首页 > 最新文献

Journal of emergency and critical care medicine (Hong Kong, China)最新文献

英文 中文
Pheochromocytoma crisis treated with veno-arterial extracorporeal membrane oxygenation and urgent adrenalectomy—case report 静脉-动脉体外膜肺氧合及肾上腺皮质激素酶紧急治疗肾上腺皮质瘤危象报告
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-21-32
Yael Lichter, A. Nini, Y. Szekely, Noam Goder, Reut Schvartz, Lilach Zac, Y. Topilsky, Jacob Vine, A. Gal-Oz
A 61-year-old woman, presented to the Emergency Department (ED) with respiratory failure and cardiogenic shock following a face lift surgery earlier that day. Her intraoperative course included highly labile blood pressure (BP) and heart rate (HR). Initial investigation revealed severe global left ventricular (LV) failure with sparing of the base, high levels of troponin-I and bilateral chest infiltrates, without electrocardiographic evidence of acute myocardial ischemia. Her condition quickly deteriorated to severe hypoxemia and refractory shock. Peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was installed during resuscitation, resulting in rapid hemodynamic stabilization, normalization of lactate levels and restoration of normal urinary output. Laboratory investigation and computed tomography (CT) revealed a round lesion with a hypodense core in the left adrenal gland, and high blood levels of epinephrine and norepinephrine, supporting a diagnosis of pheochromocytoma. The patient gradually recovered and was weaned from ECMO support on day 5, but continued to experience repeated, life threatening, events of hemodynamic instability. Following a multidisciplinary discussion that included intensivists, endocrinologists, anesthetists and surgeons, urgent adrenalectomy was successfully performed. The patient made a full recovery and was discharged home. This case emphasizes the role of ECMO as a life-saving mean in cases of potentially reversible cardiogenic shock, and triggers the discussion as to the optimal timing and safety of adrenalectomy in cases of pheochromocytoma crisis.
一名61岁的女性在当天早些时候接受面部提升手术后,因呼吸衰竭和心源性休克被送往急诊科。她的术中疗程包括高度不稳定的血压(BP)和心率(HR)。初步调查显示,严重的整体左心室(LV)衰竭,保留基底,肌钙蛋白I水平高,双侧胸部浸润,没有急性心肌缺血的心电图证据。她的病情迅速恶化为严重低氧血症和难治性休克。复苏过程中安装了外周静脉-动脉体外膜肺氧合(VA-ECMO),使血流动力学快速稳定,乳酸水平正常化,并恢复正常尿量。实验室调查和计算机断层扫描(CT)显示,左肾上腺有一个圆形病变,核心低密度,血液中肾上腺素和去甲肾上腺素水平高,支持对嗜铬细胞瘤的诊断。患者逐渐康复,并在第5天脱离ECMO支持,但仍持续出现危及生命的血液动力学不稳定事件。经过包括重症医生、内分泌学家、麻醉师和外科医生在内的多学科讨论,成功地进行了紧急肾上腺切除术。病人完全康复出院回家了。该病例强调了ECMO作为潜在可逆性心源性休克患者的救命手段的作用,并引发了对嗜铬细胞瘤危象患者肾上腺切除术最佳时机和安全性的讨论。
{"title":"Pheochromocytoma crisis treated with veno-arterial extracorporeal membrane oxygenation and urgent adrenalectomy—case report","authors":"Yael Lichter, A. Nini, Y. Szekely, Noam Goder, Reut Schvartz, Lilach Zac, Y. Topilsky, Jacob Vine, A. Gal-Oz","doi":"10.21037/jeccm-21-32","DOIUrl":"https://doi.org/10.21037/jeccm-21-32","url":null,"abstract":"A 61-year-old woman, presented to the Emergency Department (ED) with respiratory failure and cardiogenic shock following a face lift surgery earlier that day. Her intraoperative course included highly labile blood pressure (BP) and heart rate (HR). Initial investigation revealed severe global left ventricular (LV) failure with sparing of the base, high levels of troponin-I and bilateral chest infiltrates, without electrocardiographic evidence of acute myocardial ischemia. Her condition quickly deteriorated to severe hypoxemia and refractory shock. Peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was installed during resuscitation, resulting in rapid hemodynamic stabilization, normalization of lactate levels and restoration of normal urinary output. Laboratory investigation and computed tomography (CT) revealed a round lesion with a hypodense core in the left adrenal gland, and high blood levels of epinephrine and norepinephrine, supporting a diagnosis of pheochromocytoma. The patient gradually recovered and was weaned from ECMO support on day 5, but continued to experience repeated, life threatening, events of hemodynamic instability. Following a multidisciplinary discussion that included intensivists, endocrinologists, anesthetists and surgeons, urgent adrenalectomy was successfully performed. The patient made a full recovery and was discharged home. This case emphasizes the role of ECMO as a life-saving mean in cases of potentially reversible cardiogenic shock, and triggers the discussion as to the optimal timing and safety of adrenalectomy in cases of pheochromocytoma crisis.","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46625338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sepsis versus anaphylaxis—differentiating shock etiology: a case report involving Smoflipid 脓毒症与过敏区分性休克病因学:涉及smof脂的病例报告
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-21-28
Robert Anderson, M. Pitlick, Armando Pérez, K. Kashani
: This case study illustrates a clinically observed interaction between Smoflipid and the development of anaphylactic shock in a patient on long-term parenteral nutrition. This patient had a history of a well-differentiated retroperitoneal liposarcoma, now resected, which was complicated by duodenal perforation and intraperitoneal drain placement; due to significant gastrointestinal tract dysfunction the patient was maintained on continuous parenteral nutrition via a PICC line. Following a routine and drain exchange, the patient was admitted to the hospital. The patient subsequently developed anaphylactic-like shock symptomatology, necessitating admission to the critical care unit. Intermittent dual vasopressor use was required. There was also an intermittently visible rash that was noted. The etiology of the shock state was unclear. After review of the patient’s case and clinical course, a potential etiology of his shock state was the inpatient protocolized substitution of Smoflipid instead of Intralipid in the parenteral nutrition regimen. After consultation with Allergic Diseases, Nutrition, and Pharmacy the Smoflipid was discontinued and the patient’s regimen was reverted to the standing home regimen including Intralipid. Following discontinuation of Smoflipid and resumption of Intralipid, the shock physiology resolved. The patient was subsequently transferred from the critical care unit and discharged soon thereafter by the primary surgical service. A formal Allergic Disease evaluation was completed in the outpatient setting. Continuous parenteral nutrition therapy was maintained at home using the previous home Intralipid regimen without issue. This case illustrates a multidisciplinary approach including Surgery, Allergic Diseases, Nutrition, Pharmacy, and Critical Care to address the patient’s acute shock state. In addition, a review of different shock states is presented. A literature review evaluating side effects of Smoflipid and an association of shock to its use is presented.
:本病例研究说明了在长期胃肠外营养的患者中,临床观察到的Smoflipid与过敏性休克发展之间的相互作用。该患者有高分化腹膜后脂肪肉瘤病史,现已切除,并发十二指肠穿孔和腹膜内引流;由于严重的胃肠道功能障碍,患者通过PICC线维持持续的胃肠外营养。在例行和排水管交换后,患者被送入医院。患者随后出现过敏性休克症状,需要进入重症监护室。需要间歇性使用双血管升压药。还有一个间歇性可见的皮疹。休克状态的病因尚不清楚。在回顾了患者的病例和临床过程后,其休克状态的潜在病因是住院患者在胃肠外营养方案中用Smoflipid代替Intralipid。在咨询过敏性疾病、营养和药房后,Smoflipid停止使用,患者的治疗方案恢复为包括Intralipid在内的居家治疗方案。在停用Smoflipid并恢复Intralipid后,休克生理学得到解决。患者随后被从重症监护室转移,不久后由初级外科服务出院。在门诊环境中完成了正式的过敏性疾病评估。使用之前的家庭Intralipid方案在家中维持持续的肠外营养治疗,没有出现问题。该病例说明了一种多学科方法,包括外科、过敏性疾病、营养、药学和重症监护,以解决患者的急性休克状态。此外,还对不同的冲击状态进行了综述。本文对Smoflipid的副作用以及休克与使用的关系进行了文献综述。
{"title":"Sepsis versus anaphylaxis—differentiating shock etiology: a case report involving Smoflipid","authors":"Robert Anderson, M. Pitlick, Armando Pérez, K. Kashani","doi":"10.21037/jeccm-21-28","DOIUrl":"https://doi.org/10.21037/jeccm-21-28","url":null,"abstract":": This case study illustrates a clinically observed interaction between Smoflipid and the development of anaphylactic shock in a patient on long-term parenteral nutrition. This patient had a history of a well-differentiated retroperitoneal liposarcoma, now resected, which was complicated by duodenal perforation and intraperitoneal drain placement; due to significant gastrointestinal tract dysfunction the patient was maintained on continuous parenteral nutrition via a PICC line. Following a routine and drain exchange, the patient was admitted to the hospital. The patient subsequently developed anaphylactic-like shock symptomatology, necessitating admission to the critical care unit. Intermittent dual vasopressor use was required. There was also an intermittently visible rash that was noted. The etiology of the shock state was unclear. After review of the patient’s case and clinical course, a potential etiology of his shock state was the inpatient protocolized substitution of Smoflipid instead of Intralipid in the parenteral nutrition regimen. After consultation with Allergic Diseases, Nutrition, and Pharmacy the Smoflipid was discontinued and the patient’s regimen was reverted to the standing home regimen including Intralipid. Following discontinuation of Smoflipid and resumption of Intralipid, the shock physiology resolved. The patient was subsequently transferred from the critical care unit and discharged soon thereafter by the primary surgical service. A formal Allergic Disease evaluation was completed in the outpatient setting. Continuous parenteral nutrition therapy was maintained at home using the previous home Intralipid regimen without issue. This case illustrates a multidisciplinary approach including Surgery, Allergic Diseases, Nutrition, Pharmacy, and Critical Care to address the patient’s acute shock state. In addition, a review of different shock states is presented. A literature review evaluating side effects of Smoflipid and an association of shock to its use is presented.","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44363074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial stewardship programmes focused on de-escalation: a narrative review of efficacy and risks 以降级为重点的抗菌药物管理方案:对疗效和风险的叙述性审查
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-22-6
H. Umpleby, Ahilanandan Dushianthan, Timothy Catton, K. Saeed
{"title":"Antimicrobial stewardship programmes focused on de-escalation: a narrative review of efficacy and risks","authors":"H. Umpleby, Ahilanandan Dushianthan, Timothy Catton, K. Saeed","doi":"10.21037/jeccm-22-6","DOIUrl":"https://doi.org/10.21037/jeccm-22-6","url":null,"abstract":"","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47351849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Management of heatstroke using the novel, reusable, CarbonCool® suit: a case report 使用新型可重复使用的CarbonCool®防护服治疗中暑:一例报告
Pub Date : 2021-01-01 DOI: 10.21037/JECCM-20-107
P. J. M. Tay, A. Ho, N. Shahidah, G. Nadarajan
: Heatstroke is a life-threatening condition with high morbidity and mortality. Prompt recognition and institution of cooling measures has been shown to greatly improve outcomes. This is a case report demonstrating the use of a novel cooling suit (CarbonCool ® suit) in a case of exertional heatstroke (EHS). The CarbonCool ® suit is a half-body suit with cooling pads (MPad TM ) that are filled with a graphite water solution found to be 15 times more thermally conductive than ice. In this case report, a previously well 31-year-old male presented to the Emergency Department (ED) with EHS, subsequently requiring intubation. The CarbonCool ® suit was used to reduce his core (rectal) temperature from 41 ℃ to 38.7 ℃ in two hours. Patient’s core temperature subsequently normalized to 37 ℃ and he was discharged well and neurologically intact. The case report demonstrates that the suit can be easily worn and secured in place, while resuscitative measures are ongoing. This reduces the need for constant monitoring and replacement of ice packs, hence serving as a convenient alternative to ice packs for initial management of patients with EHS. While alternative cooling methods such as powered cooling devices may be utilized, these devices are often only available in the intensive care unit, with significantly higher operative costs. Use of the CarbonCool ® suit as an adjunct to other cooling methods may be a simple solution for rapid initiation of cooling in the patient with heatstroke.
中暑是一种危及生命的疾病,发病率和死亡率都很高。迅速认识到并建立冷却措施已被证明可以大大改善结果。这是一个案例报告,展示了在劳力中暑(EHS)的情况下使用一种新型冷却服(CarbonCool®服)。CarbonCool®宇航服是一种带有冷却垫(MPad TM)的半身宇航服,冷却垫填充了石墨水溶液,其导热性是冰的15倍。在本病例报告中,一名先前健康的31岁男性因EHS来到急诊科(ED),随后需要插管。使用CarbonCool®套装在两小时内将其核心(直肠)温度从41℃降至38.7℃。病人的核心体温随后恢复到37℃,出院时情况良好,神经系统完好。病例报告表明,该套装可以很容易地穿着并固定到位,而复苏措施正在进行中。这减少了持续监测和更换冰袋的需要,因此在EHS患者的初始管理中,作为冰袋的方便替代方案。虽然可以使用其他冷却方法,如动力冷却装置,但这些装置通常仅在重症监护病房可用,操作成本明显较高。使用CarbonCool®套装作为其他冷却方法的辅助,可能是中暑患者快速开始冷却的简单解决方案。
{"title":"Management of heatstroke using the novel, reusable, CarbonCool® suit: a case report","authors":"P. J. M. Tay, A. Ho, N. Shahidah, G. Nadarajan","doi":"10.21037/JECCM-20-107","DOIUrl":"https://doi.org/10.21037/JECCM-20-107","url":null,"abstract":": Heatstroke is a life-threatening condition with high morbidity and mortality. Prompt recognition and institution of cooling measures has been shown to greatly improve outcomes. This is a case report demonstrating the use of a novel cooling suit (CarbonCool ® suit) in a case of exertional heatstroke (EHS). The CarbonCool ® suit is a half-body suit with cooling pads (MPad TM ) that are filled with a graphite water solution found to be 15 times more thermally conductive than ice. In this case report, a previously well 31-year-old male presented to the Emergency Department (ED) with EHS, subsequently requiring intubation. The CarbonCool ® suit was used to reduce his core (rectal) temperature from 41 ℃ to 38.7 ℃ in two hours. Patient’s core temperature subsequently normalized to 37 ℃ and he was discharged well and neurologically intact. The case report demonstrates that the suit can be easily worn and secured in place, while resuscitative measures are ongoing. This reduces the need for constant monitoring and replacement of ice packs, hence serving as a convenient alternative to ice packs for initial management of patients with EHS. While alternative cooling methods such as powered cooling devices may be utilized, these devices are often only available in the intensive care unit, with significantly higher operative costs. Use of the CarbonCool ® suit as an adjunct to other cooling methods may be a simple solution for rapid initiation of cooling in the patient with heatstroke.","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42957905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theophylline toxicity: a case report of an unusual mimicker of septic shock 茶碱毒性:1例不寻常的脓毒性休克模拟物
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-22-10
Rehman Jinah, Jerrold L Perrott, V. Dhingra
{"title":"Theophylline toxicity: a case report of an unusual mimicker of septic shock","authors":"Rehman Jinah, Jerrold L Perrott, V. Dhingra","doi":"10.21037/jeccm-22-10","DOIUrl":"https://doi.org/10.21037/jeccm-22-10","url":null,"abstract":"","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45208115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rescue veno-arterial extracorporeal membrane oxygenation in venlafaxine overdose: a case report 文拉法辛过量静脉-动脉体外膜氧合抢救1例
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-22-2
A. Felix, D. Campbell, M. Neavyn, P. Hackett
{"title":"Rescue veno-arterial extracorporeal membrane oxygenation in venlafaxine overdose: a case report","authors":"A. Felix, D. Campbell, M. Neavyn, P. Hackett","doi":"10.21037/jeccm-22-2","DOIUrl":"https://doi.org/10.21037/jeccm-22-2","url":null,"abstract":"","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44083531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sepsis and acute kidney failure outcomes investigated in a rural, Midwestern population 脓毒症和急性肾衰竭的结果调查在农村,中西部人口
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-21-117
Jenessa Lemon, Quinn Bohn, S. N. Sloan, Greg Stahl, Kerry Johnson, S. Goade, R. Arnce
{"title":"Sepsis and acute kidney failure outcomes investigated in a rural, Midwestern population","authors":"Jenessa Lemon, Quinn Bohn, S. N. Sloan, Greg Stahl, Kerry Johnson, S. Goade, R. Arnce","doi":"10.21037/jeccm-21-117","DOIUrl":"https://doi.org/10.21037/jeccm-21-117","url":null,"abstract":"","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41808870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delays in subsequent antibiotic dosing for septic patients undergoing early interhospital transfer 败血症患者早期院间转院后抗生素剂量的延迟
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-21-100
M. Dettmer, Michael D. Miller, Z. Jerusalem, Vase Bari, Gretchen L. Sacha, Alyssa Y. Chen, A. Duggal
{"title":"Delays in subsequent antibiotic dosing for septic patients undergoing early interhospital transfer","authors":"M. Dettmer, Michael D. Miller, Z. Jerusalem, Vase Bari, Gretchen L. Sacha, Alyssa Y. Chen, A. Duggal","doi":"10.21037/jeccm-21-100","DOIUrl":"https://doi.org/10.21037/jeccm-21-100","url":null,"abstract":"","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41525612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of rescue in extremis of mediastinal impalement: more fear than harm 纵隔穿刺抢救一例:恐惧大于伤害
Pub Date : 2021-01-01 DOI: 10.21037/JECCM-20-116
Narindra N. M. Raza manjato, Andriamanantsialonina Andrianony, A. Rabemazava, H. Rakotovao
: Mediastinal impalement by a sharp object is both an extraordinary and fortunately exceptional situation. The cases are infrequently encountered and rarely report in literature because the majority of these patients die in pre-hospital care. In the literature, only a few cases have been published to date. A review of the literature reveals that most patients with mediastinal impalement do not survive or have an unpredictable injury pattern. In this presentation, the authors report a strange case of attempted homicide in the context of family vindictiveness with a sharp knife of a 58-year-old woman was reported. The surgical exploration was chosen, allowing good exposure of the object but no visceral or vascular lesions were observed. The marking hazard we encountered with this observation was that the innominate artery passed through the hole in the tail of the knife, which was already broken at the lower edge without causing any damage to the vessel. Perioperative management may involve multiple surgeons performing simultaneous surgical procedures. The removal of the intra-mediastinal knife is a delicate process that requires a careful etiopathogenic analysis of the victim and the intrathoracic impaled object to prevent other damages to the patient. The authors describe an unexpected non-fatal of penetrating intra-mediastinal injury and via a literature review, the tricks and tips of surgical management are discussed in a stable patient.
纵隔被尖锐物体刺穿是一种非常罕见的情况。这些病例很少遇到,也很少在文献中报道,因为大多数患者死于院前护理。在文献中,迄今为止只有少数病例被发表。文献回顾显示,大多数纵隔穿刺患者不能存活或有不可预测的损伤模式。在本报告中,作者报告了一起奇怪的谋杀未遂案件,在家庭报复的背景下,用一把锋利的刀杀害了一名58岁的妇女。选择手术探查,可以很好地暴露物体,但没有观察到内脏或血管病变。我们在这个观察中遇到的标记危险是,无名动脉穿过刀尾的洞,而刀尾的下缘已经断裂,但没有对血管造成任何损害。围手术期管理可能涉及多名外科医生同时进行手术。取出纵隔内刀是一个精细的过程,需要对受害者和胸腔内刺穿的物体进行仔细的病因分析,以防止对患者造成其他伤害。作者描述了一个意外的非致命性穿透纵隔损伤,并通过文献回顾,技巧和技巧的手术管理讨论在一个稳定的病人。
{"title":"A case report of rescue in extremis of mediastinal impalement: more fear than harm","authors":"Narindra N. M. Raza manjato, Andriamanantsialonina Andrianony, A. Rabemazava, H. Rakotovao","doi":"10.21037/JECCM-20-116","DOIUrl":"https://doi.org/10.21037/JECCM-20-116","url":null,"abstract":": Mediastinal impalement by a sharp object is both an extraordinary and fortunately exceptional situation. The cases are infrequently encountered and rarely report in literature because the majority of these patients die in pre-hospital care. In the literature, only a few cases have been published to date. A review of the literature reveals that most patients with mediastinal impalement do not survive or have an unpredictable injury pattern. In this presentation, the authors report a strange case of attempted homicide in the context of family vindictiveness with a sharp knife of a 58-year-old woman was reported. The surgical exploration was chosen, allowing good exposure of the object but no visceral or vascular lesions were observed. The marking hazard we encountered with this observation was that the innominate artery passed through the hole in the tail of the knife, which was already broken at the lower edge without causing any damage to the vessel. Perioperative management may involve multiple surgeons performing simultaneous surgical procedures. The removal of the intra-mediastinal knife is a delicate process that requires a careful etiopathogenic analysis of the victim and the intrathoracic impaled object to prevent other damages to the patient. The authors describe an unexpected non-fatal of penetrating intra-mediastinal injury and via a literature review, the tricks and tips of surgical management are discussed in a stable patient.","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42397027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of thiamine on patients with sepsis and septic shock 硫胺素对败血症和感染性休克患者的影响
Pub Date : 2021-01-01 DOI: 10.21037/jeccm-21-74
Yelena Sahakian, D. Dyakov
Background: There is growing evidence that thiamine alone or in combination with vitamin C and steroids may have benefits in patients with sepsis. The purpose of this study is to evaluate the effects of intravenous thiamine following creation of an institutional thiamine guideline for sepsis. Methods: In this biphasic IRB-approved study, the pre-intervention group consisted of patients 18 years or older admitted to a critical care unit with sepsis/septic shock who received intravenous thiamine plus standard care (n=26). In the retrospective phase, they were matched with patients with the same diagnosis who served as a control group (n=26). The primary endpoint was hospital mortality. Secondary endpoints were time to death, critical care length of stay, time to lactate level <2 mmol/L, vasopressor use and duration, renal replacement therapy (RRT) requirement, and PaO 2 /FiO 2 ratio. An evidence-based thiamine guideline for sepsis, standardizing the dose, duration, and time of initiation, was developed and implemented. In the prospective phase, the post-intervention thiamine group was compared with both the pre-intervention thiamine and control groups measuring the same endpoints. Results: In the pre- and post-intervention phase, there was no difference in hospital mortality. However, more patients in the control group required RRT as compared to pre-intervention thiamine group (65.4% vs. 42.3%, P=0.013). The post-intervention thiamine group also showed decreased RRT requirement compared to the control group (36.8% vs. 65.4%, P=0.02). Conclusions: Thiamine did not show hospital mortality benefit. However, it may be considered for use in patients with renal dysfunction. Future studies should further explore renally-protective effects of thiamine.
背景:越来越多的证据表明,硫胺素单独使用或与维生素C和类固醇联合使用可能对败血症患者有益。本研究的目的是在制定机构硫胺素治疗败血症指南后,评估静脉注射硫胺素的效果。方法:在这项经IRB批准的双相研究中,干预前组由18岁或以上的败血症/感染性休克重症监护室患者组成,他们接受了静脉注射硫胺素加标准护理(n=26)。在回顾性阶段,他们与具有相同诊断的患者进行匹配,作为对照组(n=26)。主要终点是住院死亡率。次要终点是死亡时间、重症监护住院时间、乳酸水平<2 mmol/L的时间、血管升压药的使用和持续时间、肾脏替代治疗(RRT)要求和PaO2/FiO2比率。制定并实施了一项基于证据的败血症硫胺素指南,标准化了剂量、持续时间和起始时间。在前瞻性阶段,将干预后硫胺素组与干预前硫胺素和对照组进行比较,测量相同的终点。结果:在干预前和干预后阶段,住院死亡率没有差异。然而,与干预前硫胺素组相比,对照组中需要RRT的患者更多(65.4%对42.3%,P=0.013)。与对照组相比(36.8%对65.4%,P=0.02),干预后硫胺素也显示出RRT需求降低。结论:硫胺素没有显示出医院死亡率的益处。然而,它可以考虑用于肾功能障碍患者。未来的研究应该进一步探索硫胺素对肾脏的保护作用。
{"title":"The effects of thiamine on patients with sepsis and septic shock","authors":"Yelena Sahakian, D. Dyakov","doi":"10.21037/jeccm-21-74","DOIUrl":"https://doi.org/10.21037/jeccm-21-74","url":null,"abstract":"Background: There is growing evidence that thiamine alone or in combination with vitamin C and steroids may have benefits in patients with sepsis. The purpose of this study is to evaluate the effects of intravenous thiamine following creation of an institutional thiamine guideline for sepsis. Methods: In this biphasic IRB-approved study, the pre-intervention group consisted of patients 18 years or older admitted to a critical care unit with sepsis/septic shock who received intravenous thiamine plus standard care (n=26). In the retrospective phase, they were matched with patients with the same diagnosis who served as a control group (n=26). The primary endpoint was hospital mortality. Secondary endpoints were time to death, critical care length of stay, time to lactate level <2 mmol/L, vasopressor use and duration, renal replacement therapy (RRT) requirement, and PaO 2 /FiO 2 ratio. An evidence-based thiamine guideline for sepsis, standardizing the dose, duration, and time of initiation, was developed and implemented. In the prospective phase, the post-intervention thiamine group was compared with both the pre-intervention thiamine and control groups measuring the same endpoints. Results: In the pre- and post-intervention phase, there was no difference in hospital mortality. However, more patients in the control group required RRT as compared to pre-intervention thiamine group (65.4% vs. 42.3%, P=0.013). The post-intervention thiamine group also showed decreased RRT requirement compared to the control group (36.8% vs. 65.4%, P=0.02). Conclusions: Thiamine did not show hospital mortality benefit. However, it may be considered for use in patients with renal dysfunction. Future studies should further explore renally-protective effects of thiamine.","PeriodicalId":73727,"journal":{"name":"Journal of emergency and critical care medicine (Hong Kong, China)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45647877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of emergency and critical care medicine (Hong Kong, China)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1