成像技术在研究和临床环境中被广泛用于评估神经肌肉骨骼结构的形态学和形态计量学。该技术已经报道了在受控条件下测量各种肌肉大小的有效性和可靠性。本研究的目的是在一个健康的中年老年人队列中使用US成像评估大腿前部厚度。方法参与者包括17名健康的老年人，他们参加有规律的中等强度活动（年龄范围39-66岁）。自基线测量后两年对大腿前部进行的US成像扫描。离线分析图像，以比较在基线和两年后拍摄的大腿前部肌肉厚度和皮下脂肪（SF）的US成像测量值。结果基线和两年后测量的肌肉厚度没有显著差异（平均值，标准差；基线=2.80±0.71cm；随访=2.77±0.72cm，p=0.33）在两年内使用US成像研究的健康队列中SF的增加。这些发现证明了US成像测量随时间变化的稳健性。

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引用次数: 3

The association between SARC-F status and quality of life in High Risk Foot Clinic patients 高危足患者SARC-F状态与生活质量的关系

JCSM clinical reports

Pub Date : 2019-01-01 DOI: 10.17987/jcsm-cr.v4i1.73

Irina Churilov, Leonid Churilov, Michelle Proctor, Anna Galligan, David Murphy, Mark Westcott, Richard J MacIsaac, Elif I Ekinci

Background

High Risk Foot Clinic (HRFC) patients have foot ulceration commonly associated with poorer quality of life (QoL). A positive SARC-F test is predictive of sarcopenia. The objective of this study is to investigate whether SARC-F positive status is associated with lower QoL among attendees of HRFC, which is currently unknown.

Methods and results

In this cross-sectional study ambulatory HRFC patients were recruited at metropolitan tertiary referral hospital over one year. Demographics, comorbidities, SARC-F and EQ-5D-3L (EuroQol Group) outcomes were collected. Association between SARC-F status and EQ-5D visual analogue scale measurement, as well as individual EQ-5D-3L dimensions were investigated using, respectively, linear robust and ordinal logistic regression modelling. The clinic was attended by 122 new patients, 85 of whom (69%) completed the questionnaires with no selection bias identified. 43/85 (51%) patients were SARC-F positive as indicated by a score of 4 or greater. No significant differences between SARC-F positive and negative patients were identified in age or diabetes status. SARC-F positive patients had consistently lower EQ-5D-3L visual analogue scale measurement [mean 5.3 (SD 2.0); median 5 (IQR: 4, 6.5)] compared to SARC-F negative patients [6.6 (SD 1.9); 7 (5.5, 7.5)], adjusted mean difference -1.2 (95%CI: -2.1, -0.4; p=0.007). SARC-F positive patients demonstrated consistent and statistically significantly worse EQ-5D-3L scores on mobility, personal care and usual activities, but not on anxiety/depression and pain/discomfort components.

Conclusions

Approximately half of HRFC patients are SARC-F positive and exhibit significantly lower QoL as measured by EQ-5D-3L compared to SARC-F negative patients.

背景:高风险足部门诊(HRFC)患者的足部溃疡通常与较差的生活质量(QoL)相关。SARC-F检测阳性可预测肌肉减少症。本研究的目的是调查SARC-F阳性状态是否与HRFC参与者较低的生活质量相关，目前尚不清楚。方法和结果在这项横断面研究中，在大城市三级转诊医院招募了一年以上的HRFC门诊患者。收集人口统计学、合并症、SARC-F和EQ-5D-3L (EuroQol组)结果。采用线性稳健和有序逻辑回归模型分别研究了SARC-F状态与EQ-5D视觉模拟量表测量以及EQ-5D- 3l个体维度之间的关系。122名新患者参加了该诊所，其中85名(69%)完成了问卷调查，没有发现选择偏差。43/85(51%)患者为SARC-F阳性，评分为4分或更高。SARC-F阳性和阴性患者在年龄或糖尿病状态方面无显著差异。SARC-F阳性患者的EQ-5D-3L视觉模拟量表测量值持续较低[平均5.3 (SD 2.0);中位数为5 (IQR: 4,6.5)]，而SARC-F阴性患者为6.6 (SD 1.9);7(5.5, 7.5)]，调整后平均差-1.2 (95%CI: -2.1， -0.4;p = 0.007)。SARC-F阳性患者在活动能力、个人护理和日常活动方面的EQ-5D-3L评分一致且在统计学上显著较差，但在焦虑/抑郁和疼痛/不适方面没有表现出来。结论:大约一半的HRFC患者为SARC-F阳性，EQ-5D-3L测量的生活质量明显低于SARC-F阴性患者。

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引用次数: 1

SARC-F Questionnaire: Rapid and Easy Tool for Identifying Physical Limitations in Hemodialysis Patients SARC-F问卷:识别血液透析患者身体局限性的快速简便工具

JCSM clinical reports

Pub Date : 2019-01-01 DOI: 10.17987/jcsm-cr.v4i1.74

Shohei Yamamoto, Ryota Matsuzawa, Manae Harada, Takaaki Watanabe, Takahiro Shimoda, Yuta Suzuki, Kentaro Kamiya, Shiwori Osada, Atsushi Yoshida, Atsuhiko Matsunaga

Background

SARC-F is a simple questionnaire for rapidly assessing physical function and screening for sarcopenia. This study aimed to determine whether the SARC-F questionnaire is useful for identifying impaired physical function and the risk of physical limitations in hemodialysis patients.

Methods and results

This cross-sectional study included 281 patients undergoing hemodialysis at two dialysis units. SARC-F, handgrip strength, leg strength, one-leg standing time, usual gait speed, and short physical performance battery (SPPB) score were measured. Patients were classified according to the SARC-F score (SARC-F <4 and SARC-F ≥4), indicating the risk of sarcopenia. Furthermore, we defined physical limitations as handgrip strength of <26 kg for men and <18 kg for women, leg strength of <40%, usual gait speed of ≤0.8 m/s, and SPPB score of ≤8 points. To calculate the areas under the curves (AUCs) of the SARC-F score for physical limitations, receiver-operating characteristic curve analysis was performed. SARC-F ≥4 was observed in 75 (26.7 %) hemodialysis patients. The SARC-F ≥4 group had a significantly lower handgrip and leg strength, shorter one-leg standing time, slower usual gait speed, and lower SPPB score than the SARC-F <4 group, even after adjusting for potential confounders (all P <0.001). Further, SARC-F demonstrated good accuracy in identifying the risk of physical limitations (all AUCs > 0.75).

Conclusions

The SARC-F questionnaire is useful for screening impaired physical function and for identifying the risk of physical limitations in hemodialysis patients and can be easily and rapidly administered to this patient group in clinical practice.

SARC-F是一种快速评估身体功能和筛查肌肉减少症的简单问卷。本研究旨在确定SARC-F问卷是否有助于识别血液透析患者的身体功能受损和身体限制的风险。方法和结果本横断面研究包括281例在两个透析单位接受血液透析的患者。测量SARC-F、握力、腿部力量、单腿站立时间、通常步态速度和短时间物理性能电池(SPPB)评分。根据SARC-F评分(SARC-F <4和SARC-F≥4)对患者进行分类，表明发生肌肉减少症的风险。此外，我们将身体限制定义为男性握力26 kg，女性18 kg，腿部力量40%，通常步速≤0.8 m/s, SPPB评分≤8分。为了计算生理限制的SARC-F评分曲线下面积(auc)，进行了受试者工作特征曲线分析。75例(26.7%)血液透析患者SARC-F≥4。即使校正了潜在的混杂因素(P均为0.001)，src - f≥4组的握力和腿部力量明显低于src - f <4组，单腿站立时间短，通常步态速度慢，SPPB评分也低于src - f <4组。此外，SARC-F在识别身体限制风险方面表现出良好的准确性(所有auc >0.75)。结论SARC-F问卷可用于血透析患者身体功能受损的筛查和身体限制风险的识别，在临床实践中可方便、快速地应用于该患者组。

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引用次数: 9

Race and socioeconomic effect on sarcopenia and sarcopenic obesity in the Louisiana Osteoporosis Study (LOS). 路易斯安那骨质疏松研究(LOS)中，种族和社会经济因素对肌肉减少症和肌肉减少性肥胖的影响。

JCSM clinical reports

Pub Date : 2018-07-01

Cassie Jeng, Lan-Juan Zhao, Kehao Wu, Yu Zhou, Ted Chen, Hong-Wen Deng

Background: Sarcopenia and sarcopenic obesity are emerging public health issues. True prevalence rates are unknown and estimates differ substantially between studies. No large-scale single study has compared prevalence rates between whites, blacks, Asians, and Hispanics, as we intend to do here. This study also examined the effects of race and socioeconomic factors on sarcopenia and sarcopenic obesity.

Methods: This study included 10,325 participants from Louisiana. Appendicular lean mass (ASM), measured through dual energy x-ray absorptiometry (DXA) scans, was divided by height squared (ASM/h²) to define sarcopenia. Sarcopenic obesity was defined as sarcopenia plus obesity (waist-to-hip ratio).

Results: Overall sarcopenia and sarcopenic obesity rates were 17.6% and 7.0% for males, and 13.7% and 2.5% for females, respectively. The highest sarcopenia and sarcopenic obesity rates were found in Asian males (40.6%, 14.4%) and females (30.1%, 8.0%). The lowest sarcopenic obesity rates were observed in black males (3.7%) and females (0.9%). We found significant associations with sarcopenic obesity in males for age, race, and income; in females, for age, race, and education.

Conclusions: Under one diagnostic definition, the prevalence of sarcopenia and sarcopenic obesity is highest among Asians and lowest amongst blacks. Income and education had significant associations with sarcopenia and sarcopenic obesity, in males and females, respectively.

背景:肌少症和肌少性肥胖是新兴的公共卫生问题。真正的流行率是未知的，不同研究之间的估计差异很大。没有大规模的单一研究比较白人、黑人、亚洲人和西班牙人之间的患病率，而我们打算在这里做。本研究还考察了种族和社会经济因素对肌肉减少症和肌肉减少性肥胖的影响。方法:本研究包括10325名来自路易斯安那州的参与者。通过双能x线吸收仪(DXA)扫描测量的阑尾瘦质量(ASM)除以身高的平方(ASM/h2)来定义肌肉减少症。肌肉减少性肥胖被定义为肌肉减少加上肥胖(腰臀比)。结果:男性总体肌少症和肌少性肥胖率分别为17.6%和7.0%，女性为13.7%和2.5%。亚洲男性(40.6%，14.4%)和女性(30.1%，8.0%)的肌肉减少症和肌肉减少性肥胖率最高。黑人男性(3.7%)和女性(0.9%)的肌肉减少肥胖率最低。我们发现男性肌肉减少性肥胖与年龄、种族和收入有显著关联;在女性中，根据年龄、种族和教育程度。结论:在一种诊断定义下，肌肉减少症和肌肉减少性肥胖的患病率在亚洲人中最高，在黑人中最低。在男性和女性中，收入和教育程度分别与肌肉减少症和肌肉减少性肥胖有显著关联。

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引用次数: 0

Profiles Associated with Sarcopenia in Hepatoma Patients Underwent Transcatheter Arterial Chemoembolization: A Data-Mining Analysis 经导管动脉化疗栓塞的肝癌患者肌肉减少的相关概况:数据挖掘分析

JCSM clinical reports

Pub Date : 2018-07-01 DOI: 10.17987/jcsm-cr.v3i2.66

Keisuke Hirota, Takumi Kawaguchi, Ryuki Hashida, Shunji Koya, Masafumi Bekki, Norihiro Goshima, Teruhito Yoshiyama, Takashi Otsuka, Ryosuke Nozoe, Dan Nakano, Tomotake Shirono, Shigeo Shimose, Hideki Iwamoto, Takashi Niizeki, Hiroo Matsuse, Hironori Koga, Naoto Shiba, Takuji Torimura

Aims

Sarcopenia is a prognostic factor in patients with hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may aggravate sarcopenia because of post-embolization syndrome. The aims of this study are to investigate changes in skeletal muscle mass after TACE and its risk profiles in patients with HCC.

Methods and results

We enrolled 104 HCC patients (age 73.5 [41.0–88.0] years, female/male 35/69, body mass index 22.4 [16.0–32.7]). Changes in skeletal muscle mass were evaluated by Δskeletal muscle index (SMI) using computed tomography before and after TACE. Factors correlated with ΔSMI were evaluated. Independent factors and profiles associated with a decrease in SMI were evaluated by multivariate analysis and decision-tree analysis, respectively. SMI was significantly decreased after TACE in patients with HCC (32.8 vs. 30.6 cm²/m²; P=0.0001). However, there was no significant correlation between the ΔSMI and other variables including Δalbumin. In the logistic regression analysis, no factor was significantly associated with a decrease in SMI. In the decision-tree analysis, sex was selected as the initial split and, in female, 74% of subjects showed a decrease in SMI. While, in male, an estimated glomerular filtration rate (eGFR) ≤81.7 ml/min/1.73 m² was the second split; of these patients, 74% of subjects had a decreased SMI.

Conclusions

We demonstrated that skeletal muscle mass was decreased after TACE in patients with HCC. “female” and “male who had a lower eGFR” were profile for a decrease in skeletal muscle mass. Thus, such patients who have HCC treated with TACE may benefit from preventive treatment for sarcopenia.

目的肌少症是影响肝细胞癌(HCC)患者预后的因素之一。经导管动脉化疗栓塞(TACE)可因栓塞后综合征加重肌肉减少症。本研究的目的是探讨HCC患者接受TACE后骨骼肌质量的变化及其风险概况。方法与结果纳入104例HCC患者，年龄73.5[41.0-88.0]岁，男女比例35/69，体重指数22.4[16.0-32.7]。采用计算机断层扫描Δskeletal肌肉指数(SMI)评估TACE前后骨骼肌质量的变化。评估与ΔSMI相关的因素。分别通过多变量分析和决策树分析评估与重度精神分裂症减少相关的独立因素和概况。HCC患者接受TACE治疗后SMI显著降低(32.8 vs 30.6 cm2/m2;P = 0.0001)。然而，ΔSMI与Δalbumin等其他变量之间没有显著的相关性。在logistic回归分析中，没有任何因素与重度精神分裂症的减少显著相关。在决策树分析中，性别被选择作为初始分割，在女性中，74%的受试者表现出重度精神障碍的减少。而在男性中，估计肾小球滤过率(eGFR)≤81.7 ml/min/1.73 m2为第二次分裂;在这些患者中，74%的受试者重度精神障碍有所下降。结论:我们证明肝癌患者接受TACE治疗后骨骼肌质量下降。“女性”和“eGFR较低的男性”是骨骼肌质量减少的特征。因此，接受TACE治疗的HCC患者可能受益于肌肉减少症的预防性治疗。

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引用次数: 4

Muscle wasting diseases has two distinct trajectories on the 3-dimensional age-BMI-peak VO2 scatterplot 肌肉萎缩疾病在三维年龄- bmi - VO2峰值散点图上有两条不同的轨迹

JCSM clinical reports

Pub Date : 2018-07-01 DOI: 10.17987/jcsm-cr.v3i2.69

Masamitsu Sugie, Kazumasa Harada, Tetsuya Takahashi, Marina Nara, Teruyuki Koyama, Hajime Fujimoto, Shunei Kyo, Hideki Ito

Aims

Frailty and sarcopenia are age-related morbid states, and a low body mass index (BMI) is a characteristic of frailty and cachexia. However, no common index for assessing these three muscle wasting states is available, making it difficult to understand the relationship among them. Peak oxygen uptake (peak VO₂), an index of life expectancy, may be a useful common index. Therefore, this study aimed to investigate the relationship among sarcopenia, frailty, and cachexia using age, BMI, and peak VO₂.

Methods and Results

Participants were 175 Japanese community dwelling older adults (58 men, 117 women; 77.6 years). We assessed biochemical, physiological, and physical factors, and symptoms associated with frailty, and cachexia. Peak VO₂ was assessed with a cardiopulmonary exercise test. Participants were classified into five groups: robust, pre-frail, frail, sarcopenia, and cachexia. We compared the groups by age, BMI, and peakVO₂ with average values and 95% confidence intervals (CIs). 17% (n=30) of participants were classified as robust, 40% (n=70) as pre-frail, 12% (n=21) as sarcopenia, 25% (n=44) as frail, and 6% (n=10) as cachexia. Significant differences were found in age (robust vs. frail, pre-frail vs. frail), BMI (robust vs. cachexia, pre-frail vs. cachexia, frail vs. cachexia), and peak VO₂ (robust vs. frail, robust vs. cachexia, pre-frail vs. cachexia) with average values and 95% CIs. Three dimensions among age, BMI and peak VO₂ revealed two trajectories (from robust to frailty via pre-frailty, and from robust to cachexia via sarcopenia) among muscle wasting diseases.

Conclusions

This study revealed two trajectories among muscle wasting diseases.

目的虚弱和肌肉减少症是与年龄相关的病态状态，低体重指数(BMI)是虚弱和恶病质的一个特征。然而，没有一个共同的指标来评估这三种肌肉消耗状态，这使得很难理解它们之间的关系。峰值摄氧量(峰值VO2)，一个预期寿命的指标，可能是一个有用的常用指标。因此，本研究旨在通过年龄、BMI和峰值VO2来探讨肌肉减少症、虚弱和恶病质之间的关系。方法与结果参与者为175名居住在日本社区的老年人(男性58人，女性117人;77.6年)。我们评估了生化、生理和物理因素，以及与虚弱和恶病质相关的症状。通过心肺运动试验评估峰值VO2。参与者被分为五组:健壮、体弱、体弱、肌肉减少症和恶病质。我们按年龄、BMI和峰值vo2与平均值和95%置信区间(ci)进行比较。17% (n=30)的参与者被分类为健壮，40% (n=70)为虚弱前期，12% (n=21)为肌肉减少症，25% (n=44)为虚弱，6% (n=10)为恶病质。年龄(健壮vs体弱，体弱前期vs体弱)、BMI(健壮vs病毒质、体弱vs病毒质、体弱vs病毒质)和峰值VO2(健壮vs体弱、体弱前期vs病毒质)的平均值和95% ci均存在显著差异。年龄、BMI和峰值VO2的三个维度揭示了肌肉萎缩疾病的两条轨迹(从强壮到虚弱，通过虚弱前期，从强壮到肌肉减少，通过恶病质)。结论本研究揭示了肌肉萎缩疾病的两条轨迹。

{"title":"Muscle wasting diseases has two distinct trajectories on the 3-dimensional age-BMI-peak VO2 scatterplot","authors":"Masamitsu Sugie, Kazumasa Harada, Tetsuya Takahashi, Marina Nara, Teruyuki Koyama, Hajime Fujimoto, Shunei Kyo, Hideki Ito","doi":"10.17987/jcsm-cr.v3i2.69","DOIUrl":"10.17987/jcsm-cr.v3i2.69","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Frailty and sarcopenia are age-related morbid states, and a low body mass index (BMI) is a characteristic of frailty and cachexia. However, no common index for assessing these three muscle wasting states is available, making it difficult to understand the relationship among them. Peak oxygen uptake (peak VO<sub>2</sub>), an index of life expectancy, may be a useful common index. Therefore, this study aimed to investigate the relationship among sarcopenia, frailty, and cachexia using age, BMI, and peak VO<sub>2</sub>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Participants were 175 Japanese community dwelling older adults (58 men, 117 women; 77.6 years). We assessed biochemical, physiological, and physical factors, and symptoms associated with frailty, and cachexia. Peak VO<sub>2</sub> was assessed with a cardiopulmonary exercise test. Participants were classified into five groups: robust, pre-frail, frail, sarcopenia, and cachexia. We compared the groups by age, BMI, and peakVO<sub>2</sub> with average values and 95% confidence intervals (CIs). 17% (n=30) of participants were classified as robust, 40% (n=70) as pre-frail, 12% (n=21) as sarcopenia, 25% (n=44) as frail, and 6% (n=10) as cachexia. Significant differences were found in age (robust vs. frail, pre-frail vs. frail), BMI (robust vs. cachexia, pre-frail vs. cachexia, frail vs. cachexia), and peak VO<sub>2</sub> (robust vs. frail, robust vs. cachexia, pre-frail vs. cachexia) with average values and 95% CIs. Three dimensions among age, BMI and peak VO<sub>2</sub> revealed two trajectories (from robust to frailty via pre-frailty, and from robust to cachexia via sarcopenia) among muscle wasting diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study revealed two trajectories among muscle wasting diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73543,"journal":{"name":"JCSM clinical reports","volume":"3 2","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.17987/jcsm-cr.v3i2.69","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42877982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Race and socioeconomic effect on sarcopenia and sarcopenic obesity in the Louisiana Osteoporosis Study (LOS) 路易斯安那骨质疏松研究(LOS)中种族和社会经济因素对肌肉减少症和肌肉减少性肥胖的影响

JCSM clinical reports

Pub Date : 2018-07-01 DOI: 10.17987/jcsm-cr.v3i2.27

Cassie Jeng, Lan-Juan Zhao, Kehao Wu, Yu Zhou, Ted Chen, Hong-Wen Deng

Background

Sarcopenia and sarcopenic obesity are emerging public health issues. True prevalence rates are unknown and estimates differ substantially between studies. No large-scale single study has compared prevalence rates between whites, blacks, Asians, and Hispanics, as we intend to do here. This study also examined the effects of race and socioeconomic factors on sarcopenia and sarcopenic obesity.

Methods

This study included 10,325 participants from Louisiana. Appendicular lean mass (ASM), measured through dual energy x-ray absorptiometry (DXA) scans, was divided by height squared (ASM/h²) to define sarcopenia. Sarcopenic obesity was defined as sarcopenia plus obesity (waist-to-hip ratio).

Results

Overall sarcopenia and sarcopenic obesity rates were 17.6% and 7.0% for males, and 13.7% and 2.5% for females, respectively. The highest sarcopenia and sarcopenic obesity rates were found in Asian males (40.6%, 14.4%) and females (30.1%, 8.0%). The lowest sarcopenic obesity rates were observed in black males (3.7%) and females (0.9%). We found significant associations with sarcopenic obesity in males for age, race, and income; in females, for age, race, and education.

Conclusions

Under one diagnostic definition, the prevalence of sarcopenia and sarcopenic obesity is highest among Asians and lowest amongst blacks. Income and education had significant associations with sarcopenia and sarcopenic obesity, in males and females, respectively.

背景:肌少症和肌少性肥胖是新兴的公共卫生问题。真正的流行率是未知的，不同研究之间的估计差异很大。没有大规模的单一研究比较白人、黑人、亚洲人和西班牙人之间的患病率，而我们打算在这里做。本研究还考察了种族和社会经济因素对肌肉减少症和肌肉减少性肥胖的影响。方法本研究纳入10325名来自路易斯安那州的参与者。通过双能x线吸收仪(DXA)扫描测量的阑尾瘦质量(ASM)除以身高的平方(ASM/h2)来定义肌肉减少症。肌肉减少性肥胖被定义为肌肉减少加上肥胖(腰臀比)。结果男性总体肌肉减少率为17.6%，女性总体肌肉减少率为13.7%，女性总体肌肉减少率为2.5%。亚洲男性(40.6%，14.4%)和女性(30.1%，8.0%)的肌肉减少症和肌肉减少性肥胖率最高。黑人男性(3.7%)和女性(0.9%)的肌肉减少肥胖率最低。我们发现男性肌肉减少性肥胖与年龄、种族和收入有显著关联;在女性中，根据年龄、种族和教育程度。结论在一种诊断定义下，肌肉减少症和肌肉减少性肥胖的患病率在亚洲人中最高，在黑人中最低。在男性和女性中，收入和教育程度分别与肌肉减少症和肌肉减少性肥胖有显著关联。

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引用次数: 21