Journal of clinical and investigative dermatology最新文献

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Uncommon Petaloid Form of Seborrheic Dermatitis Seen in Fitzpatrick Skin Types V-VI. 菲茨帕特里克皮肤类型 V-VI 中常见的脂溢性皮炎花瓣状。

Journal of clinical and investigative dermatology

Pub Date : 2023-07-01 Epub Date: 2023-07-27 DOI: 10.13188/2373-1044.1000086

TongFan Wu, Timothy C Frommeyer, Craig A Rohan, Jeffrey B Travers

Background: Seborrheic dermatitis (SD) is an inflammatory disease that has a papulosquamous morphology in areas rich in sebaceous glands such as the scalp, face, and body folds. Petaloid SD is an uncommon presentation found in patients with dark skin (Fitzpatrick Skin type V-VI). This form of SD can appear as pink or hypopigmented polycyclic coalescing rings or scaly macules and patches in the typical areas SD appears, which can mimic other conditions including lupus erythematosus. There is significant disproportion in the representation of darker skin types in dermatological textbooks and scarce literature on petaloid SD. This case demonstrates the presentation of the petaloid SD in an African American patient to contribute to the limited literature on dermatological conditions within this population.

Case report: A 25-year-old African American female with a history of mild hidradenitis suppurativa and asthma who presented with asymptomatic hypopigmented rashes throughout her face, scalp, and chest. She was diagnosed with the petaloid form SD and treated with ketoconazole shampoo once weekly, ketoconazole cream 1-2x daily, and hydrocortisone 2.5% ointment twice daily as needed. At six-week post-treatment follow-up, the patient's rashes significantly improved.

Conclusions: The petaloid form of SD is commonly experienced in dark-skinned patients. While common treatments for SD are effective in this form of SD, special consideration of skin types, skincare habits, and haircare in the African American population should be explored. This case report demonstrates how this uncommon skin condition presents in patients of Fitzpatrick skin type V-VI and a successful treatment course.

背景：脂溢性皮炎（SD）是一种炎症性疾病，在头皮、面部和身体褶皱等皮脂腺丰富的部位呈丘疹鳞屑状形态。瓣状皮炎是一种不常见的表现，多见于深色皮肤（菲茨帕特里克皮肤类型 V-VI）的患者。这种 SD 可表现为粉红色或色素减退的多环状凝聚环或鳞屑性斑疹和斑块，出现在 SD 的典型部位，可与红斑狼疮等其他疾病相似。在皮肤病学教科书中，深色皮肤类型的比例严重失调，有关花瓣状 SD 的文献也很少。本病例展示了一名非裔美国患者的花瓣状 SD 表现，为该人群中有限的皮肤病文献做出了贡献：一名 25 岁的非裔美国女性，有轻度化脓性扁桃体炎和哮喘病史，面部、头皮和胸部出现无症状的色素减退性皮疹。她被诊断为花瓣状 SD，并接受了酮康唑洗发水每周一次、酮康唑乳膏每天 1-2 次、2.5% 氢化可的松软膏每天两次的治疗。在治疗后六周的随访中，患者的皮疹明显好转：结论：花瓣状 SD 常见于深肤色患者。虽然常见的 SD 治疗方法对这种形式的 SD 很有效，但应特别考虑非裔美国人的皮肤类型、护肤习惯和发型。本病例报告展示了 Fitzpatrick V-VI 型皮肤患者如何出现这种不常见的皮肤病，以及成功的治疗过程。

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引用次数: 0

Evaluation of A Natural Anti- Dandruff Technology in a Shampoo Formulation via In-vivo and In-vitro Methods 通过体内和体外方法评价洗发水配方中的天然防屑技术

Journal of clinical and investigative dermatology

Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000083

H. Ahmed

Background: Natural anti dandruff efficacy is an area of interest as there is a consumer need for natural technologies in over-the-counter shampoo formulations. Aim: This research explored dipotassium glycyrrhizate (DPG) for anti dandruff benefit utilizing in vitro and in vivo methodologies, examining a shampoo formulation with 0.15% DPG. Patients/Method: The in vitro investigation focused on the evaluation of antimicrobial efficacy of DPG in a shampoo formulation by use of bacteriostatic efficacy testing as well as a short interval kill test against well known dandruff causing microorganism i.e. Malassezia . Clinically, 28 female and male subjects possessing visible dandruff were enrolled in a non-comparative study with 1 shampoo formulation containing 0.15% DPG. A trained investigator conducted visual technical assessments evaluating dandruff intensity at baseline and after product use over 2 weeks. A product performance self-assessment questionnaire was also completed for all subjects. The clinical was conducted under the supervision of a dermatologist. Results: Shampoo formulation with 0.15% DPG showed bacteriostatic efficacy against well known dandruff causing microorganisms i.e. Malassezia . The short interval kill test shows that a shampoo formulation with 0.15% DPG is more effective against Malassezia furfur (ATCC 14521) compared to the placebo, a non-anti dandruff shampoo. Clinically, a shampoo formulation with 0.15% DPG significantly reduced visible flakes/dandruff after 1, 7 and 14 days of use from baseline and the greatest improvement as compared to baseline was seen at week 2 (P < 0.001) with 90% improvement in reduction of visible flakes/dandruff. The self-assessment questionnaire results correlated to the visual technical assessment results.

背景:天然去屑功效是一个令人感兴趣的领域，因为消费者需要在非处方洗发水配方中使用天然技术。目的:本研究利用体外和体内方法探讨甘草酸二钾(DPG)的抗头皮屑作用，考察含0.15%甘草酸二钾的洗发水配方。患者/方法:通过体外抑菌试验和短间隔杀灭试验，评价DPG在洗发制剂中的抗菌效果，并对引起头皮屑的微生物马拉色菌进行杀灭。临床上，28名有明显头皮屑的男女受试者被纳入一项非比较研究，使用一种含有0.15% DPG的洗发水配方。一名训练有素的调查员进行了视觉技术评估，在基线和产品使用超过2周后评估头皮屑强度。所有受试者还完成了一份产品性能自我评估问卷。临床试验是在皮肤科医生的监督下进行的。结果:含0.15% DPG的洗发水配方对引起头皮屑的微生物马拉色菌具有抑菌作用。短间隔杀灭试验表明，与安慰剂相比，含有0.15% DPG的洗发水配方对马拉色菌(ATCC 14521)更有效，后者是一种不抗头皮屑的洗发水。在临床上，0.15% DPG的洗发水配方在使用1、7和14天后显著减少了可见的皮屑/头皮屑，与基线相比，在第2周出现了最大的改善(P < 0.001)，可见皮屑/头皮屑减少了90%。自评问卷结果与视觉技术评价结果相关。

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引用次数: 0

Digital Dermoscopy, Reflectance Confocal Microscopy, and Pigmented Lesion Assay Gep for In-Vivo Monitoring of Multiple Halo Nevi on an Adult Patient 数字皮肤镜、反射共聚焦显微镜和色素病变测定Gep用于成人患者多发性晕痣的体内监测

Journal of clinical and investigative dermatology

Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000084

J. Ludzik

引用次数: 0

Mycosis Fungoides Presenting After Dupilumab Therapy: Case Report and Systematic Review 杜匹单抗治疗后出现蕈样真菌病:病例报告和系统评价

Journal of clinical and investigative dermatology

Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000085

D. Fivenson

．

引用次数: 0

Role of Malassezia furfur and M. globosa in Dandruff and Seborrheic Dermatitis 毛马拉色菌和球孢菌在头皮屑和脂溢性皮炎中的作用

Journal of clinical and investigative dermatology

Pub Date : 2023-01-01 DOI: 10.13188/2373-1044.1000082

CD Silvanose, V. Jibin

Dandruff is a common problem in both teens and adults. This study is to evaluate the role of bacteria and fungi associated with dandruff and seborrheic dermatitis. Malassezia furfur (70%) was the predominant isolate, followed by Malassezia globosa (30%) which included mixed infection (15%) of both M. furfur and M. globosa together adding as the significant causative agents (p < 0.00001) as compared to healthy teens. A qualitative in-vitro susceptibility study was performed with Ketoconazole which showed good in-vitro anti-Malassezia activity with a greater inhibitory zone, and similar anti-Malassezia activity was shown by tea tree oil and 1% selenium sulfide. A follow-up study was performed after treatment with 1% selenium sulfide shampoo and showed 92.5% efficiency which suggests a possible solution for dandruff and seborrheic dermatitis.

头皮屑在青少年和成年人中都是一个常见的问题。本研究旨在评估细菌和真菌在头皮屑和脂溢性皮炎中的作用。与健康青少年相比，毛马拉色菌(70%)是优势菌，其次是球形马拉色菌(30%)，其中毛马拉色菌和球形马拉色菌混合感染(15%)是显著病原体(p < 0.00001)。酮康唑体外抗马拉色菌活性较好，抑菌区较大;茶树油和1%硫化硒体外抗马拉色菌活性相近。在用1%硫化硒洗发水治疗后进行了随访研究，显示出92.5%的效率，这表明可能解决头皮屑和脂溢性皮炎。

引用次数: 0

Moisturizers Free of Paraben, Mineral Oil, Alcohol and Ingredients from Animal Origin (Pama) - A New Way Forward 不含对羟基苯甲酸酯、矿物油、酒精和动物源性成分(帕玛)的保湿霜——一种新的前进方式

Journal of clinical and investigative dermatology

Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000079

Myn Gala

Effective management of dry skin conditions involves the treatment of a defective skin barrier. Moisturizers enhance and preserve the smoothness of the skin in patients with dry skin conditions as well as those with healthy skin. Many ingredients of moisturizers have the potential to cause irritant and allergic contact dermatitis; therefore, it is necessary for clinicians to be aware of such potential allergens to manage and advise their patients’ accordingly. Moisturizers free of paraben, mineral oil, alcohol and ingredients from animal origin (PAMA) have an advantage since they don’t cause sensitivity, allergy or dermatitis. This review will help dermatologists understand the need and benefits of low allergen containing moisturizers.

干燥皮肤状况的有效管理涉及到有缺陷的皮肤屏障的治疗。润肤霜增强和保持皮肤的光滑，干燥的皮肤状况的病人，以及那些健康的皮肤。保湿霜的许多成分都有可能引起刺激性和过敏性接触性皮炎;因此，临床医生有必要了解这些潜在的过敏原，并据此管理和建议患者。不含对羟基苯甲酸酯、矿物油、酒精和动物源性成分(PAMA)的保湿霜有一个优势，因为它们不会引起敏感、过敏或皮炎。这篇综述将帮助皮肤科医生了解低过敏原保湿霜的需求和好处。

引用次数: 0

Nursing-Specific Management on Toxic Epidermal Necrolysis (Ten) In Cml Patient: Case Report Cml患者中毒性表皮坏死松解的护理特异性处理(10例

Journal of clinical and investigative dermatology

Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000078

Aswathy Asokan AN

引用次数: 0

Insights into Lichen Planus Pigmentosus Inversus using Minimally Invasive Dermal Patch and Whole Transcriptome Analysis. 利用微创皮肤斑块和全转录组分析深入了解扁平苔藓色素沉着症。

Journal of clinical and investigative dermatology

Pub Date : 2022-01-01 Epub Date: 2022-04-05 DOI: 10.13188/2373-1044.1000077

Jacob Dickman, Michael Howell, Robert Hoopes, Yipeng Wang, Tobin J Dickerson, Michael Bottomley, H Nicholas Shamma, Christine M Rapp, Matthew J Turner, Craig A Rohan, Jeffrey B Travers

Lichen Planus Pigmentosus inversus (LPPi) is a rare interface and lichenoid dermatitis (ILD) and supposed variant of lichen planus (LP) that presents as well-demarcated brown to grey macules in flexural and intertriginous areas. LPPi is deemed 'inversus' because its anatomical distribution in skin folds is opposite that seen in lichen planus pigmentosus (LPP) whose pigmented lesions arise on sun-exposed skin. Biopsy is required for the clinical diagnosis of all ILDs. Though multiple clinically-oriented studies have reported differences between LPP, LPPi, and LP, few molecular studies have been performed. In this case study, 3 patients, 2 with LPPi and one with LP, provided samples using minimally invasive whole transcriptome analysis using a dermal biomarker patch. This study confirms the involvement of interferon signaling and T-cell activation in LPPi and suggests an expression profile distinct from LP. Specific genes significantly upregulated in LPPi vs LP include an intergenic splice variant of the primary pigmentation determining receptor in humans and dysregulation of genes essential for ceramide synthesis and construction of the cornified envelope. This work expands upon our knowledge of the pathogenesis of LPPi vs LP, and supports the potential use of this technology in the diagnostic clinical setting to mitigate the need for invasive procedures.

色素沉着性扁平苔藓（LPPi）是一种罕见的界面和苔藓样皮炎（ILD），应该是扁平苔藓（LP）的变异型，表现为挠曲区和三叉神经间区分界清楚的棕色至灰色斑丘疹。LPPi 被认为是 "变异型"，因为它在皮肤褶皱处的解剖分布与色素沉着性扁平苔藓（LPP）相反，后者的色素病变发生在暴露于阳光的皮肤上。所有 ILD 的临床诊断都需要活组织检查。虽然多项以临床为导向的研究报告了 LPP、LPPi 和 LP 之间的差异，但很少进行分子研究。在本病例研究中，3 名患者（其中 2 人患有 LPPi，1 人患有 LP）提供了样本，使用皮肤生物标记贴片进行了微创全转录组分析。这项研究证实了干扰素信号转导和 T 细胞活化参与了 LPPi 的发病，并提出了有别于 LP 的表达谱。与 LP 相比，LPPi 中明显上调的特定基因包括人类主要色素决定受体的基因间剪接变体，以及神经酰胺合成和粟粒状包膜构建所必需的基因失调。这项研究拓展了我们对LPPi与LP发病机理的认识，并支持将这项技术用于临床诊断，以减少对侵入性程序的需求。

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引用次数: 0

Valuing the Inpatient Dermatology Consult Service at a Single Academic Institution 评估单一学术机构的住院皮肤科咨询服务

Journal of clinical and investigative dermatology

Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000080

F. Yang

引用次数: 0

Sequencing of within-Subject Primary and Metastatic Cutaneous Squamous Cell Carcinomas Reveals Novel Diagnostic and Therapeutic Targets for Metastatic Disease 体内原发性和转移性皮肤鳞状细胞癌的测序揭示了转移性疾病的新诊断和治疗靶点

Journal of clinical and investigative dermatology

Pub Date : 2022-01-01 DOI: 10.13188/2373-1044.1000081

Shang I. Brian Jiang

．

引用次数: 0

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