Pub Date : 2022-12-06DOI: 10.29245/2767-5092/2022/4.1165
Alison Tran, Lio Yu
{"title":"Old Solutions May Be the New Answer: How the Use of Modern Superficial Radiation Therapy Might Address Disparities in Dermatologic Care","authors":"Alison Tran, Lio Yu","doi":"10.29245/2767-5092/2022/4.1165","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/4.1165","url":null,"abstract":"","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42844044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.29245/2767-5092/2022/4.1261
Simon J. Madorsky, Orr A. Meltzer, A. Miller
Superficial radiotherapy (SRT) treatment for non-melanoma skin cancer has been reported to yield variable cure rates. When patients are highly selected, adequate margins of treatment are chosen, and hypofractionation is avoided, cure rates of SRT can approach that of Mohs surgery. The objective of this study is to evaluate long term results of our center’s SRT selection criteria and define proper decision-making parameters of optimal candidates for treatment, and to review the literature. A retrospective chart analysis was done of all SRT cases from 2012-2018. Location, size, type and depth of the treated tumors were defined. Treatment energy, fractionation, and radiation field size were documented. Recurrences and complications were analyzed. Of 131 treated lesions treated, head and neck lesions (105, 80%) were the most common location, primarily on the lower nose (60, 46%). Of 122 lesions analyzed for recurrence, 2 (1.6%) recurred, with a mean follow-up time of 5 years. Acute ulcerations in 29 (28%) head and neck lesions, 5 (63%) trunk lesions, and 9 (50%) leg lesions occurred. Delayed ulcerations occurred in 5 (28%) leg lesions. In conclusion, when patients are highly selected, long-term SRT cure rates up to 98% can be achieved.
{"title":"Superficial Radiotherapy: Long Term Follow-Up of Highly Selected Basal and Squamous Cell Carcinomas in Skin Cancer Patients","authors":"Simon J. Madorsky, Orr A. Meltzer, A. Miller","doi":"10.29245/2767-5092/2022/4.1261","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/4.1261","url":null,"abstract":"Superficial radiotherapy (SRT) treatment for non-melanoma skin cancer has been reported to yield variable cure rates. When patients are highly selected, adequate margins of treatment are chosen, and hypofractionation is avoided, cure rates of SRT can approach that of Mohs surgery. The objective of this study is to evaluate long term results of our center’s SRT selection criteria and define proper decision-making parameters of optimal candidates for treatment, and to review the literature. A retrospective chart analysis was done of all SRT cases from 2012-2018. Location, size, type and depth of the treated tumors were defined. Treatment energy, fractionation, and radiation field size were documented. Recurrences and complications were analyzed. Of 131 treated lesions treated, head and neck lesions (105, 80%) were the most common location, primarily on the lower nose (60, 46%). Of 122 lesions analyzed for recurrence, 2 (1.6%) recurred, with a mean follow-up time of 5 years. Acute ulcerations in 29 (28%) head and neck lesions, 5 (63%) trunk lesions, and 9 (50%) leg lesions occurred. Delayed ulcerations occurred in 5 (28%) leg lesions. In conclusion, when patients are highly selected, long-term SRT cure rates up to 98% can be achieved.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48050963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-30DOI: 10.29245/2767-5092/2022/3.1162
Denise Ann Tsang, Chee Leong Cheng, Laura Hui
A 75-year-old Chinese man with a history of diabetes mellitus presented with multiple tender dermal violaceous ulcerative nodules over his extremities, which have increased in size and extent since their appearance 3 months ago (Figure 1). He reported a history of weight loss without fever or nasal symptoms. Histology from skin punch biopsies taken from his left arm and left thigh showed sheet-like infiltrate of medium-to-large atypical lymphoid cells. Immunohistochemistry (IHC) revealed positive staining with cytoplasmic CD3, CD2, CD56, CD30 and granzyme B. IHC staining for CD30 was variably weakly positive in a minority of the atypical lymphoid cells, ranging from less than 5% positivity in the left thigh specimen and 10-20% weak positivity in the left arm specimen, where atypical lymphoid cells appear larger. Ki-67 proliferation fraction was 90%. There was widespread nuclear positivity for Epstein-Barr virus-encoded small RNAs (EBER). IHC staining was negative for CD10, CD79a, CD 123 and TCL1 (Figures 2 and 3). A Positron Emission Tomography and Computed Tomography (PETCT) showed multiple enhancing and hypermetabolic nodular skin lesions with no involvement of lymph nodes and other organs (Figure 4). He was diagnosed with high-risk, advanced stage primary cutaneous extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT). He received upfront treatment with Brentuximab vedotin (BV) in addition to chemotherapy (Table 1) which resulted in complete response.
{"title":"Successful Use of Brentuximab Vedotin for Treatment of CD30-positive Primary Cutaneous Extranodal Natural Killer/T-Cell Lymphoma","authors":"Denise Ann Tsang, Chee Leong Cheng, Laura Hui","doi":"10.29245/2767-5092/2022/3.1162","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/3.1162","url":null,"abstract":"A 75-year-old Chinese man with a history of diabetes mellitus presented with multiple tender dermal violaceous ulcerative nodules over his extremities, which have increased in size and extent since their appearance 3 months ago (Figure 1). He reported a history of weight loss without fever or nasal symptoms. Histology from skin punch biopsies taken from his left arm and left thigh showed sheet-like infiltrate of medium-to-large atypical lymphoid cells. Immunohistochemistry (IHC) revealed positive staining with cytoplasmic CD3, CD2, CD56, CD30 and granzyme B. IHC staining for CD30 was variably weakly positive in a minority of the atypical lymphoid cells, ranging from less than 5% positivity in the left thigh specimen and 10-20% weak positivity in the left arm specimen, where atypical lymphoid cells appear larger. Ki-67 proliferation fraction was 90%. There was widespread nuclear positivity for Epstein-Barr virus-encoded small RNAs (EBER). IHC staining was negative for CD10, CD79a, CD 123 and TCL1 (Figures 2 and 3). A Positron Emission Tomography and Computed Tomography (PETCT) showed multiple enhancing and hypermetabolic nodular skin lesions with no involvement of lymph nodes and other organs (Figure 4). He was diagnosed with high-risk, advanced stage primary cutaneous extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT). He received upfront treatment with Brentuximab vedotin (BV) in addition to chemotherapy (Table 1) which resulted in complete response.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48681831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-09DOI: 10.29245/2767-5092/2022/3.1159
Stan J. Monstrey
Topical antimicrobials are essential in wound care as they aid the healing process by preventing and at the same time treating infections in wounds1. Broad spectrum antiseptics with high efficacy towards planktonic and sessile bacterial communities are preferred as wound healing can be delayed by the formation of biofilms often developed by antimicrobial resistant organisms2. Additionally, ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp), which are the leading causes of nosocomial infections across the world, are also becoming multidrug-resistant (MDR)3. The correct use of antiseptics can be tricky, and, in this commentary, an overview of key challenges in antisepsis, namely antimicrobial efficacy, antiseptic resistance, antibiotic and antiseptic cross-resistance, wound healing, cytotoxicity, and tolerability, focusing on povidone-iodine (PVP-I) in comparison with other commonly used antiseptics such as chlorhexidine gluconate (CHG), polyhexanide (PHMB) or octenidine (OCT) is provided.
{"title":"Commentary: Addressing the Challenges in Antisepsis: Focus on Povidone Iodine","authors":"Stan J. Monstrey","doi":"10.29245/2767-5092/2022/3.1159","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/3.1159","url":null,"abstract":"Topical antimicrobials are essential in wound care as they aid the healing process by preventing and at the same time treating infections in wounds1. Broad spectrum antiseptics with high efficacy towards planktonic and sessile bacterial communities are preferred as wound healing can be delayed by the formation of biofilms often developed by antimicrobial resistant organisms2. Additionally, ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp), which are the leading causes of nosocomial infections across the world, are also becoming multidrug-resistant (MDR)3. The correct use of antiseptics can be tricky, and, in this commentary, an overview of key challenges in antisepsis, namely antimicrobial efficacy, antiseptic resistance, antibiotic and antiseptic cross-resistance, wound healing, cytotoxicity, and tolerability, focusing on povidone-iodine (PVP-I) in comparison with other commonly used antiseptics such as chlorhexidine gluconate (CHG), polyhexanide (PHMB) or octenidine (OCT) is provided.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41608325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-03DOI: 10.29245/2767-5092/2022/2.1153
A. Mackay
Photodynamic therapy (aPDT) has become an important component in the treatment of human infection. This report highlights the scientific literature and clinical guidelines on aPDT in the context of dermatology and considers the treatment of skin infection in all settings now, and in the future. Antibiotic resistance, infection control strategies and technologies able to eradicate microbes without building up new resistance are considered, and their mechanisms of action are described. Published work and National Institute for Clinical Excellence (NICE) Technology appraisals (TA) and research recommendations within Clinical Guidelines were used to identify future applications for PDT. Nanotheranostics can include PDT and were found to be highly relevant, and so treatment combinations and their novel applications will be subject to TA and Randomised Clinical Trials (RCTs). The resistance of some microbes to antibiotics can be reversed through use of supplementary drugs, and so they are likely to remain a mainstay of treatment for skin infection.
{"title":"Antimicrobial Photodynamic Therapy of Human Skin","authors":"A. Mackay","doi":"10.29245/2767-5092/2022/2.1153","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/2.1153","url":null,"abstract":"Photodynamic therapy (aPDT) has become an important component in the treatment of human infection. This report highlights the scientific literature and clinical guidelines on aPDT in the context of dermatology and considers the treatment of skin infection in all settings now, and in the future. Antibiotic resistance, infection control strategies and technologies able to eradicate microbes without building up new resistance are considered, and their mechanisms of action are described. Published work and National Institute for Clinical Excellence (NICE) Technology appraisals (TA) and research recommendations within Clinical Guidelines were used to identify future applications for PDT. Nanotheranostics can include PDT and were found to be highly relevant, and so treatment combinations and their novel applications will be subject to TA and Randomised Clinical Trials (RCTs). The resistance of some microbes to antibiotics can be reversed through use of supplementary drugs, and so they are likely to remain a mainstay of treatment for skin infection.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46428020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-19DOI: 10.29245/2767-5092/2022/2.1147
D. Yates, S. Miles
Dermatological manifestations of connective tissue diseases (CTDs) are common and frequently precede other symptoms. Thus, dermatologists may be the first clinicians to diagnose these disorders. Silica exposure is an acknowledged cause of several CTDs, but this is under-appreciated by clinicians, who may also be unaware of the wide range of jobs in which silica exposure can occur. The CTDs associated with silica exposure include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibody (ANCA) positive vasculitis and overlap syndromes. Silica-related systemic sclerosis (Si-SSc) is associated with a specific antibody profile and more severe disease. Silicosis has re-emerged worldwide recently due to several new workplace exposures, including a new type of silicosis (artificial stone (AS) silicosis), which is associated with a particularly high rate of auto-antibody formation. Dangerous work practices are still occurring. This article summarises recent literature on the topic of the resurgence of silicosis and silica-induced CTDs and reminds dermatologists of the importance of taking a thorough occupational history in all patients. Early intervention in CTDs and reduction in dust exposure can reduce risk and improve prognosis. Treatment options are rapidly improving.
{"title":"Silica and Connective Tissue Disorders: The Important Role of the Dermatologist","authors":"D. Yates, S. Miles","doi":"10.29245/2767-5092/2022/2.1147","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/2.1147","url":null,"abstract":"Dermatological manifestations of connective tissue diseases (CTDs) are common and frequently precede other symptoms. Thus, dermatologists may be the first clinicians to diagnose these disorders. Silica exposure is an acknowledged cause of several CTDs, but this is under-appreciated by clinicians, who may also be unaware of the wide range of jobs in which silica exposure can occur. The CTDs associated with silica exposure include systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibody (ANCA) positive vasculitis and overlap syndromes. Silica-related systemic sclerosis (Si-SSc) is associated with a specific antibody profile and more severe disease. Silicosis has re-emerged worldwide recently due to several new workplace exposures, including a new type of silicosis (artificial stone (AS) silicosis), which is associated with a particularly high rate of auto-antibody formation. Dangerous work practices are still occurring. This article summarises recent literature on the topic of the resurgence of silicosis and silica-induced CTDs and reminds dermatologists of the importance of taking a thorough occupational history in all patients. Early intervention in CTDs and reduction in dust exposure can reduce risk and improve prognosis. Treatment options are rapidly improving.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46243292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-05DOI: 10.29245/2767-5092/2022/2.1150
Chelsea Shope, BA, Laura Andrews, BS, Alan Snyder, MD MSCR, Manuel Valdebran, MD
{"title":"Commentary: Solar Ultraviolet Exposure in Individuals Who Perform Outdoor Sport Activities","authors":"Chelsea Shope, BA, Laura Andrews, BS, Alan Snyder, MD MSCR, Manuel Valdebran, MD","doi":"10.29245/2767-5092/2022/2.1150","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/2.1150","url":null,"abstract":"","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45391775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-16DOI: 10.29245/2767-5092/2022/1.1148
Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, G. Braga, F. A. D. de Morais, R. B. Balbinot, W. Caetano
The therapeutic benefits of copaiba oil-resin have encouraged its use in developing dermatological emulsions. Here, the anti-inflammatory, healing, antimicrobial, analgesic, and permeation-promoting properties of this medicinal oil are shown by reviewing articles from 2005 to 2021. Their properties encourage research to develop an herbal medicinal effective in treating skin diseases and cutaneous leishmaniasis.
{"title":"Minireview about Medicinal Copaiba Oil in the Treatment of Skin Diseases","authors":"Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, G. Braga, F. A. D. de Morais, R. B. Balbinot, W. Caetano","doi":"10.29245/2767-5092/2022/1.1148","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/1.1148","url":null,"abstract":"The therapeutic benefits of copaiba oil-resin have encouraged its use in developing dermatological emulsions. Here, the anti-inflammatory, healing, antimicrobial, analgesic, and permeation-promoting properties of this medicinal oil are shown by reviewing articles from 2005 to 2021. Their properties encourage research to develop an herbal medicinal effective in treating skin diseases and cutaneous leishmaniasis.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42405645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-06-28DOI: 10.29245/2767-5092/2022/2.1154
David Solano, Kush R Patel, Adelaida B Perez, Lindsey Seldin
Epithelial tissues, while diverse in form, share a critical barrier function that must be properly established throughout development, maintained during homeostasis, and restored following injury. The barrier function of the epidermis, the largest epithelial organ, is essential for animal survival, serving as the body’s outermost protective layer that prevents pathogen entry while promoting fluid retention. Disruptions to epidermal homeostasis require the rapid replacement of lost or damaged cells to efficiently restore barrier integrity. This regenerative capacity relies on quiescent stem cell populations that are primed to proliferate and able to generate the diverse cell types required for tissue function. Nevertheless, stem cell proliferation and plasticity must be stringently controlled, as dysregulation of these behaviors could have tumorigenic consequences1, 2.
{"title":"Commentary: DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation.","authors":"David Solano, Kush R Patel, Adelaida B Perez, Lindsey Seldin","doi":"10.29245/2767-5092/2022/2.1154","DOIUrl":"https://doi.org/10.29245/2767-5092/2022/2.1154","url":null,"abstract":"Epithelial tissues, while diverse in form, share a critical barrier function that must be properly established throughout development, maintained during homeostasis, and restored following injury. The barrier function of the epidermis, the largest epithelial organ, is essential for animal survival, serving as the body’s outermost protective layer that prevents pathogen entry while promoting fluid retention. Disruptions to epidermal homeostasis require the rapid replacement of lost or damaged cells to efficiently restore barrier integrity. This regenerative capacity relies on quiescent stem cell populations that are primed to proliferate and able to generate the diverse cell types required for tissue function. Nevertheless, stem cell proliferation and plasticity must be stringently controlled, as dysregulation of these behaviors could have tumorigenic consequences1, 2.","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":"4 2","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.29245/2767-5092/2022/3.1157
Daniela Frasca, Natasa Strbo
Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced health span and life span, decreased responses to infections and vaccination and increased frequency of inflammatory conditions. In this review, we summarize published data showing that obesity increases the risk of different types of infections, with a special focus on skin infections. Obesity also induces skin changes and conditions (inflammation-based and hypertrophic) which are often associated with fungi or bacteria overgrowth. The association of obesity with the skin microbiome has been established in both mice and humans. Balance of commensal microbes controls skin homeostasis and the host immune response, while changes in normal physiologic skin microbiome composition and pathologic bacteria contribute to skin diseases. We also summarize the major steps in wound healing and how obesity affects each of them. The role that immune cells have in this process is also described. Although the studies summarized in this review clearly demonstrate the deleterious effects of obesity on wound healing, additional studies are needed to better characterize the cellular and molecular mechanisms involved and identify specific targets of intervention.
{"title":"Effects of Obesity on Infections with Emphasis on Skin Infections and Wound Healing.","authors":"Daniela Frasca, Natasa Strbo","doi":"10.29245/2767-5092/2022/3.1157","DOIUrl":"10.29245/2767-5092/2022/3.1157","url":null,"abstract":"<p><p>Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced health span and life span, decreased responses to infections and vaccination and increased frequency of inflammatory conditions. In this review, we summarize published data showing that obesity increases the risk of different types of infections, with a special focus on skin infections. Obesity also induces skin changes and conditions (inflammation-based and hypertrophic) which are often associated with fungi or bacteria overgrowth. The association of obesity with the skin microbiome has been established in both mice and humans. Balance of commensal microbes controls skin homeostasis and the host immune response, while changes in normal physiologic skin microbiome composition and pathologic bacteria contribute to skin diseases. We also summarize the major steps in wound healing and how obesity affects each of them. The role that immune cells have in this process is also described. Although the studies summarized in this review clearly demonstrate the deleterious effects of obesity on wound healing, additional studies are needed to better characterize the cellular and molecular mechanisms involved and identify specific targets of intervention.</p>","PeriodicalId":73705,"journal":{"name":"Journal of dermatology and skin science","volume":"4 3","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10448872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10103676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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