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Complex Management of AV Nodal Agent Toxicity in Patients with Cardiac Devices: Massive Calcium Channel Antagonist Overdose in a Patient with a Permanent Pacemaker. 心脏装置患者房室结药物毒性的复杂管理:永久性起搏器患者大量钙通道拮抗剂过量。
Pub Date : 2022-01-01
Patric W Gibbons, Peter R Chai, Timothy B Erickson

We present a unique case of a massive calcium channel antagonist overdose in a patient with a permanent pacemaker. Upon presentation after the acute overdose, the patient's cardiac device was found to be pacing to an adequate rate (75 beats per minute) and she was admitted to the cardiac intensive care unit. Approximately 24 hours after her ingestion, she acutely decompensated and became hypotensive. The patient was started on infusions of norepinephrine, epinephrine, phenylephrine, and vasopressin. Her mean arterial pressure was unresponsive to multi-vasopressor therapy. She was then given a bolus of methylene blue and high-dose insulin euglycemic therapy. Despite these treatments, the patient remained hypotensive Therefore, intralipid emulsion therapy and IV epinephrine pushes were also administered. As a result of her shock and hemodynamic instability, her course was further complicated by hypoxemic respiratory failure for which she required ventilatory support and developed oliguric renal failure for which she was initiated on continuous veno-venous hemofiltration. This case emphasizes the challenges in managing complex physiology associated with nodal agent toxicity and is the first, to our knowledge, to describe management in a patient who already had a pacemaker, though it was ultimately ineffective in avoiding the patient's profound decompensation.

我们提出了一个独特的情况下,大量钙通道拮抗剂过量的病人与永久起搏器。在急性用药过量后就诊时,发现患者的心脏装置起搏速度正常(每分钟75次),她被送入心脏重症监护病房。摄入后约24小时,患者出现急性代偿失代偿并出现低血压。患者开始输注去甲肾上腺素、肾上腺素、苯肾上腺素和抗利尿激素。她的平均动脉压对多种血管加压药物治疗无反应。随后给予大剂量亚甲蓝和高剂量胰岛素治疗。尽管进行了这些治疗,患者仍然处于低血压状态,因此,脂质乳内治疗和静脉肾上腺素推压也被给予。由于休克和血流动力学不稳定,她的病程因低氧性呼吸衰竭而进一步复杂化,她需要呼吸机支持,并发展为少尿性肾衰竭,她开始持续静脉-静脉血液滤过。据我们所知,该病例强调了管理与结剂毒性相关的复杂生理的挑战,并且是第一个描述已经安装了起搏器的患者的管理,尽管它最终无法避免患者的严重失代偿。
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引用次数: 0
Penetrating Aortic Ulcer, Intramural Hematoma, and Aortic Dissection - All in One 穿透性主动脉溃疡,壁内血肿,主动脉夹层-一体
Pub Date : 2022-01-01 DOI: 10.15761/jccr.1000179
Mostafa Mahmoud Fahmy, Sangeetha Palanivelu, Qamar Al tinawi, Mostafa Reda Mostafa, Yomna Elbandrawy, Q. Radaideh, A. Smer
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引用次数: 0
Contained Rupture of a Left Coronary Sinus of Valsalva Aneurysm: A Case Report 左冠状动脉窦破裂1例
Pub Date : 2022-01-01 DOI: 10.15761/jccr.1000178
Kipson Charles, Arroj Ali, Ann T. Tong
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引用次数: 0
Correlation of Angiographic and Anatomic Findings with the Study of Intracoronary Pressure Wire in Patients with Intramyocardial Bridges Presenting Different Clinical Profiles 不同临床表现的心桥患者冠状动脉内压丝的血管造影和解剖表现的相关性研究
Pub Date : 2022-01-01 DOI: 10.15761/jccr.1000177
Novo García Enrique, Castillo Sandoval Alicia, Jurado López Juan Carlos, Jiménez Martínez Maria Eulalia, Benitez Peyrat Jaime, Angulo Llanos Rocio, Seidelberger Bernhard, García Magallón Belen, Torán Martínez Claudio, Balaguer Recena Javier
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引用次数: 0
Successful Use of Extracorporeal Cardiopulmonary Resuscitation in a COVID-19 Patient 体外心肺复苏在COVID-19患者中的成功应用
Pub Date : 2022-01-01 DOI: 10.15761/jccr.1000176
Fatima S. Alwan, Zachary R. Bergman, Jillian K. Wothe, Jason A. Bartos, R. Bakken, Melissa E. Brunsvold
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引用次数: 0
An Unusual Sticky Situation of New-Onset Right Sided Heart Failure. 新发右侧心力衰竭的不寻常粘性情况。
Pub Date : 2021-09-01 DOI: 10.15761/jccr.1000168
Demetrio Sharp Dimitri, Priya V Parikh, Sneha Sharma, Sven Wang, Ahmed Souka, Mohamed Effat

This case highlights the importance of having constrictive pericarditis (CP) as a differential diagnosis in unexplained sign and symptoms of right-sided heart failure. This case portrays challenges in diagnosing CP caused by certain rheumatologic diseases despite advances in diagnostic modalities, clinical suspicion remains the most important tool for this diagnosis.

本病例强调了缩窄性心包炎(CP)作为右侧心力衰竭不明体征和症状鉴别诊断的重要性。本病例描述了诊断某些风湿病引起的CP的挑战,尽管诊断方式有所进步,但临床怀疑仍然是诊断的最重要工具。
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引用次数: 0
Left ventricular pseudoaneurysm complicating acute inferoposterior myocardial infarction 左心室假性动脉瘤并发急性后段心肌梗死
Pub Date : 2021-08-25 DOI: 10.15761/JCCR.1000155
V. Yadav, R. Gajurel, C. Poudel, Manju Sharma, S. Adhikari
Left ventricular pseudoaneurysm is a rare mechanical complication of acute myocardial infarction. The study aims at early detection of a rare complication of myocardial infarction which carries a grave prognosis and whose mainstay of management is surgical. We describe a 60 year old male who presented with typical ischemic type of chest pain with low blood pressure and heart rate. A 12 lead electrocardiogram showed atrioventricular (AV) dissocation with ST segment elevation in the inferior leads. The initial echocardiography depicted moderate pericardial effusion without tamponade. The possibilities of both, acute mechanical complications of myocardial infarction, and acute aortic dissection were sought of. The echocardiography on the following day revealed a free wall rupture of the infero-posterior wall of left ventricle with formation of a pseudoaneurysm. This was further proved by the computed tomography (CT) of chest with contrast, which in addition, ruled out acute aortic dissection. The patient was planned for an early surgery. Pre-operative coronary angiogram revealed complete occlusion of distal left circumflex artery and 70-80% discrete stenosis of mid left anterior descending artery.
摘要左心室假性动脉瘤是急性心肌梗死中一种罕见的机械并发症。该研究旨在早期发现一种罕见的心肌梗死并发症,这种并发症预后严重,主要的治疗方法是手术。我们描述了一个60岁的男性谁提出了典型的缺血性胸痛与低血压和心率。12导联心电图显示房室(AV)脱离伴下导联ST段抬高。最初的超声心动图显示中度心包积液,无心包填塞。急性机械并发症的心肌梗死和急性主动脉夹层的可能性进行了探讨。第二天的超声心动图显示左心室下后壁自由破裂并形成假性动脉瘤。胸部CT造影剂进一步证实了这一点,并排除了急性主动脉夹层的可能。该病人计划进行早期手术。术前冠状动脉造影显示左旋远端动脉完全闭塞,左中前降支70-80%离散狭窄。
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引用次数: 0
Pitiriasis rosada, una reacción exantemática 粉红色糠疹,一种皮疹反应
Pub Date : 2021-08-24 DOI: 10.15446/cr.v7n2.95527
Michel Faizal-Geagea
Las urgencias dermatológicas son eventos poco frecuentes que puedenser causados por alteraciones agudas de la salud, con o sin afectaciónsistémica, o por enfermedades crónicas cuando se presentan cuadros de agudización.
皮肤紧急情况是罕见的事件,可能由有或没有全身性影响的急性健康损害引起,或由出现恶化情况的慢性疾病引起。
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引用次数: 0
Condrosarcoma de células claras en tibia proximal. Reporte de caso
Pub Date : 2021-08-24 DOI: 10.15446/cr.v7n2.89300
D. Gutiérrez-Zúñiga, H. Martín, Oscar Messa-Botero, Jerónimo Sotomayor, F. Linares
Introducción. El condrosarcoma de células claras es un subtipo de tumor poco frecuente del grupo de los condrosarcomas de bajo grado. A diferencia de los condrosarcomas convencionales, estos tumores se presentan principalmente en epífisis de huesos largos. Dadas sus características líticas de aspecto quístico, pueden confundirse con quistes óseos, por lo que su diagnóstico debe hacerse por histopatología e inmunohistoquímica mediante biopsia. Igualmente, la negatividad para citoqueratinas y anticuerpos antiendomisio es una herramienta para descartar el diagnóstico diferencial de metástasis. Su tratamiento es quirúrgico, bien sea con manejo intralesional o resección completa con márgenes libres.Presentación del caso. Mujer de 46 años quien consultó al servicio de ortopedia oncológica de una institución de IV nivel de atención por un cuadro clínico de 8 meses de evolución consistente en dolor en la cara medial de la rodilla izquierda a nivel de la tibia proximaluna. Se practicaron imágenes diagnósticas que mostraron una lesión quística en el platillo tibial lateral; se ordenó biopsia de la lesión, y mediante histopatología e inmunohistoquímica se diagnosticó condrosarcoma de células claras. Se realizó un manejo quirúrgico con resección de la lesión con márgenes libres y una reconstrucción del defecto óseo con un aloinjerto estructural de tibia proximal, con lo cual se obtuvo una evolución satisfactoria.Conclusiones. Se presenta el caso de una paciente con un subtipo de condrosarcoma de bajo grado infrecuente en su presentación y localización, quien fue diagnosticada mediante inmunohistoquímica y tratada quirúrgicamente para lograr un salvamento exitoso de su extremidad.
介绍。透明细胞软骨肉瘤是低级别软骨肉瘤组中罕见的肿瘤亚型。与传统的软骨肉瘤不同,这些肿瘤主要发生在长骨骨骺。由于其溶解性囊肿特征,可与骨囊肿混淆,诊断应通过组织病理学和活检免疫组化。同样,细胞角蛋白和抗子宫内膜抗体阴性是排除转移鉴别诊断的工具。其治疗方法为手术,可采用病灶内处理或完全切除游离边缘。案件陈述。一名46岁的妇女,在IV级护理机构的肿瘤骨科服务中咨询了一份8个月的临床病程,包括左膝关节内侧胫骨近端疼痛。诊断影像显示胫骨外侧板囊性病变;对病变进行活检,组织病理学和免疫组化诊断为透明细胞软骨肉瘤。本研究的目的是评估胫骨近端结构异体移植后的骨缺损,并评估胫骨近端结构异体移植后的骨缺损。本研究的目的是描述一种罕见的低级别软骨肉瘤亚型,通过免疫组化诊断,并通过手术治疗成功挽救其肢体。
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引用次数: 0
Rosai-Dorfman disease: a rare presentation of extranodal involvement of isolated bone. Case report 罗赛-多夫曼病:结外受累孤立骨的罕见表现。病例报告
Pub Date : 2021-08-24 DOI: 10.15446/cr.v7n2.88306
C. García-Prada, Tomás Rodríguez-Yánez, Carlos Alberto Ferrer-Santos
Introduction: Rosai-Dorfman disease (RDD), also known as sinus histiocytosis, is a rare disorder characterized by histiocyte proliferation. Case presentation: A 33-year-old man consulted the emergency department of a tertiary care institution in Cartagena de Indias, Colombia, due to a 6-month history of progressive deformity in the frontal right side of the face, associated with pain of slow progression, without any other symptoms or dermatological involvement. There were no other major findings on physical examination and laboratory tests performed were negative. Imaging scans obtained showed extensive inflammatory involvement of the frontal bone, which led to suspect osteomyelitis as the first diagnostic possibility. A biopsy of the lesion was performed with negative cultures for bacteria, which allowed establishing a diagnosis of extranodal Rosai-Dorfman disease with isolated bone involvement. Treatment with systemic corticosteroids was indicated with poor response, so methotrexate was added, achieving an evident improvement after 2 months. Conclusions: Little is known about the manifestations of Rosai-Dorfman disease and its treatment in the adult population. The present case report contributes to expanding the literature on this topic, which can present with rare symptoms that may pose challenges for its diagnosis.
Rosai-Dorfman病(RDD),又称窦性组织细胞增多症,是一种罕见的以组织细胞增生为特征的疾病。病例介绍:一名33岁男子就诊于哥伦比亚Cartagena de Indias一家三级保健机构的急诊科,因6个月的面部右侧额部进行性畸形史,伴有缓慢进展的疼痛,无任何其他症状或皮肤病变。身体检查没有其他重大发现,实验室检查也呈阴性。成像扫描显示额骨广泛的炎症累及,这导致怀疑骨髓炎作为第一诊断可能性。对病变进行活检,细菌培养阴性,从而确定结外Rosai-Dorfman病伴孤立骨累及的诊断。全身性糖皮质激素治疗效果不佳,因此加用甲氨蝶呤,2个月后明显改善。结论:成人Rosai-Dorfman病的临床表现及治疗方法尚不清楚。本病例报告有助于扩大关于该主题的文献,该主题可以呈现罕见的症状,可能对其诊断构成挑战。
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Journal of cardiology case reports
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