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Journal of emergency and critical care medicine (Hong Kong, China)最新文献

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Napping: is it really a means by which short sleepers can have their cake and eat it too? 小睡:这真的是一种能让短睡眠者鱼与熊掌兼得的方法吗?
Pub Date : 2019-05-01 DOI: 10.21037/jeccm.2019.05.02
Marie-Pierre St-Onge, Brooke Aggarwal, Sanja Jelic
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引用次数: 0
Critically Hematological Ill Patients Antimicrobial Stewardship (C.H.I.P.S) in intensive care unit: a global cross-sectional survey—an international research project within the Nine-i investigators network 重症监护室的危重血液病患者抗菌药物管理(C.H.I.P.S):一项全球横断面调查——Nine-I研究人员网络内的一个国际研究项目
Pub Date : 2019-04-24 DOI: 10.21037/JECCM.2019.04.01
C. Sarda, A. Tabah, D. Mokart, E. Alp, K. Arvaniti, M. Akova, J. Rello
Background: Critically Hematological Ill Patients Antimicrobial Stewardship (C.H.I.P.S) is a global cross-sectional survey will describe the most clinical relevant bacteria and antimicrobial pattern of resistance among hematological patients admitted to intensive care units (ICU). At the same time, a global expert challenges on infection control and treatment will be provided. Methods: A global survey will be performed using an electronic platform (SurveyMonkey ® ). The survey will compile data on key aspects of the current treatment of antimicrobial-resistant bacteria infections among hematological patients admitted in ICU worldwide. All responses to survey questions will be presented as summary statistics and reporting proportions. Statistical analysis by Chi-square test or Fisher’s exact test will be performed to evaluate potential associations. Discussion: Efforts on the development of recommendations and antimicrobial stewardship (AMS) programs focused on critical hematological patients should be directed in the near future. Prevention strategies, type and, timing of antimicrobial therapy, de-escalation (ADE) approach have to be tailored to these patients.
背景:危重血液病患者抗菌药物管理(C.H.I.P.S)是一项全球横断面调查,将描述入住重症监护室(ICU)的血液病患者中最具临床相关性的细菌和耐药性模式。与此同时,将提供一个关于感染控制和治疗的全球专家挑战。方法:将使用电子平台(SurveyMonkey®)进行全球调查。这项调查将汇编有关目前全球ICU血液病患者抗微生物细菌感染治疗的关键方面的数据。对调查问题的所有答复都将以汇总统计数字和报告比例的形式呈现。将通过卡方检验或Fisher精确检验进行统计分析,以评估潜在的关联性。讨论:在不久的将来,应致力于制定针对危重血液病患者的建议和抗菌管理(AMS)计划。预防策略、类型、抗菌治疗时间、降级(ADE)方法必须针对这些患者。
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引用次数: 1
Antifungal drug dosing adjustment in critical patients with invasive fungal infections 侵袭性真菌感染危重患者抗真菌药物剂量调整
Pub Date : 2019-04-09 DOI: 10.21037/jeccm.2019.08.01
A. Pyrpasopoulou, E. Iosifidis, C. Antachopoulos, E. Roilides
Critically ill patients suffer from invasive fungal infections, mainly due to Candida spp., but also to Aspergillus spp., Cryptococcus spp. and other more rare yeasts or filamentous fungi. These infections are prevented or treated with various antifungal agents belonging to one of the following classes: polyenes (mainly amphotericin B formulations with liposomal amphotericin B as the most frequently used compound), azoles (fluconazole, itraconazole, voriconazole, posaconazole and isavuconazole) or echinocandins (caspofungin, micafungin and anidulafungin). Administration of these agents may be challenging due to various factors in patients hospitalized in the intensive care unit (ICU). Such factors frequently found in these patients are renal and liver insufficiencies, extreme ages (prematurely born infants or elderly patients), obesity, thermal injury, other co-morbidities, and interactions with many simultaneously administered other drugs. In addition, sepsis itself may cause such hemodynamic changes resulting in increased clearance of antifungal agents. The use of continuous renal replacement therapy and extracorporeal membrane oxygenation needs special attention when antifungal agents are administered. It is very important that the physicians caring for these patients are aware of the impact of such factors on the pharmacokinetics and pharmacodynamics of the antifungal agents administered in the ICU. In addition, they should be aware of the adverse effects of these agents that they administer on the biology and physiology of host’s various organs and the metabolism of other co-administered drugs occurring through these organs. This knowledge may lead to optimization of dosing of the antifungal agents and other interacting medications in order to maximize antifungal effect in the care of critically ill patients.
危重患者遭受侵袭性真菌感染,主要是念珠菌感染,但也有曲霉菌、隐球菌等较为罕见的酵母菌或丝状真菌感染。预防或治疗这些感染的各种抗真菌药物属于以下一类之一:多烯类(主要是两性霉素B制剂,两性霉素B是最常用的脂体化合物)、唑类(氟康唑、伊曲康唑、伏立康唑、泊沙康唑和异唑康唑)或棘白菌素类(卡泊芬宁、米卡芬宁和阿杜拉芬宁)。由于重症监护病房(ICU)住院患者的各种因素,这些药物的施用可能具有挑战性。在这些患者中经常发现的这些因素是肾脏和肝脏功能不全、极端年龄(早产婴儿或老年患者)、肥胖、热损伤、其他合并症以及与许多同时使用的其他药物的相互作用。此外,脓毒症本身可能引起这种血流动力学改变,从而增加抗真菌药物的清除率。当使用抗真菌药物时,需要特别注意持续肾替代治疗和体外膜氧合。照顾这些患者的医生意识到这些因素对在ICU使用的抗真菌药物的药代动力学和药效学的影响是非常重要的。此外,他们应该意识到这些药物对宿主各器官的生物学和生理学的不良影响,以及通过这些器官发生的其他共给药药物的代谢。这一知识可能导致抗真菌药物和其他相互作用药物的剂量优化,以便在重症患者的护理中最大限度地发挥抗真菌作用。
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引用次数: 6
Translational thoracolumbar injury after motor vehicle collision with uretero-thecal fistulization: a case report 汽车碰撞致胸腰椎平移损伤并输尿管鞘瘘1例
Pub Date : 2019-04-09 DOI: 10.21037/jeccm.2019.08.05
H. Kapoor, James T Lee, Ahmed A. Farag, B. Tucker, A. Pereira
Blunt torso trauma leading to translational thoracolumbar injury is a rare and serious injury requiring high amount of energy to produce this injury pattern. Translational thoracolumbar injuries have high association with spinal dural tears and traumatic aortic injuries however, associated traumatic ureteral injury is rare. This case report presents a unique combination of traumatic ureteral and dural injury resulting in an abnormal fistulous communication between the two, in a patient with translational thoracolumbar injury after motor vehicular collision. Unexpected “myelogram-like” appearance was seen with excreted urinary contrast mixing with the CSF in the spinal and intracranial subarachnoid spaces. No other reports of such a traumatic uretero-thecal fistula were found in our comprehensive search through the published English literature.
导致胸腰椎平移损伤的钝性躯干创伤是一种罕见且严重的损伤,需要大量的能量才能产生这种损伤模式。转化性胸腰椎损伤与硬膜撕裂和创伤性主动脉损伤有很高的相关性,然而,相关的创伤性输尿管损伤是罕见的。本病例报告介绍了一名机动车碰撞后平移性胸腰段损伤患者的创伤性输尿管和硬膜损伤的独特组合,导致两者之间的异常瘘管连通。在脊髓和颅内蛛网膜下腔,排泄的尿液造影剂与脑脊液混合,出现了意外的“骨髓图样”外观。在我们对已发表的英文文献的全面搜索中,没有发现其他关于这种创伤性输尿管鞘瘘的报告。
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引用次数: 0
Inter-hospital variations in resuscitation processes and outcomes of out-of-hospital cardiac arrests in Singapore 新加坡院外心脏骤停复苏过程和结果的院间差异
Pub Date : 2019-04-05 DOI: 10.21037/JECCM.2019.04.02
T. Z. Tan, Y. Hao, A. Ho, N. Shahidah, S. Yap, Y. Ng, N. Doctor, B. Leong, H. N. Gan, D. Mao, M. Y. Chia, S. O. Cheah, M. Ong
Background: Variability in post-resuscitation care of out-of-hospital cardiac arrests (OHCA) contributes to differences in survival outcomes. Interventions of significance include targeted temperature management (TTM) and percutaneous coronary intervention (PCI). In this study, we sought to determine the magnitude and factors involved. Methods: From April 2010 to December 2014, all consecutive OHCAs presenting to hospitals across Singapore were considered for analysis. Primary outcome was survival to discharge or 30 days. Secondary outcomes included survival to admission, and neurological outcome (Glasgow-Pittsburgh Cognitive Performance Categories ≤2). The effects of hospital-based resuscitative interventions and admitting hospital on outcome were compared using Chi-squared tests and multivariate logistic regression models. Results: A total of 7,609 OHCA cases were included from six hospitals in Singapore. TTM and PCI usage varied significantly (P<0.001). Hospitals B, C, D had a lower survival to discharge or 30 days post-arrest [adjusted odds ratio (AOR) 0.392, 95% CI: 0.229–0.671, P=0.0006; AOR 0.499, 95% CI: 0.298–0.837, P=0.008; AOR 0.495, 95% CI: 0.304–0.805, P=0.005, respectively]. Hospitals B, D had lower survival to discharge with good neurological function (AOR 0.390, 95% CI: 0.206–0.738, P=0.004; AOR 0.443, 95% CI: 0.249–0.791, P=0.006 respectively). Hospitals B, C, D, E had lower survival to ED admission (AOR 0.582, 95% CI: 0.462–0.733, P<0.0001; AOR 0.600, 95% CI: 0.474–0.759, P<0.001; AOR 0.678, 95% CI: 0.542–0.847, P=0.0007; AOR 0.620, 95% CI: 0.494–0.777, P<0.0001 respectively). Both teaching status and bed number (≥1,000 beds) are associated with improved survival to discharge or 30 days (OR 1.488, P=0.007; OR 1.536, P=0.005). Conclusions: TTM and PCI usage, and OHCA outcomes vary between hospitals. This is associated with teaching status, bed number, and post-resuscitation care.
背景:院外心脏骤停(OHCA)复苏后护理的可变性导致了生存结果的差异。重要的干预措施包括靶向温度管理(TTM)和经皮冠状动脉介入治疗(PCI)。在这项研究中,我们试图确定所涉及的规模和因素。方法:从2010年4月到2014年12月,考虑所有连续出现在新加坡各地医院的OHCA进行分析。主要结果是存活至出院或30天。次要结果包括入院生存率和神经系统结果(格拉斯哥-匹兹堡认知表现类别≤2)。使用卡方检验和多变量逻辑回归模型比较医院复苏干预和入院对结果的影响。结果:共有7609例OHCA病例来自新加坡的六家医院。TTM和PCI的使用差异显著(P<0.001)。B、C、D医院出院或停药后30天的存活率较低[调整比值比(AOR)分别为0.392,95%CI:0.229-0.671,P=0.006;AOR分别为0.499,95%CI:0.298-0.837,P=0.008;AOR为0.495,95%CI:0.304-0.805,P=0.005]。在神经功能良好的情况下,B、D医院的出院生存率较低(AOR分别为0.390、95%CI:0.206–0.738,P=0.004;AOR分别是0.443、95%CI:0.249–0.791,P=0.006)。医院B、C、D、E的ED入院生存率较低(AOR分别为0.582,95%CI:0.462-0.733,P<0.001;AOR为0.600,95%CI=0.474-0.759,P<0.001,AOR为0.678,95%CI0.542-0.847,P=0.0007;AOR分别是0.620,95%CI0.494-0.77,P<0.001)。教学状况和床位数量(≥1000张床位)都与出院或30天生存率的提高有关(or 1.488,P=0.007;or 1.536,P=0.005)。结论:TTM和PCI的使用以及OHCA的结果因医院而异。这与教学状态、床位和复苏后护理有关。
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引用次数: 6
Pulmonary infection caused by Aspergillus glaucus in patient with leucocythemia 白细胞增多症患者青光曲霉所致肺部感染
Pub Date : 2019-03-26 DOI: 10.21037/JECCM.2019.03.02
Chunhui Xu, Shu Li, Mi Zhou, Yuetian Yu
A 52-year-old female was admitted to our hospital with cough, fever and fatigue for a week. Her medical history included leukocytosis and myeloproliferative neoplasma for about 3 months. On physical examination, she appeared shallow breathing with fever up to 38.5 ℃ and moist rale could be clearly heard on the left lower lobe.
一名52岁的女性因咳嗽、发烧和疲劳入院一周。她的病史包括约3个月的白细胞增多症和骨髓增生性肿瘤。体检时,她出现浅呼吸,发烧高达38.5℃,左下叶可清晰听到潮湿的啰音。
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引用次数: 0
Knowledge retention of the traumatic brain injury guidelines at a Level 1 trauma center 一级创伤中心创伤性脑损伤指南的知识保留
Pub Date : 2019-03-20 DOI: 10.21037/JECCM.2019.02.06
Kimberly M. Gorman, R. Dumire
Trauma is the leading cause of death in those age 1–45 and the 3rd leading cause of death overall in all groups in the United States and is associated with an annual cost of 671 billion dollars. Education remains one of our most valuable tools in combatting this public health epidemic called “Trauma” and must, therefore, be provided in an efficient manner not only for nursing personnel but for all healthcare providers involved in the care of trauma patients. An on-line educational platform was utilized to introduce updates and revisions to our institutional traumatic brain injury (TBI) guidelines and protocols to a multidisciplinary group of nurses and surgical residents. In addition, a hands-on module was also utilized to ensure accuracy and consistency across all disciplines. Utilizing the NetLearning® educational process, an active learning platform, resulted in an improvement in test scores which was sustained at the 6-month point for both nurses and resident physicians. There was a statistically significant improvement in the nurse and resident physician combined scores between the pre-test and immediate post-test mean scores (74%±9.35% pre vs. 88%±6.23% post, P<0.0005), and no meaningful change between the immediate post-test and 6-month post-test scores, indicating sustained improvement. Multidisciplinary health care education via and on-line educational platform utilizing pre and posttest was found to be an effective teaching as well a process improvement methodology with sustained knowledge out to 6 months at a community based academic Level 1 trauma center.
创伤是造成1-45岁人群死亡的主要原因在美国所有人群中是第三大死亡原因每年造成的损失高达6710亿美元。教育仍然是我们对抗这种被称为“创伤”的公共卫生流行病的最有价值的工具之一,因此,不仅必须以有效的方式向护理人员提供教育,而且必须以有效的方式向参与护理创伤患者的所有医疗保健提供者提供教育。我们利用一个在线教育平台向多学科的护士和外科住院医师介绍我们的机构创伤性脑损伤(TBI)指南和协议的更新和修订。此外,实践模块也被用来确保所有学科的准确性和一致性。利用NetLearning®教育过程(一个积极的学习平台),护士和住院医师的考试成绩在6个月后持续提高。护士和住院医师的综合得分在测试前和测试后的平均得分之间有统计学意义的改善(测试前74%±9.35% vs测试后88%±6.23%,P<0.0005),测试后和测试后6个月的得分之间没有显著变化,表明持续改善。在一个以社区为基础的学术一级创伤中心,利用前测和后测的在线教育平台进行多学科卫生保健教育是一种有效的教学方法,也是一种持续6个月的过程改进方法。
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引用次数: 2
Nothing to sneeze at: tension pneumocephalus causing an acute stroke following endoscopic sinus surgery 没有什么可以打喷嚏:内窥镜鼻窦手术后引起急性中风的张力性脑气
Pub Date : 2019-03-18 DOI: 10.21037/JECCM.2019.02.08
A. Cancelliere
Pneumocephalus is a rare condition caused by abnormal air entrapment in the intracranial compartment following disruption of the meninges. Most cases self-resolve and typically do not cause neurological sequelae. However, excessive expansion of the pneumocele results in rapid neurological deterioration, termed tension pneumocephalus. Left untreated, this leads to tissue ischemia, herniation syndromes, and death. Rapid differentiation between the above entities and immediate multimodal management dictate the success of recovery. The author reports an exceptional case of an 82-year-old male who presented to an outside hospital with focal neurological deficits in the early postoperative period following endoscopic sinus surgery. Computed tomography imaging revealed a large pneumocele resulting in severe mass-effect on the underlying brain parenchyma. Prompt surgical evacuation of the pneumocele resulted in dramatic recovery with only minor disability from the initial ischemic insult. Tension pneumocephalus is an uncommon, albeit life-threatening neurosurgical emergency wherein the developing pneumocele results in abnormally high intracranial pressure. Prompt recognition by emergency physicians and appropriate management are critical to limit further morbidity and mortality.
脑膜炎是一种罕见的由脑膜破裂后颅内隔室异常空气滞留引起的疾病。大多数病例自行解决,通常不会引起神经系统后遗症。然而,肺炎球菌的过度扩张会导致神经系统迅速恶化,称为张力性肺炎球菌。如果不及时治疗,就会导致组织缺血、疝综合征和死亡。上述实体之间的快速分化和即时的多式联运管理决定了恢复的成功。作者报告了一例例外病例,一名82岁的男性在鼻窦内窥镜手术后的术后早期因局灶性神经功能缺损到外医院就诊。计算机断层扫描成像显示一个巨大的肺炎球菌,对下面的脑实质造成严重的肿块影响。肺水肿的迅速手术切除导致了戏剧性的恢复,从最初的缺血性损伤中只有轻微的残疾。张力性肺炎球菌病是一种罕见的,尽管危及生命的神经外科紧急情况,其中发展中的肺炎球菌血症导致异常高的颅内压。急诊医生的及时识别和适当的管理对于限制进一步的发病率和死亡率至关重要。
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引用次数: 1
Utility of ultrasound of upper airway for confirmation of endotracheal intubation and confirmation of the endotracheal tube position in the intensive care unit patients 上呼吸道超声在重症监护病房患者气管插管和气管插管位置确认中的应用
Pub Date : 2019-03-14 DOI: 10.21037/JECCM.2019.02.07
V. Patil, S. Bhosale, A. Kulkarni, N. Prabu, Vikas Bhagat, Harish K. Chaudhary, Suhail Sarawar, Amit M Narkhede, J. Divatia
Background: Endotracheal intubation in the intensive care unit (ICU) is an extremely high risk procedure. Rapid confirmation of endotracheal tube (ETT) placement and position to the correct depth is vitally important. Various methods are used to confirm placement of ETT. Capnography is the gold standard for confirmation of ETT placement in the trachea, but is not useful for ETT placement at the correct depth in the trachea. We conducted this study to evaluate the utility of airway ultrasonography for real time confirmation of ETT placement and also to confirm appropriate depth of the ETT. Methods: In this prospective, single-centre study, we included all adult patients intubated in the ICU. We obtained deferred consent from the Institutional Ethics Committee. We performed airway ultrasonography real time during intubation and detected ETT placement by loss of snow storm sign. Tracheal placement was also confirmed by capnography. We used saline filled cuff method to place ETT cuff depth at 3 rd and 4 rd tracheal ring and confirmed the appropriateness of the ETT depth on chest X-ray. We calculated the sensitivity and specificity of this technique. Results: We included 89 patients for the study. The ultrasound detection of the placement of the tube with the loss of snow storm sign was seen in 86 patients. The incidence of esophageal intubations was 2.0%. The overall sensitivity of airway ultrasound for confirmation of ETT placement was 96% (CI: 0.89–0.99) and specificity was 100%. The PPV was 100% (CI: 0.94–1.00). The accuracy for appropriateness of final position of ETT by airway ultrasound as compared to X-ray was found to be 96% (CI: 0.71–0.87). No complications were observed related to cuff inflation and deflation and to the use of airway ultrasound. Conclusions: Airway ultrasonography can be used for rapidly detecting ETT placement in the trachea as well as for determining appropriate depth insertion of the ETT with saline filled cuff technique.
背景:重症监护病房(ICU)气管插管是一项高危手术。快速确认气管内插管(ETT)的位置和正确的深度是至关重要的。使用各种方法来确认ETT的放置。气管造影是确认气管内ETT放置的金标准,但对于气管内ETT放置在正确的深度是没有用的。我们进行这项研究是为了评估气道超声在实时确认气管插管位置和确定气管插管适当深度方面的效用。方法:在这项前瞻性单中心研究中,我们纳入了所有在ICU插管的成年患者。我们获得了机构伦理委员会的延期同意。我们在插管期间实时进行气道超声检查,并通过暴风雪征象的消失来检测ETT的放置。气管置入术也经导管造影证实。我们采用盐水袖带法在第3和第4气管环处放置ETT袖带深度,并在胸片上确认ETT深度的适宜性。我们计算了该技术的敏感性和特异性。结果:我们纳入了89例患者。86例患者超声检测置管时无暴风雪征象。食管插管发生率为2.0%。气道超声确认ETT放置的总体敏感性为96% (CI: 0.89-0.99),特异性为100%。PPV为100% (CI: 0.94 ~ 1.00)。与x线相比,气道超声对ETT最终位置的准确性为96% (CI: 0.71-0.87)。没有观察到与袖带充气和充气以及气道超声使用相关的并发症。结论:气道超声可快速检测气管内ETT的放置位置,并可应用盐水袖带技术确定ETT的合适放置深度。
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引用次数: 7
The missing piece of the concussion discussion: primary prevention of mild traumatic brain injury in student athletes 脑震荡讨论的缺失部分:学生运动员轻度创伤性脑损伤的初级预防
Pub Date : 2019-03-02 DOI: 10.21037/JECCM.2019.01.06
Shawna L. Morrissey, R. Dumire, T. Causer, A. Colton, E. Oberlander, D. Frye, Kosie Shepherd-Porada, L. Frye
The majority of concussion research has focused on timely diagnosis and treatment, yet little has been reported on primary prevention. The goal of this study is to examine the use of core training as a preventative tool. We performed a non-randomized prospective study involving high school athletes. They participated in a 10-week training session with exercises focused on increasing core strength [mobility, agility, stability, strength and flexibility (MASSf)]. Logs were kept of all concussions diagnosed using ImPACT concussion testing. Statistical analysis was done using Chi-square to calculate expected/observed frequency and Chi-squared test statistic, χ 2 . Test significance was accepted at a P 2 =9.84, corresponds to a P value of 0.0017. The MASSf program was repeated in the 2015 season with 2 concussions in 121 participants. Our study showed a statistically significant decrease in concussion rates after participating in MASSf training. This program shows a promise as a primary prevention method to reduce sports related concussions.
大多数脑震荡研究都集中在及时诊断和治疗上,但关于初级预防的报道很少。本研究的目的是检验核心训练作为预防工具的使用情况。我们进行了一项涉及高中运动员的非随机前瞻性研究。他们参加了为期10周的训练,重点是提高核心力量[灵活性、灵活性、稳定性、力量和灵活性(MASSf)]。记录使用ImPACT脑震荡测试诊断的所有脑震荡。使用卡方计算预期/观察频率和卡方检验统计量χ2进行统计分析。在P 2=9.84时,接受了测试显著性,对应于P值0.0017。MASSf项目在2015赛季重复进行,121名参与者中发生了2次脑震荡。我们的研究显示,参加MASSf训练后,脑震荡发生率在统计学上显著下降。该项目有望成为减少运动相关脑震荡的主要预防方法。
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引用次数: 5
期刊
Journal of emergency and critical care medicine (Hong Kong, China)
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