Abstract Background: India, one of the countries with the highest incidence of oral cancer, accounting for 30% of all new oral cancer cases in the world. Therefore, strong diagnostic markers are critical for the diagnosis and survival of patients suffering from oral cancer. Based on this relationship between inflammation and cancer progression, several inflammation-based scores have been demonstrated to have diagnostic and prognostic value in many types of malignant solid tumours. Objective: To compare the correlation between systemic inflammation based prognostic scores and tumour node metastasis (TNM) stage in patients undergoing oral cancer treatment. Methods: The inflammation-based scores were calculated for 120 patients with oral squamous cell carcinoma divided into four groups based on TNM staging. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), tumour size, nodes involved were analysed. Statistics were performed to compare the diagnostic value of the selected scores and TNM stage. Results: This current study compares 30 patients in each stage of TNM stages 1,2,3 and 4. The mean tumour size is 1.8 x 1.41, 3.23x2.28, 2.85x2.43 and 3.78x 3.06 in stage 1,2,3 and 4 respectively. The largest lymph node measurable was 1.33x1.36 in stage 3 and 1.84x 1.38 in stage 4. The number of lymph nodes involved in stage 3 are 1.1 and 2.82 in stage 4. The mean NLR in stage 1,2,3 and 4 were 2.68, 2.72, 3.17 and 3.68 respectively. The mean PLR in stage 1, 2,3 and 4 were 106.4, 117.8, 108.2 and 182.2 respectively. Conclusion: The present study indicates that elevated NLR and PLR values are associated with advanced stages of TNM staging for Oral squamous cell carcinoma.
摘要背景：印度是口腔癌症发病率最高的国家之一，占全球口腔癌症新增病例的30%。因此，强有力的诊断标志物对于口腔癌症患者的诊断和生存至关重要。基于炎症和癌症进展之间的关系，几种基于炎症的评分已被证明在许多类型的恶性实体瘤中具有诊断和预后价值。目的：比较癌症口腔治疗患者全身炎症预后评分与肿瘤节点转移（TNM）分期的相关性。方法：计算120例口腔鳞状细胞癌患者的炎症评分，根据TNM分期分为四组。分析中性粒细胞淋巴细胞比率（NLR）、血小板淋巴细胞比率（PLR）、肿瘤大小、涉及的淋巴结。进行统计以比较所选评分和TNM分期的诊断价值。结果：本研究比较了TNM 1、2、3和4期各阶段的30名患者。1、2、3和4期的平均肿瘤大小分别为1.8 x 1.41、3.23x2.28、2.85x2.43和3.78x3.06。可测量的最大淋巴结在第3阶段为1.33x1.36，在第4阶段为1.84x1.38。第三阶段涉及的淋巴结数量为1.1，第四阶段为2.82。1、2、3和4期的平均NLR分别为2.68、2.72、3.17和3.68。第1、2、3和4阶段的平均PLR分别为106.4、117.8、108.2和182.2。结论：本研究表明，NLR和PLR值的升高与口腔鳞状细胞癌TNM分期的晚期有关。
{"title":"Comparison Between Preoperative Inflammation Based Scores and TNM Staging in Patients with Oral Cancer","authors":"Bhargav Ram","doi":"10.54289/jdoe2200104","DOIUrl":"https://doi.org/10.54289/jdoe2200104","url":null,"abstract":"Abstract Background: India, one of the countries with the highest incidence of oral cancer, accounting for 30% of all new oral cancer cases in the world. Therefore, strong diagnostic markers are critical for the diagnosis and survival of patients suffering from oral cancer. Based on this relationship between inflammation and cancer progression, several inflammation-based scores have been demonstrated to have diagnostic and prognostic value in many types of malignant solid tumours. Objective: To compare the correlation between systemic inflammation based prognostic scores and tumour node metastasis (TNM) stage in patients undergoing oral cancer treatment. Methods: The inflammation-based scores were calculated for 120 patients with oral squamous cell carcinoma divided into four groups based on TNM staging. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), tumour size, nodes involved were analysed. Statistics were performed to compare the diagnostic value of the selected scores and TNM stage. Results: This current study compares 30 patients in each stage of TNM stages 1,2,3 and 4. The mean tumour size is 1.8 x 1.41, 3.23x2.28, 2.85x2.43 and 3.78x 3.06 in stage 1,2,3 and 4 respectively. The largest lymph node measurable was 1.33x1.36 in stage 3 and 1.84x 1.38 in stage 4. The number of lymph nodes involved in stage 3 are 1.1 and 2.82 in stage 4. The mean NLR in stage 1,2,3 and 4 were 2.68, 2.72, 3.17 and 3.68 respectively. The mean PLR in stage 1, 2,3 and 4 were 106.4, 117.8, 108.2 and 182.2 respectively. Conclusion: The present study indicates that elevated NLR and PLR values are associated with advanced stages of TNM staging for Oral squamous cell carcinoma.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47039071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Oral manifestations in acute leukemia patients is a serious medical condition. The aim of the current research was to compare the periodontal condition in a group of acute, myeloid and lymphoblastic, leukemia (AM/ALL) patients with a control group of healthy individuals. Methods: 98 patients with AM/ALL and 196 controls were selected. The clinical measurements used to diagnose periodontal condition concerned probing depths (PPDs), clinical attachment loss (CAL), gingival index (GI), bleeding on probing (BOP), and oral hygiene habits. The models of chi-square test and logistic regression were used to assess the possible differences between AM/ALL patients and controls. Results: The mean ages were 65.7 ± 3.4 years and 66.2 ± 2.8 years for cases and controls, respectively. AM/ALL patients had worst periodontal parameters such as PPD (p = 0.052, OR =1.725, 95% CI = 0.995-2.00), tooth-brushing frequency (p = 0.046, OR = 0.581, 95% CI = 0.341-0.00), GI (p = 0.091, OR = 1.632, 95% CI = 0.924-2.88), and BOP (p = 0.011, OR = 2.05, 95% CI = 1.18-3.563), after adjustment for smoking, socio-economic and educational status, compared with healthy individuals. Conclusion: Individuals with AM/ALL presented deeper periodontal pockets than healthy controls, worse gingival inflammation, and bleeding on probing than healthy controls and poor oral hygiene practices such as daily tooth brushing.
{"title":"Investigation of Periodontal Disease Status in Acute Leukemia (Myeloid and Lymphoblastic) Greek Patients: A Case - Control Study","authors":"N. Chrysanthakopoulos","doi":"10.54289/jdoe2200103","DOIUrl":"https://doi.org/10.54289/jdoe2200103","url":null,"abstract":"Objectives: Oral manifestations in acute leukemia patients is a serious medical condition. The aim of the current research was to compare the periodontal condition in a group of acute, myeloid and lymphoblastic, leukemia (AM/ALL) patients with a control group of healthy individuals. Methods: 98 patients with AM/ALL and 196 controls were selected. The clinical measurements used to diagnose periodontal condition concerned probing depths (PPDs), clinical attachment loss (CAL), gingival index (GI), bleeding on probing (BOP), and oral hygiene habits. The models of chi-square test and logistic regression were used to assess the possible differences between AM/ALL patients and controls. Results: The mean ages were 65.7 ± 3.4 years and 66.2 ± 2.8 years for cases and controls, respectively. AM/ALL patients had worst periodontal parameters such as PPD (p = 0.052, OR =1.725, 95% CI = 0.995-2.00), tooth-brushing frequency (p = 0.046, OR = 0.581, 95% CI = 0.341-0.00), GI (p = 0.091, OR = 1.632, 95% CI = 0.924-2.88), and BOP (p = 0.011, OR = 2.05, 95% CI = 1.18-3.563), after adjustment for smoking, socio-economic and educational status, compared with healthy individuals. Conclusion: Individuals with AM/ALL presented deeper periodontal pockets than healthy controls, worse gingival inflammation, and bleeding on probing than healthy controls and poor oral hygiene practices such as daily tooth brushing.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42978075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Temporomandibular Disorders (TMDs) are the most common form of non-odontogenic orofacial pain. TMDs are considered a biopsychosocial disorder with a multifactorial pathogenesis. Patients with TMDs frequently present with cervical spine disorders, headaches and otological complaints. Physiotherapists are often sought to assess and treat TMDs. The use of a radar graph and triangulation to represent phenotyping patients with complex pain presentations has been discussed in the literature with the aim of supporting the best course of treatment for patients with complex and enigmatic pain presentations.
{"title":"The Use of a New Clinical Reasoning Framework to Facilitate The Assessment and Management of Temporomandibular Disorders","authors":"Alexander Weden","doi":"10.54289/jdoe2200101","DOIUrl":"https://doi.org/10.54289/jdoe2200101","url":null,"abstract":"Background: Temporomandibular Disorders (TMDs) are the most common form of non-odontogenic orofacial pain. TMDs are considered a biopsychosocial disorder with a multifactorial pathogenesis. Patients with TMDs frequently present with cervical spine disorders, headaches and otological complaints. Physiotherapists are often sought to assess and treat TMDs. The use of a radar graph and triangulation to represent phenotyping patients with complex pain presentations has been discussed in the literature with the aim of supporting the best course of treatment for patients with complex and enigmatic pain presentations.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47960878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Megha Satpathy, Yuanyuan Duan, Logan Betts, Matthew Priddy, Jason A Griggs
Background: To evaluate the effect of bone remodelling around a reduced-diameter dental implant on its fatigue limit using finite element analysis (FEA).
Methods: A dental implant assembly, which included a reduced-diameter dental implant (Biomet-3i external hex), an abutment (GingiHue®) and a connector screw (Gold-Tite Square screw), was scanned using micro-computed tomography (Skyscan 1172). Its dimensions were measured using Mimics (Materialise) and an optical microscope (Keyence). The digital replicas of the physical specimens were constructed using SOLIDWORKS (Dassault Systems). A cylindrical bone specimen holder with two layers (cortical and cancellous bone) was designed in SOLIDWORKS. Two assemblies were created: (a) Model 1: Having non-remodelled bone; (b) Model 2: Cancellous bone remodelled at the regions adjacent to the implant screw threads. FEA was performed in ABAQUS (SIMULIA). In Model 1, the Young's modulus of cortical and cancellous bone were 20 GPa and 14 GPa, respectively. For Model 2, the region of the cancellous bone adjacent to the implant screw threads was assigned a Young's modulus of 20 GPa. fe-safe (SIMULIA) was used to estimate the fatigue limit.
Results: The maximum von Mises stress under 100 N load was 439.9 MPa for both models 1 and 2 and was located at the connector screw. The fatigue limit was 116.4 N for both models 1 and 2.
Conclusions: The results suggest that implant fatigue resistance tested according to ISO 14801 may be accurately predicted without bothering to simulate the non-homogeneous stiffness that occurs at the bone-implant interface in the clinical case.
{"title":"Effect of Bone Remodeling on Dental Implant Fatigue Limit Predicted Using 3D Finite Element Analysis.","authors":"Megha Satpathy, Yuanyuan Duan, Logan Betts, Matthew Priddy, Jason A Griggs","doi":"10.54289/jdoe2200102","DOIUrl":"https://doi.org/10.54289/jdoe2200102","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the effect of bone remodelling around a reduced-diameter dental implant on its fatigue limit using finite element analysis (FEA).</p><p><strong>Methods: </strong>A dental implant assembly, which included a reduced-diameter dental implant (Biomet-3i external hex), an abutment (GingiHue<sup>®</sup>) and a connector screw (Gold-Tite Square screw), was scanned using micro-computed tomography (Skyscan 1172). Its dimensions were measured using Mimics (Materialise) and an optical microscope (Keyence). The digital replicas of the physical specimens were constructed using SOLIDWORKS (Dassault Systems). A cylindrical bone specimen holder with two layers (cortical and cancellous bone) was designed in SOLIDWORKS. Two assemblies were created: (a) Model 1: Having non-remodelled bone; (b) Model 2: Cancellous bone remodelled at the regions adjacent to the implant screw threads. FEA was performed in ABAQUS (SIMULIA). In Model 1, the Young's modulus of cortical and cancellous bone were 20 GPa and 14 GPa, respectively. For Model 2, the region of the cancellous bone adjacent to the implant screw threads was assigned a Young's modulus of 20 GPa. fe-safe (SIMULIA) was used to estimate the fatigue limit.</p><p><strong>Results: </strong>The maximum von Mises stress under 100 N load was 439.9 MPa for both models 1 and 2 and was located at the connector screw. The fatigue limit was 116.4 N for both models 1 and 2.</p><p><strong>Conclusions: </strong>The results suggest that implant fatigue resistance tested according to ISO 14801 may be accurately predicted without bothering to simulate the non-homogeneous stiffness that occurs at the bone-implant interface in the clinical case.</p>","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The purpose of this randomized double-blind clinical trial was to compare the effect of a single pretreatment dose of Curcumin and placebo on post-operative pain for patients diagnosed with symptomatic irreversible pulpitis in mandibular molars treated in single visit. Methods: Forty-four patients with severe to moderate pain randomly received either Curcumin (400mg +20 mg pepper) or placebo (420 mg Starch) one hour before starting root canal treatment (n = 22 per group). Participants rated their pain using visual analogue pain scale (VAS): preoperatively and at 5 time points: immediately post-operative, 8, 12, 24 and 48 hours postoperative. Patients also stated emergency analgesic intake. The need for supplemental anesthesia during treatment was recorded. Mann-Whitney U-test compared the two groups at each time point, while Repeated-Measure ANOVA and Wilcoxon Signed Rank test compared time points within each group. A p-value <0.05 was considered statistically significant. Results: Baseline characteristics of both groups showed non-significant differences (P > 05). Curcumin group at 8, 12 and 24 hours revealed statistically significantly less VAS values (44.2, 26.7, 19.1) than the placebo (58.5, 43.3, 30.3), respectively, (P > 05). All patients in Curcumin group did not need emergency analgesics. Curcumin group revealed statistically significantly lower percentages for the need of supplemental anesthesia (27.3%) compared to placebo (68.2%), (P < 05). Conclusion: Single preoperative oral dose of Curcumin proved to be an effective premedication that reduced post-operative pain as well as the need of supplemental anesthesia for patients diagnosed with symptomatic irreversible pulpitis of mandibular molars.
{"title":"The Effect of Premedication with Curcumin on Post-Operative Pain in Single Visit Endodontic Treatment of Acute Pulpitis in Mandibular Molars: A Randomized Controlled Trial","authors":"Ghada El Hilaly Mohamed Eid","doi":"10.54289/jdoe2100111","DOIUrl":"https://doi.org/10.54289/jdoe2100111","url":null,"abstract":"Objective: The purpose of this randomized double-blind clinical trial was to compare the effect of a single pretreatment dose of Curcumin and placebo on post-operative pain for patients diagnosed with symptomatic irreversible pulpitis in mandibular molars treated in single visit. Methods: Forty-four patients with severe to moderate pain randomly received either Curcumin (400mg +20 mg pepper) or placebo (420 mg Starch) one hour before starting root canal treatment (n = 22 per group). Participants rated their pain using visual analogue pain scale (VAS): preoperatively and at 5 time points: immediately post-operative, 8, 12, 24 and 48 hours postoperative. Patients also stated emergency analgesic intake. The need for supplemental anesthesia during treatment was recorded. Mann-Whitney U-test compared the two groups at each time point, while Repeated-Measure ANOVA and Wilcoxon Signed Rank test compared time points within each group. A p-value <0.05 was considered statistically significant. Results: Baseline characteristics of both groups showed non-significant differences (P > 05). Curcumin group at 8, 12 and 24 hours revealed statistically significantly less VAS values (44.2, 26.7, 19.1) than the placebo (58.5, 43.3, 30.3), respectively, (P > 05). All patients in Curcumin group did not need emergency analgesics. Curcumin group revealed statistically significantly lower percentages for the need of supplemental anesthesia (27.3%) compared to placebo (68.2%), (P < 05). Conclusion: Single preoperative oral dose of Curcumin proved to be an effective premedication that reduced post-operative pain as well as the need of supplemental anesthesia for patients diagnosed with symptomatic irreversible pulpitis of mandibular molars.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49056953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The split-increment horizontal placement (SHP) is the popular technique being used, along with other therapeutic modus operandi. As more than adequate, SHP methods are being enhanced in barricade cavities for reducing the shrinkage stress that were generated during light polymerization. Such stress, if released unrestrained, may redress within the composite, tooth or at the adhesive contact .
{"title":"Abutment and Orthodontics for Endurance of Dental Crowns","authors":"Ramya Chowdary","doi":"10.54289/jdoeop1","DOIUrl":"https://doi.org/10.54289/jdoeop1","url":null,"abstract":"The split-increment horizontal placement (SHP) is the popular technique being used, along with other therapeutic modus operandi. As more than adequate, SHP methods are being enhanced in barricade cavities for reducing the shrinkage stress that were generated during light polymerization. Such stress, if released unrestrained, may redress within the composite, tooth or at the adhesive contact .","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47012937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obstructive sleep apnea (OSA) is a disorder caused by a number of factors like an obstruction of the upper airway during sleep because of insufficient motor tone of the tongue and/or airway dilator muscles or inadequate growth of the maxillary jaw bone etc. Oral appliances (OAs) are commonly used as a non-invasive treatment for obstructive sleep apnea syndrome. The primary oral appliance (OA) used in obstructive sleep apnea (OSA) treatment is the mandibular advancement device (MAD). Tongue-retaining devices or tongue-stabilizing devices (TSDs) are a second type of OA, which displace the tongue anteriorly and may be customized or come in different stock sizes. This review article aims to examine the best in class on this particular subject of treatment of OSA with oral appliances, explaining acceptability of an appliance in patients on the basis of its construction and results, while providing enough cognizance regarding the diagnosis, management and causes of discontinuation.
{"title":"Treatment with Oral Appliances in Obstructive Sleep Apnea","authors":"Palak Srivastava","doi":"10.54289/jdoe2100108","DOIUrl":"https://doi.org/10.54289/jdoe2100108","url":null,"abstract":"Obstructive sleep apnea (OSA) is a disorder caused by a number of factors like an obstruction of the upper airway during sleep because of insufficient motor tone of the tongue and/or airway dilator muscles or inadequate growth of the maxillary jaw bone etc. Oral appliances (OAs) are commonly used as a non-invasive treatment for obstructive sleep apnea syndrome. The primary oral appliance (OA) used in obstructive sleep apnea (OSA) treatment is the mandibular advancement device (MAD). Tongue-retaining devices or tongue-stabilizing devices (TSDs) are a second type of OA, which displace the tongue anteriorly and may be customized or come in different stock sizes. This review article aims to examine the best in class on this particular subject of treatment of OSA with oral appliances, explaining acceptability of an appliance in patients on the basis of its construction and results, while providing enough cognizance regarding the diagnosis, management and causes of discontinuation.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47046500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Oral ulceration forms a major category of oral lesions. Due to its effect on the quality of life, the patients seek treatment using various substances. This study investigated the types of treatments used by a sample of patients having all types of oral ulcers and its positive and negative effects on the patients' lives. Methods: This cross-sectional study included patients having different types of oral ulcers. Participants provided information about their previous treatments, the source of recommendation of its use and side effects linked to them. They filled the oral health impact profile-14 questionnaire to report the change in their quality of life after treatment. The patients' educational and social levels were tested as predictors for the use of non-conventional treatments. Results: Correct pharmaceutical treatments were administered y 34% of the participants; the most effective of which were systemic and topical steroids by ulcerative oral lichen planus patients; and vitamin supplements in recurrent aphthous stomatitis patients. The majority (64.2%) of the previously treated patients used non-conventional treatments, the most widely used of which was Tahini. Half of the patients using non-conventional treatments suffered side effects. The source of information of the self-medication was attributed mainly to the patients themselves, followed by friends and family members. Conclusion: This study reflects the widely spread habit of self-medication in our sample of patients having oral ulcers. It highlights the negative influence of these remedies.
{"title":"What do Patients Use for Treating Their Oral Ulcers? And How do these Treatments Affect Their Quality of Life?","authors":"Ayat Gamal-AbdelNaser","doi":"10.54289/jdoe2100109","DOIUrl":"https://doi.org/10.54289/jdoe2100109","url":null,"abstract":"Objectives: Oral ulceration forms a major category of oral lesions. Due to its effect on the quality of life, the patients seek treatment using various substances. This study investigated the types of treatments used by a sample of patients having all types of oral ulcers and its positive and negative effects on the patients' lives. Methods: This cross-sectional study included patients having different types of oral ulcers. Participants provided information about their previous treatments, the source of recommendation of its use and side effects linked to them. They filled the oral health impact profile-14 questionnaire to report the change in their quality of life after treatment. The patients' educational and social levels were tested as predictors for the use of non-conventional treatments. Results: Correct pharmaceutical treatments were administered y 34% of the participants; the most effective of which were systemic and topical steroids by ulcerative oral lichen planus patients; and vitamin supplements in recurrent aphthous stomatitis patients. The majority (64.2%) of the previously treated patients used non-conventional treatments, the most widely used of which was Tahini. Half of the patients using non-conventional treatments suffered side effects. The source of information of the self-medication was attributed mainly to the patients themselves, followed by friends and family members. Conclusion: This study reflects the widely spread habit of self-medication in our sample of patients having oral ulcers. It highlights the negative influence of these remedies.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46110028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: A systematic review was performed to evaluate if the use of botulinum toxin was able to reduce the intensity of myofascial pain compared to other treatments in adult patients. Material and Methods: A comprehensive search was carried out in the MEDLINE via Pub-Meb, Scopus, Web of Science, LILACS, BBO and Cochrane Library. In addition, the gray literature was also researched. The risk of bias tool from the Cochrane Collaboration was used by two independent reviewers for quality assessment of the studies. Results: A total of 4372 studies were identified, 9 remained in qualitative study, 8 of these studies were considered at “unclear” risk of bias and just one study was “low” risk of bias in the key domains. Only two studies presented similar data to be included in the meta-analysis. Both studies evaluated the pain relief used the botulinum toxin (BTX-A) versus saline solution. The meta-analysis demonstrated that after 3 months follow-up the pain relief was 15.70 (95 % confidence interval [CI] = 0.80 to 30.61; p = 0.04). Conclusion: The BTX-A reduced the intensity of myofascial pain compared to saline solution in adults after 3 months. However, further studies should be conducted to corroborate this finding.
目的：进行一项系统综述，以评估与其他治疗方法相比，肉毒杆菌毒素的使用是否能够减轻成年患者的肌筋膜疼痛强度。材料和方法：通过Pub-Meb、Scopus、Web of Science、LILACS、BBO和Cochrane Library在MEDLINE上进行全面检索。此外，还对灰色文献进行了研究。两名独立评审员使用来自Cochrane协作的偏倚风险工具对研究进行质量评估。结果：共确定了4372项研究，其中9项仍在定性研究中，其中8项研究被认为存在“不清楚”的偏倚风险，只有一项研究在关键领域存在“低”偏倚风险。只有两项研究提供了类似的数据纳入荟萃分析。这两项研究都评估了肉毒杆菌毒素（BTX-A）与盐水溶液的止痛效果。荟萃分析表明，随访3个月后，疼痛缓解为15.70（95%置信区间[CI]=0.80至30.61；p=0.04）。然而，应该进行进一步的研究来证实这一发现。
{"title":"Does the Use of Botulinum Toxin Reduce the Intensity of Myofascial Pain in Adult Patients? A Systematic Review and Meta-Analysis","authors":"L. Wambier","doi":"10.54289/jdoe2100107","DOIUrl":"https://doi.org/10.54289/jdoe2100107","url":null,"abstract":"Objective: A systematic review was performed to evaluate if the use of botulinum toxin was able to reduce the intensity of myofascial pain compared to other treatments in adult patients. Material and Methods: A comprehensive search was carried out in the MEDLINE via Pub-Meb, Scopus, Web of Science, LILACS, BBO and Cochrane Library. In addition, the gray literature was also researched. The risk of bias tool from the Cochrane Collaboration was used by two independent reviewers for quality assessment of the studies. Results: A total of 4372 studies were identified, 9 remained in qualitative study, 8 of these studies were considered at “unclear” risk of bias and just one study was “low” risk of bias in the key domains. Only two studies presented similar data to be included in the meta-analysis. Both studies evaluated the pain relief used the botulinum toxin (BTX-A) versus saline solution. The meta-analysis demonstrated that after 3 months follow-up the pain relief was 15.70 (95 % confidence interval [CI] = 0.80 to 30.61; p = 0.04). Conclusion: The BTX-A reduced the intensity of myofascial pain compared to saline solution in adults after 3 months. However, further studies should be conducted to corroborate this finding.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43800511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Proper osseointegration is crucial for the success of dental and orthopedic implants. Titanium-6Aluminum-4Vanadium (TAV) is one of the most popular implant materials; however, polyetheretherketone (PEEK) has gained the interest of implant researchers and manufacturers over the past several years due to its lower modulus of elasticity compared to metallic implant materials. Porosity and patterned surface morphologies are thought to improve mechanical interlocking and play an important role in the differentiation of pre-osteoblasts into mature osteoblasts. This study aimed to determine the effects a macro patterned PEEK surface has on the material’s mechanical properties and the proliferation, differentiation, and maturation of pre-osteoblasts. Mechanical testing data indicated that the macro patterning improved the mechanical interlocking and has no detrimental effect on compression strength. DNA data and live/dead imaging showed that pre-osteoblasts on solid PEEK specimens did not readily differentiate but instead encouraged proliferation only. However, ALP data in comparison to the DNA data showed that cells on patterned PEEK specimens more readily entered the differentiation pathway to mineralization. This is further confirmed by the patterned PEEK specimens showing an overall higher amount of cell mineralization. Clinical significance: This study concludes that surface macro patterning of PEEK material increases the mechanical interlocking and enhances the osseointegration capability without diminishing mechanical properties.
{"title":"PEEK as a Potential Material for Dental Implants and its Biomechanical Properties and Osteoblast Cell Response","authors":"Randall S. Williamson","doi":"10.54289/jdoe2100106","DOIUrl":"https://doi.org/10.54289/jdoe2100106","url":null,"abstract":"Proper osseointegration is crucial for the success of dental and orthopedic implants. Titanium-6Aluminum-4Vanadium (TAV) is one of the most popular implant materials; however, polyetheretherketone (PEEK) has gained the interest of implant researchers and manufacturers over the past several years due to its lower modulus of elasticity compared to metallic implant materials. Porosity and patterned surface morphologies are thought to improve mechanical interlocking and play an important role in the differentiation of pre-osteoblasts into mature osteoblasts. This study aimed to determine the effects a macro patterned PEEK surface has on the material’s mechanical properties and the proliferation, differentiation, and maturation of pre-osteoblasts. Mechanical testing data indicated that the macro patterning improved the mechanical interlocking and has no detrimental effect on compression strength. DNA data and live/dead imaging showed that pre-osteoblasts on solid PEEK specimens did not readily differentiate but instead encouraged proliferation only. However, ALP data in comparison to the DNA data showed that cells on patterned PEEK specimens more readily entered the differentiation pathway to mineralization. This is further confirmed by the patterned PEEK specimens showing an overall higher amount of cell mineralization. Clinical significance: This study concludes that surface macro patterning of PEEK material increases the mechanical interlocking and enhances the osseointegration capability without diminishing mechanical properties.","PeriodicalId":73703,"journal":{"name":"Journal of dentistry and oral epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44256915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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