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Nodular Melanoma: A Review of Pathogenesis, Presentation, Diagnosis, and Treatment 结节性黑色素瘤：发病机制、表现、诊断和治疗综述
Journal of dermatology and skin science
Pub Date : 2021-12-24 DOI: 10.29245/2767-5092/2021/3.1144
L. Hernandez, F. Frech, Noreen Mohsin, I. Dreyfuss, K. Nouri
Nodular melanoma is the second most common subtype of melanoma. Unlike other subtypes, nodular melanoma is characterized by early vertical growth rather than the typical initial radial growth of most melanomas. As a result, nodular melanoma presents clinically in a more aggressive phenotype. Given its more aggressive nature and intrinsic ability to mimic benign lesions, a modified acronym has been developed to allow clinicians to better evaluate, diagnose and treat nodular melanoma in earlier stages. Surgical excision with wide margins is the gold standard of nodular melanoma therapy; however, an emphasis in early detection, diagnosis, staging, and treatment needs to be emphasized among clinicians due to its dismal prognosis in later stages, as compared to other subtypes. A better understanding of the molecular pathophysiology that allows nodular melanoma to act aggressively very early in diagnosis is necessary for the development of therapeutics that may effectively target lesions in more advanced stages.
结节性黑色素瘤是黑色素瘤的第二常见亚型。与其他亚型不同，结节性黑色素瘤的特征是早期垂直生长，而不是大多数黑色素瘤典型的初始径向生长。因此，结节性黑色素瘤在临床上表现为更具侵袭性的表型。鉴于其更具攻击性的性质和模仿良性病变的内在能力，已经开发了一个经过修改的缩写词，使临床医生能够在早期更好地评估、诊断和治疗结节性黑色素瘤。宽切缘的手术切除是结节性黑色素瘤治疗的金标准；然而，临床医生需要强调早期检测、诊断、分期和治疗，因为与其他亚型相比，其后期预后较差。更好地了解使结节性黑色素瘤在诊断早期发挥积极作用的分子病理生理学，对于开发可能有效靶向更晚期病变的治疗方法是必要的。
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引用次数: 1
Thymidine Kinase 1: Making Its Mark In Immunotherapy 胸苷激酶1在免疫治疗中的应用
Journal of dermatology and skin science
Pub Date : 2021-12-08 DOI: 10.29245/2767-5092/2021/3.1143
Toni O. Mortimer, R. Morris, Abigail Schekall, Kai Barlow, K. O’Neill
Cancer is one of the leading causes of death worldwide. In the U.S. alone, almost 2 million people will be diagnosed with cancer each year and just over a quarter of those diagnosed will pass away from the disease. Skin cancers are the most common forms of cancer. Early detection of cancer and cancer biomarkers enables clearer understanding of cancer progression in a patient and more effective treatments in response to the disease. Clinically relevant biomarkers are not only tools for early diagnosis of cancer but may also prove useful as immune targets for various immunotherapies, such as monoclonal antibody-based therapy and chimeric antigen receptor (CAR) T-cell therapy. This review provides a brief overview of the rescue pathway enzyme thymidine kinase 1 (TK1) and its history and biology, as well as discusses its role as a biomarker and potential immune target.
癌症是世界范围内导致死亡的主要原因之一。仅在美国，每年就有近200万人被诊断出患有癌症，其中超过四分之一的人将死于这种疾病。皮肤癌是最常见的癌症。癌症和癌症生物标志物的早期检测可以更清楚地了解患者的癌症进展，并对疾病进行更有效的治疗。临床相关的生物标志物不仅是癌症早期诊断的工具，而且可能被证明是各种免疫疗法的免疫靶点，如基于单克隆抗体的治疗和嵌合抗原受体(CAR) t细胞治疗。本文综述了胸苷激酶1 (TK1)的救援途径及其历史和生物学，并讨论了其作为生物标志物和潜在免疫靶点的作用。
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引用次数: 0
Commentary: Sensitivity of Fite-faraco Versus Auramine-rhodamine in Mycobacterial Infection 解说：Fite-faraco与Auramine罗丹明在分枝杆菌感染中的敏感性
Journal of dermatology and skin science
Pub Date : 2021-10-08 DOI: 10.29245/2767-5092/2021/3.1138
K. Atherton, Latiffa J Smith, Alan Snyder, John Plante, D. Elston
Kelly Atherton BS1*, Latiffa Smith BS2, Alan Snyder MD MSCR3, John Plante MD MSCR3, Dirk Elston MD3 1College of Medicine, Medical University of South Carolina, Charleston, South Carolina; College of Graduate Studies, Medical University of South Carolina, Charleston, South Carolina 2College of Medicine, Medical University of South Carolina, Charleston, South Carolina 3Department of Dermatology and Dermatologic Surgery, Medical University South Carolina, Charleston, South Carolina
Kelly Atherton BS1*、Latifa Smith BS2、Alan Snyder医学博士、John Plante医学博士、Dirk Elston医学博士1南卡罗来纳州查尔斯顿医科大学医学院；南卡罗来纳州查尔斯顿南卡罗来纳医科大学研究生院
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引用次数: 1
Intense Pulsed Light (IPL) from Dermatology to Ophthalmology 强脉冲光(IPL)从皮肤病学到眼科
Journal of dermatology and skin science
Pub Date : 2021-10-06 DOI: 10.29245/2767-5092/2021/3.1139
J. S. Borges, C. Vergés, J. Lima, March de Ribot F
Intense pulsed light (IPL) are medical-esthetical procedures that emit light at a wavelength of 500 – 1200 nm, interacting with epidermal and dermal tissues. IPL is a relatively new treatment of growing popularity thanks to its versatility and efficacy, mainly in dermatology and recently also in ophthalmology. These devices are used to treat dry eye disease, meibomian gland dysfunction, rosacea, and periocular lesions with outstanding results.
强脉冲光(IPL)是一种医疗美容程序，它发射波长为500 - 1200纳米的光，与表皮和真皮组织相互作用。由于其多功能性和有效性，IPL是一种相对较新的治疗方法，越来越受欢迎，主要用于皮肤科，最近也用于眼科。这些装置用于治疗干眼病、睑板腺功能障碍、酒渣鼻和眼周病变，效果显著。
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引用次数: 0
Pemphigus Vulgaris in a Black Patient: Early Recognition of Disease Saves Lives 黑人患者的寻常性天疱疮：早期识别疾病挽救生命
Journal of dermatology and skin science
Pub Date : 2021-06-30 DOI: 10.29245/2767-5092/2021/2.1137
M. Rodríguez-Santiago, Javier García‐Marín, Alfredo Lamela-Domenech, M. Vega-Martínez
There is a well-known shortage of racial diversity in medical textbooks and literature contributing to race-based health care inequalities1. We present the case of a black puertorrican 58-year-old female who developed a painful non-pruritic blistering ulcer in the inner oral mucosa with associated erythema six months prior to the evaluation. She was misdiagnosed on multiple occasions leading to a rapid progression of the disease, and subsequently, her death. Lack of images in medical textbooks and scarce literature describing initial presentation per-skin-tone of Pemphigus Vulgaris (PV) in patients with dark skin color led to misdiagnosis, delay in treatment, and thus, this catastrophic outcome. This case report describes the appearance of PV in patients with dark skin tone and serves as an educational resource by providing images of a rare skin disease in people with dark skin. The purpose of this case report is to fill major gaps in medical literature, highlight the importance of timely recognizing PV in patients with dark skin, and to create awareness among physicians.
众所周知，医学教科书和文献中缺乏种族多样性，这导致了基于种族的保健不平等1。我们提出了一个58岁的黑人女性，在评估前六个月，在口腔内黏膜出现了疼痛的非瘙痒性水泡性溃疡并伴有红斑。她多次被误诊，导致疾病迅速发展，随后死亡。在医学教科书中缺乏图像和缺乏文献描述的最初表现为肤色较深的寻常型天疱疮(PV)患者的皮肤颜色导致误诊，延误治疗，因此，这一灾难性的结果。本病例报告描述了深色皮肤患者的PV外观，并通过提供深色皮肤患者罕见皮肤病的图像作为教育资源。本病例报告的目的是填补医学文献的主要空白，强调及时识别深色皮肤患者PV的重要性，并提高医生的认识。
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引用次数: 0
Pressure Injury Related to Friction and Shearing Forces in Older Adults 老年人与摩擦和剪切力相关的压力损伤
Journal of dermatology and skin science
Pub Date : 2021-06-30 DOI: 10.29245/2767-5092/2021/2.1136
Vianna Broderick, L. Cowan
The scientific literature describes many physiologic changes to the human body with age. These changes have a significant impact on the potential harm from pressure, friction, and shearing forces on the skin.1 Prolonged stay or immobility on surfaces such as beds and chairs are known to increase the risk of pressure injuries (PIs).2 Most PI prevention strategies target pressure force risk reduction through mechanical offloading, repositioning, and pressure redistribution support surfaces.3 However, the movement of repositioning may increase friction and shearing forces that may lead to PIs if not done properly especially in the older population.4 Diminished skin integrity and increased skin fragility with aging highlight the need for PI prevention strategies to address friction and shear risk reduction.2,4 This mini review of the literature provides a brief summary of PI injury related to friction and shearing forces in older adults.
科学文献描述了人体随着年龄的增长而发生的许多生理变化。这些变化对皮肤上的压力、摩擦力和剪切力的潜在危害有重大影响。1众所周知，在床和椅子等表面上长时间停留或不动会增加压力伤害（PI）的风险。2大多数压力伤害预防策略的目标是通过机械卸载、重新定位，和压力再分配支撑表面。3然而，重新定位的运动可能会增加摩擦力和剪切力，如果操作不当，可能会导致PI，尤其是在老年人群中。4随着年龄的增长，皮肤完整性的下降和皮肤脆性的增加突出了PI预防策略的必要性，以解决摩擦和剪切风险的降低问题。2，4这篇文献的小型综述简要总结了与老年人的摩擦力和剪切力。
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引用次数: 3
Vision Loss and Blindness Following Fillers. 填充物后的视力下降和失明。
Journal of dermatology and skin science
Pub Date : 2021-01-01 Epub Date: 2021-05-26
Ann Q Tran, Wendy W Lee

Facial aging associated with volume loss can be addressed with soft tissue fillers. This minimally invasive technique has quickly gained popularity and is commonly performed in many outpatient settings. The composition of injectable dermal fillers includes marketed hyaluronic acid, calcium hydroxyapatite, polylactic acid, silicone and polymethylmethacrylate. Complications, such as vision loss, are rare, but can result in a devastating and irreversible sequala from iatrogenic vascular occlusion. Understanding the facial anatomy, specific filler characteristics, and having a safe injection technique is crucial to assure optimal aesthetics results while avoiding complications. Injectors need to be able to recognize early complications and treat them appropriately, especially if vision loss is encountered. This review will focus on vision loss from fillers, techniques to prevent such complications and possible treatment strategies.

与体积损失相关的面部老化可以用软组织填充物来解决。这种微创技术已迅速普及，并在许多门诊设置普遍执行。可注射真皮填充剂的组成包括市售透明质酸、羟基磷灰石钙、聚乳酸、有机硅和聚甲基丙烯酸甲酯。并发症，如视力丧失，是罕见的，但可导致破坏性和不可逆转的后遗症医源性血管闭塞。了解面部解剖，特定的填充物特征，并有安全的注射技术是至关重要的，以确保最佳的美学效果，同时避免并发症。注射者需要能够识别早期并发症并适当治疗，特别是如果遇到视力丧失。本文将重点介绍填充物引起的视力下降、预防此类并发症的技术以及可能的治疗策略。
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引用次数: 0
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