Pub Date : 2022-08-31DOI: 10.33696/signaling.3.075
{"title":"Phosphoinositide-Specific Phospholipases C in Psychiatric Diseases and Suicide","authors":"","doi":"10.33696/signaling.3.075","DOIUrl":"https://doi.org/10.33696/signaling.3.075","url":null,"abstract":"","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87623589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.33696/signaling.3.077
{"title":"Repurposed Anti-IL-6 Therapeutics, Another Way to Quell the Cytokine Storm in Tuberculosis","authors":"","doi":"10.33696/signaling.3.077","DOIUrl":"https://doi.org/10.33696/signaling.3.077","url":null,"abstract":"","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74867439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.33696/signaling.3.073
Zhaodan Wang, Xueqin Chen, Qingxiang Sun
The synthetic activity of serine is significantly upregulated in several cancers [1]. Homo sapiens 3-phosphoglycerate dehydrogenase (PHGDH) catalyzes the rate-limiting step of serine synthesis, which converts 3-phosphoglycerate (3PG) and NAD+ to 3-phosphohydroxypyruvate and NADH [2,3]. PHGDH inhibitors were extensively pursued recently for their use in the treatment of affected cancers [4,5]. Among the inhibitors identified, three natural products including azacoccone E [6], ixocarpalactone A [7], withaferin A and oridonin [8] were shown to effectively inhibit PHGDH enzyme activity and cancer cell growth.
{"title":"Insights from Natural Product PHGDH Inhibitor Studies","authors":"Zhaodan Wang, Xueqin Chen, Qingxiang Sun","doi":"10.33696/signaling.3.073","DOIUrl":"https://doi.org/10.33696/signaling.3.073","url":null,"abstract":"The synthetic activity of serine is significantly upregulated in several cancers [1]. Homo sapiens 3-phosphoglycerate dehydrogenase (PHGDH) catalyzes the rate-limiting step of serine synthesis, which converts 3-phosphoglycerate (3PG) and NAD+ to 3-phosphohydroxypyruvate and NADH [2,3]. PHGDH inhibitors were extensively pursued recently for their use in the treatment of affected cancers [4,5]. Among the inhibitors identified, three natural products including azacoccone E [6], ixocarpalactone A [7], withaferin A and oridonin [8] were shown to effectively inhibit PHGDH enzyme activity and cancer cell growth.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86535347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.33696/signaling.3.070
M. Cho, S. Park, Soon‐Kyung Hwang
Akt, or protein kinase B, a serine/threonine protein kinase [4], is activated downstream from phosphatidylinositol 3-kinase (PI3K), by various growth factors, including insulin, insulin-like growth factor-I, and epidermal growth factor [5]. Activated Akt (phospho-Akt, p-Akt) is a strong promoter of cell survival because it antagonizes and inactivates various components of the apoptotic cascade such as proapoptotic Bad, caspase-9, and forkhead transcription factor family members [6,7]. The PI3K/Akt signaling pathway regulates the G1/S cell cycle transition by modulating the transcription of cell cycle proteins and suppressing cell cycle inhibitors [8]. A dysregulated cell cycle is often associated with increased tumorigenesis and accelerated tumor growth [9].
{"title":"The Role of FCH Domain Only 1 (FCHO1) as an Oncogene in Lung Cancer","authors":"M. Cho, S. Park, Soon‐Kyung Hwang","doi":"10.33696/signaling.3.070","DOIUrl":"https://doi.org/10.33696/signaling.3.070","url":null,"abstract":"Akt, or protein kinase B, a serine/threonine protein kinase [4], is activated downstream from phosphatidylinositol 3-kinase (PI3K), by various growth factors, including insulin, insulin-like growth factor-I, and epidermal growth factor [5]. Activated Akt (phospho-Akt, p-Akt) is a strong promoter of cell survival because it antagonizes and inactivates various components of the apoptotic cascade such as proapoptotic Bad, caspase-9, and forkhead transcription factor family members [6,7]. The PI3K/Akt signaling pathway regulates the G1/S cell cycle transition by modulating the transcription of cell cycle proteins and suppressing cell cycle inhibitors [8]. A dysregulated cell cycle is often associated with increased tumorigenesis and accelerated tumor growth [9].","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86220186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.33696/signaling.3.074
L. Uyttebroek, S. V. Remoortel, Laura Buyssens, Nastasia Popowycz, G. Hubens, Jean-Pierre, Timmermans, L. Nassauw
Obesity is a worldwide epidemic and a major risk factor for numerous diseases. The regulation of feeding behavior and body weight depends on a wide range of neuronal pathways influencing satiety and hunger. Serotonin (5-HT) is one of those players identified to have a profound effect on energy homeostasis. The effect of obesity on 5-HT metabolism in the gastrointestinal (GI) tract and its underlying mechanisms still needs to be further elaborated. The aim of the present study was to investigate the effect of diet-induced obesity (DIO) on 5-HT in the enteric nervous system, the expression of different enzymes and receptors of the 5-HT pathway in the brain and GI tract, GI transit and behavior. Zebrafish were fed either a high caloric diet during 4 weeks or a normal diet (CNTL). The proportion of serotonergic neurons in the GI tract was analyzed using immunofluorescent double staining. Quantitative PCR (qPCR) was performed on brain and GI tissue to analyze the expression of 5-HT receptors, the 5-HT precursor, tryptophan hydroxylase (tph), 5-HT transporter (SERTa/b) and monoamine oxidase (MAO). GI transit was measured by gavaging glass beads or providing fluorescently labeled food and calculating the geometric centre (GC). Swim behavior was calculated as preferential swim area, swim speed and distance. Results showed an increase in body mass index after 4 weeks. Overfeeding increased the proportion of serotonergic neurons in the proximal GI tract. qPCR revealed significantly elevated levels for tph2, but not for tph1a/b, in the brain and the intestine of DIO fish. Furthermore, a significant increase in the expression of the 5-HT4 receptor and SERTa were observed in the brain, but not in the GI tract, while 5-HT2b receptor showed to be upregulated in the GI tract, but not the brain. GC was increased after feeding with fluorescently labeled food. Also, the intestinal length in DIO fish was significantly larger, indicating higher transit rates compared to CNTL fish. No differences in behavior were observed between the two groups. This study, revealed an increase in 5-HT expression in enteric neurons probably due to an increased tph2 expression in the intestine, resulting in increased GI transit. Furthermore, DIO exhibited increased expression of the 5-HT4 receptor and SERTa in the brain, and 5-HT2b receptor in the GI tract, respectively. The present data obtained from zebrafish are in line with earlier findings in mammalian models and further validate the zebrafish as a model for GI research.
{"title":"The Effect of Diet Induced Obesity on Serotonin in Zebrafish","authors":"L. Uyttebroek, S. V. Remoortel, Laura Buyssens, Nastasia Popowycz, G. Hubens, Jean-Pierre, Timmermans, L. Nassauw","doi":"10.33696/signaling.3.074","DOIUrl":"https://doi.org/10.33696/signaling.3.074","url":null,"abstract":"Obesity is a worldwide epidemic and a major risk factor for numerous diseases. The regulation of feeding behavior and body weight depends on a wide range of neuronal pathways influencing satiety and hunger. Serotonin (5-HT) is one of those players identified to have a profound effect on energy homeostasis. The effect of obesity on 5-HT metabolism in the gastrointestinal (GI) tract and its underlying mechanisms still needs to be further elaborated. The aim of the present study was to investigate the effect of diet-induced obesity (DIO) on 5-HT in the enteric nervous system, the expression of different enzymes and receptors of the 5-HT pathway in the brain and GI tract, GI transit and behavior. Zebrafish were fed either a high caloric diet during 4 weeks or a normal diet (CNTL). The proportion of serotonergic neurons in the GI tract was analyzed using immunofluorescent double staining. Quantitative PCR (qPCR) was performed on brain and GI tissue to analyze the expression of 5-HT receptors, the 5-HT precursor, tryptophan hydroxylase (tph), 5-HT transporter (SERTa/b) and monoamine oxidase (MAO). GI transit was measured by gavaging glass beads or providing fluorescently labeled food and calculating the geometric centre (GC). Swim behavior was calculated as preferential swim area, swim speed and distance. Results showed an increase in body mass index after 4 weeks. Overfeeding increased the proportion of serotonergic neurons in the proximal GI tract. qPCR revealed significantly elevated levels for tph2, but not for tph1a/b, in the brain and the intestine of DIO fish. Furthermore, a significant increase in the expression of the 5-HT4 receptor and SERTa were observed in the brain, but not in the GI tract, while 5-HT2b receptor showed to be upregulated in the GI tract, but not the brain. GC was increased after feeding with fluorescently labeled food. Also, the intestinal length in DIO fish was significantly larger, indicating higher transit rates compared to CNTL fish. No differences in behavior were observed between the two groups. This study, revealed an increase in 5-HT expression in enteric neurons probably due to an increased tph2 expression in the intestine, resulting in increased GI transit. Furthermore, DIO exhibited increased expression of the 5-HT4 receptor and SERTa in the brain, and 5-HT2b receptor in the GI tract, respectively. The present data obtained from zebrafish are in line with earlier findings in mammalian models and further validate the zebrafish as a model for GI research.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85443927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.33696/signaling.3.071
Eirini Papamanoli, K. Kyriakidou, I. Karoussis
Eirini Papamanoli1, Kyriaki Kyriakidou2, Ioannis K Karoussis3* 1DDS, MS Molecular Physiology, National Kapodistrian University of Athens, Greece 2Biologist, PhD, University of Ancona Italy, Post-doctoral researcher, National Kapodistrian University of Athens, Greece 3Associate Professor, Department of Periodontology, School of Dentistry, National Kapodistrian University of Athens, Greece *Correspondence should be addressed to Ioannis K Karoussis, ikaroussis@dent.uoa.gr
Eirini Papamanoli1, Kyriaki Kyriakidou2, Ioannis K Karoussis3* 1DDS, MS分子生理学，希腊雅典国立Kapodistrian大学2生物学家，博士，意大利安科纳大学，博士后研究员，希腊雅典国立Kapodistrian大学3副教授，牙周病学系，希腊雅典国立Kapodistrian大学牙科学院*通信请发送至Ioannis K Karoussis, ikaroussis@dent.uoa.gr
{"title":"Low-level Laser Therapy in the Oral Cavity: A Retrospection in the Future","authors":"Eirini Papamanoli, K. Kyriakidou, I. Karoussis","doi":"10.33696/signaling.3.071","DOIUrl":"https://doi.org/10.33696/signaling.3.071","url":null,"abstract":"Eirini Papamanoli1, Kyriaki Kyriakidou2, Ioannis K Karoussis3* 1DDS, MS Molecular Physiology, National Kapodistrian University of Athens, Greece 2Biologist, PhD, University of Ancona Italy, Post-doctoral researcher, National Kapodistrian University of Athens, Greece 3Associate Professor, Department of Periodontology, School of Dentistry, National Kapodistrian University of Athens, Greece *Correspondence should be addressed to Ioannis K Karoussis, ikaroussis@dent.uoa.gr","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87216721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.33696/signaling.3.069
Olaf Latta, A. Bechthold
Natural products play a crucial role in the development of drugs. Over the last forty years one third of all approved drugs are natural products or derivatives from them. Additionally, another third uses at least a pharmacophore of a natural product. The therapeutic areas do not only cover the widely known fields of antibiotics and cytostatics, but also anticoagulants, anti-hypertensive or anti-diabetic drugs and many more [1]. Nevertheless, antibiotics are one of the most prominent fields for natural products. Increasing antibiotic resistance in the upcoming years is leading to an urgent need for the development of new antibiotics [2]. The World Health Organization stated the antibiotic resistance crisis to be a “global public health concern”. Also, the Center for Disease Control and Prevention and the European Medicines Agency are substantially concerned about the course in the last decades [2-4]. Streptomyces, a genus of the family Streptomycetaceae and the class Actinobacteria, are the largest source of natural products among microorganisms. A large proportion of all antibiotics originally derive from them [5]. However, in the last years only a handful of new drugs in the antibiotic field were approved. So, there is an urgent need to search for new natural compounds beyond of the existing ones [6]. A high rate of rediscovered compounds is one problem of common techniques for screening for new Abstract
{"title":"C-di-GMP and Its Role in Regulation of Natural Products Production","authors":"Olaf Latta, A. Bechthold","doi":"10.33696/signaling.3.069","DOIUrl":"https://doi.org/10.33696/signaling.3.069","url":null,"abstract":"Natural products play a crucial role in the development of drugs. Over the last forty years one third of all approved drugs are natural products or derivatives from them. Additionally, another third uses at least a pharmacophore of a natural product. The therapeutic areas do not only cover the widely known fields of antibiotics and cytostatics, but also anticoagulants, anti-hypertensive or anti-diabetic drugs and many more [1]. Nevertheless, antibiotics are one of the most prominent fields for natural products. Increasing antibiotic resistance in the upcoming years is leading to an urgent need for the development of new antibiotics [2]. The World Health Organization stated the antibiotic resistance crisis to be a “global public health concern”. Also, the Center for Disease Control and Prevention and the European Medicines Agency are substantially concerned about the course in the last decades [2-4]. Streptomyces, a genus of the family Streptomycetaceae and the class Actinobacteria, are the largest source of natural products among microorganisms. A large proportion of all antibiotics originally derive from them [5]. However, in the last years only a handful of new drugs in the antibiotic field were approved. So, there is an urgent need to search for new natural compounds beyond of the existing ones [6]. A high rate of rediscovered compounds is one problem of common techniques for screening for new Abstract","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75378346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-02DOI: 10.33696/signaling.3.072
H. Ageta, K. Tsuchida
The multivesicular body (MVB), also called late endosome, is a subset of specialized endosomal compartments rich in intraluminal vesicles (ILVs). Multiple ILVs accumulate within MVBs [1,2]. ILVs are formed by invagination of the limiting membrane of early endosomes and budding into the lumen of the organelle. ILVs sequester specific proteins, lipids and cytosolic components. Although exosome release is known to be mediated by MVB, its regulation is not fully understood. Once MVBs fuse with lysosomes, the cargo of the ILVs is degraded. On the other hand, when MVBs fuse with the plasma membrane, the contents of ILVs are secreted outside the cell via exosomes. Most synthesized proteins are modified by post-translational modifiers, which regulate the amount, localization, stability, and activity of proteins. Post-translational modifications (PTM) are involved in the regulation of cellular functions [3]. The formation of MVB is known to be regulated by the endosomal sorting complexes required for transport (ESCRT) systems [1], as well as tetraspanins and UBLs. ESCRT systems are also dependent on ubiquitination [4]. Recently, ubiquitin and UBLs were reported to be involved in the regulation of ILV and MVB. Proteins modified by ubiquitin, SUMO, or UBL3 were incorporated into MVB.
{"title":"Novel Therapeutic Strategies for Exosome-Related Diseases","authors":"H. Ageta, K. Tsuchida","doi":"10.33696/signaling.3.072","DOIUrl":"https://doi.org/10.33696/signaling.3.072","url":null,"abstract":"The multivesicular body (MVB), also called late endosome, is a subset of specialized endosomal compartments rich in intraluminal vesicles (ILVs). Multiple ILVs accumulate within MVBs [1,2]. ILVs are formed by invagination of the limiting membrane of early endosomes and budding into the lumen of the organelle. ILVs sequester specific proteins, lipids and cytosolic components. Although exosome release is known to be mediated by MVB, its regulation is not fully understood. Once MVBs fuse with lysosomes, the cargo of the ILVs is degraded. On the other hand, when MVBs fuse with the plasma membrane, the contents of ILVs are secreted outside the cell via exosomes. Most synthesized proteins are modified by post-translational modifiers, which regulate the amount, localization, stability, and activity of proteins. Post-translational modifications (PTM) are involved in the regulation of cellular functions [3]. The formation of MVB is known to be regulated by the endosomal sorting complexes required for transport (ESCRT) systems [1], as well as tetraspanins and UBLs. ESCRT systems are also dependent on ubiquitination [4]. Recently, ubiquitin and UBLs were reported to be involved in the regulation of ILV and MVB. Proteins modified by ubiquitin, SUMO, or UBL3 were incorporated into MVB.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77538641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-24DOI: 10.33696/signaling.3.063
G. H. Bomfim
The electrochemical driving forces across the plasma membrane mediated by ion channels, pumps, and exchangers are essential for cellular homeostasis, regulating a wide range of biological processes [1,2]. Although both excitable (e.g., neurons) and non-excitable (e.g., lymphocytes) cells manage their cellular functions through plasmalemmal ion flux, excitable cells change the membrane potential mediated by depolarization and voltage-gated ion channels, while nonexcitable cells control this process by the different downstream processes and ligand-gated ion channels [2,3]. Sodium (Na+) is the principal extracellular cation, being carried to the intracellular space mainly through inward Na+ currents (INa) [2]. Pioneering studies documented that inhibition of INa, but not the calcium (Ca2+) absence, abolished the action potential, indicating that Na+ influx is essential for cell excitability, action Abstract
{"title":"TRPM8 Channels and SOCE: Modulatory Crosstalk between Na+ and Ca2+ Signaling","authors":"G. H. Bomfim","doi":"10.33696/signaling.3.063","DOIUrl":"https://doi.org/10.33696/signaling.3.063","url":null,"abstract":"The electrochemical driving forces across the plasma membrane mediated by ion channels, pumps, and exchangers are essential for cellular homeostasis, regulating a wide range of biological processes [1,2]. Although both excitable (e.g., neurons) and non-excitable (e.g., lymphocytes) cells manage their cellular functions through plasmalemmal ion flux, excitable cells change the membrane potential mediated by depolarization and voltage-gated ion channels, while nonexcitable cells control this process by the different downstream processes and ligand-gated ion channels [2,3]. Sodium (Na+) is the principal extracellular cation, being carried to the intracellular space mainly through inward Na+ currents (INa) [2]. Pioneering studies documented that inhibition of INa, but not the calcium (Ca2+) absence, abolished the action potential, indicating that Na+ influx is essential for cell excitability, action Abstract","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83349024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-24DOI: 10.33696/signaling.3.066
Mélissa Ferrad, N. Ghazzaui, Hussein Issaoui, J. Cook-Moreau, Y. Denizot
Melissa Ferrad1,#, Nour Ghazzaui1,#, Hussein Issaoui2, Jeanne Cook-Moreau1, Yves Denizot1* 1Equipe Labellisée LIGUE 2018, UMR CNRS 7276, INSERM U1262, Université de Limoges, CBRS, rue Pr. Descottes, 87025 Limoges, France 2Present address : Nour Ghazzaui Vaccine Research Institute, INSERM U955, Hôpital Henri Mondor, 94010 Créteil, France; Hussein Issaoui Université Côte d'Azur, INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3 M), 06204, Nice, France #These authors contributed equally to this work *Correspondence should be addressed to Yves Denizot, yves.denizot@unilim.fr
Melissa Ferrad1，#， Nour Ghazzaui1，#， Hussein Issaoui2, Jeanne Cook-Moreau1, Yves Denizot1* 1team labeled LIGUE 2018, UMR CNRS 7276, INSERM U1262, universite de Limoges, CBRS, rue Pr. Descottes, 87025 Limoges，法国2Present地址:Nour Ghazzaui疫苗研究所，INSERM U955, hospital Henri Mondor, 94010 creteil，法国;Hussein Issaoui universite cote d’Azur, INSERM U1065, Centre mediterrenne de medecine molmolecular (C3 M)， 06204, Nice, France #这些作者对这项工作做出了同等的贡献*通信应发送到Yves Denizot, yves.denizot@unilim.fr
{"title":"AID and APOBEC3 Involvements in Non-Conventional IgD Class Switch Recombination in Mice","authors":"Mélissa Ferrad, N. Ghazzaui, Hussein Issaoui, J. Cook-Moreau, Y. Denizot","doi":"10.33696/signaling.3.066","DOIUrl":"https://doi.org/10.33696/signaling.3.066","url":null,"abstract":"Melissa Ferrad1,#, Nour Ghazzaui1,#, Hussein Issaoui2, Jeanne Cook-Moreau1, Yves Denizot1* 1Equipe Labellisée LIGUE 2018, UMR CNRS 7276, INSERM U1262, Université de Limoges, CBRS, rue Pr. Descottes, 87025 Limoges, France 2Present address : Nour Ghazzaui Vaccine Research Institute, INSERM U955, Hôpital Henri Mondor, 94010 Créteil, France; Hussein Issaoui Université Côte d'Azur, INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3 M), 06204, Nice, France #These authors contributed equally to this work *Correspondence should be addressed to Yves Denizot, yves.denizot@unilim.fr","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91267873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：